Iberibe TB 500 17-13 10mg

▎ TB500 iberibe (17-13) Ọdịdị

Isi mmalite: PubChem

Usoro: LKKTETQ Ụdị mkpụrụ ndụ: C 36H 66N 10O13 Ibu ibu: 847.0 g/mol Nọmba CAS: 476014-70-7 PubChem CID: 10169788 Okwu: Fequesetide;HY-P2463;LKKTETQ

▎ TB500 iberibe (17-13) nyocha

Kedu usoro eji arụ ọrụ nke iberibe TB500 (17-13)?

1. Usoro nke ịkwalite mmeghari anụ ahụ

Iberibe TB500 (17-13) na-arụ ọrụ dị mkpa n'ịkwalite mmegharị anụ ahụ. Ọ nwere ike nweta ọrụ a site na usoro ndị a:

Na-akpali akpali cell mmụba na iche iche

Iberibe a nwere ike jikọta na ndị na-anabata ya kpọmkwem n'elu cell ma mee ka ụzọ mgbaàmà intracellular rụọ ọrụ, si otú ahụ na-akwalite mmụba cell na ọdịiche. Dịka ọmụmaatụ, ọ nwere ike mee ka ụzọ mgbaàmà na-emetụta uto cell na nkewa, dị ka ụzọ mitogen-activated protein kinase (MAPK) na phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) ụzọ ^[1] . Ịkwalite ụzọ ndị a nwere ike ịkwalite ọganihu nke cell cell, mee ka ọnụ ọgụgụ nke mkpụrụ ndụ dịkwuo elu, ma si otú ahụ kwalite mmepụta anụ ahụ.

Na mgbakwunye, iberibe TB500 (17-13) nwekwara ike ịkwalite ọdịiche nke cell site n'ịchịkwa okwu nke mkpụrụ ndụ ihe nketa. Ọ nwere ike imetụta ọrụ nke ihe odide ederede metụtara ihe dị iche iche nke cell, si otú ahụ na-achịkwa ihe dị iche iche nke mkpụrụ ndụ na ntụziaka dị iche iche ma na-enye ụdị mkpụrụ ndụ dị iche iche achọrọ maka ịmaliteghachi anụ ahụ.

Na-akwalite angiogenesis

Mweghachi anụ ahụ na-achọkarị inye ọbara zuru oke, na angiogenesis bụ usoro dị mkpa maka inye ọbara. Mpempe akwụkwọ TB500 (17-13) nwere ike ịkwalite angiogenesis site n'ịkwalite mmụba, mbugharị, na lumen nhazi nke mkpụrụ ndụ endothelial vaskụla. Ọ nwere ike mee ka nkwupụta nke pro-angiogenic ihe dị ka vascular endothelial growth factor (VEGF), si otú ahụ na-akwalite nhazi nke arịa ọbara ọhụrụ ^[1] . Ọkpụkpụ ọbara ndị e hiwere ọhụrụ nwere ike inye oxygen, nri, na ihe ndị na-eto eto na anụ ahụ mebiri emebi, na-eme ka usoro ahụ na-emegharị ahụ ngwa ngwa.

2. Usoro nke ime mmetụta mgbochi mkpali

Mbufụt bụ nzaghachi nchebe nke ahụ maka mmerụ ahụ ma ọ bụ ọrịa, mana mmeghachi omume mkpasu iwe nwere ike ibute mmebi anụ ahụ na arụ ọrụ. Iberibe TB500 (17-13) nwere mmetụta mgbochi mkpali, na usoro ya nwere ike ịgụnye akụkụ ndị a:

Na-egbochi ịgbalite na iwere mkpụrụ ndụ mkpali

Nzaghachi na-egbuke egbuke na-agụnyekarị ịgbalite na iwere mkpụrụ ndụ mkpali dị iche iche, dị ka neutrophils, macrophages, na lymphocytes. Mpempe akwụkwọ TB500 (17-13) nwere ike ibelata nzaghachi mkpali site na igbochi ọrụ na ntinye nke sel ndị a na-akpasu iwe. Dịka ọmụmaatụ, ọ nwere ike igbochi nkwupụta nke ndị na-anabata ya n'elu sel ndị na-egbuke egbuke, na-ebelata nzaghachi nke mkpụrụ ndụ na-egbuke egbuke na akara ngosi; ma ọ bụ site n'ịhazi akara mbugharị nke mkpụrụ ndụ mkpali, na-ebelata mbanye nke mkpụrụ ndụ mkpali na saịtị mebiri emebi ^[1].

