Cocer Peptides ye 
ŋlɔe ɣleti 1 enye sia
NYATAKAKAWO KPLE NUSIWO WOTSƆ ƑE NYATAKAKA SIWO KAtã WOÐO LE NYATAKAKADZRAÐOƑE SIA ME LA KPLE NYATAKAKAWO kaka KPLEE NUFIAFIA ƑE TAÐOÐOWO KO.
Wotrɔ asi le atike siwo wona le nyatakakadzraɖoƒe sia ŋu na numekuku le vitro ɖeɖeko. Wowɔa numekuku le vitro (Latingbe me: *le ahuhɔ̃e me*, si gɔmee nye le ahuhɔ̃e me) le amegbetɔ ƒe ŋutilã godo. Atike siawo menye atikewo o, United States ƒe Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) meda asi ɖe wo dzi o, eye mele be woazã wo atsɔ axe mɔ ɖe atikewɔwɔ, dɔléle, alo dɔléle aɖeke nu, adae, alo adae o. Se de se vevie be woatsɔ atike siawo ade amegbetɔ alo lãwo ƒe ŋutilã me le mɔ ɖesiaɖe nu.
Kpɔkplɔyiɖeme
Esi agbeŋutinunya le ŋgɔ yim ɖaa ta la, numekuku siwo ku ɖe tsitsi ƒe mɔnuwo ŋu va le goglom ɖe edzi, eye mɔnu nyui siwo woatsɔ atsi tsitsi nu didi va zu nyati vevi aɖe le dzɔdzɔmeŋutinunyalawo dome. Telomeres, abe ametakpɔnu siwo le domenyiŋusẽfianu ƒe nuwuwu ene, do ƒome kplikplikpli kple lãmenugbagbeviwo ƒe tsitsi. Epitalon, si nye peptide kpui aɖe si wowɔ eye wòtsia tsitsi nu la he amewo ƒe susu le ƒe ʋɛ siwo va yi me.
Telomere Didime Nya Siwo Do Ƒome Kplii
(1) Telomeres ƒe Dɔwɔɖoɖo Kple Dɔwɔwɔ
Telomeres nye nucleotide gbugbɔgagblɔ ƒe ɖoɖo siwo wodzra ɖo ŋutɔ le domenyiŋusẽfianu ƒe nuwuwu, siwo me DNA tandem gbugbɔgagblɔ ƒe ɖoɖo bɔbɔewo kple protein siwo do ƒome kplii le. Telomeres wɔa akpa vevi aɖe le domenyiŋusẽfianu ƒe wɔwɔme ƒe blibonyenye kple domenyiŋusẽfianu ƒe liƒo me léle ɖe asi me. Le lãmenugbagbeviwo ƒe mama ɖesiaɖe me la, telomerewo nɔa kpuie vivivi le DNA ƒe dzidziɖedzi ƒe mɔnuwo ƒe seɖoƒe ta. Ne telomerewo le kpuie va ɖo afi aɖe la, lãmenugbagbeviwo gena ɖe tsitsi alo apoptosis ƒe afɔɖeɖe me, eyata woyɔa telomere le kpɔɖeŋunyagbɔgblɔ nu be 'lãmenugbagbeviwo ƒe agbe ƒe gaƒoɖokui.'
Nɔnɔmetata 1 Epitalon ɖe ROS ƒe agbɔsɔsɔ si le lãmenugbagbeviwo me dzi kpɔtɔ.
