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BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, U BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.
Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *glasi kɔnɔ*, o kɔrɔ ye gilasi kɔnɔ) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki ka dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.
Kuma bɛɛ lajɛlen
Ninakili kɛnɛya ye ɲininiw yɔrɔba ye kabini tuma jan furakɛli ni ɲɛnamaya dɔnniya siratigɛ la. Ni an ka ɲɛnamaya gundo faamuyali bɛ ka bonya, fɛn suguya caman jɔyɔrɔ minnu bɛ ninakili farikolo baarakɛcogo ɲuman sabatili la ani banaw daminɛni n’u taabolo la, olu ɲɛfɔra dɔɔnin dɔɔnin. Jɛɲɔgɔnya min bɛ Bronchogen ni ninakili kɛnɛya cɛ, o tɛ farikoloɲɛnajɛ kɛcogo jɔnjɔnw dɔrɔn de ye, nka a ni ninakilibana suguya caman ka bana kɛcogo fana bɛ tali kɛ ɲɔgɔn na kosɛbɛ.
Bronchogen ka ɲɛnamaya kɛcogo
(1) Jagokɛyɔrɔ cogoyaw
Bronchogène bɛ ni molekiyɔmu jɔcogo kɛrɛnkɛrɛnnen ye. Baarakɛyɔrɔ kɛrɛnkɛrɛnnenw bɛ a kɔnɔ minnu bɛ u sen don jɛɲɔgɔnyaw la ni biyomolekuli wɛrɛw ye, i n’a fɔ a sirili selilɛri sanfɛla minɛbagaw la ani ka farikolojɔlifɛnw dɔn minnu bɛ tali kɛ selilu kɔnɔ taamasiɲɛw siraw la. O sigicogo in de bɛ kɛ a ka ɲɛnamaya baarakɛcogo basigi ye, k’a laɲini yɔrɔw n’a kɛcogo jira ninakiliyɔrɔ kɔnɔ.
(2) Sɔrɔyɔrɔw ani u jɛnsɛnni
Farikolo kɔnɔ, Bronchogen sɔrɔyɔrɔ caman bɛ a la. A bɛ se ka kɛ ka a bɔ sigida farikolokisɛw fɛ ninakiliyɔrɔ la, i n’a fɔ ninakilidegunw ni farikolo tangalanw. O farikolokisɛw bɛ jɛnɛya minnu bɛ tali kɛ o la, olu jirali baara kɛ ka kɛɲɛ ni fɛn kɛrɛnkɛrɛnnenw ye minnu bɛ mɔgɔ bila ka wuli, o la, Bronchogen bɛ kɛ. Bronchogène fana bɛ se ka taa ninakiliyɔrɔ la joli fɛ ka bɔ farikolo yɔrɔ wɛrɛw ni farikolo yɔrɔ wɛrɛw la. A jɛnsɛnni siratigɛ la, Bronchogène bɛ sɔrɔ hakɛ dɔw la ninakiliyɔrɔ bɛɛ la, i n’a fɔ nugulatumu, nugulatumu, fiɲɛbɔyɔrɔ, sɔgɔsɔgɔninjɛ ani ɲɛgɛnɛsira. Bronchogène hakɛ bɛ se ka ɲɔgɔn ta yɔrɔ wɛrɛw la ka da sigida farikolo baarakɛcogo ni bana cogoyaw kan. O tilali cogoya in bɛ tali kɛ kosɛbɛ ninakiliyɔrɔ farikolo baarakɛyɔrɔw la ani banaw ka teli ka kɛ yɔrɔ minnu na.
Bronchogène jɔyɔrɔ ninakilila farikoloɲɛnajɛ baarakɛcogo la
(1) Banakisɛfagalanw ka nɔ bila
Banakisɛfagalanw ka baarakɛcogo ɲɛnabɔli
Bronchogène bɛ se ka farikolo tangalanw ka baara ɲɛnabɔ ka ɲɛ ninakiliyɔrɔ kɔnɔ. A bɛ se ka makɔrɔfagaw ka fagositɛri baara bonya, o la, a bɛ fanga di u ka se ka banakisɛw dɔn ani k’u ban. I n’a fɔ ninakilila farikolo tangalan jɔnjɔn, makɔrɔfaga baara min bɛ bonya, o bɛ banakisɛw, banakisɛw ani banakisɛ wɛrɛw bɔli nɔgɔya teliya la, o la, farikolo tangalanw bɛ balansi mara ninakilila la. Bronchogène fana bɛ T lanposotiw ni B lanposotiw danfara ni u caya labɛn, o bɛ nɔ bila farikolo tangacogo kɛrɛnkɛrɛnnenw fanga n’u ɲɛsincogo la. Ni banakisɛfagalanw bɛ u kunbɛn, Bronchogen bɛ se ka T lanposotiw bilasira walasa u ka danfara don u ni ɲɔgɔn cɛ ka kɛ suguya fitininw ye i n’a fɔ Th1 walima Th2, o la, a bɛ a dɔn ni farikolo tangalan jaabi bɛ sɔrɔ selilɛri fɛ walima ni a bɛ kɛ ni humoral ye, o bɛ a to farikolo tangalanw bɛ se ka jaabi fɛɛrɛ ɲumanba ta ka da banakisɛ suguya kan.
