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1 kits (10 Vials)
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▎ Tsarin Motc
Source: PubChem |
Jeri: MRWQEMGYIFYPRKLR Tsarin kwayoyin halitta: C101H152N28O22S2 Nauyin Kwayoyin Halitta: 2174.6g/mol Lambar CAS: 1627580-64-6 Kamfanin CID na PubChem: 146675088 Synonyms: UNII-A5CV6JFB78 |
▎ Motc Binciken
Menene asalin bincike na Motc?
Mitochondria, yana aiki azaman 'gidan wutar lantarki' na sel, yana taka muhimmiyar rawa wajen kiyaye homeostasis na salula. Hanyoyin sadarwa tsakanin mitochondria da tsakiya sun dade suna mayar da hankali kan binciken kimiyya. Mitochondria yana da kwayar halitta mai zaman kanta. Bayan al'adar kwayoyin halitta guda 37, binciken baya-bayan nan ya nuna cewa mitochondrial DNA shima yana sanya gajerun peptides masu aiki da ilimin halitta, ɗayansu shine peptide Motc wanda ya samo asali daga mitochondrial, wanda yanki na mitochondrial 12S rRNA ya ƙunshi. Wannan binciken yana faɗaɗa fa'idar ƙwayoyin halittar mitochondrial sosai, yana ba da sabon hangen nesa don haɓaka mahimman hanyoyin rayuwa kamar sadarwar mitochondrial-nukiliya da tsarin rayuwa.
A halin yanzu, jiyya ga cututtuka masu ƙalubale da yawa kamar metabolism da ciwon hanta na B na yau da kullun suna fuskantar matsaloli masu yawa. Babban rawar da Motc ke takawa a cikin ƙa'idodin ƙayyadaddun ƙwayar tsoka, kamar haɓaka metabolism na glucose, yana ba da shawarar yuwuwar sa wajen magance rikice-rikice na rayuwa. Bugu da ƙari kuma, ƙananan matakan Motc da aka lura a cikin matakai daban-daban na cututtuka sun sa masu bincike suyi bincike game da rawar da ta taka a farkon cutar, ci gaba, da magani, neman sababbin hanyoyi don shawo kan waɗannan yanayi maras kyau.
Menene tsarin aiki don Motc?
Sarrafa Hannun Sigina masu alaƙa da Metabolism
Kunna Tafarkin Siginar AICAR-AMPK: Motc yana kunna hanyar siginar AICAR-AMPK ta hanyar rushe zagayowar folate-methionine na ciki. AMPK da aka kunna yana daidaita metabolism na makamashin salula, kamar haɓaka ɗaukar glucose da fatty acid oxidation. A cikin metabolism na glucose, yana haɓaka jujjuyawar mai jigilar glucose GLUT4 zuwa membrane tantanin halitta, ta haka yana haɓaka ƙarfin karɓar glucose ta salula, haɓaka juriya na insulin, da kuma taimakawa cikin rigakafi da magance cututtukan rayuwa kamar nau'in 2 metabolism [1]..
Tasiri akan Sauran Hanyoyi: Bayan hanyar AMPK, Motc kuma yana aiki akan hanyar AKT, hanyar damuwa na oxidative, da hanyoyin da ke da alaƙa da kumburi. Game da hanyar AKT, yana iya yin tasiri kan hanyoyin salula kamar haɓaka, haɓakawa, da rayuwa ta hanyar daidaita ayyukan hanyar. A cikin hanyar damuwa na oxidative, Motc yana rage matakan damuwa na ciki na ciki, yana rage yawan samar da nau'in oxygen (ROS), kuma yana kare kwayoyin halitta daga lalacewar oxidative. A cikin hanyoyin da ke da alaƙa da kumburi, yana hana sakin masu shiga tsakani kuma yana rage martanin kumburi. Misali, a cikin nau'ikan ciwon kumburin kumburi, Motc yana rage sakin matsakanci mai kumburi a cikin kahon dorsal na kashin baya, ta haka yana inganta alamun zafi [2].
Hoto 1 Babban ayyukan ilimin lissafin jiki na Motc sun haɗa da rage juriya na insulin, hana kiba, haɓaka aikin tsoka, haɓaka metabolism na kashi, haɓaka tsarin rigakafi, da jinkirta tsufa [1].
