Cocer Peptides ye ŋlɔe 
ŋkeke 29 enye sia
NYATAKAKAWO KPLE NUSIWO WOTSƆ ƑE NYATAKAKA SIWO KAtã WOÐO LE NYATAKAKADZRAÐOƑE SIA ME LA KPLE NYATAKAKAWO kaka KPLEE NUFIAFIA ƑE TAÐOÐOWO KO.
Wotrɔ asi le atike siwo wona le nyatakakadzraɖoƒe sia ŋu na numekuku le vitro ɖeɖeko. Wowɔa numekuku le vitro (Latingbe me: *le ahuhɔ̃e me*, si gɔmee nye le ahuhɔ̃e me) le amegbetɔ ƒe ŋutilã godo. Atike siawo menye atikewo o, United States ƒe Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) meda asi ɖe wo dzi o, eye mele be woazã wo atsɔ axe mɔ ɖe atikewɔwɔ, dɔléle, alo dɔléle aɖeke nu, adae, alo adae o. Se de se vevie be woatsɔ atike siawo ade amegbetɔ alo lãwo ƒe ŋutilã me le mɔ ɖesiaɖe nu.
Kpɔɖeŋu bliboa
Gbɔgbɔ ƒe lãmesẽ nye nusi ŋu wotsia dzi ɖo le numekuku me le atikewɔwɔ kple agbeŋutinunya me ɣeyiɣi didi aɖee nye sia. Esi míaƒe gɔmesese le agbe ƒe nya ɣaɣlawo ŋu le sesẽm ɖe edzi la, wova le akpa siwo nugbagbevi vovovo siwo wɔa dɔ le gbɔgbɔtsixe ƒe dɔwɔwɔ nyuie me léle ɖe asi me kple le dɔlélewo ƒe gɔmedzedze kple woƒe ŋgɔyiyi me me kɔ vivivi. Menye ɖeko ƒomedodo si le Bronchogen kple gbɔgbɔtsixe ƒe lãmesẽ dome lɔ ŋutilã ƒe dɔwɔwɔ veviwo ɖe eme ko o, ke edo ƒome kplikplikpli kple gbɔgbɔmedɔléle vovovowo ƒe dɔlélenutsiŋutete hã.
Bronchogen ƒe Nu gbagbewo ƒe Nɔnɔmewo
(1) Xɔtuɖoɖo ƒe Nɔnɔmewo
Molekyulã ƒe wɔwɔme tɔxɛ aɖe le bronchogen si. Dɔwɔnu tɔxɛ aɖewo le eme siwo kpɔa gome le kadodo kple nugbagbeŋusẽ bubuwo me, abe alesi wòbla ɖe lãmenugbagbeviwo ƒe lãkusi ƒe yame xɔlawo ŋu kple protein siwo do ƒome kple lãmenugbagbeviwo me dzesimɔwo nyanya ene. Dɔwɔɖoɖo siae nye nusi dzi wotu eƒe nugbagbeŋusẽ ƒe dɔwɔwɔwo ɖo, si fiaa teƒe siwo wòɖo taɖodzinu ɖo kple alesi wòwɔa dɔe le gbɔgbɔtsixe ƒe mɔ̃a me.
(2) Dzɔtsoƒewo Kple Wo Mama
Le ŋutilãa me la, Bronchogen ƒe dzɔtsoƒe vovovowo le eme. Lãmenugbagbevi siwo le gbɔgbɔtsixe me, abe gbɔgbɔtsixe ƒe lãmenugbagbeviwo kple dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ene, ate ŋu awɔe ahaɖee ɖa. Lãmenugbagbevi siawo naa domenyiŋusẽfianu siwo sɔ ƒe ɖeɖefia wɔa dɔ le nusiwo koŋ doa ŋusẽ ame ƒe ŋuɖoɖo me, si wɔnɛ be wowɔa Bronchogen. Woate ŋu atsɔ bronchogen hã ayi gbɔgbɔtsixe me to ʋuka me tso lãkusi kple ŋutinu bubuwo me. Le mama gome la, Bronchogen le agbɔsɔsɔ aɖewo me le gbɔgbɔtsixe ƒe mɔ̃ bliboa me, siwo dometɔ aɖewoe nye no me do, aɖuɖɔtoe, yagbɔgbɔ, aɖuɖɔtoe, kple ʋuka me. Bronchogen ƒe agbɔsɔsɔ ateŋu ato vovo le nuto vovovowo me le nutoa me ƒe ŋutilã ƒe dɔwɔwɔ kple dɔléle ƒe nɔnɔmewo ta. Mama ƒe ɖoɖo sia do ƒome kplikplikpli kple gbɔgbɔtsixe ƒe dɔwɔwɔ ƒe akpa siwo le ŋutilã me kple nuto siwo me dɔlélewo dzɔna le zi geɖe.
