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1kits (10Vials) .
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▎ Cagrilintide ƒe Dɔwɔɖoɖo
Dzɔtsoƒe: PubChem |
Nusiwo kplɔ wo nɔewo ɖo: Pyr-KCNTATCATQRLAEFLRHSSNNFGPILPPTNVGSNTP CAS: 1415456-99-3 ƒe xexlẽdzesi Mɔfiame: C 174H 269N 45O 52S2 MW 4409 g/mol |
▎ Cagrilintide Ŋuti Numekuku
Nukae nye numekuku si wowɔ le Cagrilintide ŋu?
Cagrilintide nye dual amylin kple calcitonin receptor agonist (DACRA) si wotu ɖe amylin ƒe wɔwɔme dzi. Dɔgbo ƒe ƒukpo β lãmenugbagbeviwoe ɖea amylin ɖe go eye wòwɔa dɔ aduadu kple insulin tsɔ wɔa ŋutilã ƒe dɔwɔwɔ vovovowo. Ate ŋu ana woase le wo ɖokui me be yeɖi ƒo eye wòaɖe nuɖuɖu dzi akpɔtɔ, vevietɔ to lãmenugbagbevi siwo le nuto si le postrema megbe le ʋuka enelia ƒe gɔme la ƒe dɔwɔwɔ me. Ahɔhɔ̃mekawo ƒe dzesiawo toa ʋuka ɖekaɖeka ƒe nucleus me yia ŋgɔgbe ahɔhɔ̃a me eye woate ŋu atsɔ wo ayi axadzi hypothalamic nuto kple nuklia ƒuƒoƒo bubuwo hã to axadzi parabrachial nucleus dzi, si wɔnɛ be dzidzeme ƒe titina doa dzidzɔ na ame eye wòxea mɔ na nuɖuɖu ɖuɖu [1] . Amylin ateŋu aɖɔ sukli ƒe homeostasis hã ɖo to mɔxexe ɖe insulin kple glucagon ƒe dodo nu be sukli ƒe agbɔsɔsɔ le ʋu me nali ke [2] . Eƒe mɔnuwo dometɔ aɖewoe nye ŋusẽ si wòkpɔna ɖe dɔgboa ƒe ƒukpo α lãmenugbagbeviwo dzi tẽ eye wòkpɔa glucagon ƒe dodo dzi tẽ to ahɔhɔ̃mekawo ƒe dzesi siwo le hypothalamus me dzi. Le dɔnɔ siwo ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ le lãmenugbagbeviwo me gome la, β lãmenugbagbeviwo ƒe tsɔtsrɔ̃ nana amylin ƒe dodo dzi ɖena kpɔtɔna. Amylin kpɔa gome le sukli ƒe homeostasis ƒe ɖoɖowɔwɔ me to mɔxexe ɖe dɔgboa ƒe ƒuƒlu kple aklã me sukli ƒe wɔwɔ le nuɖuɖu megbe nu, si ɖea sukli ƒe tɔtrɔ le ʋu me le nuɖuɖu megbe dzi kpɔtɔna. Ate ŋu ahe dɔgboa ƒe ƒuƒlu hã ɖe megbe, axe mɔ ɖe dɔgboa ƒe ʋuʋu nu, ana nuɖuɖu nanɔ anyi didi, eye wòaxe mɔ ɖe sukli ƒe dzidziɖedzi gã aɖe nu le ʋu me. Gake dzɔdzɔme amylin ƒe afã ƒe agbenɔƒe kpui la xea mɔ na eƒe zazã le atikewɔnyawo me. Togbɔ be pramlintide li abe atike si kpena ɖe ame ŋu ene hã la, ebia be woadoe zi etɔ̃ gbesiagbe, si mebɔ o eye wònana womewɔa sea dzi nyuie o [3] . Be woakpɔ nya sia gbɔ la, woto Cagrilintide vɛ. Wotu eƒe numekuku kple ewɔwɔ ɖe dzɔdzɔme amylin ƒe ŋutilã me dɔwɔwɔwo gɔmesese deto dzi, eye woƒe taɖodzinue nye be woasrɔ̃ eƒe dɔwɔwɔ ƒe mɔnu esime wòle atike la ƒe liƒo kple eƒe dɔwɔwɔ ɣeyiɣi didi ƒe nɔnɔmewo nyom ɖe edzi be wòakpɔ dɔdamɔnu ƒe nuhiahiãwo gbɔ.
Nukae nye Cagrilintide?