Tụkwasị na nke a, mpempe akwụkwọ a nwekwara ike imetụta usoro metabolic nke mkpụrụ ndụ na-egbuke egbuke ma na-egbochi ọrụ nke mkpụrụ ndụ mkpali. Dịka ọmụmaatụ, ọ nwere ike ịhazi metabolism ume nke mkpụrụ ndụ mkpali, belata mmepụta nke ụdị oxygen reactive (ROS) na cytokines pro-inflammatory site na mkpụrụ ndụ na-egbuke egbuke, ma si otú ahụ belata nzaghachi mkpali.

Ịchịkwa okwu na ntọhapụ nke ndị ogbugbo mkpali

N'oge mmeghachi omume mkpali, a na-emepụta ụdị mgbasa ozi dị iche iche, dị ka cytokines, chemokines, na prostaglandins. Ndị mgbasa ozi ndị a na-agba ọkụ nwere ike ime ka mmeghachi omume ahụ dịkwuo elu, na-eduga na mmebi anụ ahụ. Iberibe TB500 (17-13) nwere ike inwe mmetụta mgbochi mkpali site na ịhazi okwu na ntọhapụ nke ndị mgbasa ozi mkpali. Dịka ọmụmaatụ, ọ nwere ike igbochi okwu nke cytokines pro-inflammatory, dị ka tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), na interleukin-6 (IL-6); ma n'otu oge ahụ, kwalite nkwupụta nke cytokines na-egbochi mkpali, dị ka interleukin-10 (IL-10) ^[1].

Tụkwasị na nke a, mpempe akwụkwọ a nwekwara ike imetụta nkwupụta nke chemokines, na-ebelata ntinye nke mkpụrụ ndụ mkpali; ma ọ bụ na-ahazi njikọ nke prostaglandins, na-ebelata nzaghachi mkpali.

3. Usoro nke inweta nrụzi ngwa ngwa

Usoro omume nke iberibe TB500 (17-13) na nrụzi ngwa ngwa nwere ike jikọta ya na mmetụta ya nke ịkwalite mmeghari anụ ahụ na mgbochi mbufụt. Kpọmkwem, ọ nwere ike nweta nrụzi ngwa ngwa site na akụkụ ndị a:

Na-eme ngwa ngwa njikọ na nhazigharị nke matrix extracellular

Matrix extracellular bụ akụkụ dị mkpa nke anụ ahụ ma dị oke mkpa maka idowe nhazi na ọrụ nke anụ ahụ. Iberibe TB500 (17-13) nwere ike mee ka mmezi nke anụ ahụ mebiri emebi ngwa ngwa site n'ịkwalite njikọ nke akụkụ matrix extracellular, dị ka collagen, elastin, na glycosaminoglycans. Ọ nwere ike ịgbalite ụzọ mgbaama metụtara njikọ nke matriks extracellular, na-akwalite mkpụrụ ndụ ka ha mekọrịta na zoo akụkụ matrix extracellular ^[1].

Na mgbakwunye, iberibe a nwekwara ike ịhazi usoro nhazigharị nke matrix extracellular. N'oge usoro nrụzi anụ ahụ, matriks extracellular kwesịrị ka a na-emezigharị ya mgbe niile iji mee mgbanwe maka uto na nrụzi anụ ahụ. Mpempe akwụkwọ TB500 (17-13) nwere ike ijikwa nguzozi n'etiti mmebi na njikọ nke matrix extracellular site na ịhazi ọrụ nke enzymes dị ka matrix metalloproteinases (MMPs), na-akwalite mmezi ngwa ngwa nke anụ ahụ.

