TB 500 kakɛ 17-13 10mg

▎ TB500 kakɛ(17-13) Dɔwɔɖoɖo

Dzɔtsoƒe: PubChem

Nusiwo kplɔ wo nɔewo ɖo: LKKTETQ Molekyulãwo ƒe Mɔfiame: C 36H 66N 10O13 Molekyulã ƒe Kpekpeme: 847.0 g/mol CAS ƒe xexlẽdzesi: 476014-70-7 PubChem ƒe CID: 10169788 Nya siwo sɔ kple wo nɔewo: Fequesetide;HY-P2463;LKKTETQ

▎ TB500 kakɛ(17-13) Numekuku

Nukae nye TB500 kakɛ ƒe dɔwɔwɔ ƒe mɔnuwo (17-13)?

1. Mɔnu siwo dzi woato ado lãmenugbagbeviwo ƒe gbugbɔgadzɔ ɖe ŋgɔ

TB500 ƒe kakɛ (17-13) wɔa akpa vevi aɖe le lãmenugbagbeviwo ƒe gbugbɔgadzɔ dodo ɖe ŋgɔ me. Ate ŋu awɔ dɔ sia to mɔnu siwo gbɔna dzi:

Lãmenugbagbeviwo ƒe dzidziɖedzi kple vovototodedeameme ƒe ʋuʋu

Kakɛ sia ate ŋu abla ɖe lãmenugbagbevi ƒe xɔla tɔxɛ siwo le lãmenugbagbeviwo ƒe anyime ŋu eye wòana lãmenugbagbeviwo me dzesimɔwo nawɔ dɔ, si ana lãmenugbagbeviwo nadzi ɖe edzi ahaɖe vovototodedeameme ɖe ŋgɔ. Le kpɔɖeŋu me, ate ŋu ana dzesimɔ siwo do ƒome kple lãmenugbagbeviwo ƒe tsitsi kple mama nawɔ dɔ, abe mitogen-activated protein kinase (MAPK) mɔ kple phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) mɔ ene ^[1] . Mɔ siawo ƒe dɔwɔwɔ ate ŋu ado lãmenugbagbeviwo ƒe tsatsam ƒe ŋgɔyiyi ɖe ŋgɔ, ana lãmenugbagbeviwo nadzi ɖe edzi, eye wòato esia me ado lãmenugbagbeviwo ƒe gbugbɔgadzɔ ɖe ŋgɔ.

Tsɔ kpe ɖe eŋu la, TB500 kakɛa (17-13) ate ŋu ado lãmenugbagbeviwo ƒe vovototodedeameme hã ɖe ŋgɔ to domenyiŋusẽfianu tɔxɛwo ƒe ɖeɖefia dzi kpɔkpɔ me. Ate ŋu akpɔ ŋusẽ ɖe nuŋɔŋlɔ ƒe nusiwo do ƒome kple lãmenugbagbeviwo ƒe vovototodedeameme ƒe dɔwɔwɔ dzi, si ana wòaɖɔ lãmenugbagbeviwo ƒe vovototodedeameme ɖo le mɔ aɖe koŋ nu eye wòana lãmenugbagbevi ƒomevi vovovo siwo hiã na lãmenugbagbeviwo ƒe gbugbɔgadzɔ.

Ʋukawo ƒe dzɔdzɔ dodo ɖe ŋgɔ

Zi geɖe la, lãmekawo ƒe gbugbɔgadzɔ bia be woakpɔ ʋu si sɔ, eye ʋukawo ƒe dzɔdzɔ nye nu vevi aɖe si nana ʋu naɖo ame ŋu. TB500 ƒe kakɛa (17-13) ate ŋu ado ʋukawo ƒe dzɔdzɔ ɖe ŋgɔ to ʋuka me lãmenugbagbeviwo ƒe dzidziɖedzi, ʋuʋu, kple lumen wɔwɔ me. Ate ŋu ana nusiwo doa alɔ ʋukawo abe ʋukawo me ʋukawo ƒe tsitsi ƒe nuwɔna (VEGF) ene ƒe ɖeɖefia nawɔ dɔ, si ana ʋuka yeyewo nadzɔ ^[1] . Ʋuka yeye siwo wowɔ la ate ŋu ana ɔksidzin, nunyiame, kple tsitsinu siwo gblẽ la, si ana lãmenugbagbeviwo ƒe gbugbɔgadzɔ kabakaba.

