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▎ Kagrilintide (Kagrilintide) jɔcogo
Sɔrɔyɔrɔ: PubChem |
A kɛcogo: Pyr-KCNTATCATQRLAEFLRHSSNNFGPILPPTNVGSNTP CAS: 1415456-99-3. Bamako, Mali Formula: C 174H 269N 45O 52S. Bamako, Mali2 MW 4409 g/mol |
▎ Kagrilintide ɲinini
Cagrilintide bɔyɔrɔ ye mun ye?
Kagrilintidi—amilini ɲɔgɔnna dɔ:
Amilini ye ɔrimɔni ye min bɛ bɔ pankreyasi gun β selilɛriw fɛ. Farikoloɲɛnajɛ cogoyaw la, a ni inisɔndiya bɛ jɛ ka baara kɛ ɲɔgɔn fɛ, wa farikolo baara nafama caman bɛ a la.
A fɔlɔ, amilini jɔyɔrɔ ka bon kosɛbɛ fasa bilali la ani ka dumuni dunta dɔgɔya. A baarakɛcogo fanba bɛ tali kɛ fɛnw minɛyɔrɔw la minnu bɛ Area Postrema kɔnɔ, minnu bɛ kɔnɔbara naaninan da la. O sɔgɔsɔgɔninjɛ taamasiɲɛw bɛ taa ɲɛfɛla la Nucleus of the Solitary Tract fɛ. O waati kelen na, u bɛ se ka lase fana Lateral Hypothalamic Area ani hypothalamic nucléaire kulu wɛrɛw la Lateral Parabrachial Nucleus fɛ. Amilini bɛ se ka fɛnɲɛnama fasa yɔrɔ lawuli ani ka dumuni dunta bali baganw na [1] ..
Amilini bɛ se ka sukaro homeostasis labɛn, o bɛ sɔrɔ ni insuline ni glucagon fila bɛɛ bɔli balili ye [2] . O baara in bɛ dɛmɛba don joli sukaro hakɛ sabatili la, wa a nafa ka bon kosɛbɛ banaw furakɛli la i n’a fɔ sukarodunbana.
Ka fara o kan, amilini b’a nɔw jira ni a bɛ nɔ bila farikolojidɛsɛ furaw bɔli la. Misali la, a bɛ dopamine bɔli bali sosow ka hypothalamus la, ka sɔrɔ a tɛ nɔba bila norepinephrine ni serotonin na [3] . Sukaro homeostase (sɔgɔsɔgɔninjɛ) siratigɛ la, amilini bɛ joli sukaro sabatili sabati ni a bɛ inisɔndiya ni sukaro bɔli bali. A kɛcogo dɔw ye ka baara Kɛ k’a ɲɛsin pankreyasi gun α selilɛriw ma ani ka glucagon bɔli ɲɛnabɔ cogo wɛrɛ la ni senfagabana taamasiɲɛw cili ye hipotalamus kɔnɔ. Sukarodunbana bɛ banabagatɔ minnu na, β selilɛriw tiɲɛni tɛ kɛ sababu ye ka insuline dɛsɛ dɔrɔn, nka o bɛ na ni C-peptide ni amyline fila bɛɛ bɔli dɔgɔyali ye fana. A jɛlen don ko amilini sen bɛ sukaro homeostasis labɛnni na ni a bɛ kɔnɔbara lankolonya ni sugunɛbilenni bɔli bali dumuni kɔfɛ, a laban na, a bɛ dɔ bɔ joli la sukaro jiginni na kɔfɛ dumuni Ka fara o kan, amilini bɛ se ka kɔnɔbara lankolonya bila kɔfɛ, ka kɔnɔbara basigilen bali ka tɛmɛ farikolo yɔrɔw fɛ, ani ka dumuni toli waati janya kɔnɔbara la, o la, a bɛ joli sukaro hakɛ caya teliya bali.
