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1 kits (10 Vials)
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▎ Tsarin FOXO4-DRI
Source: PubChem |
Jeri: LTLRKEPASEIAQSILEAYSQNGWANRRSGGKRPPPPRRRQRRKKRG Tsarin kwayoyin halitta: C 228H 388N 86O64 Nauyin Kwayoyin: 5358g/mol PubChem CID: 168431240 Saukewa: EX-A7431 |
▎ Binciken FOXO4-DRI
Menene asalin bincike na FOXO4-DRI?
Bincike mai zurfi akan Senescence na Salon salula:
Tare da ci gaba da bincike mai zurfi game da tsarin salon salula, an gano cewa salon salula yana taka muhimmiyar rawa a yawancin tsarin ilimin lissafi da kuma abubuwan da suka faru da ci gaban cututtuka. Kwayoyin jin dadi za su tara da kuma ɓoye nau'o'in cytokines da masu shiga tsakani masu kumburi, suna shafar ayyukan sel da ke kewaye da su, kuma hakan zai haifar da raguwar nama da ayyukan gabobin. Sabili da haka, gano hanyoyin da za a shiga tsakani a cikin tsarin jin daɗin salula ya zama wurin bincike.
Gano furotin FOXO4:
FOXO4 memba ne na furotin akwatin forkhead O iyali (FOXO) kuma yana taka muhimmiyar rawa a cikin hanyoyin rayuwa daban-daban kamar haɓakar tantanin halitta, bambance-bambance, apoptosis, da amsa damuwa. Nazarin ya gano cewa FOXO4 yana da alaƙa da kusancin salon salula, kuma yana iya shafar tsarin jin daɗin sel ta hanyar daidaita maganganun jerin kwayoyin halitta. Misali, FOXO4 na iya kunna furcin wasu kwayoyin halittar antioxidant da kwayoyin gyara DNA, suna kara karfin juriyar kwayar halitta ga danniya da lalata DNA, ta haka yana jinkirta jinkirin salon salula.
Nuna Kananan Haɗin Molecule:
Dangane da fahimtar aikin furotin FOXO4, masana kimiyya sun fara bincika ƙananan ƙwayoyin ƙwayoyin cuta waɗanda zasu iya daidaita ayyukan FOXO4. Sun yi fatan samun wani ɗan ƙaramin abu wanda zai iya kunna furotin na FOXO4 musamman, don haka yana aiwatar da tasirinsa na rigakafin tsufa da kuma magance cututtukan da ke da alaƙa. Bayan ɗimbin gwaje-gwajen gwaje-gwaje da haɓakawa, an gano ƙaramin fili na FOXO4-DRI a ƙarshe. Yana iya ɗaure musamman ga furotin FOXO4, kunna hanyar siginar sa ta ƙasa, kuma yana taka rawa wajen daidaita yanayin salon salula da ayyukan ilimin lissafi masu alaƙa.
Menene tsarin aikin FOXO4-DRI?
1. Anti-tsufa
FOXO4-DRI na iya kunna furotin FOXO4, sa'an nan kuma daidaita tsarin metabolism na tantanin halitta, yaduwa, da tsarin apoptosis. Sunan furotin FOXO4 yana taka muhimmiyar rawa wajen daidaitawa a cikin sel. Yana iya haɓaka juriya na tantanin halitta ga damuwa ta hanyar daidaita maganganun jerin kwayoyin halitta na ƙasa, da rage jin daɗin salula da lalacewa. Alal misali, FOXO4 na iya inganta maganganun enzymes na antioxidant kuma ya rage matakin nau'in oxygen mai amsawa na ciki na ciki, don haka ya rage lalacewar ƙwayar cuta ga sel [1, 2] . Bugu da ƙari, FOXO4 kuma na iya daidaita maganganun kwayoyin halittar da ke da alaƙa da zagayowar tantanin halitta, hana haɓakar ƙwayoyin sel da yawa, da kuma kula da al'ada na al'ada da aikin sel.