2. Mɔnu siwo dzi woato awɔ dɔ ɖe dɔlékuiwutikewo dzi

Dzoxɔxɔ nye ŋutilã ƒe ametakpɔnu ne exɔ abi alo dɔlékui, gake dɔdzẽ ƒe ŋuɖoɖo si gbɔ eme ate ŋu ana lãmenugbagbeviwo nagblẽ eye woƒe dɔmawɔmawɔ nyuie. TB500 kakɛa (17-13) ƒe dɔwɔwɔ tsia dɔdzẽ nu, eye eƒe dɔwɔwɔ ate ŋu anye nusiwo gbɔna:

Mɔxexe ɖe dɔdzẽ ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ kple wo xɔxɔ nu

Zi geɖe la, dɔdzẽ ƒe ŋuɖoɖowo lɔa dɔdzẽ ƒe lãmenugbagbevi vovovowo abe neutrophils, macrophages, kple lymphocytes ene ƒe dɔwɔwɔ kple wo xɔxɔ ɖe dɔ me ɖe eme. TB500 kakɛa (17-13) ate ŋu aɖe dɔdzẽ ƒe ŋuɖoɖo dzi akpɔtɔ to mɔxexe ɖe dɔdzẽ ƒe lãmenugbagbevi siawo ƒe dɔwɔwɔ kple wo xɔxɔ nu me. Le kpɔɖeŋu me, ate ŋu axe mɔ na lãmenugbagbevi siwo xɔa dɔlékuiwo ƒe ɖeɖefia le dɔdzẽ ƒe lãmenugbagbeviwo ƒe anyime, si aɖe dɔdzẽ ƒe lãmenugbagbeviwo ƒe ŋuɖoɖo ɖe dɔdzẽ ƒe dzesiwo ŋu dzi akpɔtɔ; alo to dɔdzẽ ƒe lãmenugbagbeviwo ƒe ʋuʋu ƒe dzesiwo dzi kpɔkpɔ me, si ɖea dɔdzẽ ƒe lãmenugbagbeviwo ƒe amewo xɔxɔ ɖe teƒe si gblẽ la dzi kpɔtɔna ^{[1] .}.

Tsɔ kpe ɖe eŋu la, kakɛ sia ate ŋu akpɔ ŋusẽ ɖe lãmenugbagbevi siwo naa dɔdzẽ ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ hã dzi eye wòaxe mɔ na lãmenugbagbevi siwo naa dɔdzẽ ƒe dɔwɔwɔ. Le kpɔɖeŋu me.

Dɔdzẽ ƒe domenɔlawo ƒe ɖeɖefia kple woƒe dodo dzi kpɔkpɔ

Le dɔdzẽ ƒe ŋuɖoɖo me la, wowɔa dɔdzẽ ƒe domenɔla vovovowo, abe cytokines, chemokines, kple prostaglandins ene. Dzoxɔxɔ ƒe domenɔla siawo ate ŋu ana dɔdzẽ ƒe ŋuɖoɖoa nadzi ɖe edzi, si ana lãmenugbagbeviwo nagblẽ. TB500 ƒe kakɛa (17-13) ate ŋu awɔ dɔlékuiwutikewo to dɔdzẽ ƒe domenɔlawo ƒe ɖeɖefia kple woƒe dodo dzi kpɔkpɔ me. Le kpɔɖeŋu me, ate ŋu axe mɔ ɖe cytokines siwo doa alɔ dɔdzẽ, abe tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), kple interleukin-6 (IL-6) ene ƒe ɖeɖefia nu; eye le ɣeyiɣi ma ke me la, wodoa cytokines siwo tsia dzodzodzoetsitsi nu, abe interleukin-10 (IL-10) ene, ƒe ɖeɖefia ɖe ŋgɔ ^{[1] .}.

Tsɔ kpe ɖe eŋu la, kakɛ sia ate ŋu akpɔ ŋusẽ ɖe chemokines ƒe ɖeɖefia hã dzi, si ana lãmenugbagbevi siwo xɔa dɔdzẽ ƒe xɔxɔ dzi naɖe akpɔtɔ; alo aɖɔ prostaglandins ƒe wɔwɔme ɖo, si ɖea dɔdzẽ ƒe ŋuɖoɖo dzi kpɔtɔna.

