Motc 40mg

Imiterere ya Motc

Research bwa Motc Ubushakashatsi

Ni ubuhe bushakashatsi bwakozwe na Motc?

Mitochondria, ikora nka 'powerhouse ' ya selile, igira uruhare runini mukubungabunga homeostasis. Uburyo bwitumanaho hagati ya mitochondria na nucleus bumaze igihe byibandwaho mubushakashatsi bwa siyansi. Mitochondria ifite genome yigenga. Kurenga ingirabuzimafatizo 37, ubushakashatsi buherutse gukorwa bwerekanye ko ADN ya mitochondial nayo ikubiyemo peptide ngufi ikora mu binyabuzima, imwe muri zo ikaba ari peptide Motc ikomoka kuri mitochondial, ikozwe n'akarere ka mitochondrial 12S rRNA. Ubu buvumbuzi bwaguye ku buryo bugaragara imiterere y’imiterere y’imiterere y’imiterere y’imiterere y’imiterere y’imiterere y’imiterere y’imiterere y’imiterere y’imiterere y’imiterere y’imiterere y’imiterere y’imiterere y’imiterere y’imiterere y’imiterere y’imiterere y’imiterere y’imiterere y’imiterere y’imiterere y’imiterere y’imiterere y’imiterere y’imiterere y’ibinyabuzima nka itumanaho rya kirimbuzi na kirimbuzi no kugenzura imikorere ya metabolike.

Kugeza ubu, kuvura indwara nyinshi zitoroshye nka metabolism na hepatite B idakira ihura n'ikibazo gikomeye. Uruhare rukomeye rwa Motc muguhindura imitsi ya skeletale imitsi, nko kongera glucose metabolism, byerekana ubushobozi bwayo mukuvura indwara ziterwa na metabolike. Byongeye kandi, urwego rwa Motc rudasanzwe rwagaragaye mubikorwa bitandukanye byindwara byatumye abashakashatsi bakora ubushakashatsi ku ruhare rwarwo mu gutangira indwara, gutera imbere, no kuvura, bashaka inzira nshya zo gutsinda ibyo bibazo bitoroshye.

Nubuhe buryo bwo gukora kuri Motc?

Kugenga Metabolism-Bifitanye isano Ibimenyetso Inzira

Gukora inzira yerekana ibimenyetso bya AICAR-AMPK: Motc ikora inzira yerekana ibimenyetso bya AICAR-AMPK muguhagarika ingirabuzimafatizo ya folate-methionine. AMPK ikora igenga ingufu za selile metabolism, nko guteza imbere glucose no gufata aside irike. Muri glucose metabolism, byongera guhinduranya glucose itwara glucose GLUT4 muri membrane selile, bityo bikongerera ubushobozi bwo gufata glucose selile, kunoza insuline, no gufasha mukurinda no kuvura indwara ziterwa na metabolism nkubwoko bwa 2 metabolism ^[1].

Ingaruka ku zindi Nzira: Kurenga inzira ya AMPK, Motc nayo ikora kumuhanda AKT, inzira ya stress ya okiside, n'inzira zijyanye no gutwika. Kubireba inzira ya AKT, irashobora guhindura inzira ya selile nko gukura, gukwirakwira, no kubaho muguhuza ibikorwa byinzira. Mu nzira ya okiside itera imbaraga, Motc igabanya umuvuduko ukabije wa okiside itera imbaraga, igabanya ubwoko bwa ogisijeni ikora (ROS), kandi ikarinda selile kwangirika kwa okiside. Mu nzira zijyanye no gutwika, irwanya irekurwa ryabunzi batera umuriro kandi igabanya ibisubizo byokongoka. Kurugero, mubyitegererezo byububabare bukabije, Motc igabanya kurekura mediator kurekura mumahembe ya dorsal yumugongo, bityo bikagaragaza ibimenyetso byububabare ^[2].

