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1kits (10Vials) .
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▎ Cagrilintide ƒe Dɔwɔɖoɖo
Dzɔtsoƒe: PubChem |
Nusiwo kplɔ wo nɔewo ɖo: Pyr-KCNTATCATQRLAEFLRHSSNNFGPILPPTNVGSNTP CAS: 1415456-99-3 ƒe xexlẽdzesi Mɔfiame: C 174H 269N 45O 52S2 MW 4409 g/mol |
▎ Cagrilintide Ŋuti Numekuku
Nukae nye Cagrilintide ƒe dzɔtsoƒe?
Cagrilintide—si nye amylin ƒe nɔnɔmetata: .
Amylin nye lãmetsi si dɔgboa ƒe ƒukpo β lãmenugbagbeviwo ɖena dona. Le ŋutilã ƒe nɔnɔmewo me la, ewɔa dɔ aduadu kple insulin eye ŋutilã ƒe dɔwɔwɔ ɖedzesi gbogbo aɖewo le esi.
Gbã la, amylin wɔa akpa vevi aɖe le nuɖuɖu ƒe dzidzeme kple nuɖuɖu dzi ɖeɖe kpɔtɔ me. Eƒe dɔwɔwɔ ƒe mɔnu koŋ lɔa dɔlékuixɔla siwo le Area Postrema me le ventricle enelia ƒe gɔme. Wotoa Nucleus of the Solitary Tract dzi ɖoa ahɔhɔ̃mekawo ƒe dzesiawo ɖe ŋgɔgbe ahɔhɔ̃a. Le ɣeyiɣi ma ke me la, woate ŋu atsɔ wo ayi Lateral Hypothalamic Area kple hypothalamic nuklia ƒuƒoƒo bubuwo hã to Lateral Parabrachial Nucleus dzi. Ŋutete le amylin ŋu be wòaʋã nugbagbevi la ƒe dzidzeme ƒe titina eye wòaxe mɔ ɖe nuɖuɖu ɖuɖu nu le lãwo me [1] ..
Amylin te ŋu ɖɔa sukli ƒe homeostasis ɖo, si wokpɔna to mɔxexe ɖe insulin kple sukli siaa ƒe dodo nu me [2] . Dɔ sia kpena ɖe ame ŋu ŋutɔ be sukli ƒe agbɔsɔsɔ le ʋu me nali ke eye wòle vevie ŋutɔ le dɔlélewo abe suklidɔ ene dada me.
Gawu la, amylin wɔa eƒe ŋusẽkpɔɖeamedziwo to ŋusẽkpɔkpɔ ɖe ahɔhɔ̃mekawo ƒe dodo dzi me. Le kpɔɖeŋu me, exea mɔ na dopamine ƒe dodo le sisiblisiwo ƒe hypothalamus me, evɔ mekpɔa ŋusẽ sue aɖe ko ɖe norepinephrine kple serotonin dzi [3] . Le sukli ƒe homeostasis gome la, amylin nana ʋumesukli ƒe liƒo nɔa anyi to insulin kple sukli ƒe dodo dzi ɖeɖe kpɔtɔ me. Eƒe mɔnuwo dometɔ aɖewoe nye dɔwɔwɔ ɖe dɔgboa ƒe ƒukpo α lãmenugbagbeviwo dzi tẽ eye wòɖɔa glucagon ƒe dodo ɖo le mɔ si mele tẽ o nu to ahɔhɔ̃mekawo ƒe dzesiwo ƒe tɔtrɔ le hypothalamus me. Le suklidɔléla siwo ŋu suklidɔ le gome la, menye ɖeko β lãmenugbagbeviwo ƒe tsɔtsrɔ̃ hea insulin ƒe veve vɛ ko o, ke enaa C-peptide kple amylin siaa ƒe dodo dzi ɖena kpɔtɔna hã. Edze ƒã be amylin kpɔa gome le sukli ƒe homeostasis ƒe ɖoɖowɔwɔ me to mɔxexe ɖe dɔgboa ƒe ƒuƒlu kple aklã me sukli ƒe wɔwɔ le nuɖuɖu megbe nu, eye mlɔeba la, eɖea sukli ƒe tɔtrɔ le ʋu me le nuɖuɖu megbe dzi kpɔtɔna [4] . Tsɔ kpe ɖe eŋu la, amylin ate ŋu ahe dɔgboa ƒe ƒuƒlu ɖeɖe ɖe megbe, axe mɔ na dɔgbo ƒe peristalsis to titina lãmekawo me, eye wòana nuɖuɖu nanɔ dɔgboa me nadidi ɖe edzi, si ana ʋumesukli ƒe dzidziɖedzi kabakaba nagadzɔ o.