Banakisɛfagalanw bɔli ɲɛnabɔli
Banakisɛfagalanw labɛnni waati, Bronchogen fana jɔyɔrɔ ka bon ɲɛnabɔli la farikolo tangalan suguya caman bɔli la. A bɛ se ka banakisɛfagalanw bɔli damatɛmɛ i n’a fɔ interleukins (misali la, IL-1, IL-6) ani tumor necrosis factor (TNF-α). Nin fɛn ninnu bɛ farikolo tangalanw ta ka taa banakisɛ sɔrɔyɔrɔ la banakisɛ daminɛ na, ka funu jaabi daminɛ, walasa ka banakisɛw ka binkanni kɛlɛ. Bronchogène fana bɛ nin funu dɛmɛnanw bɔli damatɛmɛ, ka a yɛrɛ tanga funu jaabiw ma minnu tɛ se ka kunbɛn, minnu bɛ se ka ninakiliyɔrɔw tiɲɛ. Ka fara o kan, Bronchogen bɛ banakisɛfagalanw bɔli sabati (i n’a fɔ IL-10), minnu bɛ funu kɛlɛli nɔ bila funu kɔfɛ, o bɛ ninakiliyɔrɔw dilancogo nɔgɔya ani ka funu kunbɛnni nɔgɔya, o la, ninakiliyɔrɔ kɔnɔna sigida sabatili bɛ to sen na.
(2) Ninakilidegun yɔrɔw dafalen marali
Ka selilɛriw caya ani ka u dilan
Ninakilidegunbanakisɛw bɛ kɛ ninakilidegun farikolo barikalan fɔlɔ ye, wa u dafalen nafa ka bon kosɛbɛ walasa ka banakisɛw tanga banakisɛw ka don u ma. Bronchogène bɛ ninakilila ɲɛgɛnɛsiralabanaw caya sabati ani ka ɲɛgɛnɛsira tiɲɛnenw dilancogo teliya. Ninakiliyɔrɔ jogin kɔfɛ min bɛ sɔrɔ kɛnɛma fɛnw fɛ (i n’a fɔ sisi walima fɛnɲɛnamafagalanw), Bronchogen bɛ selilɛri kɔnɔ taamasiɲɛw siraw baara, i n’a fɔ MAPK taamasiɲɛw sira ani PI3K-Akt taamasiɲɛw. O sira ninnu baarakɛli bɛ selilɛriw ka ɲɛtaa sabati, o bɛ kɛ sababu ye ka ɲɛgɛnɛsiralabanaw ka se ka bɔ yɔrɔ lafiyalen na ka taa yɔrɔ la min bɛ caya, o bɛ dɔ fara selilu hakɛ kan walasa ka yɔrɔw fa minnu tiɲɛna ani ka ɲɛgɛnɛsiralabanaw dafalen segin.
Selilu ni ɲɔgɔn cɛ jɛɲɔgɔnyaw labɛnni
Ka fara farikolokisɛw caya sabatili kan, Bronchogen fana bɛ a sen don ninakilidegunw ni ɲɔgɔn cɛ jɛɲɔgɔnyaw labɛnni na. Epiteliyali selilɛriw bɛ barika kɛ min bɛ to senna ka tɛmɛ fɛnw fɛ i n’a fɔ ɲɔgɔndan sirilenw ani adherens ɲɔgɔndanw. Bronchogène bɛ se ka nin ɲɔgɔndan furakisɛ ninnu jirali n’u jɛnsɛnni ɲɛnabɔ (i n’a fɔ ocludin ni claudin), ka seliluw ni ɲɔgɔn cɛ jɛɲɔgɔnya sabatili sabati. Ni ninakilidegunbanakisɛw ye banakisɛw sɔrɔ walima ni funu ye u lawuli, farikolokisɛw ni ɲɔgɔn cɛ jɛɲɔgɔnyaw bɛ se ka tiɲɛ, o bɛ na ni barikalan baara dɔgɔyali ye. Bronchogène bɛ se ka o ɲɔgɔndan ninnu dilan joona ani ka barika don u la, ka banakisɛw ni fɛn juguw bali ka don epiteliyali selilɛri la ka don ninakiliyɔrɔ la, o la, ninakiliyɔrɔ farikolo baara bɛ kɛ cogo bɛnnen na.
