Kagrilintidi miligaramu 10

▎ Kagrilintide (Kagrilintide) jɔcogo

▎ Kagrilintide ɲinini

Cagrilintide ka ɲininiw kɛcogo ye mun ye?

Kagrilintidi ye amilini ni kalisitɔni minɛbaga fila ye (DACRA) min dilannen don ka da amilini sigicogo kan. Amilini bɛ bɔ pankreyasi gun β selilɛriw fɛ ani a bɛ baara kɛ ɲɔgɔn fɛ ni inisɔndiya ye walasa ka farikoloɲɛnajɛ baara suguya caman kɛ. A bɛ se ka fasa dusukunnata bila mɔgɔ la ani ka dumuni dunta dɔgɔya, kɛrɛnkɛrɛnnenya la ni a bɛ farikolojɔlifɛnw baara yɔrɔ la min bɛ ɲɛgɛnɛsira kɔfɛ ɲɛgɛnɛsira naaninan da la. Senfagabana taamasiɲɛw bɛ taa ɲɛfɛla la ka tɛmɛ ɲɛda kelen na ani u bɛ se ka lase fana ka taa kɔkanna hipotalamu yɔrɔ la ani nukili kulu wɛrɛw la kɛrɛfɛla parabrachial nucleus fɛ, o bɛ fasa yɔrɔ lawulili kɛ ani ka dumuni ^bali dunni Amilini bɛ se fana ka sukaro homeostasis labɛn ni a bɛ inisɔndiya ni sukaro bɔli bali walasa ka sukaro hakɛ sabati joli la ^[2] . A kɛcogo dɔw ye nɔ tilennen ye pankreyasi gun α selilɛriw la ani ka glucagon bɔli ɲɛnabɔ cogo tilennen na ni senfagabana taamasiɲɛw ye hipotalamus kɔnɔ. Sukarodunbana bɛ banabagatɔ minnu na, β selilɛriw tiɲɛni bɛ na ni amilini bɔli dɔgɔyali ye. Amilini bɛ a sen don sukaro homeostase labɛnni na ni a bɛ kɔnɔbara lankolonya ni sugunɛbilenni bɔli bali dumuni kɔfɛ, ka dɔ bɔ joli la sukaro jiginni na dumuni kɔfɛ. A bɛ se fana ka kɔnɔbara lankolonya bila kɔfɛ, ka kɔnɔbara basigilen bali, ka dumuni sigi waati janya, ani ka joli sukaro jiginni jugumanba bali. Nka, amilini nafama tilancɛ waati kunkurunnin bɛ dan a tali ma kɛnɛyaso la. Hali ni pramlintide bɛ sɔrɔ fura dɛmɛnan ye, a bɛ pikiri saba kɛ tile kɔnɔ, o tɛ nɔgɔya, wa a bɛ na ni sariya labatoli jugu ye ^[3] . Walasa ka o ko ɲɛnabɔ, Cagrilintide (Cagrilintide) dabɔra. A ɲininiw n’a yiriwali sinsinnen bɛ amilini nafama farikolo baarakɛcogo faamuyali jugu kan, k’a laɲini k’a kɛcogo ladege ka sɔrɔ ka fura in sabatili n’a baara kuntaalajan ɲɛ walasa ka kɛnɛyaso magow ɲɛ.

Cagrilintide ye mun ye?

Kagrilintidi ye amilini analozi kura ye min bɛ baara kɛ waati jan kɔnɔ, a seko ka bon, a y’a jira kaban ko a bɛ se ka kɛ fasa ni sukarodunbana furakɛli la fɔlɔ. A kɛra tuluma ye ani a bɛ ni jogo sabatilenw ye ani a bɛ baara kɛ waati jan kɔnɔ ^[3] . Amilini ni inisɔndiya bɛ bɔ ɲɔgɔn fɛ pankreyasi β selilɛriw fɛ ani a bɛ fasa dusukunnata bila mɔgɔ la ni a bɛ baara kɛ sugunɛ ka homɛostatiki ni diyanye yɔrɔw la. I n’a fɔ analozi, Cagrilintide bɛ se ka o nɔ in ladege, ka fasa bila mɔgɔ la walasa ka dɛmɛ don ka farikolo girinya kunbɛn. O waati kelen na, i n’a fɔ amilini ni kalisitɔni minɛbaga fila (DACRA), a bɛ bɔ amilini kɔkolo la, wa a kɛcogo kɛrɛnkɛrɛnnen don farikoloɲɛnajɛ labɛnni na.