Ke hã, amylin ƒe agbenɔƒe afã le kpuie vie, si wɔnɛ be womezãnɛ le atikewɔnyawo me o. Numekukuwo ɖee fia be amylin ƒe kpeɖeŋutɔ si li fifia, si nye pramlintide, abe atike kpeɖeŋutɔ ene na suklidɔ dada, hiã be woadoe zi etɔ̃ gbesiagbe. Menye ɖeko esia hea kuxiwo vɛ na dɔnɔwo ko o, ke eɖea woƒe sedziwɔwɔ dzi kpɔtɔna hã [5] . Be woakpɔ dzɔdzɔme amylin ƒe afã ƒe agbenɔƒe kpui ƒe nya la gbɔ la, woto Cagrilintide vɛ be wòanye nusi sɔ kple esia si wɔa dɔ ɣeyiɣi didi. Wotu Cagrilintide ƒe wɔwɔme ɖe dzɔdzɔme amylin ƒe ŋutilã ƒe dɔwɔwɔ gɔmesese deto dzi. Eƒe taɖodzinue nye be yeasrɔ̃ alesi amylin wɔa dɔe esime wòle atike la ƒe liƒo kple dɔwɔwɔ ɣeyiɣi didi ƒe nɔnɔmewo dom ɖe ŋgɔ be wòawɔ ɖe dɔdamɔnu ƒe nudidiwo dzi.
Cagrilintide ƒe Ŋutete Kple Atikeŋutinunya ƒe Nɔnɔmewo
Cagrilintide nye amylin ƒe nɔnɔmetata yeye si wɔa dɔ ɣeyiɣi didi si ŋu ŋutete gã aɖe le, si ɖe ŋusẽkpɔɖeamedzi ɖedzesiwo fia le lolo akpa kple suklidɔ dada me. Lipidated le eme eye nɔnɔme siwo li ke siwo wɔa dɔ ɣeyiɣi didi le esi [5] . Amylin nye lãmetsi aɖe si dɔgboa ƒe β lãmenugbagbeviwo ɖena ɖe go kpe ɖe insulin ŋu, si naa ame ƒe dzi dzea eme to dɔwɔwɔ ɖe ahɔhɔ̃a ƒe akpa siwo nye homeostatic kple hedonic dzi. Abe amylin ƒe kpɔɖeŋu ene la, Cagrilintide ate ŋu asrɔ̃ ŋusẽkpɔɖeamedzi sia, si ana ame naɖi ƒo eye wòato esia me akpe ɖe ame ƒe kpekpeme dzi ɖeɖe kpɔtɔ ŋu. Gawu la, Cagrilintide nye amylin kple calcitonin xɔla ƒe mɔxenu eve, si woɖe tso amylin ƒe megbeƒu me, si naa dɔwɔwɔ ƒe mɔnu tɔxɛ aɖee le lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe ɖoɖowɔwɔ me.
Dɔdamɔnu Ŋuti Numekukuwo ƒe Ŋgɔyiyi le Cagrilintide ŋu
Le dɔdamɔnu dodokpɔwo me la, Cagrilintide na nu nyuiwo do tso eme le lolo dzi ɖeɖe kpɔtɔ me. Le kpɔɖeŋu me. Kpekpeme dzi ɖeɖe kpɔtɔ ƒe alafa memamã le mama dedie nu tso gɔmedzedzea me le Cagrilintide ƒe agbɔsɔsɔme katã (0.3 - 4.5 mg) sɔ gbɔ (6.0% - 10.8%) wu esi le placebo ƒuƒoƒoa me (3.0%). Kpekpeme dzi ɖeɖe kpɔtɔ le ƒuƒoƒo si wotsɔ Cagrilintide mg 4.5 da dɔe me hã lolo wu esi le ƒuƒoƒo si wotsɔ liraglutide mg 3.0 da dɔe me (10.8% tsɔ wu 9.0%). Nusiwo do tso eme siawo ɖee fia be Cagrilintide ateŋu anye tiatia nyui aɖe na lolo dzi ɖeɖe kpɔtɔ [6]..
Cagrilintide kple GLP-1 receptor agonist semaglutide ƒe dɔwɔwɔ ƒe mɔnu vovovowo gake wodo ƒome kple wo nɔewo. Semaglutid wɔa eƒe ŋusẽkpɔɖeamedzi to dɔwɔwɔ ɖe GLP-1 xɔla siwo le hypothalamus me dzi, si wɔnɛ be nuɖuɖu ƒe dzodzro dzi ɖena kpɔtɔna, insulin ƒe dodo dzina ɖe edzi, eye dɔgboa me tsi ƒuƒlu tsia megbe. Le go bubu me la, Cagrilintide gatea nuɖuɖudzroame ɖe to to amylin-xɔlawo ƒe dɔwɔwɔ me. Atike eve siawo zazã ɖekae hea ŋusẽ si wotsɔ ɖoa nuɖuɖudzroame dzi to mɔnu vovovowo dzi, si wɔnɛ be lolo dzi ɖeɖe kpɔtɔ ƒe ŋutete dzina ɖe edzi ŋutɔ [7] . Esi lolo akpa ƒe nɔnɔme sesẽ ta la, atikewɔwɔ ƒokpli si tɔa ŋku dɔlélenutsiŋutete ƒe nuwuƒe geɖe la tsi tre ɖi na mɔnu si me susu le eye wòwɔa dɔ nyuie.