3. Mɔnu siwo dzi woato akpɔ nuwo ɖɔɖɔɖo kabakaba gbɔ

Alesi TB500 kakɛ (17-13) wɔa dɔ le edzadzraɖo kabakaba me ate ŋu ado ƒome kplikplikpli kple eƒe ŋusẽkpɔɖeamedzi le lãmenugbagbeviwo ƒe gbugbɔgadzɔ dodo ɖe ŋgɔ kple dɔdzẽ nutsitsi me. Etɔxɛe la, ate ŋu akpɔ nuwo ɖɔɖɔɖo kabakaba to akpa siwo gbɔna dzi:

Lãmenugbagbevi siwo le lãmenugbagbeviwo godo ƒe wɔwɔme kple wo gbugbɔgawɔ kabakaba

Lãmenugbagbeviwo godo ƒe ƒuƒoƒo nye lãmenugbagbeviwo ƒe akpa vevi aɖe eye wòle vevie ŋutɔ na lãmenugbagbeviwo ƒe wɔwɔme kple dɔwɔwɔ me léle ɖe asi. TB500 ƒe kakɛa (17-13) ate ŋu ana lãmenugbagbevi siwo gblẽ la dzadzraɖo kabakaba to lãmenugbagbeviwo godo ƒe matrix ƒe akpawo abe collagen, elastin, kple glycosaminoglycans ene ƒe wɔwɔme dodo ɖe ŋgɔ me. Ate ŋu ana dzesimɔ siwo do ƒome kple lãmenugbagbeviwo godo ƒe wɔwɔme nawɔ dɔ, si ana lãmenugbagbeviwo nawɔ lãmenugbagbeviwo godo ƒe akpawo ahaɖe wo ɖa ^{[1] .}.

Tsɔ kpe ɖe eŋu la, kakɛ sia ate ŋu aɖɔ lãmenugbagbeviwo godo ƒe matriki ƒe gbugbɔgaɖɔɖo ƒe ɖoɖoa hã ɖo. Le lãmenugbagbeviwo ɖɔɖɔɖodɔa me la, ele be woatrɔ asi le lãmenugbagbeviwo godo ƒe ƒuƒoƒoa ŋu ɣesiaɣi be wòatrɔ ɖe lãmenugbagbeviwo ƒe tsitsi kple wo dzadzraɖo ŋu. TB500 kakɛa (17-13) ate ŋu akpɔ lãmenugbagbeviwo godo ƒe matriki ƒe gbegblẽ kple eƒe wɔwɔme ƒe dadasɔ dzi to enzymewo abe matrix metalloproteinases (MMPs) ene ƒe dɔwɔwɔ dzi kpɔkpɔ me, si ana lãmenugbagbeviwo naɖɔ ɖo kabakaba.

Lãmenugbagbeviwo ƒe ʋuʋu kple woƒe léle ɖe wo nɔewo ŋu ƒe ŋutete dodo ɖe ŋgɔ

Lãmenugbagbeviwo ƒe ʋuʋu kple woƒe ƒoƒo ɖe wo nɔewo ŋu ƒe ŋutete hã le vevie ŋutɔ na lãmenugbagbeviwo ɖɔɖɔɖo. TB500 kakɛa (17-13) ate ŋu ana lãmenugbagbeviwo ƒe ʋuʋu kple woƒe ƒoƒo ɖe wo nɔewo ŋu ƒe ŋutete nadzi ɖe edzi to lãmenugbagbeviwo ƒe anyigbadzixɔlawo ƒe ɖeɖefia kple dɔwɔwɔ dzi kpɔkpɔ me. Le kpɔɖeŋu me, ate ŋu ado lãmenugbagbeviwo ƒe ƒoƒo ɖe wo nɔewo ŋu ƒe moleculewo abe integrins ene ƒe ɖeɖefia ɖe ŋgɔ, si ana lãmenugbagbeviwo kple lãmenugbagbeviwo godo ƒe matriki dome nalé ɖe wo nɔewo ŋu ɖe edzi; alo aɖɔ lãmenugbagbeviwo ƒe ƒunukpeƒewo ƒe ɖoɖo yeye ɖo, si doa lãmenugbagbeviwo ƒe ʋuʋu ɖe ŋgɔ ^{[1] .}.