Cagrinlintide ka sigicogo misali

Source:PubMed ^{[3] Bamako, Mali.}

Cagrilintide kɛcogo minnu bɛ tali kɛ o la, olu ye mun ye?

Kɛnɛyaso sɛgɛsɛgɛliw la, Cagrilintide ye nɔ ɲumanw sɔrɔ ka ɲɛsin mɔgɔ girinya dɔgɔyali ma. Misali la, santiri caman kɔnɔ, min kɛra k’a sɔrɔ a ma kɛ cogo si la, min kɛra ni mɔgɔ fila ye, min kɛra ni furakisɛ ye, ani min bɛ baara kɛ ni a bɛ tali kɛ ɲɔgɔn na Fasa 2 fura tata hakɛ ɲinini sɛgɛsɛgɛli la, ni i ye a suma ni furakisɛ tali kulu ye, Cagrilintide tata hakɛ kulu kelen-kelen bɛɛ la, girinya dɔgɔyali kɛmɛsarada la ka bɔ a daminɛ na (miligaramu 0,3 - 4,5) (6,0% - 10,8%) ka ca ni furakisɛ ta kulu ta ye (3,0%). Kisɛya dɔgɔyali miligaramu 4,5 kulu la fana ka ca ni liraglutidi miligaramu 3,0 kulu ta ye (10,8% ni 9,0%), o b’a jira ko a bɛ se ka kɛ fɛɛrɛ ɲuman ye farikolo girinya ^na kunbɛnni Kagrilintidi ka baarakɛcogo tɛ kelen ye nka a bɛ tali kɛ ɲɔgɔn na ni i ye a suma ni GLP-1 minɛbaga agoniste semaglutide ye. Semaglutidi bɛ dumuni nege dɔgɔya, ka dɔ fara inisɔndiya bɔli kan, ka kɔnɔbara lankolonya bila kɔfɛ ni a bɛ baara kɛ GLP-1 minɛbagaw kan hipotalamus kɔnɔ, ka sɔrɔ Cagrilintide bɛ dumuni nege dɔgɔya ka taa a fɛ ni amilini minɛbaga baara ye. Nin fila ninnu tali faralen ɲɔgɔn kan, o bɛ se ka kɛ sababu ye ka nɔ bila u kan, ka farikolo girinya dɔgɔyali nɔ bonya kosɛbɛ ^[5] . Ni an y’a jateminɛ ko fasa ka gɛlɛn, nin furakɛli faralen ɲɔgɔn kan, o ye fɛɛrɛ ye min bɛnnen don ani min bɛ nɔ bɔ.

Sukarodunbana suguya 2 bɛ banabagatɔ minnu na, Cagrilintide fana ye joli sukaro kunbɛnni seko ɲuman jira. Dɔgɔtɔrɔso ka sɛgɛsɛgɛliw y’a jira ko a sabatili ka ɲi ani a bɛ se ka kɛ fasa ni sukarodunbana suguya 2 furakɛli la. Misali la, sukarodunbana suguya 2 banabagatɔ minnu na, olu ka kɛnɛyako sɛgɛsɛgɛli la, Cagrilintide ni GLP-1 minɛbaga agoniste semaglutide tali faralen ɲɔgɔn kan, o ye joli sukaro kunbɛncogo ɲuman jira ani ka girinya ^dɔgɔya bɛ Kɔrɔbɔli wɛrɛ fana y’a jira ko a muɲuni ka ɲi ani a lakanani ni a kɛra a kelen na walima ni a ni semaglutide faralen don ɲɔgɔn kan ^[6] , barisa fura in sabatili bɛ tali kɛ a muɲuni n’a lakanani na kosɛbɛ.

