Cagrilintide 10mg

▎ Hanganga Cagrilintide

▎ Te Rangahau Cagrilintide

He aha te ahuatanga o te rangahau o Cagrilintide?

Ko te Cagrilintide he amylin rua me te calcitonin receptor agonist (DACRA) i whakawhanakehia i runga i te hanganga o te amylin. He mea huna a Amylin e te pancreatic islet β cell me te mahi tahi me te insulin ki te mahi i nga momo mahi tinana. Ka taea e ia te whakapouri i te ahua o te makona me te whakaiti i te kai o te kai, ko te nuinga ma te whakahohe i nga kaiwhakawhiwhi i te waahi postrema i te turanga o te wha o te ventricle. Ka tukuna nga tohu neural ki te roro o mua na roto i te karihi o te waahanga mokemoke, ka taea hoki te tuku ki te rohe hypothalamic lateral me etahi atu roopu karihi ma te parabrachial nucleus lateral, na reira ka whakaihiihi i te pokapū makona me te aukati i te kai kai ^[1] . Ka taea hoki e Amylin te whakahaere i te homeostasis huka ma te aukati i te whakaputanga o te insulin me te glucagon kia mau tonu ai nga taumata huka toto ^[2] . Kei roto i ana tikanga he awenga tika ki nga pūtau α o te motu pancreatic me te ture autaki mo te hunanga glucagon ma nga tohu neural i roto i te hypothalamus. I nga turoro me te mate huka, ko te whakangaromanga o nga pūtau β ka arahi ki te heke o te hunanga amylin. Ka whai waahi a Amylin ki te whakariterite i te homeostasis glucose ma te aukati i te putunga o te kopu me te hanga huka ate ate muri i te kai, te whakaheke i te rerekee o te huka toto postprandial. Ka taea hoki te whakaroa i te puhanga o te kopu, te aukati i te peristalsis gastrointestinal, te whakaroa i te wa noho o te kai, me te aukati i te piki nui o te huka toto. Heoi, ko te haurua poto o te amylin taiao ka whakawhäiti i tana whakamahinga haumanu. Ahakoa kei te waatea te pramlintide hei rongoa taapiri, me toru nga werohanga i ia ra, he mea whakararuraru, he kino te hanganga ture ^[3] . Hei whakatutuki i tenei take, i whakawhanakehia a Cagrillitide. Ko tana rangahau me te whakawhanaketanga i ahu mai i te maaramatanga hohonu ki nga mahi aa-tinana o te amylin maori, e whai ana ki te peehi i tana tikanga mahi i te wa e pai ake ai te pumau me nga ahuatanga roa o te rongoa hei whakatutuki i nga matea haumanu.

He aha te Cagrilintide?

Ko te Cagrilintide he tairitenga amylin kua roa e mahi ana me te kaha nui, na te mea kua kitea te whai huatanga tuatahi ki te rongoa i te momona me te mate huka. Kua lipopihia, kua mau i nga ahuatanga pumau me te mahi roa ^[3] . Ka tukuna tahi a Amylin me te insulin e nga pūtau β pancreatic me te whakaoho i te ahua o te makona ma te mahi ki nga rohe homeostatic me te ngahau o te roro. Ka rite ki te tairitenga, ka taea e Cagrilintide te whakataurite i tenei paanga, ka whakapouri i te makona ki te awhina i te taumaha o te tinana. I te wa ano, hei rua amylin me te calcitonin receptor agonist (DACRA), i ahu mai i te tuara amylin me te whai tikanga ahurei i roto i te whakaritenga metabolic.

Tauira Hanganga o Cagrinlintide

Puna:PubMed ^[3]

He aha nga tono e pa ana ki te Cagrilintide?

I roto i nga whakamatautau haumanu, kua tutuki nga hua pai o te Cagrilintide ki te whakaheke i te taumaha. Hei tauira, i roto i te waahi maha, matapōkere, rua-matapo, placebo-whakahaere, me te whakatairite kaha Wāhanga 2 whakamātautau horopeta-kitenga, whakaritea ki te rōpū placebo, te ōrau toharite o te mate taimaha i te turanga i roto i ia rōpū horopeta o Cagrilintide (0.3 - 4.5 mg) (6.0% - 10.8%) he teitei ake i tera i te roopu placebo. Ko te mate taimaha i roto i te roopu 4.5 mg he nui atu ano i tera i roto i te roopu liraglutide 3.0 mg (10.8% vs. 9.0%), e tohu ana ka taea te whai hua mo te whakahaere taumaha ^[4] . He rereke te tikanga o te mahi a Cagrilintide engari he rite ki te GLP-1 agonist agonist semaglutide. Ka whakaitihia e te Semaglutid te hiahia, te whakanui ake i te hunanga o te insulin, me te whakaroa i te waatea o te kopu ma te mahi i runga i nga kaiwhakawhiwhi GLP-1 i roto i te hypothalamus, i te mea ka whakaitihia e Cagrilintide te hiahia ma te whakahohe i te kaitautoko amylin. Ko te whakakotahitanga o nga mea e rua ka taea te whakaputa i te paanga o runga, ka tino whakanui ake i te paanga o te mate taimaha ^[5] . I runga i te uaua o te momona, ko tenei maimoatanga whakakotahi he rautaki whaitake me te whai hua.