Igicapo 1 Ibikorwa byambere byimikorere ya Motc harimo kugabanya kurwanya insuline, kwirinda umubyibuho ukabije, kunoza imikorere yimitsi, guteza imbere metabolisme yamagufa, kongera imbaraga mumubiri, no gutinda gusaza ^[1].

Amabwiriza yo Kugaragaza Gene

Amabwiriza agenga imiterere ya nucleaire: Iyo selile zihuye nihungabana rya metabolike, nko guhagarika glucose no guhagarika umutima, Motc ihinduranya nucleus kugirango igenzure neza imiterere ya gene ya kirimbuzi, bityo iteza imbere homeostasis. Kurugero, Motc ihindura imvugo ya genes zijyanye na metabolism nka GLUT4, STAT3, na IL-10, bigira ingaruka kumikorere ya physiologique harimo glucose metabolism no kugenzura immunite. Kwiyongera kwa GLUT4 imvugo byongera glucose selile; STAT3 igira uruhare mu gukwirakwiza selile, gutandukanya, no kugenzura indwara; IL-10, cytokine irwanya inflammatory, igabanya ibisubizo byumuriro mugihe imvugo yayo yazamutse ^[1,3].

Gutezimbere Metabolism

Glycolysis yongerewe imbaraga: Mu buryo butandukanye bw’indwara, urugero nko gukomeretsa ibihaha ischemia-reperfusion (LIRI) byatewe na cardiopulmonary bypass (CPB), Kwiyitirira Motc byongera umuvuduko wa glycolitike mu ngirabuzimafatizo ya mikorobe ya endoteliyale (PMVECs). Igabanya imvune ya LIRI mu kugarura ingufu za selile homeostasis no kugabanya lipide peroxidisation binyuze muguhuza urufunguzo rwa glycolitike PFKFB3. Ibi birerekana ko Motc ihindura inzira ya glycolitike kugirango itange ingufu zihagije zingirabuzimafatizo, bityo bikomeze imikorere isanzwe ya selile ^[4].

Ingaruka zo Kurinda Ingirabuzimafatizo

Kugabanya ibyangiritse bya Mitochondrial: Mu buryo bwerekana imishwarara ya pneumonite (RP), Motc yagabanije cyane imvune yimitsi yibihaha, gutwika, hamwe na stress ya okiside mugihe ihindura alveolar epithelial selile apoptose no kwangirika kwa mitochondial. Ubu buryo bukubiyemo kongera ingufu za kirimbuzi E2 zijyanye na 2 (Nrf2) no guteza imbere itumanaho rya kirimbuzi. Nrf2 ikora urukurikirane rwa antioxydeant na selile ikingira ingirabuzimafatizo, ikingira imikorere ya mito-iyambere. Ibi byerekana ko Motc irinda ingirangingo zangiritse mu kurinda mitochondriya no kugabanya apoptose ^[5].

Kurinda Izindi selile: Mu bushakashatsi bwakozwe kuri Duchenne muscular dystrofiya (DMD), Motc yasanze ifite imitsi yibasira imitsi. Yongera imbaraga za glycolytike nubushobozi bwo gutanga ingufu mumitsi ya dystrofique, bigira uruhare mumikorere myiza yimitsi. Byongeye kandi, mubyitegererezo byububabare bukabije, Motc yatanzwe hagati cyangwa igabanya kugabanya ububabare bukabije bwumubyigano muguhagarika ibisubizo byumuriro hamwe na hyperexcitability ya neuronal, itanga ingaruka za neuroprotective ^[2,6].

Ni ubuhe buryo bukoreshwa na Motc?