Ka fara o kan, Cagrilintide muɲuna kosɛbɛ kɛnɛyaso sɛgɛsɛgɛliw la. Fasa 2nan fura tata hakɛ ɲinini sɛgɛsɛgɛli la, furakɛli dabila kudayi hakɛ minnu bɛ furakɛli kulu kelen-kelen bɛɛ la, olu tun bɛ ɲɔgɔn ta, a fanba tun bɛ bɔ ko juguw la. Nka, a kɔlɔlɔ minnu ka teli ka sɔrɔ, olu tun ye kɔnɔboli ye ani pikiri kɛyɔrɔ la, wa u fanba tun ka nɔgɔn fo ka se a danma ma. Fase 1b sɛgɛsɛgɛli la, min kɛra ni mɔgɔw ye, min kɛra ni mɔgɔw ye, Cagrilintide ni semaglutide miligaramu 2,4 furakɛli faralen ɲɔgɔn kan, o fana ye muɲuni ni lakana ɲuman jira ^[7] . Kɔrɔbɔlibaw ni kuntaalajanw ka kan ka kɛ don nataw la walasa ka nin furakɛli faralen in nafa ni a lakanani jateminɛ kosɛbɛ.

Cagrilintide bɛ jigiya kura lase fasa ni sukarodunbana suguya 2 furakɛli ma. A bɛ furakɛli suguya kura di banabagatɔ fasalenw ma, kɛrɛnkɛrɛnnenya la minnu tɛ jaabi ɲuman di ɲɛnamaya kɛcogo fɛɛrɛw ma, wa u ma bɛn bariatric opereli ma. A ka baarakɛcogo kɛrɛnkɛrɛnnen bɛ hakilina kuraw ni fɛɛrɛ kuraw di fasa furakɛli ma, wa a bɛ se ka kɛ ko nafa caman bɛ a la ka tɛmɛ laadala farikolojidɛsɛ furaw kan (D’Ascanio AM, 2024). Cagrilintide ni semaglutide (CagriSema) tali faralen ɲɔgɔn kan, o min ɲɛnabɔra, o b’a jira ko furakɛli faralen ɲɔgɔn kan ni laɲini caman ye, o ye fɛɛrɛ ɲuman ye min bɛ se ka furakɛli jaabi ɲɛ ^la fasa Nin misali in bɛ misali kura di fasa furakɛli ma, wa a bɛ na ni farikoloɲɛnajɛ ɲɛtaa caman ye fana sukarodunbana suguya 2 banabagatɔw ma.

Kuncɛli la, i n’a fɔ amilini analozi kura min bɛ baara kɛ waati jan kɔnɔ, Cagrilintide bɛ se ka mɔgɔ farikolo girinya dɔgɔya ani ka joli sukaro kunbɛn. A bɛ fasa taamasiɲɛ sira baara ni amilini ka baara ladege ye ani ka farikoloɲɛnajɛ labɛn i n’a fɔ agoniste dual receptor. Kɛnɛyaso sɛgɛsɛgɛliw y’a jira ko Cagrilintide, a kelen walima a ni semaglutide faralen ɲɔgɔn kan, o bɛ se ka farikolo girinya dɔgɔya kosɛbɛ, wa a bɛ muɲu kosɛbɛ. Ka fara o kan, a ye joli sukaro kɔlɔsili seko ɲuman jira fana sukarodunbana suguya 2 bɛ banabagatɔ minnu na, ka furakɛli suguya kura di fasa ni sukarodunbana furakɛli ma, ka furakɛli kɛcogo kɔrɔw fa, kɛrɛnkɛrɛnnenya la banabagatɔw ma minnu tɛ jaabi ɲuman di ɲɛnamaya kɛcogo fɛɛrɛw ma, wa u ma bɛn opereli ma. A furakɛli fɛɛrɛ min bɛ kɛ ni laɲini caman ye, o bɛ hakilina kuraw di farikoloɲɛnajɛ banaw furakɛli ma.

A sɛbɛnbaga ko la

Fɛn minnu kofɔlen dòn san fɛ, olu bɛɛ ɲinini Kɛra, k’u Labɛn ani k’u Lajɛ Cocer Peptides fɛ.

Dɔnniya gafe sɛbɛnbaga

Dɔgɔtɔrɔ DCW Lau ye karamɔgɔ ye Cumming furakɛli kalanso la, Calgary Iniwɛrisite la, Kanada. A ka ɲininiw ɲɛsinnen bɛ kɔnɔbara ni farikoloɲɛnajɛ, furakɛli bɛɛjɛfanga ni kɔnɔna furakɛli, dusukun ni jolisiraw ni dusukunnakow, foroba kɛnɛya, sigida ni baarakɛyɔrɔ kɛnɛya, ani kansɛri furakɛli. A bɛ jɔyɔrɔw fana sɔrɔ Alberta Health Services (AHS) ani Obesity Canada la ani a bɛ baara kɛ Julia McFarlane sukarodunbana ɲininikɛyɔrɔ la. Dɔgɔtɔrɔ Lau ka dɔnniya ka bon sukarodunbana ni fasa ɲinini siratigɛ la, a ka baara bɔra kalanko gafew kɔnɔ i n’a fɔ Canadian Journal of Diabetes. Dɔgɔtɔrɔ DCW tɔgɔ sɛbɛnnen bɛ citation (citation) kɔnɔ [4].

