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1 kits (10 Vials)
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▎ TB500 guntu (17-13) Tsarin
Source: PubChem |
Jerin: LKKTETQ Tsarin kwayoyin halitta: C 36H 66N 10O13 Nauyin Kwayoyin: 847.0 g/mol Lambar CAS: 476014-70-7 PubChem CID: 10169788 Synonyms: Fequesetide; HY-P2463; LKKTETQ |
▎ TB500 guntu (17-13) Bincike
Menene hanyoyin aiwatar da guntun TB500 (17-13)?
1. Hanyoyi na inganta farfadowa na nama
Rukunin TB500 (17-13) yana taka muhimmiyar rawa wajen haɓaka farfadowar nama. Yana iya cimma wannan aikin ta hanyoyi masu zuwa:
Ƙarfafa haɓakar ƙwayoyin sel da bambanta
Wannan guntu na iya ɗaure ga takamaiman masu karɓa akan saman tantanin halitta kuma kunna hanyoyin siginar intracellular, ta haka yana haɓaka haɓakar tantanin halitta da bambanta. Misali, yana iya kunna hanyoyin siginar da ke da alaƙa da haɓakar tantanin halitta da rarrabuwa, irin su hanyar mitogen-activated protein kinase (MAPK) da phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) hanya [1] . Ƙaddamar da waɗannan hanyoyi na iya inganta ci gaba da sake zagayowar tantanin halitta, ƙara yawan adadin kwayoyin halitta, don haka inganta farfadowa na nama.
Bugu da kari, guntun TB500 (17-13) na iya haɓaka bambance-bambancen tantanin halitta ta hanyar daidaita maganganun takamaiman kwayoyin halitta. Yana iya rinjayar ayyukan abubuwan rubutun da ke da alaƙa da bambance-bambancen tantanin halitta, ta haka ne ke daidaita bambance-bambancen sel a cikin takamaiman jagora da samar da nau'ikan sel daban-daban da ake buƙata don sabunta nama.
Inganta angiogenesis
Farfadowar nama yawanci yana buƙatar isassun jini, kuma angiogenesis shine babban tsari don samar da jini. Rukunin TB500 (17-13) na iya haɓaka angiogenesis ta hanyar haɓaka haɓakawa, ƙaura, da haɓakar lumen ƙwayoyin jijiyoyi na jijiyoyi. Yana iya kunna maganganun pro-angiogenic dalilai irin su vascular endothelial girma factor (VEGF), don haka inganta samuwar sabon jini [1] . Sabbin hanyoyin jini da aka kafa na iya samar da iskar oxygen, abubuwan gina jiki, da abubuwan haɓaka ga nama mai lalacewa, yana haɓaka tsarin farfadowa na nama.
2. Hanyoyi na yin tasirin maganin kumburi
Kumburi shine martanin tsaro na jiki ga rauni ko kamuwa da cuta, amma yawan ƙwayar kumburi na iya haifar da lalacewar nama da rashin aiki. Rukunin TB500 (17-13) yana da tasirin anti-mai kumburi, kuma hanyoyinsa na iya haɗawa da abubuwa masu zuwa:
Hana kunnawa da ɗaukar sel masu kumburi
Amsoshin kumburi yawanci sun haɗa da kunnawa da ɗaukar nauyin ƙwayoyin kumburi daban-daban, kamar su neutrophils, macrophages, da lymphocytes. Rukunin TB500 (17-13) na iya rage martanin kumburi ta hanyar hana kunnawa da ɗaukar waɗannan ƙwayoyin kumburi. Alal misali, yana iya hana maganganun masu karɓa a kan farfajiyar ƙwayoyin ƙwayoyin cuta, rage amsawar ƙwayoyin cuta zuwa sigina masu kumburi; ko ta hanyar daidaita alamun ƙaura na ƙwayoyin kumburi, rage ɗaukar ƙwayoyin kumburi zuwa wurin da aka lalace [1].
Bugu da ƙari, wannan guntu na iya rinjayar tsarin tafiyar matakai na rayuwa na ƙwayoyin cuta da kuma hana ayyukan ƙwayoyin cuta. Alal misali, yana iya daidaita makamashin makamashi na ƙwayoyin ƙwayoyin cuta, rage samar da nau'in oxygen mai amsawa (ROS) da kuma cytokines masu tasowa ta hanyar ƙwayoyin ƙwayoyin cuta, kuma ta haka ne ya rage amsawar kumburi.