Tsarin Maganar Halitta
Ka'idar Maganar Jigon Nukiliya: Lokacin da sel suka haɗu da damuwa na rayuwa, kamar ƙuntatawar glucose da damuwa na oxyidative, Motc yana canzawa zuwa tsakiya don daidaita maganganun kwayoyin halittar nukiliya kai tsaye, ta haka yana haɓaka homeostasis na intracellular. Misali, Motc yana daidaita maganganun kwayoyin halittar da ke da alaƙa da metabolism kamar GLUT4, STAT3, da IL-10, suna tasiri hanyoyin ilimin lissafin jiki gami da metabolism na glucose da tsarin rigakafi. Ƙara GLUT4 magana yana haɓaka ɗaukar glucose na salula; STAT3 yana shiga cikin yaduwar kwayar halitta, bambance-bambance, da tsarin rigakafi; IL-10, cytokine anti-mai kumburi, yana rage martanin kumburi lokacin da aka ɗaga maganarsa [1,3].
Haɓaka Metabolism na Makamashi
Ingantaccen Glycolysis: A cikin nau'ikan cututtuka daban-daban, irin su huhu ischemia-reperfusion rauni (LIRI) samfurin wanda ya haifar da bypass na zuciya (CPB), Motc pretreatment yana haɓaka glycolytic flux a cikin huhu microvascular endothelial sel (PMVECs). Yana rage raunin LIRI ta hanyar maido da makamashin salula homeostasis da rage lipid peroxidation ta hanyar haɓaka maɓallin glycolytic enzyme PFKFB3. Wannan yana nuna cewa Motc yana daidaita hanyar glycolytic don samar da isasshen makamashi don sel a ƙarƙashin damuwa, don haka yana riƙe da aikin salula na yau da kullun [4].
Tasirin Kariyar Salon salula
Rage lalacewa na Mitochondrial: A cikin samfurin pneumonitis na radiation (RP), Motc ya rage yawan raunin huhu na huhu, kumburi, da damuwa na oxidative yayin da yake jujjuya alveolar epithelial cell apoptosis da lalacewar mitochondrial. Wannan tsarin ya ƙunshi haɓaka matakan abubuwan da ke da alaƙa da E2 (Nrf2) matakan nukiliya da haɓaka jujjuyawar makaman nukiliya. Nrf2 yana kunna jerin antioxidant da kwayoyin kare-kwayoyin kariya, yana kare aikin mitochondrial. Wannan yana nuna cewa Motc yana kare lalacewar kyallen takarda ta hanyar adana mitochondria da rage apoptosis [5].
Kariyar Wasu Kwayoyin: A cikin binciken akan Duchenne muscular dystrophy (DMD), an gano Motc yana da kaddarorin tsokar tsoka. Yana haɓaka haɓakar glycolytic da ƙarfin samar da makamashi a cikin tsokoki na dystrophic, yana ba da gudummawa ga haɓaka aikin tsoka. Bugu da ƙari kuma, a cikin nau'o'in ciwo mai kumburi, Motc da aka gudanar a tsakiya ko na gefe yana rage jin zafi ta hanyar kawar da martani mai kumburi da hyperexcitability na neuronal, yana ba da tasirin neuroprotective [2,6]..
Menene aikace-aikacen Motc?
Maganin Ciwon Jiki:
Inganta juriya na insulin da hana metabolism: Motc yana haɓaka juriya na insulin, wanda ke da mahimmanci don hana nau'in 2 metabolism. Juriya na insulin shine maɓalli mai mahimmanci a farkon nau'in metabolism na nau'in 2. Motc na iya haɓaka hankalin insulin ta hanyar kunna hanyar siginar AICAR-AMPK da daidaita zagayowar folate-methionine na intracellular. Bincike na Gao Y yana nuna yana haɓaka ɗaukar glucose na kwarangwal da amfani, daidai da buɗe ƙarin hanyoyin sha glucose a cikin sel, ta haka yana rage matakan glucose na jini [1].
Daidaita metabolism na lipid da kuma yaƙi da kiba: Game da metabolism na lipid, Motc yana haɓaka thermogenesis mai launin ruwan kasa kuma yana haɓaka launin fata mai launin fata. Kitse mai launin ruwan kasa yana cinye kuzari ta hanyar thermogenesis, yayin da farin mai launin ruwan kasa yana nuna canjin makamashi-ajiye farin kitse zuwa kitsen mai launin ruwan kasa mai kuzari. Wannan tsari yana taimakawa jiki wajen daidaitawa da sanyi kuma, mafi mahimmanci, yana hana kiba da rikice-rikice na lipid metabolism, yana ba da sabbin fahimta don rigakafin kiba da jiyya [1].