Gawu la, Cagrilintide ɖe ʋumesukli dzi ɖuɖu ƒe ŋutete nyui aɖe hã fia le dɔnɔ siwo ŋu suklidɔ ƒomevi eve le ŋu. Dɔdaƒewo ƒe numekukuwo ɖee fia be Cagrilintide ɖea liƒo nyui kple dɔwɔwɔ nyuie fiana le lolo akpa kple suklidɔ ƒomevi evelia siaa dzi kpɔkpɔ me. Le kpɔɖeŋu me, le dɔdamɔnu dodokpɔ aɖe si me suklidɔ ƒomevi eve le dɔnɔ siwo ŋu suklidɔ ƒomevi eve le me la, Cagrilintide kple GLP-1 receptor agonist semaglutide ƒe ƒuƒoƒo ɖe ʋumesukli dzi ɖuɖu kple lolo dzi ɖeɖe kpɔtɔ ƒe ŋusẽkpɔɖeamedzi ɖedzesi aɖe fia. Esia fia be Cagrilintide léa liƒo gã aɖe ɖe te le atikewɔnyawo me eye wòte ŋu wɔa atikewɔwɔ ƒe ŋusẽkpɔɖeamedzi siwo nɔa anyi ɖaa. Le dɔdamɔnu dodokpɔ bubu me la, Cagrilintide, eɖanye esi wodoe ɖeɖeko alo wotsɔe kpe ɖe semaglutide ŋu o, ɖee fia be woate ŋu alɔ̃ ɖe edzi nyuie eye wòle dedie [8] . Esia gaɖo kpe Cagrilintide ƒe liƒo dzi, abe alesi le atikewɔnyawo me la, atike ƒe liƒo do ƒome kple eƒe mɔɖeɖe ɖe eŋu kple eƒe dedienɔnɔ vevie ene.
Mlɔeba le dɔdamɔnu dodokpɔwo me la, woɖe mɔ ɖe cagrilintide zazã ŋu nyuie. Le afɔɖeɖe 2 ƒe agbɔsɔsɔme didi dodokpɔ me la, alesi wodzudzɔ atikewɔwɔ tegbee ƒe agbɔsɔsɔme sɔ le atikewɔwɔ ƒe hatsotso vovovowo me, eye nu gbegblẽ siwo dzɔ koŋ gbɔe wòtso. Ke hã, nu gbegblẽ siwo bɔ wue nye dɔgbo ƒe dɔlélewo kple alesi wodoa atike na ame le, eye wo dometɔ akpa gãtɔ ƒe sesẽme nu mesẽ o va ɖo esi mede nenema o. Le afɔɖeɖe 1b dodokpɔ si wowɔ le vome, si dzi wokpɔ ŋusẽ ɖo me la, atikewɔwɔ si wozã le ɣeyiɣi ɖeka me kple cagrilintide kple semaglutide mg 2.4 hã ɖee fia be woate ŋu alɔ̃ ɖe edzi nyuie eye dedienɔnɔ ƒe nɔnɔme si dzi woda asi ɖo [9]. Ehiã be woawɔ dodokpɔ gãwo kple esiwo axɔ ɣeyiɣi didi wu le etsɔme be woatsɔ ada atikewɔwɔ sia si wotsɔ tsakae ƒe dɔwɔwɔ kple dedienɔnɔ kpɔ bliboe.
Cagrinlintide ƒe xɔtuɖoɖo ƒe kpɔɖeŋu
Dzɔtsoƒe:PubMed [5] .