Akpa Si Bronchogen Wɔna Le Yagbɔgbɔ ƒe Lãmesẽnyawo Me
(1) Dɔlélenutsiŋutete ƒe Ŋusẽkpɔɖeamedzi
Dɔlélenutsiŋutete ƒe Lãmenugbagbeviwo ƒe Dɔwɔwɔ Dzikpɔkpɔ
Bronchogen ate ŋu aɖɔ dɔlélenutsiŋutete ƒe lãmenugbagbevi siwo le gbɔgbɔtsixe ƒe dɔwɔwɔ me ɖo nyuie. Ate ŋu ana macrophages ƒe phagocytic dɔwɔwɔ nanyo ɖe edzi, si ana woƒe ŋutete be woade dzesi dɔlékuiwo ahaɖe wo ɖa. Esi wònye gbɔgbɔtsixe ƒe dɔlélenutsiŋutete ƒe ametakpɔnu vevi aɖe ta la, macrophage ƒe dɔwɔwɔ si nyo ɖe edzi nana dɔlékui, dɔlékui, kple dɔlékui bubu siwo va dzea wo dzi la ɖeɖeɖa kabakaba nɔa bɔbɔe, si wɔnɛ be dɔlélenutsiŋutete nɔa dadasɔ le gbɔgbɔtsixe me. Bronchogen hã kpɔa T ʋumenugbagbevi dzĩwo kple B ʋumenugbagbevi dzĩwo ƒe vovototodedeameme kple woƒe dzidziɖedzi dzi, si kpɔa ŋusẽ ɖe dɔlélenutsiŋutete ƒe ŋuɖoɖo tɔxɛwo ƒe sesẽme kple mɔfiame dzi. Ne Bronchogen dze ŋgɔ dɔlékuiwo ƒe dɔlékuiwo la, ate ŋu afia mɔ T ʋumenugbagbevi dzĩwo be woato vovo ɖe hatsotso sue vovovowo abe Th1 alo Th2 ene me, si ana woakpɔe ɖa be dɔlélenutsiŋutete ƒe ŋuɖoɖoa tso lãmenugbagbeviwo gbɔ alo humoral gbɔe wòtso, si ana woakpɔ egbɔ be dɔlélenutsiŋutete ate ŋu awɔ ŋuɖoɖo ƒe mɔnu nyuitɔ kekeake si wotu ɖe dɔlékui ƒe ƒomevi dzi.