Daidaita magana da sakin masu shiga tsakani
A lokacin amsawar kumburi, ana samar da masu shiga tsakani iri-iri, irin su cytokines, chemokines, da prostaglandins. Wadannan masu shiga tsakani masu kumburi na iya kara haɓaka amsawar kumburi, haifar da lalacewar nama. Rukunin TB500 (17-13) na iya yin tasirin maganin kumburi ta hanyar daidaita magana da sakin masu shiga tsakani. Alal misali, yana iya hana maganganun cytokines masu kumburi, irin su ƙwayar necrosis factor-α (TNF-α), interleukin-1β (IL-1β), da interleukin-6 (IL-6); kuma a lokaci guda, inganta maganganun anti-mai kumburi cytokines, irin su interleukin-10 (IL-10) [1].
Bugu da ƙari, wannan juzu'i na iya rinjayar maganganun chemokines, rage yawan ɗaukar ƙwayoyin ƙwayoyin cuta; ko daidaita kira na prostaglandins, rage amsawar kumburi.
3. Hanyoyin samun nasarar gyara cikin sauri
Tsarin aikin ɓangarorin TB500 (17-13) a cikin gyare-gyare mai sauri na iya kasancewa da alaƙa da tasirin sa na haɓaka farfadowar nama da rigakafin kumburi. Musamman, yana iya samun gyare-gyare cikin sauri ta hanyoyi masu zuwa:
Haɓaka haɗawa da sake fasalin matrix extracellular
Matrix extracellular wani muhimmin sashi ne na kyallen takarda kuma yana da mahimmanci don kiyaye tsari da aikin kyallen takarda. Rukunin TB500 (17-13) na iya haɓaka gyare-gyaren da suka lalace ta hanyar haɓaka haɗin abubuwan matrix na waje, kamar collagen, elastin, da glycosaminoglycans. Yana iya kunna hanyoyin siginar da ke da alaƙa da haɗin matrix na extracellular, haɓaka sel don haɗawa da ɓoye abubuwan abubuwan matrix na extracellular [1].
Bugu da ƙari, wannan guntu na iya tsara tsarin gyaran matrix na extracellular. A lokacin aikin gyaran nama, matrix na extracellular yana buƙatar ci gaba da gyare-gyare don dacewa da girma da gyaran kyallen takarda. Rukunin TB500 (17-13) na iya sarrafa ma'auni tsakanin lalacewa da haɗin haɗin matrix na extracellular ta hanyar daidaita ayyukan enzymes kamar matrix metalloproteinases (MMPs), inganta saurin gyaran kyallen takarda.
Inganta ƙaurawar tantanin halitta da ikon mannewa
Ƙaura da ikon mannewa na sel suma suna da matukar mahimmanci don gyaran nama. Rukunin TB500 (17-13) na iya haɓaka ƙaura da ikon mannewa na sel ta hanyar daidaita magana da ayyukan masu karɓar saman sel. Alal misali, yana iya inganta maganganun ƙwayoyin mannewa tantanin halitta irin su integrins, ƙara haɓaka tsakanin sel da matrix extracellular; ko tsara sake tsara cytoskeleton, inganta ƙaura ta tantanin halitta [1].
Ƙaurawar ƙwayoyin sel na iya ba da damar sel da ke kewaye da nama mai lalacewa da sauri zuwa wurin da aka lalace kuma su shiga cikin tsarin gyaran nama; kuma mannewar sel na iya tabbatar da cewa sel suna taka rawa sosai a wurin da aka lalace, suna haɓaka saurin gyaran kyallen takarda.
HCD MS/MS da aka yi rikodin a 20eV (a) da 700MHz-NMR (b) bakan TB-500.
Source:PubMed [1]
Ta yaya guntun TB500 (17-13) ke tsara tsarin juyayi don inganta wasan motsa jiki da rage gajiya?
Ayyukan kai tsaye akan neurons
Rukunin TB500 (17-13) na iya yin aiki kai tsaye akan neurons, yana shafar haɓakawa, watsa synaptic, da filastik na neurons. Alal misali, yana iya ɗaure masu karɓa a saman ƙwayoyin jijiya, kunna hanyoyin siginar ciki, da daidaita aikin ƙwayoyin cuta.
Wasu nazarin sun nuna cewa thymosin β4 na iya ɗaure ga masu karɓa iri-iri, ciki har da masu karɓa na integrin da masu karɓa na girma, waɗanda ke taka muhimmiyar rawa wajen ci gaba da aiki na tsarin jin tsoro [1]..