(2) Mɔnu Siwo Wozãna Na Telomerewo Didi
Telomerase ƒe mɔnu
Telomerase nye ribonucleoprotein ƒe ƒuƒoƒo si me reverse transcriptase ƒe dɔwɔwɔ le. Ate ŋu azã eya ŋutɔ ƒe RNA abe nɔnɔmetata ene atsɔ awɔ telomere ƒe gbugbɔgadzɔ ƒe ɖoɖo eye wòatsɔ wo akpe ɖe domenyiŋusẽfianu ƒe nuwuwu ŋu, si ana telomere ƒe didime nanɔ anyi. Le amegbetɔ ƒe lãmenugbagbevi siwo sɔ me la, telomerase ƒe dɔwɔwɔ mebɔ o alo menɔa anyi o, eye telomerewo nɔa kpuie vivivi le lãmenugbagbeviwo ƒe mama ɖesiaɖe me. Gake le dɔdzẽ ƒe lãmenugbagbevi geɖe me la, telomerase gawɔa dɔ, si wɔnɛ be dɔdzẽ ƒe lãmenugbagbeviwo te ŋu dzina ɖe edzi tegbee eye wokpɔa makumakunyenye. Le ɖeviwo ƒe primary metastatic medulloblastoma me la, dɔdzẽ ƒe lãmenugbagbevi aɖewo kpɔa telomere ƒe didime dzi to telomerase ƒe dɔwɔwɔ me. Anɔ abe 10.7% le metastatic medulloblastomas me hea telomerase ƒe dɔwɔwɔ vɛ to TERT promoter mutations kple UTSS hypermethylation dzi, si wɔnɛ be telomere didi gbɔ.
ALT ƒe mɔ
Tsɔ kpe ɖe telomerase mɔa ŋu la, mɔnu aɖe li si me telomerase mele o si woyɔna be alternation lengthening of telomeres (ALT) mɔ. ATRX ƒe dɔmawɔmawɔ koŋue ʋãa mɔ sia eye wòwɔa akpa vevi aɖe le dɔdzẽ ƒe lãmenugbagbevi aɖewo me. Le ɖeviwo ƒe medulloblastoma gbãtɔ si kaka ɖe teƒe bubuwo me la, amesiwo ade 32.1% ɖoa telomere ƒe didime gbɔ to ALT mɔnu dzi, eye kpɔɖeŋu 30% ɖea ATRX nuklia ƒe ʋuʋu fiana, si wɔnɛ be ALT mɔa wɔa dɔ.
(3) Epitalon Kple Telomere ƒe Didi ƒe Mɔnu
Epitalon ƒe Ŋusẽkpɔɖeamedzi ɖe Telomerase Dzi
Epitalon nye peptide kpui si wowɔ si me amino acid ene (alanine, glutamic acid, aspartic acid, kple glycine) le, si wotu ɖe dzɔdzɔme peptide Epithalamion si woɖe tso pineal gland me dzi. Numekukuwo ɖee fia be Epitalon ate ŋu akpɔ ŋusẽ ɖe telomere ƒe didime dzi to telomerase ƒe dɔwɔwɔ dodo ɖe ŋgɔ me. Russiatɔ numekulawo ƒe ƒuƒoƒo aɖe kpɔe zi gbãtɔ le ƒe 1980-awo me be Epitalon ate ŋu aʋã telomerase, si nye enzyme si kpɔa telomere siwo le domenyiŋusẽfianu ƒe nuwuwu ta ahakeke wo ɖe enu. Togbɔ be kpeɖodzi sẽŋu aɖeke meli fifia be Epitalon ate ŋu akeke telomeres ɖe enu tẽ le amegbetɔwo me o hã la, dodokpɔ aɖewo ɖee fia be ate ŋu ana telomerase ƒe dɔwɔwɔ nadzi ɖe edzi. Telomerase ƒe dɔwɔwɔ ƒe dzidziɖedzi fia be woate ŋu awɔ telomere ƒe gbugbɔgadzɔ ƒe ɖoɖo geɖe wu eye woatsɔe akpe ɖe domenyiŋusẽfianu ƒe nuwuwu ŋu, si ate ŋu ana telomere ƒe kpuiƒe ƒe tsɔtsɔme nagbɔdzɔ eye wòana telomere ƒe didime gɔ̃ hã nate ŋu ana.