2. Na'urar Aiki a Mazaje na Farko Marigayi Hypogonadism
Yin hulɗa tare da FOXO4 da p53:
Hypogonadism na farko na namiji cuta ce mai alaƙa da shekaru, kuma ainihin tsarinta shine rashin aiki na sel Leydig a cikin gwangwani. An gano cewa akwatin forkhead O (FOXO) FOXO4 yana bayyana musamman a cikin ƙwayoyin Leydig na ɗan adam, kuma fassararsa zuwa tsakiya a cikin tsofaffi yana da alaƙa da raguwar haɓakar testosterone. A matsayin takamaiman mai hana FOXO4, FOXO4-DRI yana zaɓan haifar da keɓancewar nukiliya na p53 da apoptosis a cikin sel Leydig mai hankali ta hanyar rushe hulɗar tsakanin FOXO4 da p53 [1].
Haɓaka Ƙwararrun Ƙwararrun Ƙwayoyin Ƙwayoyin Ƙwayoyin Ƙwayoyin Ƙwayoyin Ƙwayoyin Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararru:
A cikin berayen da suka tsufa na dabi'a, FOXO4-DRI na iya inganta microenvironment na testicular da kuma rage ƙarancin testosterone masu alaƙa da shekaru. Wannan yana nuna cewa FOXO4-DRI na iya dawo da aikin al'ada na nama na ƙwanƙwasa ta hanyar daidaita hanyar siginar da ke da alaƙa da haɓakar ƙwayoyin Leydig, don haka ƙara matakin ɓoyewar testosterone [1].
3. Tsarin Aiki a cikin Fibrosis na huhu
Rage Sel ɗin Senescent da Rage Ka'idodin SASP Magana:
Fibrosis na huhu cuta ce mai ci gaba ta tsaka-tsaki tare da iyakacin zaɓuɓɓukan magani. Senescence ana daukar kwayar cutar daya daga cikin abubuwan da ke haifar da fibrosis na huhu, kuma kawar da kwayoyin halitta na iya inganta aikin huhu. A cikin samfurin linzamin kwamfuta na fibrosis na huhu wanda bleomycin ya haifar, FOXO4-DRI, mai kama da pirfenidone da aka yarda da shi, na iya rage sel masu hankali, rage girman bayyanar da yanayin sirrin da ke da alaƙa (SASP), kuma yana rage sauye-sauyen morphological da ƙaddamarwar collagen ta hanyar bleomy [2].
Tasirin Matsayin Nau'in Tantanin halitta:
FOXO4-DRI na iya ƙara yawan nau'in nau'in 2 alveolar epithelial cell (AEC2) da fibroblasts da kuma rage yawan myofibroblasts a cikin tsarin linzamin kwamfuta na fibrosis na huhu wanda bleomycin ya haifar. A cikin gwaje-gwajen in vitro, idan aka kwatanta da linzamin kwamfuta da huhu na huhu fibroblast cell Lines, FOXO4-DRI yana da mafi girman hali don kashe myofibroblasts da aka haifar ta hanyar canza yanayin girma-β (TGF-β) [2].
Sarrafa Hanyar hulɗar Mai karɓar Matrix Extracellular Matrix:
Tasirin hanawa na FOXO4-DRI akan myofibroblasts yana haifar da raguwar tsarin matrix na extracellular (ECM) hanyar hulɗar mai karɓa a cikin fibrosis na huhu na bleomycin. Wannan yana nuna cewa FOXO4-DRI na iya inganta tsarin ilimin cututtuka na fibrosis na huhu ta hanyar tsara tsarawa da metabolism na ECM [2].
FOXO4-DRI yana inganta bleomycin (BLM) -induced pulmonary fibrosis (PF). (A) Tsarin tsari wanda ke kwatanta ƙirar gwaji. (B) Hotunan wakilcin da aka duba na haematoxylin-eosin (HE) da tabon Masson trichrome na sassan nama na huhu.
Source:PubMed [2]
Menene aikace-aikacen FOXO4-DRI?