(3) Fiɲɛbɔyɔrɔw nɔgɔ bɔli ni a bɔli ɲɛnabɔli
Nɔgɔ bɔli ɲɛnabɔli
Fiɲɛbɔyɔrɔ nɔgɔ ye ninakilila lafasalifɛn nafamaba ye, a bɛ se ka banakisɛw, buguri ani dunan fɛn wɛrɛw minɛ minnu bɛ fiyɛ ani ka u bɔ yen. Bronchogène jɔyɔrɔ ka bon kosɛbɛ fiɲɛbɔyɔrɔw nɔgɔ bɔli la. A bɛ o sɔrɔ ni a sirili ye ninakilidegunw sanfɛyɔrɔw la, ka taamasiɲɛw siraw baara, ka mucin jamu jirali ni nɔgɔ bɔli ni a bɔli labɛn nɔgɔ bɔli seliluw kɔnɔ (i n’a fɔ goblet cellules). Nɔgɔ bɔli bɛnnen nafa ka bon kosɛbɛ ninakilidegun ni farikolo tangacogo ɲuman sabatili la. Bronchogène bɛ nɔgɔ bɔli hakɛ labɛn tigitigi ka kɛɲɛ ni ninakiliyɔrɔ farikolo magow ye, o b’a to nɔgɔ bɛ dunan fɛnɲɛnamafagalanw minɛ ka ɲɛ k’a sɔrɔ a ma fiɲɛbɔyɔrɔw bali ka a sababu kɛ a bɔli kojugu ye.
Mucus Clearance (Nɔgɔ bɔli) Promotion
Ka fara nɔgɔ bɔli kan, Bronchogen bɛ nɔgɔ bɔli fana sabati fiɲɛbɔyɔrɔw la. A bɛ dɔ fara sɔgɔsɔgɔninjɛ gosili caya ni a bonya kan ninakiliyɔrɔ la. Ni ninakiliyɔrɔ 'sweepers' bɛ kɛ cogo min na, cilia ka fɔlikan bɛ nɔgɔ ni a bɛ taa ni dunanfɛn minnu ye ka taa fiɲɛbɔyɔrɔ da la, o bɛ bɔ farikolo la sɔgɔsɔgɔ walima fɛɛrɛ wɛrɛw fɛ. Bronchogène bɛ sɔgɔsɔgɔninjɛ lamagacogo ɲɛ ni a bɛ nɔ bila ionw siraw ni taamasiɲɛw siraw la ciliated cellules kɔnɔ, i n’a fɔ ka kalisiyɔmu ionw hakɛ labɛn ani ka protéine kinases baara, o la, a bɛ nɔgɔ bɔli kɛcogo ɲɛ ani ka fiɲɛbɔyɔrɔw dabɔli sabati.
Jɛkulu min bɛ Bronchogène ni ninakilibanaw cɛ
(1) Sɔgɔsɔgɔninjɛ
Yɛlɛma donna sɔgɔsɔgɔninjɛ hakɛ la sɔgɔsɔgɔninjɛ banabagatɔw la
Sɔgɔsɔgɔninjɛ banabagatɔw la, a ka ca a la, fɛn caman bɛ Changé Bronchogène hakɛ ni a baarakɛcogo la. Kɔlɔsili dɔw y’a jira ko sɔgɔsɔgɔninjɛ waati, Bronchogène hakɛ bɛ se ka caya walima ka dɔgɔya cogo la min tɛ bɛn. Sɔgɔsɔgɔninjɛ jugumanba dɔw la, Bronchogène hakɛ bɛ fiɲɛbɔyɔrɔw la, o hakɛ ka dɔgɔn kosɛbɛ ka tɛmɛ mɔgɔ kɛnɛmanw kan, o bɛ se ka kɛ sababu ye ka fiɲɛbɔyɔrɔw tiɲɛni kɛ, o bɛ na ni Bronchogène sɔrɔli ni a bɔli dɔgɔyali ye. Sɔgɔsɔgɔninjɛbanabagatɔ dɔw la, hali ni Bronchogène hakɛ bɛ se ka to fiɲɛbɔyɔrɔw la, baarakɛcogo jateminɛw b’a jira ko seko dɔgɔyara ka farikolo tangalanw ka baara kɛcogo ɲɛnabɔ ani ka banakisɛfagalanw bɔli ɲɛnabɔ, o b’a jira ko Bronchogène ka baara kɛcogo caman Changé sɔgɔsɔgɔninjɛ banabagatɔw la.