Tsarin kai tsaye na tsarin jin tsoro ta hanyar tsarin rigakafi
Akwai kusancin kusanci tsakanin tsarin rigakafi da tsarin juyayi. Rukunin TB500 (17-13) na iya shafar tsarin jijiya a kaikaice ta hanyar daidaita aikin tsarin rigakafi. Alal misali, yana iya rinjayar aiki da ɓoyewar ƙwayoyin rigakafi, daidaita matakin abubuwan da ke haifar da kumburi, don haka yana rinjayar aikin tsarin jin tsoro.
Wasu nazarin sun nuna cewa abubuwan da ke haifar da kumburi suna taka muhimmiyar rawa a cikin cututtuka na tsarin juyayi da gajiya. Rukunin TB500 (17-13) na iya rage ƙumburi na jijiyoyi da kuma inganta aikin tsarin jijiya ta hanyar daidaita matakan abubuwan da ke haifar da kumburi [1].
Tasiri kan tsarin neuroendocrine
Tsarin neuroendocrine yana taka muhimmiyar rawa wajen daidaita ayyukan ilimin lissafin jiki da amsa damuwa. Rukunin TB500 (17-13) na iya daidaita ayyukan tsarin jin daɗi ta hanyar shafar aikin tsarin neuroendocrine. Alal misali, yana iya rinjayar aikin hypothalamic-pituitary-adrenal axis, daidaita tsarin siginar kwayoyin damuwa irin su cortisol, don haka yana rinjayar aikin tsarin jin tsoro.
Wasu nazarin sun nuna cewa matakin hormones na damuwa yana da alaƙa da jin gajiya da wasan motsa jiki. Rukunin TB500 (17-13) na iya rage jin gajiya da haɓaka wasan motsa jiki ta hanyar daidaita matakin hormones na damuwa [1].
Menene sakamakon guntun TB500 (17-13)?
1. Gyaran nama da farfadowa
Warkar da raunuka na m da na kullum raunuka:
Ga manyan raunuka (kamar tiyata, konewa) da raunuka na yau da kullun (kamar masu ciwon sukari), guntun TB500 (17-13) na iya rage samuwar tabo. Tsarin aikinsa na iya kasancewa yana da alaƙa da haɓaka jigilar collagen cikin tsari da daidaita martanin kumburi [2].
An nuna farfadowar nama a gwajin dabbobi:
A cikin gwaje-gwajen dabba, wannan ɓangaren peptide zai iya inganta farfadowa na fata, tsoka, tendon, da guringuntsi. Misali, a cikin samfurin raunin fata, guntun TB500 (17-13) na iya haɓaka ƙaura da haɓakar keratinocytes, haɓakar raunin rauni (Ho ENM, 2012). Don raunin tsoka da jijiya, yana iya inganta gyaran nama ta hanyar haɓaka haɓakawa da haɓakar ƙwayoyin tauraron dan adam [3] . A cikin samfurin rauni na guringuntsi, wannan guntun peptide na iya haɓaka farfadowar guringuntsi ta hanyar daidaita tsarin metabolism da haɗin gwiwar chondrocytes [2]..
2. Anti-mai kumburi Properties
A cikin cututtuka masu kumburi na yau da kullum (irin su rheumatoid arthritis, cutar Crohn), amsawar kumburi ya ci gaba, yana haifar da lalacewar nama da rashin aiki na gabobin. A matsayin maganin adjuvant, guntun TB500 (17-13) na iya sauƙaƙa alamun cututtuka da jinkirta ci gaban cutar ta hanyar hana amsawar kumburi [4].
3. Gyaran raunukan musculoskeletal
Rukunin TB500 (17-13) yana haɓaka gyaran ƙwayar tsoka, tendonitis, da raunin jijiya, yana rage lokacin gyaran gyare-gyare na 'yan wasa. A cikin maganin wasanni, raunin ƙwayoyin cuta sune matsalolin gama gari. Wannan guntun peptide na iya haɓaka gyaran kyallen takarda da suka lalace [3].
4. Gyaran zuciya
Bayan ciwon zuciya na zuciya, guntun TB500 (17-13) na iya inganta angiogenesis da rayuwa na cardiomyocytes, inganta aikin zuciya. Ciwon zuciya na zuciya cuta ce da ke haifar da toshewar jijiyoyin jini, wanda ke haifar da ischemia na myocardial da hypoxia. Angiogenesis na iya ba da iskar oxygen da abinci mai gina jiki ga myocardium mai lalacewa, yana haɓaka rayuwa da gyaran cardiomyocytes [5].
A cikin nau'ikan dabbobi, guntun TB500 (17-13) yana rage girman infarct sosai kuma yana haɓaka gyaran zuciya. Hanyar aikinta na iya kasancewa da alaƙa da haɓaka magana da sakin abubuwan haɓaka kamar haɓakar haɓakar haɓakar jijiyoyi (VEGF).