1. Anti-tsufa
FOXO4-DRI yana da yuwuwar ƙima don haɓaka raguwar ayyukan da suka shafi shekaru. Tare da karuwar shekaru, sassa daban-daban da tsarin jiki za su fuskanci digiri daban-daban na tsufa da raguwar aiki, kamar raguwar aikin tsarin rigakafi, raunana aikin tsarin zuciya da jijiyoyin jini, da raguwar aikin tsarin juyayi. Ta hanyar kunna furotin na FOXO4, FOXO4-DRI na iya jinkirta aiwatar da salon salula, inganta yanayin rayuwa da aiki, don haka taimakawa wajen inganta lafiyar jiki gaba ɗaya. Misali, a cikin samfurin linzamin kwamfuta na zamani, jiyya tare da FOXO4-DRI na iya haɓaka ƙarfin motsa jiki da aikin fahimi na beraye da rage faruwar cututtukan da suka shafi shekaru [1, 2].
2. Maganin Cututtukan Neurodegenerative
Alakar da Neuron tsufa da Mutuwa:
Cututtukan neurodegenerative kamar cutar Alzheimer da cutar Parkinson suna da alaƙa da tsufa da mutuwar ƙwayoyin cuta. A cikin waɗannan cututtuka, ƙananan ƙwayoyin cuta za su lalace ta hanyar abubuwa daban-daban irin su damuwa na oxidative, amsawar kumburi, da haɓakar furotin, wanda zai haifar da asarar aikin neuronal a hankali kuma a ƙarshe yana haifar da rashin fahimta da rashin aikin motsa jiki. Ta hanyar kunna hanyar siginar FOXO4, FOXO4-DRI na iya inganta rayuwa da gyaran jijiyoyi da haɓaka juriya ga matsalolin oxidative da alamun apoptotic.
Furotin FOXO4 na iya daidaita maganganun kwayoyin halitta da yawa a cikin ƙwayoyin cuta, ciki har da enzymes antioxidant, anti-apoptotic proteins, abubuwan ci gaban jijiyoyi, da dai sauransu. Ƙaddamar da maganganun waɗannan kwayoyin halitta na iya kare kwayoyin halitta daga lalacewa da kuma inganta farfadowa da gyaran jijiyoyi. Alal misali, a cikin samfurin linzamin kwamfuta na cutar Alzheimer, jiyya tare da FOXO4-DRI zai iya rage ƙaddamar da sunadaran amyloid, inganta aikin neuronal, da rage jinkirin ci gaban cutar. A cikin samfurin cutar Parkinson, FOXO4-DRI kuma zai iya kare kwayoyin cutar dopaminergic da kuma inganta ƙarfin motsa jiki na mice [3, 4] . Sabili da haka, ana sa ran FOXO4-DRI za a yi amfani da shi a cikin maganin cututtuka na neurodegenerative don rage jinkirin ci gaba da cutar da kuma inganta aikin tunani da motsa jiki na marasa lafiya.
3. Rigakafi da Maganin Cututtukan Zuciya
Kare Cardiomyocytes:
A cikin tsarin zuciya da jijiyoyin jini, FOXO4-DRI na iya kare cardiomyocytes daga damuwa na oxidative da lalacewar apoptotic. Cardiomyocytes sune manyan sel masu aiki na zuciya, kuma lalacewarsu da mutuwarsu na ɗaya daga cikin mahimman abubuwan da ke haifar da cututtukan zuciya. FOXO4-DRI na iya kunna furotin na FOXO4, daidaita maganganun enzymes antioxidant, rage matakin nau'in oxygen mai amsawa na ciki a cikin cardiomyocytes, da kuma rage lalacewar danniya na oxidative zuwa cardiomyocytes. A lokaci guda, FOXO4-DRI kuma na iya haɓaka maganganun sunadaran anti-apoptotic, hana kunna hanyar siginar apoptotic, da kare cardiomyocytes daga apoptosis [4]..