Bronchogène jɔyɔrɔ sɔgɔsɔgɔninjɛ banakisɛ sɔrɔli la
Sɔgɔsɔgɔninjɛ banakisɛ sɔrɔcogo siratigɛ la, Bronchogène sen bɛ sira caman na. Banakisɛfagalanw ka baarakɛcogo ɲɛnabɔcogo jugumanba bɛ na ni farikolo tangacogo jugumanba ye faritanabanatɔw la. Sɔgɔsɔgɔninjɛbanatɔw la, Bronchogen baarakɛbaliya bɛ na ni Th2 selilɛriw baarakɛbaliya ye, minnu bɛ sitokini caman bɔ (i n’a fɔ IL-4, IL-5, IL-13, a ɲɔgɔnnaw), O sitokiniw bɛ funubanakisɛw doncogo ni u baaracogo lawuli i n’a fɔ eosinophiles fiɲɛbɔyɔrɔw la, ka fiɲɛbɔyɔrɔw funu ni fiɲɛbɔyɔrɔw daminɛ jaabi caman sɔrɔli. Bronchogen jɔyɔrɔ barika dɔgɔyali ninakilidegunw dafalen sabatili la, o bɛ kɛ sababu ye ka o farikolokisɛw tiɲɛ ka bɔ faritanabanaw ni funu cɛmancɛfɛnw na, o bɛ fiɲɛbɔyɔrɔw funu juguya ka taa a fɛ ani ka fiɲɛbɔyɔrɔw labɛn kokura, o la, a bɛ sɔgɔsɔgɔninjɛ daminɛ ni a taa ɲɛ.
(2) Fogonfogonlabana basigilen (EPOC) .
Bronchogène jogo minnu bɛ Ɲɛgɛnɛsiraw banabagatɔw la
Ɲɛgɛnɛsiraw banabagatɔw ka fiɲɛbɔyɔrɔw la, Bronchogen fana bɛ jogo dɔw jira minnu ni mɔgɔ kɛnɛmanw ta tɛ kelen ye. Ni Ɲɛgɛnɛsiraw bɛ ka taa ɲɛ, Bronchogène hakɛ ni a jɛnsɛnni bɛ Changer fiɲɛbɔyɔrɔw la. Ɲɛgɛnɛsiraw banabagatɔw ka fogonfogon ni fiɲɛbɔyɔrɔw la, Bronchogène hakɛ bɛ se ka dɔgɔya dɔɔni dɔɔni, wa a jirali fiɲɛbɔyɔrɔw la ani farikolo tangalanw na, o bɛ dɔgɔya kosɛbɛ. O fɛn caman bɛ tali kɛ fogonfogon baara dɔgɔyali la ani fiɲɛbɔyɔrɔw funu juguyali la Ɲɛgɛnɛsiraw banabagatɔw la. Bronchogen ka molekiyɔmuw jɔcogo bɛ se ka fɛn caman sɛmɛntiya Ɲɛgɛnɛsiraw banabagatɔw la, o bɛ na ni fɛnɲɛnamaw ka baara dɔgɔyali ye ani ka a ka baara kɛcogo ɲuman tiɲɛ ka taa a fɛ ninakiliyɔrɔ la.