Lãmenugbagbeviwo ƒe ʋuʋu ate ŋu ana lãmenugbagbevi siwo ƒo xlã lãkusi si gblẽ la nate ŋu aɖo teƒe si gblẽ la kaba eye woakpɔ gome le lãkusiwo ɖɔɖɔɖodɔa me; eye lãmenugbagbeviwo ƒe ƒoƒo ɖe wo nɔewo ŋu ate ŋu akpɔ egbɔ be lãmenugbagbeviawo wɔa akpa aɖe le teƒe si gblẽ la li ke, si ana lãkusiwo nadzra ɖo kabakaba.

HCD MS/MS si woŋlɔ ɖe 20eV (a) kple 700MHz-NMR (b) spectra me le TB-500 me.

Dzɔtsoƒe:PubMed ^{[1] .}

Aleke TB500 kakɛ (17-13) wɔa ɖoɖo ɖe lãmekawo ŋu be wòana kamedefefewo nanyo ɖe edzi eye wòaɖe ɖeɖiteameŋu dzi akpɔtɔ?

Dɔwɔwɔ tẽ ɖe ahɔhɔ̃mekawo ŋu

TB500 kakɛa (17-13) ate ŋu awɔ dɔ ɖe ahɔhɔ̃mekawo dzi tẽ, si akpɔ ŋusẽ ɖe ahɔhɔ̃mekawo ƒe dzodzo, lãmenugbagbeviwo ƒe kaka, kple woƒe plasticity dzi. Le kpɔɖeŋu me, ate ŋu abla ɖe lãmenugbagbevi siwo le ahɔhɔ̃mekawo ƒe anyime ŋu, ana lãmenugbagbeviwo me dzesimɔwo nawɔ dɔ, eye wòaɖɔ ahɔhɔ̃mekawo ƒe dɔwɔwɔ ɖo.

Numekuku aɖewo ɖee fia be thymosin β4 ate ŋu abla ɖe xɔla vovovowo ŋu, siwo dometɔ aɖewoe nye integrin xɔla kple tsitsi ƒe nuxɔla, siwo wɔa akpa vevi aɖe le lãmekawo ƒe tsitsi kple dɔwɔwɔ me ^[1]..

Lãmetsiŋusẽ ƒe ɖoɖowɔwɔ si mele tẽ o to dɔlélenutsiŋutete dzi

Kadodo kplikplikpli le dɔlélenutsiŋutete kple lãmekawo dome. TB500 kakɛa (17-13) ate ŋu akpɔ ŋusẽ ɖe lãmekawo dzi le mɔ si mele tẽ o nu to dɔlélenutsiŋutete ƒe dɔwɔwɔ dzi kpɔkpɔ me. Le kpɔɖeŋu me, ate ŋu akpɔ ŋusẽ ɖe dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ kple woƒe dodo dzi, aɖɔ dɔdzẽ ƒe agbɔsɔsɔme ɖo, eye wòato esia me akpɔ ŋusẽ ɖe lãmekawo ƒe dɔwɔwɔ dzi.

Numekuku aɖewo ɖee fia be dɔdzẽ wɔa akpa vevi aɖe le lãmekawo ƒe dɔlélewo kple ɖeɖiteameŋu me. TB500 kakɛa (17-13) ate ŋu aɖe lãmekawo ƒe dɔdzẽ ƒe ŋuɖoɖo dzi akpɔtɔ eye wòana lãmekawo ƒe dɔwɔwɔ nanyo ɖe edzi to dɔdzẽ ƒe nuwɔna ƒe agbɔsɔsɔme dzi kpɔkpɔ me ^[1]..

Ŋusẽkpɔɖeamedzi ɖe ahɔhɔ̃mekawo ƒe dɔwɔwɔ dzi

Ahɔhɔ̃mekawo ƒe dɔwɔwɔ wɔa akpa vevi aɖe le ŋutilãa ƒe ŋutilã ƒe dɔwɔwɔ kple nuteɖeamedzi ƒe ŋuɖoɖowo dzi kpɔkpɔ me. TB500 kakɛa (17-13) ate ŋu aɖɔ lãmekawo ƒe dɔwɔwɔ ɖo to ŋusẽkpɔkpɔ ɖe ahɔhɔ̃mekawo ƒe dɔwɔwɔ dzi. Le kpɔɖeŋu me, ate ŋu akpɔ ŋusẽ ɖe hypothalamic-pituitary-adrenal axis ƒe dɔwɔwɔ dzi, aɖɔ nuteɖeamedzi ƒe lãmetsiwo abe cortisol ene ƒe dodo ɖo, eye wòato esia me akpɔ ŋusẽ ɖe lãmekawo ƒe dɔwɔwɔ dzi.