Dɔlélenutsiŋutete ƒe nusiwo dona le lãme na ame ƒe ɖoɖowɔwɔ
Le dɔlélenutsiŋutete ƒe ɖoɖowɔwɔ me la, Bronchogen hã wɔa akpa vevi aɖe le ɖoɖowɔwɔ me le dɔlélenutsiŋutete ƒe nu vovovowo ƒe dodo me. Ate ŋu ado nusiwo doa ŋusẽ dɔdzẽ abe interleukins (le kpɔɖeŋu me, IL-1, IL-6) kple tumor necrosis factor (TNF-α) ƒe dodo le mɔ si sɔ nu ɖe ŋgɔ. Nu siawo siwo doa alɔ dɔdzẽ la xɔa dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ɖe dɔlékuia ƒe teƒea le dɔlélea ƒe gɔmedzedze, si dzea dɔdzẽ ƒe ŋuɖoɖo gɔme, be woatsɔ awɔ avu kple dɔlékuiwo ƒe amedzidzedze. Bronchogen xea mɔ na nusiwo doa ŋusẽ dɔdzẽ siawo ƒe dodo fũ akpa hã, si wɔnɛ be wòƒoa asa na dɔdzẽ ƒe ŋuɖoɖo siwo dzi womeɖu o siwo ate ŋu agblẽ nu le gbɔgbɔtsixe ƒe lãkusiwo ŋu. Tsɔ kpe ɖe eŋu la, Bronchogen doa nusiwo tsia dzodzodzoetsitsi nu (abe IL-10 ene) ƒe dodo ɖe ŋgɔ, siwo wɔa dɔ le dɔdzẽ ƒe akpa mamlɛawo me, si wɔnɛ be gbɔgbɔtsixe ƒe lãkusiwo dzadzraɖo kple dɔdzẽa ɖeɖeɖa nɔa bɔbɔe, si wɔnɛ be gbɔgbɔtsixe ƒe akpa si le eme la nɔa te.
(2) Yagbɔgbɔ ƒe Lãmenugbagbeviwo ƒe Fɔmaɖimaɖi me léle ɖe asi
Lãmenugbagbeviwo ƒe dzidziɖedzi kple wo dzadzraɖo dodo ɖe ŋgɔ
Yagbɔgbɔ ƒe lãmenugbagbeviwo nyea mɔxenu gbãtɔ si xea mɔ na gbɔgbɔtsixe, eye woƒe blibonyenye le vevie ŋutɔ na ametakpɔkpɔ tso dɔlékuiwo ƒe amedzidzedze me. Bronchogen doa gbɔgbɔtsixe ƒe lãmenugbagbeviwo ƒe dzidziɖedzi ɖe ŋgɔ eye wònaa lãmenugbagbevi siwo gblẽ la ɖɔɖɔɖo kabakaba. Le gbɔgbɔtsixe ƒe abi si gotagome nusiwo doa ŋusẽ ame (abe dzudzɔ alo atikewo ene) hena vɛ megbe la, Bronchogen naa lãmenugbagbeviwo me dzesimɔwo wɔa dɔ, siwo dometɔ aɖewoe nye MAPK dzesimɔ kple PI3K-Akt ƒe dzesimɔ. Mɔ siawo ƒe dɔwɔwɔ doa lãmenugbagbeviwo ƒe tsatsam ƒe ŋgɔyiyi ɖe ŋgɔ, si wɔnɛ be lãmenugbagbevi siwo le lãkusi me te ŋu trɔna tso akpa si me ɖoɖoezizi le yia akpa si dzina ɖe edzi me, si wɔnɛ be lãmenugbagbeviwo ƒe xexlẽme dzina ɖe edzi be woayɔ teƒe siwo gblẽ eye woagbugbɔ lãmenugbagbeviwo ƒe blibonyenye aɖo anyi.
Lãmenugbagbeviwo dome kadodowo dzi kpɔkpɔ
Tsɔ kpe ɖe lãmenugbagbeviwo ƒe dzidziɖedzi dodo ɖe ŋgɔ ŋu la, Bronchogen kpɔa gome le kadodo siwo le gbɔgbɔtsixe ƒe lãmenugbagbeviwo dome la dzi kpɔkpɔ hã me. Lãmenugbagbevi siwo le lãkusi me wɔa mɔxenu si yia edzi to xɔtuɖoɖowo abe ƒoƒo sesẽwo kple adherens ƒe ƒoƒo ene me. Bronchogen ate ŋu aɖɔ kadodo protein siawo (abe occludin kple claudin ene) ƒe ɖeɖefia kple wo mama ɖo, si ana lãmenugbagbeviwo dome kadodowo nali ke. Ne dɔlékuiwo xɔ gbɔgbɔtsixe ƒe lãmenugbagbeviwo me alo dɔdzẽ ʋã wo la, lãmenugbagbeviwo dome kadodowo ate ŋu atɔtɔ, si ana mɔxenu ƒe dɔwɔwɔ nagblẽ. Bronchogen ate ŋu adzra kadodo siawo ɖo enumake ahado ŋusẽ wo, si ana dɔlékuiwo kple nusiwo gblẽa nu le ame ŋu be woagage ɖe lãmenugbagbevi siwo le lãkusi me ƒe ƒuƒoƒoa me ayi gbɔgbɔtsixe ƒe lãkusia me o, si ana gbɔgbɔtsixe ƒe dɔwɔwɔ nawɔ dɔ nyuie le ŋutilã me.