Kuvura indwara ziterwa na metabolike:

Kunoza kurwanya insuline no kwirinda metabolisme: Motc yongera imbaraga za insuline, ningirakamaro mukurinda metabolism yo mu bwoko bwa 2. Kurwanya insuline nikintu cyingenzi mugutangira ubwoko bwa 2 metabolism. Motc irashobora kunoza insuline ikora mugukoresha inzira ya AICAR-AMPK yerekana inzira no kugenzura ingirabuzimafatizo ya folate-methionine. Ubushakashatsi bwakozwe na Gao Y bwerekana ko butera imitsi ya glucose gufata no kuyikoresha, bisa no gufungura izindi nzira zo kwinjiza glucose mu ngirabuzimafatizo, bityo bikagabanya urugero rwa glucose mu maraso ^[1].

Kugenga metabolisme ya lipide no kurwanya umubyibuho ukabije: Kubijyanye na metabolisme ya lipide, Motc yongera amavuta yumukara thermogenez kandi itera ibinure byera. Ibinure byijimye bitwara ingufu binyuze muri thermogenez, mugihe ibinure byera byera bisobanura guhindura amavuta yera abika ingufu mumavuta yumukara ukoresha ingufu. Ubu buryo bufasha umubiri kumenyera ubukonje, kandi cyane cyane, birinda umubyibuho ukabije hamwe n’indwara ya metabolisme ya lipide, bitanga ubumenyi bushya bwo kwirinda no kuvura umubyibuho ukabije ^[1].

Kwirinda no kuvura indwara ziterwa n'imitsi:

Guteza Imbere Gutandukanya Imitsi: Mu bushakashatsi bwa vitro bwerekana ko peptide yo mu bwoko bwa Motc peptide yongerera imbaraga za myotubular mu ngirabuzimafatizo z'umuntu (LHCN-M2) n'imbeba (C2C12) ingirabuzimafatizo, mu gihe peptide Y8F idafite ingaruka. Ubundi bushakashatsi bwerekanye ko Motc yongerera myotubulogenezi ikorana na IL-6 / Janus kinase / transducer ya signal hamwe nuwashinzwe inzira ya transcription 3 (STAT3), bityo bikagabanya ibikorwa byo kwanduza STAT3 ^[7].

Kwirinda imitsi ya Atrophy: Urwego rwa Plasma Motc rufitanye isano ribi na myostatine. Motc irinda myotube iterwa na palmitate mu ngirabuzimafatizo zitandukanye za C2C12 kandi igabanya urugero rwa plasma myostatin mu mbeba zifite umubyibuho ukabije. Irinda imitsi iterwa no kongera AKT fosifora, ikabuza ibikorwa bya FOXO1 - ibintu byandikirwa hejuru ya myostatine hamwe nizindi mitsi-atrophy-mugihe igenga ibikorwa bya mTORC2 na PTEN no kongera ibikorwa bya CK2 kugirango ihagarike PTEN ^[8].

Ingaruka zo kurwanya gusaza: Guhindura imvugo ya Motc bifitanye isano rya bugufi no gusaza, kandi byerekana imiti irwanya gusaza. Ibi bigerwaho hifashishijwe uburyo bwinshi, harimo kunoza glucose na lipide metabolism, kongera imikorere ya mitochondial selile, no kugabanya umuriro udakira. Ubushakashatsi bwakozwe na Gao Y n'abandi. yerekana ko metabolisme yatezimbere itanga selile nyinshi kandi zihamye zitanga ingufu. Gutezimbere imikorere ya mito-iyambere ni nko kuzamura ingirabuzimafatizo 'uruganda rukora ingufu, ' mugihe kugabanya ibisubizo byumuriro bigabanya kwangirika kwingirabuzimafatizo ^[1].