O bɛɛ n’a ta, amilini tilancɛ si hakɛ ka surun, o de bɛ dan sigi a tali la kɛnɛyaso la. Sɛgɛsɛgɛliw y’a jira ko amilini analozi min bɛ yen, n’o ye pramlintide ye, n’o ye fura dɛmɛnan ye sukarodunbana furakɛli la, o ka kan ka di siɲɛ saba tile kɔnɔ. O tɛ kɛ dɔrɔn ka gɛlɛya lase banabagatɔw ma, nka a bɛ dɔ bɔ u ka sariya labatoli la fana [5] . Walasa ka amilini nafama tilancɛ surunya ko ɲɛnabɔ, Cagrilintide dabɔra ka kɛ analozi ye min bɛ baara kɛ waati jan kɔnɔ. Cagrilintide yiriwali sinsinnen bɛ amilini nafama farikolo baarakɛcogo faamuyali jugu kan. A laɲini ye ka amilini ka baarakɛcogo ladege ka sɔrɔ ka fura in sabatili n’a ka baarakɛcogo jan bonya walasa ka kɛnɛyaso furakɛli wajibiyalenw dafa.
Cagrilintide ka seko ni a furakɛcogo
Kagrilintidi ye amilini analozi kura ye min bɛ baara kɛ waati jan kɔnɔ, a seko ka bon, a bɛ nɔ kabakoma jira fasa ni sukarodunbana furakɛli la. A bɛ kɛ ni tulumafɛnw ye ani a bɛ ni taamasiɲɛ sabatilenw ye minnu bɛ mɛn [5] . Amilini ye ɔrimɔni ye min bɛ bɔ ɲɔgɔn fɛ pankreyasi β selilɛriw fɛ ka fara inisɔndiya kan, o bɛ fasa bila mɔgɔ la ni a bɛ baara kɛ sugunɛ yɔrɔw la minnu bɛ wele ko homeostatic ani hedonic. I n’a fɔ amilini analozi, Cagrilintide bɛ se ka o nɔ in ladege, ka fasa bila mɔgɔ la ani o cogo la ka dɛmɛ don farikolo girinya kunbɛnni na. Ka fara o kan, Cagrilintide ye amilini ni kalisitɔni minɛbaga fila ye, min bɛ bɔ amilini kɔkolo la, o bɛ baara kɛcogo kɛrɛnkɛrɛnnen di a ma farikoloɲɛnajɛ labɛnni na.
Kɛnɛyaso ka sɛgɛsɛgɛliw ɲɛtaa Cagrilintide kan
Kɛnɛyaso sɛgɛsɛgɛliw la, Cagrilintide ye nɔ ɲumanw bɔ mɔgɔ girinya dɔgɔyali la. Misali la, sɛgɛsɛgɛli dɔ la min kɛra santiri caman na, min kɛra ni mɔgɔw ye, min kɛra ni mɔgɔ fila ye, min kɛra ni furakisɛ ye, ani min kɛra ni baara ye, min kɛra fasa 2nan na, fura tata hakɛ ɲinini sɛgɛsɛgɛli la, mɔgɔ minnu furakɛra ni Cagrilintide ye, olu ye girinya dɔgɔyali jira ka caya ni i ye u suma ni furakisɛ tabaga ye. Kisɛya dɔgɔyali kɛmɛsarada la ka bɔ a daminɛ na, Kagrilintidi tata hakɛ bɛɛ la (miligaramu 0,3 - 4,5) tun ka ca (6,0% - 10,8%) ka tɛmɛ furakisɛ tali kulu ta kan (3,0%). Jɛkulu min furakɛra ni Cagrilintide miligaramu 4,5 ye, o fana girinya dɔgɔyara ka tɛmɛ kulu min furakɛra ni liraglutide miligaramu 3,0 ye (10,8% ni 9,0%). Nin jaabi ninnu b’a jira ko Cagrilintide bɛ se ka kɛ fɛɛrɛ ɲuman ye farikolo girinya kunbɛnni na [6] ..