(3) Yaƒoƒomɔ̃ me ʋuʋudedi ƒe dodo kple eɖeɖe ɖa dzi kpɔkpɔ
Mucus ƒe ʋuʋu ƒe ɖoɖowɔwɔ
Yaƒoƒomɔ̃ ƒe ʋuʋudedi nye gbɔgbɔtsixe ƒe ametakpɔnu ƒe akpa vevi aɖe, si te ŋu léa dɔlékui siwo wogbɔna, ke, kple nu bubu siwo tso duta la heɖea wo ɖa. Bronchogen wɔa akpa aɖe le yaƒoƒomɔ̃ ƒe ʋuʋudedi ƒe dodo me. Ewɔa esia to kadodo kple xɔla siwo le gbɔgbɔtsixe ƒe lãmenugbagbeviwo ƒe anyime, lãmenugbagbeviwo me dzesimɔwo ƒe dɔwɔwɔ, kple mucin domenyiŋusẽfianuwo ƒe ɖeɖefia kple ʋuʋudedi ƒe wɔwɔme kple eƒe dodo le lãmenugbagbevi siwo ɖea ʋuʋudedi (abe goblet lãmenugbagbeviwo ene) me dzi kpɔkpɔ me. Mucus ƒe dodo si sɔ le vevie ŋutɔ na gbɔgbɔtsixe ƒe tsi si le lãme na ame kple ametakpɔnu siwo sɔ la léle ɖe te. Bronchogen ɖɔa ʋuʋudedi ƒe agbɔsɔsɔme ɖo pɛpɛpɛ le gbɔgbɔtsixe ƒe ŋutilã ƒe nuhiahiãwo nu, si wɔnɛ be ʋuʋudedi léa duta nusuewo nyuie evɔ mehea yaƒoƒomɔ̃wo ƒe xexe vɛ le esi wòdona fũu akpa ta o.
Mucus Clearance Dodo Ðe Ŋgɔ
Tsɔ kpe ɖe ʋuʋudedi ƒe dodo dzi kpɔkpɔ ŋu la, Bronchogen doa ʋuʋudedi ƒe ɖeɖe le yaƒoƒomɔ̃wo me hã ɖe ŋgɔ. Enaa ciliary ƒoƒo zi gbɔ zi geɖe kple eƒe sesẽme le gbɔgbɔtsixe ƒe mɔ̃a me dzina ɖe edzi. Abe gbɔgbɔtsixe ƒe 'sweepers' ene la, cilia ƒe ƒoƒo ƒe ɣeyiɣi ƒe didime ʋãa ʋuʋudedi kple duta nu suesuesue siwo wòtsɔna yia yaƒoƒomɔ̃a ƒe ʋuʋu gbɔ, si emegbe woɖea wo doa goe le ŋutilãa me to kɔdzi alo mɔ bubuwo dzi. Bronchogen doa ŋusẽ ciliary motility to ŋusẽkpɔkpɔ ɖe ion mɔwo kple dzesimɔwo dzi le ciliated cells me, abe calcium ion ƒe agbɔsɔsɔ dzi kpɔkpɔ kple protein kinases ƒe dɔwɔwɔ ene, si wɔnɛ be mucus ƒe ʋuʋu nyuie nyona ɖe edzi eye wòléa yaƒoƒo ƒe ʋuʋu me ɖe asi.