Na-akwalite mbugharị cell na ike adhesion

Mbugharị na ike nchikota nke mkpụrụ ndụ dịkwa oke mkpa maka nrụzi anụ ahụ. Iberibe TB500 (17-13) nwere ike ime ka mbugharị na ike nke sel dị elu site n'ịhazi okwu na ọrụ nke ndị na-anabata elu cell. Dịka ọmụmaatụ, ọ nwere ike ịkwalite nkwupụta nke mkpụrụ ndụ adhesion cell dị ka integrins, na-amụba adhesion n'etiti sel na matrix extracellular; ma ọ bụ hazie nhazigharị nke cytoskeleton, na-akwalite mbugharị cell ^[1].

Mbugharị nke mkpụrụ ndụ nwere ike ime ka sel ndị dị n'akụkụ anụ ahụ mebiri emebi ngwa ngwa rute ebe ahụ mebiri emebi ma sonye na usoro nrụzi anụ ahụ; na nchikota nke sel nwere ike hụ na mkpụrụ ndụ na-arụ ọrụ nke ọma na saịtị ahụ mebiri emebi, na-akwalite mmezi ngwa ngwa nke anụ ahụ.

HCD MS/MS edere na 20eV (a) na 700MHz-NMR (b) ụdịdị TB-500.

Isi mmalite: PubMed ^[1]

Kedu ka iberibe TB500 (17-13) si achịkwa usoro ụjọ ahụ iji melite arụmọrụ egwuregwu ma belata ike ọgwụgwụ?

Ime ihe ozugbo na neurons

Iberibe TB500 (17-13) nwere ike na-arụ ọrụ ozugbo na neurons, na-emetụta mkpali, nnyefe synapti, na plasticity nke neurons. Dịka ọmụmaatụ, ọ nwere ike jikọta ndị na-anabata ya n'elu neurons, mee ka ụzọ mgbaàmà intracellular rụọ ọrụ, ma na-ahazi ọrụ nke neurons.

Ụfọdụ ọmụmụ egosila na thymosin β4 nwere ike jikọta na ndị na-anabata ya dị iche iche, gụnyere integrin receptors na uto factor receptors, nke na-arụ ọrụ dị mkpa na mmepe na ọrụ nke usoro ụjọ ahụ ^[1]..

Ntuziaka na-apụtaghị ìhè nke usoro ụjọ ahụ site na usoro ahụ ji alụso ọrịa ọgụ

Enwere mmekọrịta chiri anya n'etiti usoro ahụ ji alụso ọrịa ọgụ na sistem ụjọ. Iberibe TB500 (17-13) nwere ike imetụta usoro ụjọ ahụ n'ụzọ na-apụtaghị ìhè site n'ịhazi ọrụ nke usoro ahụ ji alụso ọrịa ọgụ. Dịka ọmụmaatụ, ọ nwere ike imetụta ọrụ na nzuzo nke sel ndị na-adịghị ahụkebe, na-achịkwa ọkwa nke ihe ndị na-egbuke egbuke, ma si otú ahụ na-emetụta ọrụ nke usoro ụjọ ahụ.

Ụfọdụ nnyocha egosiwo na ihe ndị na-egbuke egbuke na-ekere òkè dị mkpa na ọrịa usoro ụjọ na ike ọgwụgwụ. Iberibe TB500 (17-13) nwere ike ibelata nzaghachi mkpali nke usoro ụjọ ahụ ma melite ọrụ nke usoro ụjọ ahụ site n'ịhazi ọkwa nke ihe ndị na-egbuke egbuke ^[1].

Mmetụta na usoro neuroendocrine

Usoro neuroendocrine na-arụ ọrụ dị mkpa n'ịhazi ọrụ physiological nke anụ ahụ na nzaghachi nrụgide. Mpempe akwụkwọ TB500 (17-13) nwere ike ịhazi ọrụ nke usoro ụjọ ahụ site na imetụta ọrụ nke usoro neuroendocrine. Dịka ọmụmaatụ, ọ nwere ike imetụta ọrụ nke hypothalamic-pituitary-adrenal axis, na-achịkwa mmepụta nke hormones nchekasị dị ka cortisol, ma si otú ahụ na-emetụta ọrụ nke usoro ụjọ ahụ.