Numekuku aɖewo ɖee fia be nuteɖeamedzi ƒe lãmetsiwo ƒe agbɔsɔsɔ do ƒome kplikplikpli kple ɖeɖiteameŋu ƒe seselelãme kple kamedefefe ƒe ŋutete. TB500 kakɛa (17-13) ate ŋu aɖe ɖeɖiteameŋu ƒe seselelãme dzi akpɔtɔ eye wòana kamedefefewo nanyo ɖe edzi to nuteɖeamedzi ƒe lãmetsiwo ƒe agbɔsɔsɔ dzi kpɔkpɔ me ^{[1] .}.

Nukae nye TB500 ƒe kakɛ (17-13) ƒe ŋusẽkpɔɖeamedzi?

1. Lãmetsiwo dzadzraɖo kple wo gbugbɔgawɔ

Abi ƒe dɔyɔyɔ na abi siwo nu sẽ kple esiwo nɔa anyi didi: 

Le abi siwo nu sẽ (abe amekoko ƒe lãɖeɖe, dzobibi) kple abi siwo nɔa anyi didi (abe suklidɔ ƒe abi ene) gome la, TB500 ƒe kakɛa (17-13) ate ŋu aɖe abi ƒe dzɔdzɔ dzi akpɔtɔ. Alesi wòwɔa dɔe ate ŋu atso collagen ƒe sisi ɖe ɖoɖo nu dodo ɖe ŋgɔ kple dɔdzẽ ƒe dɔwɔwɔ dzi kpɔkpɔ ^{[2] .}.

Lãmetsiŋusẽ ƒe gbugbɔgadzɔ si woɖe fia le lãwo ƒe dodokpɔwo me: 

Le lãwo dodokpɔ me la, peptide kakɛ sia ate ŋu ado ŋutigbalẽ, lãmeka, lãkusi, kple ƒunukpeƒe ƒe gbugbɔgadzɔ ɖe ŋgɔ. Le kpɔɖeŋu me, le ŋutigbalẽ ƒe abixɔxɔ ƒe kpɔɖeŋu me la, TB500 kakɛ (17-13) ateŋu aʋã keratinocytes ƒe ʋuʋu kple dzidziɖedzi, si ana abi ƒe dɔyɔyɔ kabakaba (Ho ENM, 2012). Le lãmeka kple lãkusi ƒe abi gome la, ate ŋu ado lãmenugbagbeviwo ɖɔɖɔɖo ɖe ŋgɔ to satelait lãmenugbagbeviwo ƒe dɔwɔwɔ kple woƒe dzidziɖedzi dodo ɖe ŋgɔ me ^[3] . Le ƒunukpeƒe ƒe abixɔxɔ ƒe kpɔɖeŋu me la, peptide kakɛ sia ate ŋu ado ƒunukpeƒe ƒe gbugbɔgadzɔ ɖe ŋgɔ to ƒunukpeƒewo ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ kple woƒe wɔwɔme ƒe dɔwɔwɔ dzi kpɔkpɔ me ^[2]..

2. Nusiwo tsia dzodzodzoetsitsi nu

Le dɔdzẽ ƒe dɔléle siwo nɔa anyi didi (abe ƒunukpeƒetetedɔ, Crohn ƒe dɔléle ene) me la, dɔdzẽ ƒe ŋuɖoɖoa nɔa anyi, si wɔnɛ be lãmenugbagbeviwo gblẽna eye ŋutinuwo megawɔa dɔ nyuie o. Abe atikewɔwɔ kpeɖeŋutɔ ene la, TB500 ƒe kakɛ (17-13) ateŋu aɖe dɔléle ƒe dzesiwo dzi akpɔtɔ eye wòahe dɔlélea ƒe ŋgɔyiyi ɖe megbe to mɔxexe ɖe dɔdzẽ ƒe ŋuɖoɖo nu ^[4]..

3. Lãmetsiŋusẽ ƒe abi siwo woxɔ la gbugbɔgaɖɔɖo

TB500 ƒe kakɛa (17-13) nana lãmekawo ƒe tete, lãkusi ƒe dɔmawɔmawɔ nyuie, kple lãkusi ƒe abixɔxɔwo ɖɔɖɔɖo kabakaba, si wɔnɛ be kamedefefewɔlawo ƒe gbugbɔgaɖɔɖo ƒe ɣeyiɣia dzi ɖena kpɔtɔna. Le kamedefefewo ƒe atikewɔwɔ me la, lãmekawo ƒe abixɔxɔ nye kuxi siwo bɔ. Peptide kakɛ sia ate ŋu ado lãmenugbagbevi siwo gblẽ la dzadzraɖo ɖe ŋgɔ ^{[3] .}.