Habɔbɔ si Le Bronchogen Kple Yagbɔgbɔdɔlélewo Dome
(1) Asrãdɔ
Tɔtrɔ siwo vaa Bronchogen ƒe agbɔsɔsɔ me le Asrãdɔnɔwo me
Le asrãdɔnɔwo gome la, zi geɖe la, Bronchogen ƒe agbɔsɔsɔ kple dɔwɔwɔ trɔna ɖedzesiwo. Numekukuwo ɖee fia be le asrã ƒe amedzidzedze me la, Bronchogen ƒe agbɔsɔsɔ le yaƒoƒomɔ̃wo me ate ŋu adzi ɖe edzi alo aɖiɖi le mɔ si mesɔ o nu. Le asrãdɔ sesẽ aɖewo gome la, Bronchogen ƒe agbɔsɔsɔ le yaƒoƒomɔ̃ me tsiwo me ɖiɖina ŋutɔ wu ame siwo le lãmesẽ me, si ate ŋu atso yaƒoƒomɔ̃ ƒe lãmenugbagbeviwo ƒe gbegblẽ gbɔ, si wɔnɛ be Bronchogen ƒe wɔwɔme kple eƒe dodo dzi ɖena kpɔtɔna. Le asrãdɔléla aɖewo siwo mesẽ o gome la, togbɔ be Bronchogen ƒe agbɔsɔsɔ le yaƒoƒomɔ̃wo me ate ŋu anɔ afisi sɔ hã la, dɔwɔwɔ ŋuti numekukuwo ɖee fia be ŋutete si le esi be wòaɖɔ dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ kple dɔlékuiwutikewo ƒe dodo ɖo dzi ɖe kpɔtɔ, si fia be Bronchogen ƒe nugbagbeŋusẽ ƒe dɔwɔwɔ trɔ le asrãdɔnɔwo me.
Akpa Si Bronchogen Wɔna Le Asrã ƒe Dɔléle Dzɔdzɔme Me
Le asrã ƒe dɔléle dzɔdzɔ ƒe nukpɔsusu nu la, Bronchogen kpɔa gome le mɔ vovovowo me. Bronchogen ƒe dɔlélenutsiŋutete ƒe dɔwɔwɔ ƒe ɖoɖowɔwɔ si mesɔ o hea dɔlélenutsiŋutete ƒe ŋuɖoɖo ɖe nusiwo nana nulɔna ŋu wògbɔa eme le asrãdɔnɔwo me. Le asrãdɔnɔwo gome la, Bronchogen ƒe dɔmawɔmawɔ nyuie nana Th2 lãmenugbagbeviwo wɔa dɔ fũ akpa, siwo ɖea cytokines gbogbo aɖewo (abe IL-4, IL-5, IL-13, kple bubuawo ene), Cytokines siawo doa ŋusẽ lãmenugbagbevi siwo naa dɔdzẽ abe eosinophils ene ƒe gege ɖe yame ƒe gege ɖe lãme eye wowɔa dɔ le yaƒoƒomɔ̃wo me, si wɔnɛ be yaƒoƒomɔ̃wo ƒe dɔdzẽ kple yaƒoƒomɔ̃wo dona nyaŋuɖoɖo si gbɔ eme. Akpa si Bronchogen wɔna si gbɔdzɔ le gbɔgbɔtsixe ƒe lãmenugbagbeviwo ƒe blibonyenye me léle ɖe asi me nana lãmenugbagbevi siawo te ŋu gblẽna bɔbɔe tso nusiwo nana nulɔna kple dɔdzẽ ƒe domenɔlawo gbɔ, si gagblẽa nu le yaƒoƒomɔ̃wo ƒe dɔdzẽ kple yaƒoƒomɔ̃wo ƒe tɔtrɔ yeye ŋu, si wɔnɛ be asrã ƒe gɔmedzedze kple eƒe ŋgɔyiyi doa ŋgɔ.
(2) Aklãdɔléle si Nɔa Anyi Didi (COPD) .