Ụfọdụ ọmụmụ egosila na ọkwa nke homonụ nchekasị nwere njikọ chiri anya na mmetụta nke ike ọgwụgwụ na ịrụ ọrụ egwuregwu. Iberibe TB500 (17-13) nwere ike ibelata mmetụta nke ike ọgwụgwụ ma melite arụmọrụ egwuregwu site na ịhazi ọkwa nke homonụ nchekasị ^[1].

Gịnị bụ mmetụta nke iberibe TB500 (17-13)?

1. Nrụzi anụ ahụ na mmeghari ohuru

Ọgwụgwọ ọnya nke nnukwu ọnya na nke na-adịghị ala ala: 

Maka nnukwu ọnya (dị ka mbepụ ịwa ahụ, ọkụ) na ọnya na-adịghị ala ala (dị ka ọnya ọrịa shuga), iberibe TB500 (17-13) nwere ike ibelata ọnya ahụ. Usoro ya nwere ike jikọta ya na ịkwalite ntinye nke collagen n'usoro na ịhazi nzaghachi mkpali ^[2].

Mweghachi anụ ahụ egosiri na nnwale anụmanụ: 

N'ime nnwale anụmanụ, iberibe peptide a nwere ike ịkwalite mmeghari akpụkpọ ahụ, akwara, akwara, na cartilage. Dịka ọmụmaatụ, na ụdị mmerụ ahụ akpụkpọ ahụ, mpempe TB500 (17-13) nwere ike ime ka mpụ na mmụba nke keratinocytes, na-eme ka ọnya na-agwọ ọrịa ngwa ngwa (Ho ENM, 2012). Maka mmerụ ahụ akwara na akwara, ọ nwere ike ịkwalite nrụzi anụ ahụ site n'ịkwalite nkwalite na mmụba nke sel satịlaịtị ^[3] . N'ụdị mmerụ ahụ nke cartilage, iberibe peptide a nwere ike ịkwalite nrụpụta cartilage site na ịhazi metabolism na njikọ njikọ nke chondrocytes ^[2]..

2. Njirimara mgbochi mkpali

N'ọrịa ndị na-adịghị ala ala (dị ka ọrịa ogbu na nkwonkwo, ọrịa Crohn), nzaghachi mkpali na-aga n'ihu, na-ebute mmebi anụ ahụ na arụ ọrụ akụkụ ahụ. Dị ka ọgwụgwọ adjuvant, iberibe TB500 (17-13) nwere ike belata mgbaàmà ọrịa na igbu oge na-aga n'ihu ọrịa site na igbochi nzaghachi mkpali ^[4]..

3. Mweghachi nke mmerụ ahụ musculoskeletal

Iberibe TB500 (17-13) na-eme ka nrụzi nke akwara anụ ahụ, tendonitis, na mmerụ ahụ ligament dị mkpụmkpụ, na-ebelata oge nhazigharị nke ndị na-eme egwuregwu. Na ọgwụ egwuregwu, mmerụ ahụ musculoskeletal bụ nsogbu nkịtị. Iberibe peptide a nwere ike ịkwalite nrụzi anụ ahụ mebiri emebi ^[3].

4. Nrụzi obi

Mgbe myocardial infarction gasịrị, iberibe TB500 (17-13) nwere ike ịkwalite angiogenesis na ndụ nke cardiomyocytes, na-eme ka ọrụ obi dịkwuo mma. Myocardial infarction bụ ọrịa na-akpata site na nkwụsị nke akwara obi, na-eduga na ischemia myocardial na hypoxia. Angiogenesis nwere ike inye oxygen na nri na myocardium mebiri emebi, na-akwalite nlanarị na mmezi nke cardiomyocytes ^[5].

N'ụdị anụmanụ, iberibe TB500 (17-13) na-ebelata oke infarct ma na-emezi mmezi myocardial. Usoro ya nwere ike jikọta ya na ịkwalite nkwupụta na ntọhapụ nke ihe ndị na-eto eto dị ka vascular endothelial growth factor (VEGF).