Cagrilintide nye amylin ƒe nɔnɔmetata yeye si wɔa dɔ ɣeyiɣi didi si ŋu ŋutete gã aɖe le, elabena eɖee fia xoxo be ewɔa dɔ nyuie le gɔmedzedzea me le lolo akpa kple lãmenugbagbeviwo ƒe dɔwɔwɔ dada me. Wotsɔ ami de eme eye nɔnɔme siwo li ke eye wòwɔa dɔ ɣeyiɣi didi le esi [3] . Dɔgbo ƒe β lãmenugbagbeviwo ɖea amylin ɖe go ɖekae kple insulin eye wònana wosena le wo ɖokui me be yeɖi ƒo to dɔwɔwɔ ɖe ahɔhɔ̃a ƒe akpa siwo nye homeostatic kple vivisese dzi. Abe nusi sɔ kple esia ene la, Cagrilintide ate ŋu asrɔ̃ ŋusẽkpɔɖeamedzi sia, si ana ame naɖi ƒo be wòakpe ɖe ame ŋu wòaɖu ame ƒe kpekpeme dzi. Le ɣeyiɣi ma ke me la, abe dual amylin kple calcitonin receptor agonist (DACRA) ene la, woɖenɛ tso amylin ƒe megbeƒu me eye mɔnu tɔxɛ aɖe le esi le lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe ɖoɖowɔwɔ me.
Cagrinlintide ƒe xɔtuɖoɖo ƒe kpɔɖeŋu
Dzɔtsoƒe:PubMed [3] .
Nukae nye Cagrilintide zazã siwo do ƒome kplii?
Le dɔdamɔnu dodokpɔwo me la, Cagrilintide kpɔ nu nyuiwo le lolo dzi ɖeɖe kpɔtɔ me. Le kpɔɖeŋu me. Kpekpeme si dzi ɖe kpɔtɔ le 4.5 mg ƒe ƒuƒoƒoa hã lolo wu esi nɔ liraglutide 3.0 mg ƒe ƒuƒoƒoa me (10.8% tsɔ wu 9.0%), si ɖee fia be ate ŋu anye tiatia nyui aɖe na lolo dzi kpɔkpɔ [4] . Cagrilintide ƒe dɔwɔwɔ ƒe mɔnu to vovo gake edo ƒome kplii ne wotsɔe sɔ kple GLP-1 receptor agonist semaglutide. Semaglutid ɖea nuɖuɖu ƒe dzodzro dzi kpɔtɔna, dzia insulin ƒe dodo ɖe ŋgɔ, eye wòhea dɔgboa ƒe tsi ƒuƒlu ɖe megbe to dɔwɔwɔ ɖe GLP-1 xɔla siwo le hypothalamus me dzi, gake Cagrilintide ya ɖea nuɖuɖu ƒe dzodzro dzi kpɔtɔna ɖe edzi to amylin xɔla ƒe dɔwɔwɔ me. Wo ame evea zazã ɖekae ate ŋu ana woawɔ dɔ ɖe wo nɔewo dzi, si ana lolo dzi ɖeɖe kpɔtɔ ƒe ŋusẽkpɔɖeamedzia nadzi ɖe edzi ŋutɔ [5] . Ne míebu alesi lolo akpa sesẽe ta la, atikewɔwɔ sia si wotsɔ ƒo ƒui nye mɔnu si me susu le eye wòwɔa dɔ nyuie.
Le dɔnɔ siwo ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ƒomevi 2 le gome la, Cagrilintide ɖe ʋumesukli dzi ɖuɖu ƒe ŋutete nyui hã fia. Dɔdaƒewo ƒe numekukuwo ɖee fia be eli ke nyuie eye wòwɔa dɔ nyuie le lolo akpa kple lãmenugbagbeviwo ƒe dɔwɔwɔ ƒomevi 2 dada me. Le kpɔɖeŋu . me Dodokpɔ bubu hã ɖe eƒe mɔɖeɖe ɖe nu ŋu nyuie kple dedienɔnɔ fia ne wozãe ɖeɖe alo wotsɔe kpe ɖe semaglutide ŋu [6] , elabena atike la ƒe liƒo do ƒome kplikplikpli kple eƒe mɔɖeɖe ɖe nu ŋu kple eƒe dedienɔnɔ.
Tsɔ kpe ɖe eŋu la, woɖe mɔ ɖe Cagrilintide ŋu nyuie le dɔdamɔnu dodokpɔwo me. Le Akpa 2 ƒe agbɔsɔsɔme didi dodokpɔ me la, alesi wodzudzɔ atikeawo zazã tegbee le atikewɔwɔ ƒe hatsotso ɖesiaɖe me sɔ, eye woƒe akpa gãtɔ tso nu gbegblẽ siwo do mo ɖa gbɔ. Gake nu gbegblẽ siwo bɔ wue nye dɔgbo ƒe dɔlélewo kple alesi wodoa atike na ame le, eye wo dometɔ akpa gãtɔ mesẽna o va ɖo esiwo mesẽ o. Le Akpa 1b dodokpɔ si wowɔ le vome, si dzi wokpɔ ŋusẽ ɖo me la, Cagrilintide kple semaglutide mg 2.4 ƒe atikewɔwɔ ƒokpli hã ɖee fia be woate ŋu alɔ̃ ɖe edzi nyuie eye wole dedie [7] . Dodokpɔ gãwo kple esiwo axɔ ɣeyiɣi didi wu hiã le etsɔme be woatsɔ ada atikewɔwɔ sia si wotsɔ ƒo ƒui ƒe dɔwɔwɔ kple dedienɔnɔ kpɔ bliboe.