Umwanzuro

Nka peptide ikomoka kuri mitochondial, Motc ikora inzira yerekana inzira nka AMPK kugirango igabanye glucose na lipide metabolisme, itume ihinduka ryamavuta yera-yijimye, kandi irwanya insuline n’umubyibuho ukabije, itanga icyerekezo gishya cyo kuvura indwara ziterwa na metabolike. Yongera itandukaniro rya osteoblast, irwanya imiterere ya osteoclast, iringaniza metabolisme yamagufwa, kandi ishyigikira kubungabunga ubuzima bwamagufwa. Igenga itandukaniro ryimitsi kandi ikarinda atrophy, ifite ubushobozi bwo kwivanga mubibazo biterwa n'imitsi. Motc yerekana amashyirahamwe akomeye ajyanye nimyitozo ngororamubiri: imyitozo ngororamubiri igenga imvugo yayo, kandi ihuza inyungu ziterwa nubuzima. Motc nayo igira uruhare mugutinda gusaza hamwe nibikorwa bifitanye isano.

Ibyerekeye Umwanditsi

Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.

Umwanditsi w'ikinyamakuru

Ning Ran ni umushakashatsi ukorana na Carlson College of Veterinary Medicine muri kaminuza ya Leta ya Oregon. Ibikorwa bye byamasomo yibinyabuzima bya molekuline nubuvuzi bwubuhinduzi, yibanda ku ngamba zo kuvura indwara zifata ubwonko. Ran yafatanije kwandika ibitabo byinshi mu binyamakuru byasuzumwe n’urungano, agira uruhare mu gusobanukirwa n’imikorere ya molekile mu buryo bw’indwara. Ibyifuzo bye mubushakashatsi birimo guteza imbere no gukoresha peptide-conjugated oligonucleotide, ndetse no gushakisha uburyo bwo kuvura peptide ikomoka kuri mitochondial. Ning Ran yanditse murutonde rwibisobanuro [6].

bifatikaIbitekerezo

[1] Gao Y, Wei X, Wei P, n'abandi. Motc Irinda Imikorere Ihindagurika. Metabolite 2023; 13(1) .DOI: 10.3390 / metabo13010125.

[2] Wang Z, Yang L, Xu L, Liao J, Lu P, Jiang J. Hagati hamwe na periferique ya Motc yerekana ububabare bukabije mu mbeba yerekana ububabare bukabije. Ubushakashatsi bwa Neurologiya 2024; 46 (2): 165-177.DOI: 10.1080 / 01616412.2023.2258584.

[3] Benayoun BA, Lee C. Motc: Igenzura rya Mitochondrial-Encoded Regular ya Nucleus. Bioessays 2019; 41 (9): e1900046.DOI: 10.1002 / bies.201900046.

[4] Shen Z, Lu P, Jin W, n'abandi. Motc Itera Glycolysis ikoresheje AMPK-HIF-1α-PFKFB3 Inzira igana Ameliorate CPB iterwa no gukomeretsa ibihaha. Ikinyamakuru cyo muri Amerika cy’ubuhumekero n’ibinyabuzima bya Molecular 2025. 10.1165 / rcmb.2024-0533OC.

[5] Zhang Y, Huang J, Zhang Y, n'abandi. Moteri ya Mitochondrial ikomoka kuri Peptide Motc igabanya imishwarara ya pneumonite ikoresheje Nrf2-Biterwa na Mechanism. Antioxydants 2024; 13. Https://api.semanticscholar.org/CorpusID:269876125.

[6] Ran N, Lin C, Leng L, n'abandi. Motc iteza imbere fosiforodiamidate morpholino oligomer gufata no gukora neza mu mbeba za dystrofique. Ubuvuzi bwa Embo Molecular 2021; 13(2): e12993.DOI: 10.15252 / emmm.202012993.

[7] García-Benlloch S, Revert-Ros F, Blesa JR, Alis R. Motc iteza itandukaniro ryimitsi muri vitro. Peptide 2022; 155: 170840.DOI: 10.1016 / j.peptide.2022.170840.

[8] Kumagai H, Coelho AR, Wan J, n'abandi. Motc igabanya myostatin na imitsi atrophy yerekana. Ikinyamakuru cyo muri Amerika cya Physiology-Endocrinology na Metabolism 2021; 320(4): E680-E690.DOI: 10.1152 / ajpendo.00275.2020.

INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.  

Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorerwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.