4. Dzi ƒe nuwo ɖɔɖɔɖo

Le dzitodzito ƒe ʋuʋu megbe la, TB500 ƒe kakɛa (17-13) ate ŋu ado ʋukawo ƒe dzɔdzɔ kple dzitodzito me lãmenugbagbeviwo ƒe agbetsitsi ɖe ŋgɔ, si ana dzitodzito ƒe dɔwɔwɔ nanyo ɖe edzi. Dzitodzito me ʋu ƒe sisi nye dɔléle si tsoa ʋuka si me ʋu sina tona ƒe xexe me, si hea dzitodzito me ʋu ƒe sisi kple ya si mebɔ o vɛ. Angiogenesis ate ŋu ana oxygen kple nunyiamewo dzitodzito si gblẽ, si ana dzitodzito me lãmenugbagbeviwo nanɔ agbe ahadzra wo ɖo ^[5]..

Le lãwo ƒe kpɔɖeŋuwo me la, TB500 kakɛa (17-13) ɖea ʋuka si me ʋu sina tona ƒe lolome dzi kpɔtɔna ŋutɔ eye wònaa dzitodzito ƒe ɖɔɖɔɖo nyona ɖe edzi. Eƒe dɔwɔwɔ ƒe mɔnu ate ŋu ado ƒome kple tsitsinu siwo nye ʋukawo ƒe lãmenugbagbeviwo ƒe tsitsi ƒe nuwɔna (VEGF) ƒe ɖeɖefia kple woƒe dodo ɖe ŋgɔ.

5. Ahɔhɔ̃mekawo takpɔkpɔ kple ahɔhɔ̃ ƒe lãmesẽ

TB500 kakɛa (17-13) xea mɔ na ahɔhɔ̃mekawo ƒe tsɔtsrɔ̃ eye wòdoa ahɔhɔ̃mekawo ƒe lãmenugbagbeviwo ƒe dzidziɖedzi ɖe ŋgɔ. Ahɔhɔ̃mekawo ƒe tsɔtsrɔ̃ nye dɔlélemɔnu vevi siwo dzi ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie kple ahɔhɔ̃ ƒe abixɔxɔ tsona la dometɔ ɖeka. Peptide kakɛ sia ate ŋu axe mɔ ɖe ahɔhɔ̃mekawo ƒe tsɔtsrɔ̃ nu to lãmenugbagbeviwo me dzesimɔwo dzi kpɔkpɔ me. Le ɣeyiɣi ma ke me la, ahɔhɔ̃mekawo ƒe lãmenugbagbeviwo ƒe dzidziɖedzi dodo ɖe ŋgɔ ate ŋu ana lãmenugbagbeviwo ƒe dzɔtsoƒe yeye nasu lãmeka siwo gblẽ la si, si ado lãmekawo ƒe ɖɔɖɔɖo ɖe ŋgɔ.

Le ʋusɔgbɔdɔ, ahɔhɔ̃ ƒe abi si nu sẽ (TBI), kple ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie (abe Alzheimer ƒe dɔléle ene) me la, lãmekawo gblẽna le agbɔsɔsɔ vovovowo me. TB500 kakɛa (17-13) ate ŋu akpe ɖe dɔnɔwo ƒe hayahaya ŋu to eƒe ahɔhɔ̃mekawo takpɔkpɔ kple lãmekawo ɖɔɖɔɖo ƒe ŋusẽkpɔɖeamedziwo me ^[4]..

6. Ŋkudɔlélewo dada

0.1% Tβ4 ŋkumeɖonu da abiawo keŋkeŋ eye wòɖe dzesiawo dzi kpɔtɔ le dɔnɔ 6 siwo ŋu ahɔhɔ̃mekawo ƒe dɔléle le ŋu. Neurotrophic keratitis nye ŋkume ƒe dɔléle si tsoa ŋkume ƒe lãmekawo ƒe dɔmawɔmawɔ nyuie gbɔ. TB500 kakɛa (17-13) ate ŋu ado ŋkume ƒe abiwo ƒe dɔyɔyɔ ɖe ŋgɔ to ŋkume ƒe lãmenugbagbeviwo ƒe dzidziɖedzi kple woƒe ʋuʋu dodo ɖe ŋgɔ kple ŋkume ƒe dɔdzẽ ƒe ŋuɖoɖo dzi kpɔkpɔ me ^{[6] .}.