Bronchogen ƒe Nɔnɔmewo le COPD Dɔnɔwo me
Le COPD dɔnɔwo ƒe yaƒoƒomɔ̃wo me la, Bronchogen hã ɖea nɔnɔme siwo to vovo na esiwo le ame siwo le lãmesẽ me gbɔ fiana. Ne COPD le ŋgɔ yim la, Bronchogen ƒe agbɔsɔsɔ kple eƒe mama le yaƒoƒomɔ̃wo me trɔna. Le COPD dɔnɔwo ƒe lãkusi kple yaƒoƒomɔ̃ me la, Bronchogen ƒe agbɔsɔsɔ ate ŋu aɖiɖi vivivi, eye eƒe ɖeɖefia le yaƒoƒomɔ̃ ƒe lãmenugbagbeviwo kple dɔlélenutsiŋutete ƒe lãmenugbagbeviwo me dzi aɖe akpɔtɔ ŋutɔ. Tɔtrɔ siawo do ƒome kplikplikpli kple lãkusi ƒe dɔwɔwɔ ƒe ɖiɖi kple yaƒoƒomɔ̃ ƒe dɔdzẽ ƒe sesẽ ɖe edzi le COPD dɔnɔwo me. Woate ŋu atrɔ asi le Bronchogen ƒe molecule ƒe wɔwɔme ŋu le COPD dɔnɔwo me, si ana nugbagbewo ƒe dɔwɔwɔ dzi naɖe akpɔtɔ eye wòagagblẽ eƒe dɔwɔwɔ nyuie le gbɔgbɔtsixe me.
Akpa si Bronchogen wɔna le COPD ƒe dɔlélenutsiŋutete me
Bronchogen hã wɔa akpa vevi aɖe le COPD ƒe dɔléle ƒe dɔwɔwɔ me. Dɔléle vevi siwo le COPD me dometɔ aɖewoe nye yaƒoƒomɔ̃wo ƒe ʋuʋu, ʋuʋudedi si gbɔ eme, lãkusi ƒe lãkusi ƒe tsɔtsrɔ̃, kple yaƒoƒomɔ̃wo ƒe tɔtrɔ. Le Bronchogen ƒe dɔlélenutsiŋutete ƒe dɔwɔwɔ ƒe ɖoɖowɔwɔ si gbɔdzɔ ta la, dɔdzẽ ƒe ŋuɖoɖo siwo le yaƒoƒomɔ̃wo me nɔa anyi eye esesẽna be woaɖu edzi. Lãmenugbagbevi siwo naa dɔdzẽ abe neutrophils kple macrophages ene ƒoa ƒu ɖe yaƒoƒomɔ̃wo me le agbɔsɔsɔ gã me, eye woɖea asi le dɔdzẽ ƒe domenɔla vovovowo kple proteases ŋu, si wɔnɛ be lãkusiwo gblẽna eye yaƒoƒomɔ̃wo ƒe wɔwɔme gblẽna. Bronchogen ƒe yaƒoƒomɔ̃ ƒe ʋuʋudedi ƒe dodo kple eɖeɖeɖa ƒe ɖoɖowɔwɔ ƒe masɔmasɔ hea ʋuʋudedi ƒe dodo fũu akpa eye ʋuʋudedi ƒe ʋuʋu me gblẽna, si gagblẽa yaƒoƒomɔ̃wo ƒe xexe ɖe edzi. Bronchogen ƒe ŋutete si dzi ɖe kpɔtɔ be wòado gbɔgbɔtsixe ƒe lãmenugbagbeviwo ɖɔɖɔɖo ɖe ŋgɔ eye wòalé lãmenugbagbeviwo dome kadodowo me ɖe asi la nana yaƒoƒomɔ̃wo ƒe gbugbɔgaɖɔɖo ƒe ɖoɖoa kabakaba, si wɔnɛ be mlɔeba la, lãkusi ƒe dɔwɔwɔ gblẽna vivivi le COPD dɔnɔwo me.