Nɔnɔmetata 2 Epitalon kpɔ mitochondria ƒe dɔwɔwɔ ta le oocyte ƒe tsitsi megbe le vitro.
Epitalon ƒe lãmenugbagbeviwo me dzesimɔwo dzi kpɔkpɔ
Lãmenugbagbeviwo me dzesimɔwo wɔa kadodo sesẽ aɖe si wɔa dɔ ɖekae tsɔ ɖɔa lãmenugbagbeviwo ƒe dɔwɔwɔwo abe tsitsi, dzidziɖedzi, kple tsitsi ene ɖo. Epitalon ate ŋu akpɔ ŋusẽ ɖe telomere ƒe didime dzi le mɔ si mele tẽ o nu to dzesimɔ siawo dzi kpɔkpɔ me. Le kpɔɖeŋu me, ate ŋu akpɔ ŋusẽ ɖe mɔ siwo do ƒome kple lãmenugbagbeviwo ƒe tsatsam ƒe ɖoɖowɔwɔ dzi, si ana telomere ƒe ametakpɔnu ƒe mɔnuwo nanyo ɖe edzi le lãmenugbagbeviwo ƒe mama me. Tsɔ kpe ɖe eŋu la, abe antioxidant ene la, Epitalon ɖea oxygen ƒomevi siwo wɔa dɔ (ROS) ƒe wɔwɔ dzi kpɔtɔna le lãmenugbagbeviwo me. ROS ƒe ƒuƒoƒo ate ŋu agblẽ nu le DNA ŋu, si ana wòagblẽ nu le telomere ƒe liƒo ŋu. To ROS ƒe agbɔsɔsɔ dzi ɖeɖe kpɔtɔ me la, Epitalon kpena ɖe ame ŋu be telomere ƒe wɔwɔme kple dɔwɔwɔ si sɔ la nanɔ anyi, si wɔnɛ be nɔnɔme nyuiwo nɔa telomere ƒe didime ŋu.
(4) Dodokpɔ ƒe Kpeɖodziwo na Akpa si Epitalon Wɔna le Telomere ƒe Didime
Lãmenugbagbeviwo dodokpɔ siwo wowɔna le vitro
Le lãmenugbagbeviwo ƒe agbledede dodokpɔ siwo wowɔ le vitro me la, Epitalon tsɔtsɔ kpe ɖe deku me na telomerase ƒe dɔwɔwɔ dzi ɖe edzi le lãmenugbagbevi aɖewo me. Numekulawo tsɔ Epitalon si ƒe agbɔsɔsɔme nye 0.1 mM kpe ɖe lãmenugbagbeviwo ƒe dekɔnu me. Le agbledede ƒe ɣeyiɣi aɖe megbe la, wokpɔe be domenyiŋusẽfianu siwo do ƒome kple telomerase ƒe ɖeɖefia ƒe agbɔsɔsɔ le lãmenugbagbeviwo me dzi ɖe edzi, si ɖee fia be Epitalon ate ŋu ado telomerase ƒe wɔwɔme alo eƒe dɔwɔwɔ ɖe ŋgɔ. Tsɔ kpe ɖe eŋu la, telomere ƒe didime dzidzedze ɖee fia be ne wotsɔe sɔ kple ƒuƒoƒo si me Epitalon mele o la, telomere ƒe kpuiƒe le dodokpɔ ƒe ƒuƒoƒoa me dzi ɖe kpɔtɔ ŋutɔ, eye le lãmenugbagbevi aɖewo me la, wokpɔ telomere ƒe didime vie.