7. Taɖa ƒe gbugbɔgadzɔ

TB500 kakɛa (17-13) naa ɖa ƒe lãmenugbagbeviwo wɔa dɔ eye wònaa ɖa ƒe tsitsi ƒe anagen ƒe akpaa didi. Taɖa ƒe lãmenugbagbeviwoe nye lãmenugbagbevi vevi siwo nana ɖa gbugbɔna. Woate ŋu ato vovo azu lãmenugbagbevi ƒomevi vovovowo le ɖa ƒe lãkusi me, si ana ɖa ƒe tsitsi kple tsitsi ɖe ŋgɔ. Peptide kakɛ sia ateŋu ado ɖa ƒe gbugbɔgadzɔ ɖe ŋgɔ to ɖa ƒe lãmenugbagbeviwo ƒe dzidziɖedzi kple vovototodedeameme dzi kpɔkpɔ me (Pan DY, 2021).

Lãwo ƒe dodokpɔwo

Afiwo: 

Taɖa ƒe tsitsi kabakaba. Le sisiblisi ƒe kpɔɖeŋu me la, TB500 kakɛ (17-13) ate ŋu ado ɖa ƒe tsitsi kple tsitsi ɖe ŋgɔ to ɖa ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ me ^[4]..

Gbɔ̃wo: 

Dzi ɖa evelia ƒe xexlẽme ɖe edzi eye nàdo ɖa si le anyime ƒe wɔwɔ ɖe ŋgɔ. Le gbɔ̃ ƒe kpɔɖeŋu me la, peptide kakɛ sia ate ŋu ado ɖa si le anyime ƒe tsitsi ɖe ŋgɔ to ɖa ƒe tsitsi ƒe tsatsam kple taɖa ƒe tsitsi ƒe agbɔsɔsɔme dzi kpɔkpɔ me ^{[4] .}.

Le nyataƒoƒo me la, TB500 kakɛa (17-13) ate ŋu ado lãmenugbagbeviwo ɖɔɖɔɖo, dɔlékuiwutikewo, kple lãmenugbagbeviwo ƒe gbugbɔgadzɔ ɖe ŋgɔ, ana abi nahaya kabakaba, eye wòana lãmekawo ƒe dɔwɔwɔ nanyo ɖe edzi. Ele vevie ŋutɔ na atikewɔwɔ si naa ame ƒe lãme gbugbɔna, si hea mɔkpɔkpɔ yeye vɛ na dɔlélewo abe dzobibi kple lãmekawo ƒe abixɔxɔ ene dada kple atike siwo tsia dzodzodzoetsitsi nu ƒe numekuku kple wo wɔwɔ, eye woate ŋu azã wo le mɔ geɖe nu.

Le Agbalẽŋlɔla La Ŋu

Nusiwo míeyɔ ɖe etame la katã nye esiwo ŋu Cocer Peptides wɔ numekuku le, trɔ asi le wo ŋu eye woƒo wo nu ƒu.

Dzɔdzɔmeŋutinunya ƒe Agbalẽŋlɔla

Choi B nye numekula kple agbalẽnyala xɔŋkɔ aɖe si do ƒome vevie kple dɔwɔƒe xɔŋkɔwo abe Yonsei Yunivɛsiti kple Seoul Dukɔa ƒe Yunivɛsiti (SNU). Dɔ si wòwɔ le dɔwɔƒe siawo katã wɔ akpa vevi aɖe le nusɔsrɔ̃ kple numekuku ƒe akpa vovovowo dodo ɖe ŋgɔ me.

Eƒe numekuku ƒe didiwo kple nunya le nyati vovovowo me. Esiawo dometɔ aɖewoe nye Nu Gbagbewo Ŋuti Nunya, Nu Gbagbewo Ŋuti Mɔ̃ɖaŋununya & Nu Gbagbewo Ŋuti Nunya, Dɔlélenutsiŋutete Ŋuti Nunya, Atikeŋutinunya & Atikeŋutinunya, kple Dzɔdzɔmeŋutinunya & Mɔ̃ɖaŋununya - Nyati Bubuwo. Numekuku geɖe siwo wòwɔ le go siawo me ɖe eƒe sidzedze geɖe kple akpa si wòwɔ na dzɔdzɔmeŋutinunyalawo fia. Woŋlɔ Choi B ɖe nyayɔyɔ ƒe numekugbalẽ [2] me.