5. Neuroprotection na ahụike ụbụrụ

Iberibe TB500 (17-13) na-egbochi apoptosis neuronal ma na-akwalite mmụba nke mkpụrụ ndụ stem neural. Neuronal apoptosis bụ otu n'ime usoro ọgwụgwọ dị mkpa nke ọrịa neurodegenerative na mmerụ ụbụrụ. Iberibe peptide a nwere ike igbochi apoptosis neuronal site n'ịhazi ụzọ mgbaàmà intracellular. N'otu oge ahụ, ịkwalite mmụba nke mkpụrụ ndụ sel akwara nwere ike inye mkpụrụ ndụ ọhụrụ maka anụ ahụ mebiri emebi, na-akwalite nrụzi akwara.

N'ime ọrịa strok, mmerụ ahụ ụbụrụ na-emerụ ahụ (TBI), na ọrịa neurodegenerative (dịka ọrịa Alzheimer), anụ ahụ akwara na-emebi ruo ogo dịgasị iche iche. Iberibe TB500 (17-13) nwere ike inye aka na mgbake nke ndị ọrịa site na nrụzi neuroprotective na nke na-akwalite akwara ^[4].

6. Ọgwụgwọ ọrịa anya

0.1% Tβ4 anya na-adaba na-agwọta ọnya ahụ kpamkpam wee belata mgbaàmà na ndị ọrịa 6 nwere keratitis neurotrophic. Neurotrophic keratitis bụ ọrịa anụ ahụ na-akpata site na arụrụ ọrụ akwara nke corneal. Mpempe akwụkwọ TB500 (17-13) nwere ike ịkwalite ọgwụgwọ nke ọnya corneal site n'ịkwalite mmụba na ịkwaga nke mkpụrụ ndụ epithelial corneal na ịhazi nzaghachi mkpali ^[6]..

7. Ntughari ntutu isi

Iberibe TB500 (17-13) na-arụ ọrụ cell stem follicle ntutu ma na-agbatị oge anagen nke ntutu isi. Mkpụrụ ndụ stem follicle ntutu bụ mkpụrụ ndụ bụ isi maka mmụgharị ntutu. Ha nwere ike ịmata ọdịiche dị n'ụdị cell dị iche iche nke ntutu isi, na-akwalite uto na mmepe nke ntutu isi. Iberibe peptide a nwere ike ịkwalite mmụba ntutu site n'ịchịkwa mmụba na ọdịiche nke cell stem follicle ntutu (Pan DY, 2021).

Nnwale anụmanụ

Oke: 

A na-eme ngwa ngwa uto ntutu. N'ụdị òké, iberibe TB500 (17-13) nwere ike ịkwalite uto na mmepe nke ntutu site na ịgbalite cell stem follicle ntutu ^[4].

ewu: 

Mụbaa ọnụ ọgụgụ nke ntutu isi nke abụọ ma kwalite mmepụta nke ntutu isi. N'ụdị ewu, iberi peptide a nwere ike ịkwalite uto nke ntutu isi site n'ịhazi usoro n'ogo nke ntutu isi na ọnụ ọgụgụ ntutu isi ^[4]..

N'ikpeazụ, iberibe TB500 (17-13) nwere ike ịkwalite nrụzi anụ ahụ, mgbochi mbufụt, na mmụgharị cell, mee ka ọgwụgwọ ọnya dịkwuo ngwa, ma melite ọrụ musculoskeletal. Ọ dị oke mkpa maka ọgwụgwọ na-emegharị ahụ, na-eweta olileanya ọhụrụ maka ọgwụgwọ ọrịa ndị dị ka ọkụ ọkụ na mmerụ ahụ anụ ahụ na nyocha na mmepe nke ọgwụ mgbochi mkpali, nwere atụmanya ngwa ngwa.

Banyere Onye dere ya

Ihe niile a kpọtụrụ aha n'elu bụ Cocer Peptides na-enyocha, dezie ma chịkọta ya.