Lãwo ƒe dodokpɔwo
Le lãwo dodokpɔwo me la, wodo Epitalon na lã siwo wodo kpɔ (abe sisiblisiwo ene) to atike si wodona ɖe lãme na ame alo dodo ɖe nu me me, eye woda woƒe lãmenugbagbeviwo kpɔ. Nusiwo do tso eme ɖee fia be telomerase ƒe dɔwɔwɔ le lãkusi aɖewo (abe aklã kple ayiku ene) me dzi ɖe edzi, eye telomere ƒe didime gakpɔtɔ li ke vie. Le numekuku siwo wowɔ le sisiblisi ƒe aklã me lãmenugbagbeviwo ŋu me la, wokpɔe be telomerase ƒe dɔwɔwɔ le sisiblisi siwo wotsɔ Epitalon da dɔe me sɔ gbɔ ŋutɔ le aklã me lãmenugbagbeviwo me ne wotsɔe sɔ kple ƒuƒoƒo si womewɔ atike na o, eye le ŋkuléle ɖe wo ŋu atraɖii ɣleti geɖe megbe la, alesi gbegbe telomere ƒe kpuiƒe le aklã me lãmenugbagbeviwo me ɖiɖi ŋutɔ wu ƒuƒoƒo si womewɔ atike na o. Esia gaɖee fia be Epitalon kpɔa ŋusẽ nyui ɖe telomere ƒe didime dzi le lãwo me.
Nyatakaka Siwo Do Ƒome Kple Tsitsi Siwo Tsi Tre Ðe Tsitsi Ŋu
(1) Tsitsi ƒe Mɔnu Siwo Wozãna
Oxidative Nuteɖeamedzi Kple Tsitsi
Ne ƒexɔxɔ le dzidzim ɖe edzi la, redox ƒe dadasɔ le lãmenugbagbeviwo me me gblẽna, si wɔnɛ be oxygen ƒomevi siwo wɔa dɔ (ROS) ƒoa ƒu. ROS ƒe oxidative ŋutete sesẽwo le esi, si te ŋu wɔa oxidation na lãmenugbagbeviwo ƒe biomolecules abe proteins, lipids, kple DNA, si wɔnɛ be wògblẽa nu le lãmenugbagbeviwo ƒe wɔwɔme kple dɔwɔwɔ ŋu. Protein siwo me oxide le ate ŋu abu woƒe nugbagbeŋusẽ ƒe dɔwɔwɔ si sɔ, ami siwo me oxidized ate ŋu agblẽ nu le lãmenugbagbeviwo ƒe lãkusi ƒe sisi kple woƒe liƒo ŋu, eye DNA ƒe oxidation ƒe gbegblẽ ate ŋu ahe domenyiŋusẽfianu ƒe tɔtrɔ kple lãmenugbagbeviwo ƒe dɔmawɔmawɔ nyuie vɛ, eye esiawo katã nana lãmenugbagbeviwo kple nugbagbevi la ƒe tsitsi kabakaba.
Lãmenugbagbeviwo ƒe Tsitsi Kple Apoptosis
Lãmenugbagbeviwo ƒe tsitsi kple woƒe kuku nye nudzɔdzɔ veviwo le tsitsi me. Ne lãmenugbagbeviwo do go nuteɖeamedzi vovovowo (abe oxidative stress, DNA ƒe gbegblẽ, kple bubuawo ene) la, wogena ɖe tsitsi ƒe nɔnɔme me. Lãmenugbagbevi siwo tsi ƒe nɔnɔmewo dometɔ aɖewoe nye lãmenugbagbeviwo ƒe tsatsam ƒe mɔxexe, lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe tɔtrɔ, kple cytokines tɔxɛwo ƒe dodo. Le ɣeyiɣi ma ke me la, apoptosis nye lãmenugbagbeviwo ƒe ku ƒe ɖoɖo si wowɔ ɖe ɖoɖo nu si wɔa akpa vevi aɖe le lãmenugbagbeviwo ƒe homeostasis me léle ɖe asi me. Gake ne ƒexɔxɔ le dzidzim ɖe edzi la, apoptosis ƒe ɖoɖowɔwɔ ƒe mɔnuwo ate ŋu agblẽ, eye apoptosis si gbɔ eme alo esi mesɔ gbɔ o ate ŋu ana lãmenugbagbeviwo ƒe dɔwɔwɔ naɖiɖi, eye mlɔeba wòadze abe nugbagbewo ƒe tsitsi ene.