I nga turoro me te mate huka momo 2, kua whakaatuhia ano e te Cagrilintide te kaha ki te whakahaere i te huka toto. Kua whakaatuhia e nga rangahau haumanu he pai te pumau me te whai hua ki te maimoatanga o te momona me te mate huka momo 2. Hei tauira, i roto i te whakamatautau haumanu o nga turoro me te mate huka momo 2, ko te whakakotahitanga o te Cagrilintide me te GLP-1 agonist agonist semaglutide i whakaatu he pai te whakahaere o te huka toto me nga paanga o te taumaha ^[6] . Ko tetahi atu whakamatautau i whakaatu ano i tana pai me te haumaru i te wa e whakamahia ana anake, i te whakakotahi ranei me te semaglutide ^[6] , na te mea ko te pumau o te rongoa e hono tata ana ki tona kaha me te haumaru.

I tua atu, ko te Cagrilintide he pai te whakamana i nga whakamatautau haumanu. I te Wāhanga 2 whakamätautau horopeta, he rite tonu nga reiti whakamutu i ia röpü maimoatanga, i te nuinga o ngä take kino. Heoi, ko te nuinga o nga mate kino ko nga mate gastrointestinal me nga tauhohenga o te waahi werohia, a ko te nuinga he ngawari ki te ngawari. I roto i te whakamatautauranga o te Waahanga 1b kua whakatauhia, ko te maimoatanga whakakotahi o Cagrilintide me te 2.4 mg semaglutide i whakaatu hoki i te pai o te manawanui me te haumaru ^[7] . Ko nga whakamatautau nui-nui me te wa-roa e hiahiatia ana a muri ake nei ki te arotake matawhānui i te whaihua me te haumaru o tenei maimoatanga whakakotahi.

Ka kawea mai e Cagrilintide te tumanako hou mo te maimoatanga o te momona me te mate huka momo 2. Ka whakaratohia he whiringa maimoatanga hou mo nga turoro momomo, ina koa ko te hunga kaore i te pai te aro ki nga momo noho, kaore hoki e pai mo te pokanga bariatric. Ko tana mahi ahurei e whakarato ana i nga whakaaro me nga tikanga hou mo te maimoatanga o te momona, a ka nui ake pea nga painga atu i nga raau taero whakaheke taumaha (D'Ascanio AM, 2024). Ko te take angitu o te whakamahinga whakakotahi o Cagrilintide me te semaglutide (CagriSema) e whakaatu ana ko te maimoatanga whakakotahi maha-whaainga he rautaki whai hua hei whakapai ake i te urupare maimoatanga mo te mate nui ^[6] . He tauira hou tenei tauira mo te whakahaeretanga o te momona, me te kawe mai i nga whakapainga nui mo nga turoro mate huka momo 2.

Hei whakamutunga, hei pukapuka tairitenga amylin roa, he nui te kaha o Cagrilintide mo te whakaheke taumaha me te whakahaere i te huka toto. Ka whakahoahohia te ara tohu karekau ma te peehi i te mahi a te amylin me te whakahaere i te paopaotanga hei agonist kaikawe rua. Kua whakaatuhia e nga whakamatautau haumanu ko te Cagrilintide, ko ia anake, ko te whakakotahitanga ranei me te semaglutide, ka taea te whakaiti i te taumaha o te tinana me te pai te whakamanawanui. I tua atu, kua whakaatu hoki i te pai o te kaha ki te whakahaere i te huka toto i roto i nga turoro me te mate huka momo 2, e whakarato ana i tetahi waahanga maimoatanga hou mo te maimoatanga o te nui me te mate huka, te whakakii i te waahi i roto i nga tikanga maimoatanga o naianei, ina koa mo nga turoro kaore i te pai te urupare ki nga mahi oranga me te kore e pai mo te pokanga. Ko tana rautaki maimoatanga maha-whaainga e whakarato ana i nga whakaaro hou mo te whakahaere i nga mate metabolic.