▎ Nyayɔyɔ Siwo Sɔ

[1] Esposito S, Deventer K, Goeman J, kple ame bubuwo. Thymosin beta 4 ƒe N-terminal acetylated 17-23 kakɛ si wokpɔ le TB-500, si nye atike si wosusu be atike muamewo zazã ƒe ŋutete le esi me ƒe wɔwɔme kple eƒe nɔnɔmewo ɖeɖefia[J]. Atikewo Dodokpɔ Kple Wo Me Dzodzro, 2012, 4 (9): 733-738.DOI: 10.1002 / dta.1402.

[2] Choi B, Lee C, Yu J. Akpa tɔxɛ si dɔdzẽ wɔna le lãmenugbagbeviwo ɖɔɖɔɖo kple wo gbugbɔgadzɔ me[J]. Atikewɔwɔ Ŋuti Numekuku ƒe Nudzraɖoƒe, 2023,46 (2): 78-89.DOI: 10.1007 / s12272-023-01428-3.

[3] Llgen HLO, Llgen RML O. Lãmesẽ kple Atikewɔwɔ le etsɔme: tɔtrɔ to kamedefefe ƒe atikewɔwɔ me. Kamedefefewo ƒe Atikewɔwɔ le tɔtrɔ me, 2018[C]. https://www.semanticscholar.org/paper/Lãmesẽ-kple-Atikewɔwɔ le etsɔme%3Tɔtrɔ toL%C3%B6llgenL%C3%B6llgen/a5d6430c8b5442f02bc3238fa48ec0e657489942

[4] Pan DY, Xu LY, Li E M. TB4 ƒe tɔtrɔ le gbegɔmeɖeɖe megbe kple eƒe dɔwɔwɔ ƒe ɖoɖowɔwɔ[J]. Agbe ƒe Dzɔdzɔmeŋusẽŋununya, 2021,41 (04): 734-740.DOI: 10.13488 / j.smhx.20200532.

[5] Eming S A. Dɔlélenutsiŋutete ƒe mɔnuwo ƒe tɔtrɔ le gbugbɔgadzɔ kple edzadzraɖo me: Nyitsɔ laa ƒe nukpɔsusuwo kple gbegɔmeɖeɖe ƒe nukpɔsusuwo[J]. Nusɔsrɔ̃wo le Dɔlélenutsiŋutete, 2014, 26 (4): 275-276.DOI: 10.1016 / j.smim.2014.09.001.

[6] Ho ENM, Kwok WH, Lau MY, kple ame bubuwo. Doping control analysis of TB-500, si nye thymosin β4 ƒe nuto si le dɔ wɔm ƒe wɔwɔme, le sɔwo ƒe aɖuɖɔ kple ʋumenugbagbeviɣi me to liquid chromatography-mass spectrometry[J]. Agbalẽ si nye Chromatography A, 2012, 1265: 57-69.DOI: 10.1016 / j.chroma.2012.09.043.

NYATAKAKAWO KPLE NUSIWO WOTSƆ ƑE NYATAKAKA SIWO KAtã WOÐO LE NYATAKAKADZRAÐOƑE SIA ME LA KPLE NYATAKAKAWO kaka KPLEE NUFIAFIA ƑE TAÐOÐOWO KO.  

Wotrɔ asi le atike siwo wona le nyatakakadzraɖoƒe sia ŋu na numekuku le vitro ɖeɖeko. Wowɔa numekuku le vitro (Latingbe me: *le ahuhɔ̃e me*, si gɔmee nye le ahuhɔ̃e me) le amegbetɔ ƒe ŋutilã godo. Atike siawo menye atikewo o, United States ƒe Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) meda asi ɖe wo dzi o, eye mele be woazã wo atsɔ axe mɔ ɖe atikewɔwɔ, dɔléle, alo dɔléle aɖeke nu, adae, alo adae o. Se de se vevie be woatsɔ atike siawo ade amegbetɔ alo lãwo ƒe ŋutilã me le mɔ ɖesiaɖe nu.