(3) Yagbɔgbɔdɔléle Siwo Xɔa Dɔlékuiwo
Akpa si Bronchogen Wɔna le Dɔlékuiwo ƒe Dɔlélewo Me
Le gbɔgbɔtsixe me dɔlékuiwo ƒe dɔlélewo me la, Bronchogen kpɔa gome le ŋutilãa ƒe dɔlélenutsiŋutete takpɔkpɔ me. Ne dɔlékuiwo ge ɖe gbɔgbɔtsixe me la, Bronchogen ate ŋu ana dɔlélenutsiŋutete ƒe lãmenugbagbeviwo nawɔ dɔ, si ana woƒe nuɖuɖu kple lãmenugbagbeviwo ƒe aɖi ƒe ŋutete nadzi ɖe edzi ɖe dɔlékuiwo ŋu. Bronchogen hã ɖɔa dɔlélenutsiŋutete ƒe dɔwɔwɔ ɖo, si wɔnɛ be dɔlélenutsiŋutete ƒe nɔnɔme sue aɖe si nyo na dɔlékuiwutikewo ƒe dɔwɔwɔ. Ate ŋu ado dɔlékuiwutike siwo nye peptide siwo wɔa dɔ ɖe dɔlékuiwo dzi tẽ, siwo gblẽa woƒe lãmenugbagbeviwo ƒe lãkusiwo kple lãmenugbagbeviwo ƒe gliwo me, si wɔnɛ be dɔlékuiwo ƒe tsitsi kple woƒe vidzidzi nu nadze egɔme. Gake le dɔlékuiwo ƒe dɔléle sesẽ aɖewo me la, dɔlékuiwo ate ŋu ado kplamatse Bronchogen ƒe wɔwɔme kple dɔwɔwɔ, si ana ŋutilãa ƒe dɔlélenutsiŋutete ƒe ametakpɔkpɔ ŋutetewo dzi naɖe akpɔtɔ eye wòana dɔlélea dzi ɖuɖu nasesẽ.
Akpa si Bronchogen Wɔna le Dɔlékuiwo ƒe Dɔlékuiwo Me
Bronchogen hã wɔa akpa vevi aɖe le gbɔgbɔtsixe ƒe dɔlékuiwo ƒe dɔlélewo me. Le dɔlékuiwo ƒe dɔléle ƒe gɔmedzedze la, Bronchogen ate ŋu ana dɔlélenutsiŋutete ƒe lãmenugbagbevi siwo wodzi (abe dendritic cells kple natural killer cells ene) nawɔ dɔ be woadze dɔlékuiwutikewo ƒe dɔlélenutsiŋutete ƒe dɔwɔwɔ gɔme. Edoa dɔlékuiwutikewo abe interferon ene ƒe dodo ɖe ŋgɔ, si ate ŋu axe mɔ ɖe dɔlékuiwo ƒe dzidziɖedzi kple kaka nu, si ana dɔlékuiwo ƒe kaka ɖe gbɔgbɔtsixetsixe me dzi ɖena kpɔtɔna. Bronchogen hã ɖɔa dɔlélenutsiŋutete ƒe ŋuɖoɖo siwo trɔna ɖe nɔnɔmewo ŋu ɖo, si doa T ʋumenugbagbevi dzĩwo kple B ʋumenugbagbevi dzĩwo ƒe dzesidede kple ŋuɖoɖo ɖe dɔlékui ƒe dɔlékuiwutikewo ŋu ɖe ŋgɔ, si wɔnɛ be wowɔa dɔlékuiwutike tɔxɛwo kple T lãmenugbagbeviwo siwo me aɖi le, si wɔnɛ be woɖea lãmenugbagbevi siwo ŋu dɔlékui le la ɖa nyuie.
Nyanuwuwuw
Bronchogen wɔa akpa vevi aɖe le gbɔgbɔtsixe ƒe lãmesẽ me léle ɖe asi kple gbɔgbɔmedɔlélewo ƒe ŋgɔyiyi me. Le gbɔgbɔtsixe ƒe nɔnɔme vovovowo abe asrã, COPD, kple gbɔgbɔmedɔléle siwo xɔa ame me ene me la, Bronchogen ƒe agbɔsɔsɔ, dɔwɔwɔ, kple eƒe mama trɔna, eye wòkpɔa gome le dɔléle siawo ƒe dɔlélenutsiŋutete ƒe dɔwɔwɔ me.
Dzɔtsoƒewo
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