Kagrilintidi ni GLP-1 minɛbaga agoniste semaglutide bɛ ni baarakɛcogo danfaralenw ye, nka u bɛ tali kɛ ɲɔgɔn na. Semaglutid bɛ a nɔw jira ni a bɛ baara kɛ GLP-1 minɛbagaw kan hipotalamus kɔnɔ, o bɛ na ni dumuni nege dɔgɔyali ye, ka insuline bɔli caya, ani ka kɔnɔbara lankolonya bila kɔfɛ. O kɔfɛ, Cagrilintide bɛ dumuni nege bali ka taa a fɛ, a kɛtɔ ka amilini minɛbagaw baara. Nin fura fila ninnu tali faralen ɲɔgɔn kan, o bɛ nɔ bila dumuni nege la ka kɛɲɛ ni fɛɛrɛ caman ye, o bɛ dɔ fara farikolo girinya dɔgɔyali nafa kan kosɛbɛ [7] . Ni an y’a jateminɛ ko fasa ka gɛlɛn, furakɛli faralen ɲɔgɔn kan min bɛ banakisɛfagalanw labanyɔrɔ caman laɲini, o bɛ fɛɛrɛ hakilitigi ni nafama jira.
Ka fara o kan, Cagrilintide fana ye joli sukaro kɔlɔsili seko ɲuman jira sukarodunbana suguya 2 banabagatɔw la. Dɔgɔtɔrɔso sɛgɛsɛgɛliw y’a jira ko Cagrilintide bɛ sabatili ni nafa ɲuman jira fasa ni sukarodunbana suguya 2 bɛɛ furakɛli la. Misali la, kɛnɛyaso sɛgɛsɛgɛli dɔ la, sukarodunbana suguya 2 bɛ banabagatɔ minnu na, Cagrilintide ni GLP-1 minɛbaga agoniste semaglutide faralen ɲɔgɔn kan, o ye joli sukaro kɔlɔsili ni farikolo girinya dɔgɔyali nɔ kabakoma jira. O b’a jira ko Cagrilintide bɛ sabatili hakɛba mara kɛnɛyaso baarakɛcogo la, wa a bɛ se ka furakɛli nɔ sabatilenw kɛ. Kɛnɛyaso sɛgɛsɛgɛli wɛrɛ la, Cagrilintide, a kɛra a kelen na walima a ni semaglutide faralen ɲɔgɔn kan, o ye muɲu ni lakana ɲuman jira [8] . O bɛ Cagrilintide sabatili sinsin ka taa a fɛ, i n’a fɔ a bɛ kɛ cogo min na kɛnɛyaso la, fura sabatili bɛ tali kɛ a muɲuni n’a lakanani na kosɛbɛ.
A laban na, kɛnɛyaso sɛgɛsɛgɛliw la, furakɛli ni kagrilintidi ye, o muɲuna kosɛbɛ. Fasa 2nan fura tata hakɛ ɲinini sɛgɛsɛgɛli la, furakɛli dabila kudayi hakɛw tun bɛ se ka suma furakɛli kulu suguya caman na, a fanba tun bɛ bɔ ko juguw de la. O bɛɛ n’a ta, kɔlɔlɔ minnu tun ka ca ni tɔw bɛɛ ye, olu tun ye kɔnɔboli ye ani pikiri kɛyɔrɔw la, a fanba tun ka jugu fo ka se a juguya hakɛ danma ma. Fasa 1b sɛgɛsɛgɛli la, min kɛra k’a sɔrɔ a ma kɛ cogo si la, furakɛli min kɛra ɲɔgɔn fɛ ni kagrilintidi ni semaglutide miligaramu 2,4 ye o fana y’a jira ko muɲuni ka ɲi ani lakanacogo min bɛ sɔn , Kɔrɔbɔlibaw ni kɔrɔbɔli kuntaalajanw ka kan ka kɛ don nataw la walasa ka furakɛli faralen in nafa n’a lakanani jateminɛ kosɛbɛ.
Cagrinlintide ka sigicogo misali
Soso:PubMed [5] Ɲɛjirali dɔw.