Haɓaka Ayyukan Kwayoyin Endothelial na Vascular:
FOXO4-DRI kuma na iya haɓaka aikin al'ada na ƙwayoyin jijiyoyi na jijiyoyi da kuma kula da kwanciyar hankali da elasticity na jini. Kwayoyin endothelial na jijiyoyi wani muhimmin bangare ne na bangon jijiyar jini, kuma rashin aikinsu na al'ada zai haifar da bayyanar cututtuka na zuciya da jijiyoyin jini kamar haɓakar ƙwayoyin cuta, thrombosis, da atherosclerosis. FOXO4-DRI na iya kunna furotin FOXO4, daidaita maganganun kwayoyin halitta masu yawa a cikin kwayoyin halitta na jijiyoyi, inganta haɓakawa, ƙaura, da gyaran gyare-gyaren ƙwayoyin cuta, da kuma kula da aikin al'ada na jini. Alal misali, FOXO4-DRI na iya haɓaka maganganun ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta, FOXO4-DRI FOXO4-DRI ta FOXO4-DRI za ta iya daidaitawa (VEGF). Hakanan yana iya haɓaka maganganun endothelial nitric oxide synthase (eNOS), inganta samar da nitric oxide, dilate tasoshin jini, da rage hawan jini [4].
Hana da Magance Cututtukan Zuciya:
A taƙaice, FOXO4-DRI yana taimakawa hanawa da magance cututtuka na zuciya da jijiyoyin jini kamar ciwon zuciya na zuciya, gazawar zuciya, da atherosclerosis. A cikin samfurin dabba na ciwon zuciya na zuciya, jiyya tare da FOXO4-DRI zai iya rage mutuwar cardiomyocytes, inganta gyaran gyare-gyare na ƙwayar zuciya, da inganta aikin zuciya. A cikin samfurin gazawar zuciya, FOXO4-DRI na iya hana apoptosis na cardiomyocytes, haɓaka haɓakar ƙwayar zuciya, da haɓaka aikin bugun zuciya. A cikin samfurin atherosclerosis, FOXO4-DRI na iya rage lalacewar sel endothelial na jijiyoyin jini, hana amsawar kumburi, da rage haɗarin atherosclerosis [4]..
A ƙarshe, ta hanyar hanyoyin aiwatar da aikinta, ciki har da haifar da apoptosis na sel masu hankali, inganta microenvironment na nama, da jinkirta tsarin tsufa, FOXO4-DRI yana nuna ƙimar aikace-aikacen da za a iya amfani da shi a cikin fagage na anti-tsufa, jiyya na hypofunction testicular, radiation-induced pulmonary fibrosis, neurodegenerative cututtuka, da rigakafin cututtuka na zuciya da jijiyoyin jini cututtuka.
Game da Marubuci
Abubuwan da aka ambata a sama duk bincike ne, gyara su kuma Cocer Peptides ne suka haɗa su.
Mawallafin Jaridar Kimiyya
Han X wani mai bincike ne wanda ke da alaƙa da manyan cibiyoyi masu yawa, ciki har da Jiangxi Academy of Sciences, Jami'ar Fudan, Jami'ar Hunan, Jami'ar Zhengzhou, Jami'ar Geosciences, Jami'ar Sichuan, Jami'ar Kasa ta Singapore, Ma'aikatar Albarkatun Halitta ta Jamhuriyar Jama'ar Jama'ar , Kwalejin Kimiyyar Kiwon Lafiya ta kasar Sin - Kwalejin Kiwon Lafiya ta Peking Union, Kwalejin Kiwon Lafiya ta Peking Union, Jami'ar Kiwon Lafiya ta Peking, Jami'ar Kiwon Lafiyar Jama'a, Jami'ar Jiang Xiilin S, Jami'ar Jiang Xiilin S, Jami'ar Kiwon Lafiya ta Jami'ar Jiang Acadci, Jami'ar Jiang Acadci, Jami'ar Kiwon Lafiya ta Jami'ar Jiang Acadci. Jami'a, da Northeast Normal University - . Waɗannan alaƙa suna nuna fa'idarsa mai fa'ida da bambance-bambancen ilimi.
Sha'awar bincikensa sun ta'allaka cikin nau'ikan batutuwa da yawa. Yana aiki sosai a cikin bincike a cikin fannonin Chemistry, Kimiyyar Muhalli & Ecology, Bincike & Magungunan Gwaji, Oncology, da Biochemistry & Halittar Halitta. Ayyukansa suna nuna ƙwararrun ƙwarewa da gagarumar gudunmawa ga waɗannan yankunan. An jera Han X a cikin ambaton ambaton [2].