5. Kariyar Neuro da lafiyar kwakwalwa
Rukunin TB500 (17-13) yana hana apoptosis neuronal kuma yana haɓaka haɓakar ƙwayoyin jijiyoyi. Neuronal apoptosis yana daya daga cikin mahimman hanyoyin ilimin cututtuka na cututtuka na neurodegenerative da raunin kwakwalwa. Wannan guntun peptide na iya hana apoptosis neuronal ta hanyar daidaita hanyoyin siginar intracellular. A lokaci guda kuma, haɓaka haɓakar ƙwayoyin jijiyoyi na jijiyoyi na iya samar da sabon tushen kwayoyin halitta don lalacewar jijiyoyi, inganta gyaran jijiyoyi.
A cikin bugun jini, raunin kwakwalwa (TBI), da cututtukan neurodegenerative (kamar cutar Alzheimer), ƙwayar jijiya ta lalace zuwa digiri daban-daban. Rukunin TB500 (17-13) na iya ba da gudummawa ga dawo da marasa lafiya ta hanyar haɓakar ƙwayoyin cuta da haɓaka jijiyoyi [4].
6. Maganin cututtukan ido
0.1% Tβ4 ido saukad da gaba daya warkar da raunuka da kuma sauke bayyanar cututtuka a 6 marasa lafiya da neurotrophic keratitis. Neurotrophic keratitis cuta ce ta corneal wacce ta haifar da tabarbarewar jijiya. Rukunin TB500 (17-13) na iya haɓaka warkar da raunuka na corneal ta hanyar haɓaka haɓakawa da ƙaura na sel epithelial na corneal da daidaita amsawar kumburi [6].
7. Gyaran gashi
Rukunin TB500 (17-13) yana kunna ƙwayoyin sel masu ɓoye gashi kuma yana tsawaita lokacin anagen girma gashi. Kwayoyin ƙwanƙolin gashin gashi sune maɓalli na sel don farfadowar gashi. Suna iya bambanta cikin nau'ikan tantanin halitta daban-daban na gashin gashi, inganta haɓaka da haɓaka gashi. Wannan juzu'in peptide na iya haɓaka haɓakar gashi ta hanyar daidaita haɓakawa da bambance-bambancen ƙwayoyin ƙwayoyin gashi (Pan DY, 2021).
Gwajin dabbobi
Mice:
Girman girman gashi yana haɓaka. A cikin ƙirar linzamin kwamfuta, guntun TB500 (17-13) na iya haɓaka haɓakawa da haɓaka gashi ta hanyar kunna sel mai tushe na gashi [4].
Awaki:
Ƙara yawan adadin gashin gashi na biyu da inganta samar da gashin ƙasa. A cikin ƙirar akuya, wannan guntun peptide na iya haɓaka haɓakar gashin ƙasa ta hanyar daidaita yanayin ci gaban gashin gashi da ƙimar girma na gashi [4].
A ƙarshe, guntun TB500 (17-13) na iya inganta gyaran nama, anti-kumburi, da farfadowar tantanin halitta, hanzarta warkar da raunuka, da inganta aikin musculoskeletal. Yana da matukar muhimmanci ga maganin farfadowa, yana kawo sabon bege don maganin cututtuka irin su ƙonawa da raunin tsoka da bincike da ci gaba da magungunan ƙwayoyin cuta, tare da fa'idodin aikace-aikace.
Game da Marubuci
Abubuwan da aka ambata a sama duk bincike ne, gyara su kuma Cocer Peptides ne suka haɗa su.
Mawallafin Jaridar Kimiyya
Choi B fitaccen mai bincike ne kuma mai ilimi tare da manyan alaƙa ga manyan cibiyoyi kamar Jami'ar Yonsei da Jami'ar Kasa ta Seoul (SNU). Ayyukan da ya yi a cikin waɗannan cibiyoyi sun taimaka wajen inganta fannonin karatu da bincike daban-daban.
Sha'awar bincikensa da ƙwarewarsa sun ta'allaka ne a cikin nau'ikan batutuwa iri-iri. Waɗannan sun haɗa da Microbiology, Biotechnology & Applied Microbiology, Immunology, Pharmacology & Pharmacy, da Kimiyya & Fasaha - Sauran batutuwa. Yawan binciken da ya yi a wadannan fagage yana nuna dimbin iliminsa da gudummawar da yake bayarwa ga al'ummar kimiyya. An jera Choi B a cikin ambaton ambaton [2].