Onye ode akwụkwọ akụkọ sayensị

Choi B bụ onye nchọpụta ama ama na agụmakwụkwọ nwere njikọ dị ukwuu na ụlọ ọrụ ama ama dị ka Mahadum Yonsei na Mahadum Mba Seoul (SNU). Ọrụ ya n'ofe ụlọ ọrụ ndị a enyerela aka n'ịkwalite ngalaba ọmụmụ na nyocha dị iche iche.

Mmasị nchọcha ya na nka nka gbasara n'ụdị isiokwu dị iche iche. Ndị a gụnyere Microbiology, Biotechnology & Applied Microbiology, Immunology, Pharmacology & Pharmacy, na Sayensị & Teknụzụ - Isiokwu ndị ọzọ. Nnyocha siri ike ya na mpaghara ndị a na-egosipụta nnukwu ihe ọmụma na ntinye aka na mpaghara sayensị. Edepụtara Choi B na ntụnye aka nke ntụaka [2].

▎ Okwu ndị dị mkpa

[1] Esposito S, Deventer K, Goeman J, et al. Nkwekọrịta na njiri mara nke N-terminal acetylated 17-23 nke thymosin beta 4 nke achọpụtara na TB-500, ngwaahịa a na-enyo enyo na ọ nwere ike doping[J]. Nnwale ọgwụ na nyocha, 2012,4 (9): 733-738.DOI: 10.1002 / dta.1402.

[2] Choi B, Lee C, Yu J. Ọrụ dị iche iche nke mbufụt na nrụzi anụ ahụ na mmụgharị [J]. Ebe nchekwa nke nyocha ọgwụ, 2023,46(2):78-89.DOI:10.1007/s12272-023-01428-3.

[3] Llgen HLO, Llgen RML O. Ahụike na Ọgwụ n'ọdịnihu: mgbanwe site na ọgwụ egwuregwu. Ọgwụ egwuregwu na mgbanwe, 2018[C]. https://www.semanticscholar.org/paper/Health-and-Medicineinthefuture%3AchangethroughL%C3%B6llgenL%C3%B6llgen/a5d6430c8b5442f02bc3238fa48ec0e657489942

[4] Pan DY, Xu LY, Li E M. Mgbanwe ntụgharị asụsụ nke TB4 na ụkpụrụ ọrụ ya [J]. Chemistry nke Ndụ, 2021,41(04):734-740.DOI:10.13488/j.smhx.20200532.

[5] Eming SA Evolution nke ụzọ mgbochi na mmeghari na nrụzi: Echiche ndị na-adịbeghị anya na echiche ntụgharị asụsụ[J]. Ọmụmụ ihe na Immunology, 2014,26(4):275-276.DOI:10.1016/j.smim.2014.09.001.

[6] Ho ENM, Kwok WH, Lau MY, et al. Nyocha nchịkwa doping nke TB-500, ụdị sịntetik nke mpaghara na-arụ ọrụ nke thymosin β4, na mmamịrị equine na plasma site na chromatography-mass spectrometry [J]. Akwụkwọ akụkọ Chromatography A, 2012,1265:57-69.DOI:10.1016/j.chroma.2012.09.043.

Edemede na ozi ngwaahịa niile enyere na webụsaịtị a bụ naanị maka mgbasa ozi na ebumnuche mmụta.  

Ngwaahịa ndị enyere na webụsaịtị a bụ naanị maka nyocha in vitro. A na-eme nyocha in vitro (Latin: * na iko *, nke pụtara na ihe eji enyo) na mpụga ahụ mmadụ. Ngwaahịa ndị a abụghị ọgwụ, ndị US Food and Drug Administration (FDA) akwadoghị ya, ha agaghịkwa eji ya gbochie, gwọọ, ma ọ bụ gwọọ ọnọdụ ahụike ọ bụla, ọrịa, ma ọ bụ ọrịa. Iwu amachibidoro nke ọma iwebata ngwaahịa ndị a n'ime ahụ mmadụ ma ọ bụ anụmanụ n'ụdị ọ bụla.