Cagrilintide hea mɔkpɔkpɔ yeye vɛ na lolo akpa kple lãmenugbagbeviwo ƒe dɔwɔwɔ ƒomevi 2 dada. Enaa atikewɔmɔnu yeye aɖe dɔnɔ siwo lolo akpa, vevietɔ amesiwo mewɔa nu nyuie ɖe agbenɔnɔ ƒe nudede nyawo me ŋu o eye womesɔ na amekoko si me woɖea ʋu le o. Eƒe dɔwɔwɔ ƒe mɔnu tɔxɛa naa susu yeyewo kple mɔnu yeyewo hena lolo akpa dada, eye ateŋu akpɔ viɖe geɖe wu lolo dzi ɖeɖe kpɔtɔ ƒe atike xoxowo (D'Ascanio AM, 2024). Cagrilintide kple semaglutide (CagriSema) zazã ɖekae ƒe nya si kpɔ dzidzedze ɖee fia be atikewɔwɔ ƒokpli si me wozãa taɖodzinu geɖe le nye mɔnu nyui aɖe si dzi woato ana atikewɔwɔ ƒe ŋuɖoɖo na lolo akpa nanyo ɖe edzi [6] . Kpɔɖeŋu sia naa kpɔɖeŋu yeye aɖe le lolo akpa dzi kpɔkpɔ me eye wòhea lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe ŋgɔyiyi ɖedzesiwo hã vɛ na dɔnɔ siwo ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ƒomevi 2 le.
Le nyataƒoƒo me la, abe amylin ƒe nɔnɔmetata yeye si wɔa dɔ ɣeyiɣi didi ene la, ŋutete gã aɖe le Cagrilintide ŋu be wòaɖe lolo dzi akpɔtɔ eye wòaɖu sukli si le ʋu me dzi. Enaa dzidzeme ƒe dzesimɔa wɔa dɔ to amylin ƒe dɔwɔwɔ sɔsrɔ̃ me eye wòɖɔa lãmenugbagbeviwo ƒe dɔwɔwɔ ɖo abe dual receptor agonist ene. Dɔdamɔnu dodokpɔwo ɖee fia be Cagrilintide, eya ɖeka alo ne wotsɔe kpe ɖe semaglutide ŋu, ate ŋu aɖe ame ƒe kpekpeme dzi akpɔtɔ ŋutɔ eye woɖea mɔ ɖe eŋu nyuie. Tsɔ kpe ɖe eŋu la, eɖe ʋumesukli dzi ɖuɖu ƒe ŋutete nyui hã fia le dɔnɔ siwo ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ƒomevi 2 lia ŋu, si na atikewɔwɔ ƒe tiatia yeye aɖe hena lolo akpa kple lãmenugbagbeviwo ƒe dɔwɔwɔ dada, si na vovototo si le atikewɔwɔmɔnu siwo li fifia me, vevietɔ na dɔnɔ siwo mewɔa nu nyuie ɖe agbenɔnɔ ƒe nudede nyawo me o eye womesɔ na amekoko o. Eƒe atikewɔwɔmɔnu si me wozãa taɖodzinu geɖe le la naa susu yeyewo le lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dɔlélewo dzi kpɔkpɔ ŋu.
Le Agbalẽŋlɔla La Ŋu
Nusiwo míeyɔ ɖe etame la katã nye esiwo ŋu Cocer Peptides wɔ numekuku le, trɔ asi le wo ŋu eye woƒo wo nu ƒu.
Dzɔdzɔmeŋutinunya ƒe Agbalẽŋlɔla
Ðɔkta D. C. W. Lau nye nufialagã le Cumming Atikewɔwɔ Suku, Calgary Yunivɛsiti, Canada. Eƒe numekukuwo ku ɖe lãmenugbagbeviwo ƒe dɔwɔwɔ kple lãmenugbagbeviwo ƒe dɔwɔwɔ, atikewɔwɔ bliboa kple ememe, dzitodzito kple dzitodzito, dukɔa ƒe lãmesẽ, nutome kple dɔwɔƒe ƒe lãmesẽ, kpakple kansa ŋuti nunya ŋu. Exɔ ɖoƒewo hã le Alberta Lãmesẽnyawo Gbɔkpɔha (AHS) kple Obesity Canada eye wòwɔa dɔ le Julia McFarlane Metabolism Research Centre. Nuteƒekpɔkpɔ geɖe le Ðɔkta Lau si le lãmenugbagbeviwo ƒe dɔwɔwɔ kple lolo akpa ŋuti numekukuwo me, eye wota eƒe dɔa ɖe agbalẽnyalawo ƒe magazinewo abe Canadian Journal of Metabolism ene me. Woŋlɔ Ðɔkta DCW ŋkɔ ɖe nyayɔyɔ ƒe nyatakaka me [4].