Bronchogène jɔyɔrɔ Ɲɛgɛnɛsiraw ka banaw taabolo la
Bronchogène fana jɔyɔrɔ ka bon Ɲɛgɛnɛsiraw ka banaw taabolo la. Ɲɛgɛnɛsiraw ka bana kunbabaw ye fiɲɛbɔyɔrɔw fununi, nɔgɔ bɔli kojugu, fogonfogonlabana tiɲɛni, ani fiɲɛbɔyɔrɔw labɛncogo kura. K’a sababu kɛ Bronchogen ka farikolo tangacogo ɲɛnabɔli barika dɔgɔyali ye, funu jaabiw bɛ to fiɲɛbɔyɔrɔw la, wa u kunbɛnni ka gɛlɛn. Funubanakisɛw i n’a fɔ neutrophils ani macrophages bɛ dalajɛ ka caya fiɲɛbɔyɔrɔw la, ka funu cɛmancɛfɛnw ni proteases suguya caman bɔ, o bɛ na ni fogonfogon yɔrɔw tiɲɛni ye ani fiɲɛbɔyɔrɔw jɔcogo tiɲɛni. Balanbaliya min bɛ Bronchogen ka fiɲɛbɔyɔrɔw nɔgɔ bɔli ni a bɔli labɛnni na, o bɛ na ni nɔgɔ bɔli ye kojugu ani a bɔli dɔgɔyali, o bɛ fiɲɛbɔyɔrɔw balili juguya ka t’a fɛ. Bronchogen seko dɔgɔyali ka ninakilidegunw dilancogo sabati ani ka seliluw ni ɲɔgɔn cɛ jɛɲɔgɔnyaw sabati, o bɛ fiɲɛbɔyɔrɔw labɛncogo kura teliya, o laban bɛ na ni fogonfogon baara tiɲɛni ye dɔɔni dɔɔni Ɲɛgɛnɛsiraw banabagatɔw la.
(3) Ninakilibanaw
Bronchogène jɔyɔrɔ banakisɛw ka banakisɛw la
Ninakilibanaw waati, Bronchogen bɛ a sen don farikolo farikolo tangacogo la. Ni banakisɛw donna ninakiliyɔrɔ la, Bronchogen bɛ se ka farikolo tangalanw baara, ka dɔ fara u ka dumunikɛcogo ni sitotokisi seko kan banakisɛw kama. Bronchogène fana bɛ farikolo tangalanw bɔli labɛn, ka farikolo tangalanw sigida fitinin dɔ dilan min bɛ se ka banakisɛfagalanw baara. A bɛ se ka banakisɛfagalan pepitiriw jirali sabati, minnu bɛ baara kɛ banakisɛw kan k’u ɲɛsin u ma, ka u ka selilɛriw ni u ka selilɛri kogow tiɲɛ, o la, u bɛ banakisɛw ka bonya ni u bangeli bali. Nka banakisɛ juguman dɔw la, banakisɛw bɛ se ka Bronchogène (Bronchogène) sɔrɔli ni a baara bali, o bɛ na ni farikolo tangacogo dɔgɔyali ye ani ka banakisɛ in kunbɛnni gɛlɛya.
Bronchogène jɔyɔrɔ banakisɛw ka banakisɛw la
Bronchogène fana jɔyɔrɔ ka bon ninakilibanakisɛw la. Banakisɛfagalanw tali daminɛ na, Bronchogène bɛ se ka farikolo tangalanw bangenenw baara (i n’a fɔ dendɛrɛsibanakisɛw ani farikolofagalanw) walasa ka banakisɛfagalanw ka farikolo tangalanw daminɛ. A bɛ banakisɛfagalanw bɔli sabati i n’a fɔ interferon, o bɛ se ka banakisɛw caya ni u jɛnsɛnni bali, ka banakisɛw jɛnsɛnni dan sigi ninakiliyɔrɔ kɔnɔ. Bronchogène fana bɛ farikolo tangalanw ka jaabiw labɛn minnu bɛ se ka ladamu, o bɛ T lanposotiw ni B lanposotiw dɔnni ni u jaabi sabati banakisɛfagalanw na, o bɛ na ni farikolojɔlifɛn kɛrɛnkɛrɛnnenw ni T-cell sitotokisikiw dilanni ye, o la, banakisɛfagalanw bɛ bɔ u la ka ɲɛ.
Kuncɛli
Bronchogène jɔyɔrɔ ka bon ninakili kɛnɛya sabatili la ani ninakilibanaw taabolo la. Ninakilidegun suguya caman na i n’a fɔ sɔgɔsɔgɔninjɛ, Ɲɛgɛnɛsiraw ani ninakilibanaw, Bronchogène hakɛ, a baarakɛcogo ani a jɛnsɛnni bɛ Changé, wa a sen bɛ o bana ninnu ka banakisɛfagalanw na.
Sosow (Sɔrɔyɔrɔw).
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