Cagrilintide tali nafa
Cagrilintide bɔli ye jigiya kura lase fasa ni sukarodunbana suguya 2 furakɛli ma. Hali ni diɲɛ kɔnɔ fasa gɛlɛya juguyara ka taa a fɛ, furakɛlicogo minnu dabɔra sisan furakɛlicogo la, olu dan ye. I n’a fɔ amilini analozi kura min bɛ baara kɛ waati jan kɔnɔ, Cagrilintide bɛ furakɛli fɛɛrɛ kura di banabagatɔ fasalenw ma, kɛrɛnkɛrɛnnenya la minnu ka jaabi man ɲi ɲɛnamaya kɛcogo fɛɛrɛw la, wa u ma bɛn bariatric opereli ma. A bɛ se ka farikolo girinya kunbɛn ni fɛɛrɛ kɛrɛnkɛrɛnnen dɔ ye, ka hakilina kuraw ni fɛɛrɛ kuraw di fasa furakɛli ma, wa a bɛ se ka nafa ni lakana ɲuman jira ni a bɛ tali kɛ fasa furaw la minnu bɛ kɛ caya Ka fara o kan, Cagrilintide ni semaglutide (CagriSema) faralen ɲɔgɔn kan ka ɲɛtaa sɔrɔ, o b’a jira ko furakɛli faralen ɲɔgɔn kan min bɛ banakisɛfagalanw laɲini caman laɲini ka o ye fɛɛrɛ ɲuman ye min bɛ furakɛli jaabi bonya fasa la , Nin furakɛlicogo min bɛ kɛ ni laɲini caman ye, o tɛ dan fasa kunbɛncogo kura dɔrɔn ma, nka a bɛ na ni farikoloɲɛnajɛ ɲɛtaa caman ye fana sukarodunbana suguya 2 banabagatɔw ma.
Kuncɛli la, i n’a fɔ amilini analozi kura min bɛ baara kɛ waati jan kɔnɔ, Cagrilintide bɛ se ka mɔgɔ farikolo girinya dɔgɔya ani ka joli sukaro kunbɛn cogo kabakoma na. A bɛ fasa taamasiɲɛ sira baara ni amilini ka baara ladege ye ani ka farikoloɲɛnajɛ labɛn i n’a fɔ agoniste dual receptor. Kɛnɛyaso sɛgɛsɛgɛliw y’a jira ko Cagrilintide, ni a bɛ kɛ a kelen na walima ni a ni semaglutide faralen don ɲɔgɔn kan, o bɛ se ka farikolo girinya dɔgɔya kosɛbɛ, wa a bɛ muɲu kosɛbɛ. Ka fara o kan, a ye joli sukaro kunbɛnni seko ɲuman jira fana sukarodunbana suguya 2 bɛ banabagatɔ minnu na, ka sugandili kura di fasa ni sukarodunbana furakɛli ma ani ka furakɛli kɛcogo kɔrɔw fa, kɛrɛnkɛrɛnnenya la banabagatɔw ma minnu ka jaabi man ɲi ɲɛnamaya kɛcogo fɛɛrɛw la, ani minnu ma bɛn opereli ma. A ka furakɛli fɛɛrɛ min bɛ kɛ ni laɲini caman ye, o bɛ hakilina kuraw di farikoloɲɛnajɛ banaw furakɛli ma.
A sɛbɛnbaga ko la
Fɛn minnu kofɔlen dòn san fɛ, olu bɛɛ ɲinini Kɛra, k’u Labɛn ani k’u Lajɛ Cocer Peptides fɛ.
Dɔnniya gafe sɛbɛnbaga
Dɔgɔtɔrɔ DCW Lau ye karamɔgɔ ye Cumming furakɛli kalanso la, Calgary Iniwɛrisite la, Kanada. A ka ɲininiw ɲɛsinnen bɛ kɔnɔbara ni farikoloɲɛnajɛ, furakɛli bɛɛjɛfanga ni kɔnɔna furakɛli, dusukun ni jolisiraw ni dusukunnakow, foroba kɛnɛya, sigida ni baarakɛyɔrɔ kɛnɛya, ani kansɛri furakɛli. A bɛ jɔyɔrɔw fana sɔrɔ Alberta Health Services (AHS) ani Obesity Canada la ani a bɛ baara kɛ Julia McFarlane sukarodunbana ɲininikɛyɔrɔ la. Dɔgɔtɔrɔ Lau ka dɔnniya ka bon sukarodunbana ni fasa ɲinini siratigɛ la, a ka baara bɔra kalanko gafew kɔnɔ i n’a fɔ Canadian Journal of Diabetes. Dɔgɔtɔrɔ DCW tɔgɔ sɛbɛnnen bɛ citation (citation) kɔnɔ [6].