Rigakafi da Maganin Cututtuka masu alaƙa da tsoka:
Haɓaka Bambance-bambancen Muscle: Nazarin in vitro ya nuna cewa nau'in Motc peptide na daji yana haɓaka samuwar myotubular a cikin ɗan adam (LHCN-M2) da linzamin kwamfuta (C2C12) sel masu haɓaka tsoka, yayin da peptide mutant Y8F ba shi da wannan tasirin. Ƙarin karatu ya nuna cewa Motc yana haɓaka myotubulogenesis ta hanyar hulɗa tare da IL-6 / Janus kinase / siginar siginar da mai kunnawa ta hanyar 3 (STAT3), ta haka yana rage ayyukan STAT3 [7].
Rigakafin ciwon tsoka: Matakan Plasma Motc sun yi daidai da matakan myostatin. Motc yana hana palmitate-induced myotube atrophy a cikin bambance-bambancen ƙwayoyin C2C12 kuma yana rage matakan myostatin na plasma a cikin berayen da ke haifar da abinci. Yana hana atrophy na tsoka ta hanyar haɓaka AKT phosphorylation, hana ayyukan FOXO1-wani nau'in juzu'in rubutu na myostatin da sauran ƙwayoyin tsoka-atrophy - yayin da ke daidaita ayyukan mTORC2 da PTEN da haɓaka ayyukan CK2 don kashe PTEN [8].
Tasirin tsufa: Canje-canjen magana na Motc yana da alaƙa da tsufa, kuma yana nuna abubuwan hana tsufa. Ana samun wannan ta hanyoyi da yawa, ciki har da inganta glucose da metabolism na lipid, haɓaka aikin mitochondrial na salula, da rage kumburi na kullum. Binciken Gao Y et al. yana nuna cewa ingantaccen metabolism yana samar da sel tare da wadataccen makamashi da kwanciyar hankali. Haɓaka aikin mitochondrial yayi daidai da haɓaka masana'antar makamashi ta tantanin halitta, yayin da rage martanin kumburi yana rage lalacewar kumburi ga sel [1].
Kammalawa
A matsayin peptide-wanda aka samo daga mitochondrial, Motc yana kunna hanyoyin sigina kamar AMPK don daidaita glucose da metabolism na lipid, inganta canjin mai mai launin fari zuwa launin ruwan kasa, da haɓaka juriya na insulin da kiba, yana ba da sabbin hanyoyin warkewa don rikicewar rayuwa. Yana haɓaka bambance-bambancen osteoblast, yana hana samuwar osteoclast, daidaita metabolism na kashi, kuma yana tallafawa kula da lafiyar kwarangwal. Yana daidaita bambance-bambancen tsoka kuma yana hana atrophy, yana riƙe da yuwuwar shiga tsakani a cikin cututtukan da ke da alaƙa da tsoka. Motc yana nuna ƙungiyoyi masu ƙarfi da ke da alaƙa da motsa jiki: motsa jiki yana daidaita maganganun sa, kuma yana daidaita fa'idodin kiwon lafiya na motsa jiki. Motc kuma yana taka rawa wajen jinkirta tsufa da matakai masu alaƙa.
Game da Marubuci
Abubuwan da aka ambata a sama duk bincike ne, gyara su kuma Cocer Peptides ne suka haɗa su.
Mawallafin Jaridar Kimiyya
Ning Ran mai bincike ne mai alaƙa da Kwalejin Carlson na Magungunan Dabbobi a Jami'ar Jihar Oregon. Ayyukansa na ilimi ya shafi ilmin kwayoyin halitta da magungunan fassara, tare da mai da hankali kan dabarun warkewa don cututtukan neuromuscular. Ran ya haɗa wallafe-wallafe da yawa a cikin mujallun da aka yi bita na ƙwararru, yana ba da gudummawa ga fahimtar matakan ƙwayoyin cuta a cikin nau'ikan cututtuka. Abubuwan bincikensa sun haɗa da haɓakawa da aikace-aikacen peptide-conjugated oligonucleotides, da kuma bincika yuwuwar hanyoyin warkewa na peptides na mitochondrial. An jera Ning Ran a cikin ambaton ambaton [6].