Telomere ƒe Kpuie Kple Tsitsi
Abe alesi míegblɔe va yi ene la, telomere ƒe kpuiƒe nye tsitsi ƒe dzesi veviwo dometɔ ɖeka. Ne lãmenugbagbeviwo yi edzi le mamam la, telomerewo va nɔa kpuie vivivi. Ne telomerewo ɖo didime vevi aɖe la, lãmenugbagbeviwo dzudzɔa mama eye wogena ɖe tsitsi ƒe nɔnɔme me. Telomere ƒe kpuiƒe ate ŋu ahe DNA ƒe gbegblẽ ƒe ŋuɖoɖo ƒe dɔwɔwɔ ɖe lãmenugbagbeviwo me hã vɛ, si ana lãmenugbagbeviwo ƒe tsitsi kple apoptosis nawɔ kabakaba ɖe edzi, si ana woakpɔ ŋusẽ ɖe nugbagbevi la ƒe tsitsi ƒe ɖoɖo bliboa dzi.
Nɔnɔmetata 3 Ŋusẽ si Epitalon kpɔna ɖe apoptosis gbãtɔ dzi le oocytes tsitsi le fugboe megbe.
(2) Epitalon ƒe Mɔnu si Tsi Tre Ðe Tsitsi Ŋu
Antioxidant ƒe Dɔwɔna
Epitalon nye antioxidant nyui aɖe si ƒe antioxidant ŋutete sɔ kple melatonin. Ate ŋu aƒo ROS le lãmenugbagbeviwo me tẽ, si aɖe oxidative ƒe nugbegblẽ le biomolecules ŋu si ROS hena vɛ dzi akpɔtɔ. Le dodokpɔ aɖe si wowɔ le vitro si me wozã sisiblisi ƒe oocytes me la, Epitalon 0.1 mM tsɔtsɔ de deku me na ROS ƒe agbɔsɔsɔ si le lãmenugbagbeviwo me dzi ɖe kpɔtɔ ŋutɔ. ROS dzi ɖeɖe kpɔtɔ kpena ɖe lãmenugbagbeviwo ƒe lãkusi ƒe blibonyenye, protein ƒe dɔwɔwɔ nyuie, kple DNA ƒe liƒo ŋu, si wɔnɛ be lãmenugbagbeviwo ƒe tsitsi hea ɖe megbe. Tsɔ kpe ɖe eŋu la, Epitalon ate ŋu ana lãmenugbagbevi la ŋutɔ ƒe antioxidant ŋutete nadzi ɖe edzi to lãmenugbagbeviwo me antioxidant enzyme systems (abe superoxide dismutase kple catalase ene) ƒe dɔwɔwɔ dzi kpɔkpɔ me, si ana lãmenugbagbeviwo ƒe gbegblẽ si oxidative stress hena vɛ dzi naɖe akpɔtɔ geɖe wu.