Mō te Kaituhi

Ko nga mea kua whakahuatia ake nei he mea rangahau, he whakatika, he whakahiato e Cocer Peptides.

Kaituhi Putaiao Putaiao

Ko Dr. DCW Lau he ahorangi i te Kura Rongoa Cumming, Te Whare Wananga o Calgary, Kanata. Ko ana hiahia rangahau ko te endocrinology me te metabolism, te rongoa whanui me te roto, te punaha ngakau me te ngakau, te hauora o te iwi, te hauora taiao me te mahi, me te oncology. Kei a ia ano nga tuunga ki Alberta Health Services (AHS) me Obesity Canada me te mahi i te Julia McFarlane Diabetes Research Centre. He nui nga wheako o Takuta Lau i roto i nga rangahau mo te mate huka me te momi, me ana mahi i taia ki roto i nga hautaka matauranga penei i te Canadian Journal of Diabetes. Kua whakarārangihia a Tākuta DCW ki te tohutoro o te whakahuatanga [4].

▎ Nga Tohutoro Tikanga

[1] Hansen KE, Murali S, Chaves IZ, et al. Ko te Glycomacropeptide ka pa ki te Amylin-Mediated Satiety, Postprandial Markers of Glucose Homeostasis, and the Fecal Microbiome in Obese Postmenopausal Women[J]. Journal of Nutrition, 2023,153(7):1915-1929.DOI:10.1016/j.tjnut.2023.03.014.

[2] Ling W, Huang Y, Qiao Y, et al. Amylin Tangata: Mai i te Pathology to Physiology and Pharmacology[J]. Pūtaiao Pūmua & Peptide o nāianei, 2019,20(9):944-957.DOI:10.2174/ 13892037206 66 19032811183 3.

[3] Kruse T, Hansen JL, Dahl K, et al. Te Whakawhanaketanga o Cagrilintide, he Amylin Analogue [J]. Journal of Medicinal Chemistry, 2021,64(15):11183-11194.DOI:10.1021/acs.jmedchem.1c00565.

[4] Lau DCW, Erichsen L, Francisco AM, et al. Ko te cagrilintide kotahi-wiki mo te whakahaere taumaha i roto i nga tangata e pa ana ki te taumaha me te nui o te taumaha: he waahi maha, matapōkeretia, rua-matapo, placebo-whakahaere me te kaha-whakahaere, horopeta-kitenga waahanga 2 whakamatautau [J]. Lancet, 2021,398(10317):2160-2172.DOI:10.1016/S0140-6736(21)01751-7.

[5] D'Ascanio AM, Mullally JA, Frishman W H. Cagrilintide: He Taapiri Amylin Roa mo te Maimoatanga o te Momona[J]. Cardiology in Review, 2024,32(1):83-90.DOI:10.1097/CRD.0000000000000513.

[6] Frias JP, Deenadayalan S, Erichsen L, et al. Te whaihua me te haumaru o te cagrilintide kotahi-wiki ia wiki 2.4 mg me te semaglutide 2.4 mg kotahi-wiki i roto i te momo mate huka momo 2: he multicentre, matapōkeretia, rua-matapo, kaha-whakahaere, waahanga 2 whakamatautau [J]. Lancet, 2023,402(10403):720-730.DOI:10.1016/S0140-6736(23)01163-7.

[7] Enebo LB, Berthelsen KK, Kankam M, et al. Ko te haumaru, te manawanui, te pharmacokinetics, me te pharmacodynamics o te whakahaere i nga wa maha o te cagrilintide me te semaglutide 2.4 mg mo te whakahaere taimaha: he waahi matapōkere, whakahaere, waahanga 1b whakamatautau [J]. Lancet, 2021,397(10286):1736-1748.DOI:10.1016/S0140-6736(21)00845-X.

KATOA KATOA ME NGA WHAKAMAHI KAUPAPA I TE WHAKAMAHI KI TENEI PAE WEHI HEI WHAKAMAHI MO TE WHAKAMAHI MAHI ME TE WHAKAMAHI MAHI.  

Ko nga hua e whakaratohia ana i runga i tenei paetukutuku he mea mo te rangahau in vitro anake. Ko te rangahau in vitro (Latin: *i roto i te karaihe*, te tikanga i roto i te karaihe) ka whakahaerehia i waho o te tinana o te tangata. Ko enei hua ehara i te rongoa, kaore ano kia whakaaetia e te US Food and Drug Administration (FDA), me kaua e whakamahia hei aukati, hei rongoa, hei whakaora ranei i tetahi mate, mate, mate ranei. Ka tino whakakorehia e te ture te whakauru i enei hua ki roto i te tinana tangata, kararehe ranei ahakoa te ahua.