Vevienyenye si Le Cagrilintide Zazã Ŋu
Cagrilintide ƒe dodo na mɔkpɔkpɔ yeye va le lolo akpa kple suklidɔ ƒomevi evelia dada me. Togbɔ be lolo akpa ƒe kuxia le sesẽm ɖe edzi le xexeame katã hã la, atikewɔmɔnu siwo dzi woda asi ɖo fifia la gakpɔtɔ le ʋɛ. Abe amylin ƒe nɔnɔmetata yeye si wɔa dɔ ɣeyiɣi didi ene la, Cagrilintide naa atikewɔmɔnu yeye aɖe na dɔnɔ siwo lolo akpa, vevietɔ amesiwo mewɔa nu ɖe agbenɔnɔ ƒe nudede nyawo me ŋu nyuie o eye womesɔ na amekoko si me woɖea ʋu le o. Eɖoa kpekpeme dzi kpɔkpɔ gbɔ to dɔwɔwɔ ƒe mɔnu tɔxɛ aɖe dzi, si naa susu yeyewo kple mɔnu yeyewo hena lolo akpa dada, eye ate ŋu aɖe dɔwɔwɔ kple dedienɔnɔ afia nyuie wu ne wotsɔe sɔ kple atike xoxo siwo wozãna tsɔ tsia lolo akpa nu [7] . Gawu la, Cagrilintide kple semaglutide (CagriSema) ƒe ƒuƒoƒo ƒe nya si kpɔ dzidzedze ɖee fia be atikewɔwɔ ƒokpli si woɖo ɖe dɔlélenutsiŋutete ƒe taɖodzinu geɖewo ŋu nye mɔnu nyui aɖe si dzi woato ado atikewɔwɔ ƒe ŋuɖoɖo ɖe ŋgɔ le lolo akpa me [8] . Menye ɖeko atikewɔwɔ ƒe kpɔɖeŋu sia si me wozãa taɖodzinu geɖe le la naa kpɔɖeŋu yeye aɖe le lolo akpa dzi kpɔkpɔ ŋu ko o, ke ehea lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe ŋgɔyiyi ɖedzesiwo vɛ na dɔnɔ siwo ŋu suklidɔ ƒomevi eve le hã.
Le nyataƒoƒo me la, abe amylin ƒe nɔnɔmetata yeye si wɔa dɔ ɣeyiɣi didi ene la, ŋutete ɖedzesi aɖe le Cagrilintide ŋu le lolo dzi ɖeɖe kpɔtɔ kple ʋumesukli dzi ɖeɖe kpɔtɔ me. Enaa dzidzeme ƒe dzesimɔa wɔa dɔ to amylin ƒe dɔwɔwɔ sɔsrɔ̃ me eye wòɖɔa lãmenugbagbeviwo ƒe dɔwɔwɔ ɖo abe dual receptor agonist ene. Dɔdamɔnu dodokpɔwo ɖee fia be Cagrilintide, si wozã ɖeɖeko alo wotsɔe kpe ɖe semaglutide ŋu, ate ŋu aɖe ame ƒe kpekpeme dzi akpɔtɔ ŋutɔ eye woate ŋu alɔ̃ ɖe edzi nyuie. Tsɔ kpe ɖe eŋu la, eɖe ʋumesukli ƒe agbɔsɔsɔ dzi ɖuɖu ƒe ŋutete nyuiwo hã fia le dɔnɔ siwo ŋu suklidɔ ƒomevi eve le ŋu, si na tiatia yeye aɖe li na lolo akpa kple suklidɔ dada eye wòɖo vovototo si le atikewɔwɔmɔnu siwo li fifia me, vevietɔ na dɔnɔ mawo siwo mewɔa nu nyuie ɖe agbenɔnɔ ƒe nudede nyawo me ŋu nyuie o eye womesɔ na amekoko o. Eƒe atikewɔwɔmɔnu si me wozãa taɖodzinu vovovowo le la naa gɔmesese yeyewo sua ame si ku ɖe lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dɔlélewo dzi kpɔkpɔ ŋu.
Le Agbalẽŋlɔla La Ŋu
Nusiwo míeyɔ ɖe etame la katã nye esiwo ŋu Cocer Peptides wɔ numekuku le, trɔ asi le wo ŋu eye woƒo wo nu ƒu.
Dzɔdzɔmeŋutinunya ƒe Agbalẽŋlɔla
Ðɔkta D. C. W. Lau nye nufialagã le Cumming Atikewɔwɔ Suku, Calgary Yunivɛsiti, Canada. Eƒe numekukuwo ku ɖe lãmenugbagbeviwo ƒe dɔwɔwɔ kple lãmenugbagbeviwo ƒe dɔwɔwɔ, atikewɔwɔ bliboa kple ememe, dzitodzito kple dzitodzito, dukɔa ƒe lãmesẽ, nutome kple dɔwɔƒe ƒe lãmesẽ, kpakple kansa ŋuti nunya ŋu. Exɔ ɖoƒewo hã le Alberta Lãmesẽnyawo Gbɔkpɔha (AHS) kple Obesity Canada eye wòwɔa dɔ le Julia McFarlane Suklidɔ Ŋuti Numekuƒe. Nuteƒekpɔkpɔ geɖe le Ðɔkta Lau si le suklidɔ kple lolo akpa ŋuti numekukuwo me, eye wota eƒe dɔa ɖe agbalẽnyalawo ƒe magazinewo abe Canadian Journal of Diabetes ene me. Woŋlɔ Ðɔkta DCW ŋkɔ ɖe nyayɔyɔ ƒe nyatakaka me [6].