Mitochondria ƒe dɔwɔwɔ dzi kpɔkpɔ
Mitochondria nye lãmenugbagbeviwo ƒe ŋusẽŋusẽ, eye woƒe dɔwɔwɔ ƒe nɔnɔme do ƒome kplikplikpli kple lãmenugbagbeviwo ƒe tsitsi. Ne ame tsi la, mitochondria ƒe dɔwɔwɔ dzi ɖena kpɔtɔna vivivi, si dzena le mitochondrial membrane ƒe ŋutete dzi ɖeɖe kpɔtɔ, ATP wɔwɔ dzi ɖeɖe kpɔtɔ, kple ROS ƒe dzidziɖedzi me. Epitalon ate ŋu ana mitochondrial membrane ƒe ŋutete kple mitochondrial DNA ƒe kɔpi xexlẽme nadzi ɖe edzi, si ana mitochondrial ƒe dɔwɔwɔ nanyo ɖe edzi. Le tsitsi dodokpɔ aɖe si wowɔ le vitro si me wozã sisiblisi ƒe oocytes me la, oocyte siwo wotsɔ Epitalon da dɔe ɖe mitochondrial membrane ŋutete si lolo ŋutɔ fia eye mitochondrial DNA ƒe kɔpi xexlẽme dzi ɖe edzi le tsitsi gaƒoƒo 12 kple 24 megbe ne wotsɔe sɔ kple ƒuƒoƒo si womewɔ atike na o. Esia ɖee fia be Epitalon ate ŋu alé mitochondria ƒe dɔwɔwɔ nyuie me ɖe asi eye wòaɖe lãmenugbagbeviwo ƒe tsitsi si mitochondria ƒe dɔmawɔmawɔ nyuie hena vɛ dzi akpɔtɔ. Mitochondria ƒe dɔwɔwɔ nyuie wu hã kpena ɖe lãmenugbagbeviwo ƒe ŋusẽ ƒe asitɔtrɔ le lãmenugbagbeviwo ŋu ƒe dadasɔ ŋu, si naa ŋusẽ si sɔ na ŋutilã ƒe dɔwɔna siwo sɔ eye wòhea lãmenugbagbeviwo ƒe tsitsi ɖe megbe.
Mɔxexe ɖe apoptosis nu
Lãmenugbagbeviwo ƒe tsɔtsrɔ̃ wɔa akpa vevi aɖe le tsitsi ƒe ɖoɖoa me. Lãmenugbagbeviwo ƒe tsɔtsrɔ̃ fũ ate ŋu ana lãmenugbagbeviwo kple ŋutinuwo ƒe dɔwɔwɔ naɖiɖi. Epitalon ɖɔa dzesimɔ siwo do ƒome kple lãmenugbagbeviwo ƒe apoptosis ɖo be wòaɖe lãmenugbagbeviwo ƒe apoptosis ƒe dzɔdzɔ dzi akpɔtɔ. Le tsitsi dodokpɔ aɖe si wowɔ le vitro si me wozã sisiblisi ƒe oocytes me la, le gaƒoƒo 24 ƒe tsitsi le vitro megbe la, oocytes ƒe apoptosis ƒe agbɔsɔsɔ le ƒuƒoƒo si wotsɔ Epitalon da dɔe me ɖiɖi ŋutɔ wu esi le ƒuƒoƒo si womeda dɔ na o me. Woate ŋu agblɔ be esia tso ŋutete si le Epitalon si be wòaxe mɔ ɖe apoptosis ƒe dzesiwo ƒe dɔwɔwɔ nu to mɔnuwo abe ROS ƒe agbɔsɔsɔ dzi ɖeɖe kpɔtɔ kple mitochondrial ƒe dɔwɔwɔ nyuie wu dzi, si to esia me ɖea apoptosis dzi kpɔtɔna eye wòkpena ɖe ame ŋu be lãmekawo kple ŋutinuwo nawɔ dɔ nyuie, eye wòahe ŋutilã ƒe tsitsi ɖe megbe.