▎ Sɛbɛn minnu bɛ tali kɛ o la

[1] Hansen KE, Murali S, Chaves IZ, ani a ɲɔgɔnnaw. Glycomacropeptide bɛ nɔ bila fasa la min bɛ sɔrɔ amilini fɛ, dumuni kɔfɛ taamasiɲɛw minnu bɛ glucose homeostasis jira, ani nɔgɔ mikrobiyɔmu la muso fasalenw na kɔnɔmaya kɔfɛ[J]. Balocogo gafe, 2023,153(7):1915-1929.DOI:10.1016/j.tjnut.2023.03.014.

[2] Ling W, Huang Y, Qiao Y, ani a ɲɔgɔnnaw. Hadamaden ka amilini: Ka bɔ banaw la ka taa farikoloɲɛnajɛ ni furakɛli la[J]. Sisan poroteyini ni peptide dɔnniya, 2019,20(9):944-957.DOI:10.2174/ 13892037206 66 19032811183 3.

[3] Kruse T, Hansen J. L., Dahl K., ani mɔgɔ wɛrɛw. Cagrilintide yiriwali, amilini analogue min bɛ baara kɛ waati jan kɔnɔ[J]. Furakɛcogo gafe, 2021,64(15):11183-11194.DOI:10.1021/acs.jmedchem.1c00565.

[4] Lau D. C. W., Erichsen L., Fransisko A. M., ani a ɲɔgɔnnaw. Kagrilintidi min bɛ di siɲɛ kelen dɔgɔkun o dɔgɔkun walasa ka farikolo girinya kunbɛn mɔgɔ minnu girinya ka ca ani minnu fasalen don: sɛgɛsɛgɛli min kɛra santiri caman na, min kɛra k’a sɔrɔ a ma kɛ cogo si la, min bɛ kɛ ni fiyentɔya fila ye, min bɛ kɛ ni furakisɛ ye ani min bɛ kɛ ni wale ye, a tata hakɛ ɲinini dakun 2nan na[J Lancet, 2021,398(10317):2160-2172.DOI:10.1016/S0140-6736(21)01751-7.

[5] D’Ascanio AM, Mullally JA, Frishman W H. Kagrilintidi: Amilini analozi min bɛ baara kɛ ka mɛn fasa furakɛli kama[J]. Dusukunnata furakɛli lajɛ la, 2024,32(1):83-90.DOI:10.1097/CRD.0000000000000513.

[6] Frias J. P., Deenadayalan S., Erichsen L., ani mɔgɔ wɛrɛw. Kagrilintidi miligaramu 2,4 ni semaglutidi miligaramu 2,4 min bɛ kɛ ɲɔgɔn fɛ dɔgɔkun kɔnɔ siɲɛ kelen dɔgɔkun kɔnɔ, o nafa ni a lakanani sukarodunbana suguya 2 la: sɛgɛsɛgɛli min kɛra santiri caman na, min kɛra k’a sɔrɔ a ma kɛ cogo si la, min kɛra fiyentɔ fila ye, min bɛ kɛ ni wale ye, min kɛra fasa 2nan na[J Lancet, 2023,402(10403):720-730.DOI:10.1016/S0140-6736(23)01163-7.

[7] Enebo L. B., Berthelsen K. K., Kankam M., ani a ɲɔgɔnnaw. Lakanali, muɲuli, furakɛlicogo, ani furakɛlicogo kagrilintidi tata hakɛ caman tali ɲɔgɔn fɛ ni semaglutide miligaramu 2,4 ye farikolo girinya kunbɛnni na: sɛgɛsɛgɛli kɛcogo kɛrɛnkɛrɛnnen, min kɛra ni kɔrɔsili ye, fasa 1b[J Lancet, 2021,397(10286):1736-1748.DOI:10.1016/S0140-6736(21)00845-X. Bamako, Mali.

BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, U BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.  

Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *glasi kɔnɔ*, o kɔrɔ ye gilasi kɔnɔ) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki ka dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.