(3) Epitalon ƒe Ŋusẽkpɔɖeamedzi si Tsi Tre Ðe Tsitsi Ŋu ƒe Kpeɖodzi Dodokpɔwo
Ametakpɔkpɔ ƒe ŋusẽkpɔɖeamedzi ɖe oocytes dzi
Le dodokpɔ siwo wowɔ tsɔ ku nu me tso ŋusẽ si Epitalon kpɔna ɖe fugboewo ƒe nyonyome dzi ŋu me la, wokpɔe be Epitalon kpɔa fugboewo ta nyuie tso nusiwo gblẽ le azigolo ƒe tsitsi le azigolo megbe ŋu me. Ne ɣeyiɣi si woatsɔ awɔ azigoloa vɔ megbe le dzidzim ɖe edzi la, vidzidɔ ƒe tsitsi ŋutete dzi ɖena kpɔtɔna vivivi. Ne wotsɔ 0.1 mM Epitalon de agblemenukua me la, woda oocyte ƒe nyonyome kpɔ le gaƒoƒo 6, 12, kple 24 ƒe dekɔnu megbe. Nusiwo do tso eme ɖee fia be Epitalon ƒe atikewɔwɔ ɖe spindle ƒe gbagbãƒewo kple cortical granules ƒe mama si mesɔ o dzi kpɔtɔ ŋutɔ, esime wòdzi mitochondrial membrane potential kple mitochondrial DNA copy number ɖe edzi, eye wòɖe oocyte apoptosis dzi kpɔtɔ. Esia ɖee fia be Epitalon ate ŋu ahe oocytes ƒe tsitsi le vitro ɖe megbe, alé woƒe nyonyome kple tsitsi ƒe ŋutete me ɖe asi, eye wòana kpeɖodzi le lãmenugbagbeviwo ƒe ɖoɖo nu be Epitalon wɔa dɔ ɖe tsitsi dzi.
Ŋusẽ si wòkpɔna ɖe tsitsi bliboa dzi le lãwo me
Le dodokpɔ siwo wowɔ le lãwo ŋu me la, le Epitalon dodo ɣeyiɣi didi to nuɖuɖu alo atike dodo me megbe la, wokpɔ ŋgɔyiyi le tsitsi ŋuti dzesi geɖe siwo le sisiblisiwo ŋu me. Ne wotsɔ wo sɔ kple sisiblisi siwo ŋu womewɔ atike na o siwo wotsɔ Epitalon da dɔe la, woɖe fu siwo le ʋeʋẽm wu, siwo klẽna wu, woƒe ʋuʋu nyo ɖe edzi, eye woƒe agbenɔƒe didi vaseɖe afi aɖe fia. Dɔléle ŋuti numekuku le sisiblisi ƒe lãkusiwo ŋu ɖee fia be lãmenugbagbeviwo ƒe gbegblẽ kple tsitsi ƒe agbɔsɔsɔ le ŋutinu veviwo abe aklã kple ayiku ene me le sisiblisi siwo wotsɔ Epitalon da dɔe me la ɖiɖi ŋutɔ wu esiwo le ƒuƒoƒo si me wokpɔa wo gbɔ le me. Esia ɖee fia be menye ɖeko Epitalon ɖea ŋusẽ si tsi tre ɖe tsitsi ŋu fiana le lãmenugbagbeviwo ƒe ɖoɖo nu ko o, ke eɖea tsitsi ƒe dɔwɔwɔ dzi kpɔtɔna le nugbagbewo ƒe ɖoɖo nu hã, si wɔnɛ be lãwo ƒe lãmesẽ kple agbenɔnɔ nyona ɖe edzi.
Epitalon ƒe Dɔwɔwɔ ƒe Mɔkpɔkpɔwo
Nusiwo Woate Ŋu Azã Le Atikewɔwɔ ƒe Dɔwɔnyawo Me
Atikewɔwɔ si Tsi Tre Ðe Tsitsi Ŋu
Wonɔ te ɖe Epitalon ƒe numekuku siwo wòkpɔ le telomere ƒe didime kple tsitsi dzi, ate ŋu anye atike yeye aɖe si tsia tsitsi nu. Esi amewo ƒe tsitsi le dzidzim ɖe edzi kabakaba ta la, atike siwo woatsɔ atsi tsitsi nu ƒe didi le dzidzim ɖe edzi. Epitalon hea lãmenugbagbeviwo ƒe tsitsi ɖe megbe to mɔnu vovovowo dzi, si naa gɔmesese yeyewo mí hena atikewɔwɔ siwo woatsɔ ato tsitsi ƒe dɔlélewo abe dzitodzito me dɔlélewo kple ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie ene vɛ. Le ahɔhɔ̃mekawo ƒe dɔléle siwo gblẽa nu le ame ŋu gome la, Epitalon ate ŋu akpɔ ahɔhɔ̃mekawo ta tso oxidative stress ƒe nugbegblẽ me eye wòalé telomere ƒe didime ɖe te, si ana ahɔhɔ̃mekawo ƒe tsitsi kple ku nagbɔdzɔ, ana dɔléle ƒe dzesiwo nanyo ɖe edzi, eye wòana dɔnɔwo ƒe agbenɔnɔ nanyo ɖe edzi.
Vidzidzi ƒe Lãmesẽ ƒe Nyonyome
Le vidzidzitikewɔwɔ gome la, Epitalon kpɔa ŋusẽ aɖe ɖe oocytes ŋu. Ne nyɔnuwo le tsitsim la, fugboe ƒe nyonyome dzi ɖena kpɔtɔna, si wɔnɛ be fugboe ƒe vidzidzi kple fugboe ƒe tsitsi ƒe tɔtrɔ ƒe afɔkua dzina ɖe edzi. Epitalon ate ŋu ahe oocyte ƒe tsitsi ɖe megbe eye wòana oocyte ƒe nyonyome nanyo ɖe edzi, si ana kpekpeɖeŋu yeye siwo woatsɔ akpe ɖe vidzidzi mɔ̃ɖaŋununya siwo kpena ɖe ame ŋu abe vidzidzi le vitro me ene ŋu. To Epitalon tsɔtsɔ kpe ɖe eŋu le vitro oocyte culture me la, wole mɔ kpɔm be ana vidzidzi ƒe agbɔsɔsɔme kple fugboe ƒe tsitsi ƒe nyonyome nanyo ɖe edzi, si ana vidzidzi si ŋu wokpena ɖo ƒe dzidzedzekpɔkpɔ nadzi ɖe edzi eye wòakpe ɖe srɔ̃tɔ siwo mate ŋu adzi vi geɖe wu ŋu be woƒe didi be yewoadzi vi nava eme.
Nyanuwuwuw
Epitalon ɖea ŋutete ɖedzesi aɖe fiana le telomere ƒe didime kple tsitretsitsi ɖe tsitsi ŋu me. Togbɔ be nya aɖewo gakpɔtɔ li siwo ŋu wòhiã be woagawɔ numekuku geɖe le ahakpɔ wo gbɔ hã la, womate ŋu aŋe aɖaba aƒu eƒe vevienyenye dzi le dzɔdzɔmeŋutinunya me nufiafia kple hadomedɔwɔwɔ siaa me o. Esi numekukuwo yi edzi le goglom ɖe edzi la, woxɔe se be Epitalon ahe nu wɔnuku kple ŋgɔyiyi geɖe vɛ le amegbetɔ ƒe lãmesẽnyawo gome.
Dzɔtsoƒewo
[1] Teterin O, Gv S. Epitalon [J]. 2023. https://www.numekuku ƒe mɔnu.net/publication/370060637_Epitalon.
[2] Yue X, Liu S. L., Guo J. N., kple ame bubuwo. Epitalon kpɔa ame ta tso nusiwo gblẽ le sisiblisi ƒe oocytes ŋu le tsitsi megbe le vitro[J]. Tsitsi (Albany Ny), 2022, 14 (7): 3191-3202.DOI: 10.18632 / tsitsi.204007.
[3] Minasi S, Baldi C, Pietsch T, kple ame bubuwo. Telomere ƒe didime to telomere ƒe didime bubu (ALT) kple telomerase ƒe dɔwɔwɔ le ɖevimenɔɣi ƒe medulloblastoma gbãtɔ si kaka me[J]. Ahɔhɔ̃mekawo ƒe Dɔdzẽŋutinunya ƒe Agbalẽ, 2019,142 (3): 435-444.DOI: 10.1007 / s11060-019-03127-w.
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