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1 kits (10 Vials)
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▎ Tsarin Cagrilintide
Source: PubChem |
Jeri: Pyr-KCNTACATQRLAEFLRHSSNNFGPILPPTNVGSNTP Saukewa: 1415456-99-3 Formula: C 174H 269N 45O 52S2 MW 4409 g/mol |
▎ Binciken Cagrilintide
Menene asalin Cagrilintide?
Cagrilintide - analog na amylin:
Amylin wani hormone ne da ke ɓoye ta ƙwayoyin β-sel na pancreatic. A ƙarƙashin yanayin ilimin lissafi, yana aiki tare da insulin kuma yana da ɗimbin mahimman ayyukan ilimin lissafi.
Na farko, amylin yana taka muhimmiyar rawa wajen haifar da gamsuwa da rage cin abinci. Tsarin aikinsa galibi ya ƙunshi kunna masu karɓa a cikin Area Postrema a gindin ventricle na huɗu. Ana watsa siginar jijiya zuwa kwakwalwar gaba ta hanyar Nucleus of the Solitary Tract. A lokaci guda, ana iya isar da su zuwa Yankin Hypothalamic na Lateral da sauran kungiyoyin nukiliya na hypothalamic ta hanyar Lateral Parabrachial Nucleus. Amylin yana da ikon motsa cibiyar satiety na kwayoyin halitta da hana cin abinci a cikin dabbobi [1].
Amylin yana da ikon daidaita glucose homeostasis, wanda aka samu ta hanyar hana fitar da insulin da glucagon [2] . Wannan aikin yana ba da gudummawa sosai don kiyaye kwanciyar hankali na matakan glucose na jini kuma yana da mahimmanci ga maganin cututtuka irin su ciwon sukari.
Bugu da ƙari, amylin yana aiwatar da tasirinsa ta hanyar yin tasiri ga sakin neurotransmitters. Misali, yana hana sakin dopamine a cikin hypothalamus na berayen, yayin da yake da ɗan ƙaramin tasiri akan norepinephrine da serotonin [3] . A cikin mahallin glucose homeostasis, amylin yana kula da kwanciyar hankali na glucose na jini ta hanyar hana fitar da insulin da glucagon. Hanyoyinsa sun haɗa da yin aiki kai tsaye akan ƙwayoyin sel na pancreatic islet α da kuma sarrafa ƙwayar glucagon a kaikaice ta hanyar watsa siginar jijiya a cikin hypothalamus. A cikin marasa lafiya da ciwon sukari, lalata ƙwayoyin β ba kawai yana haifar da ƙarancin insulin ba amma yana haifar da raguwar siginar C-peptide da amylin. Babu shakka Amylin yana da hannu a cikin tsarin glucose homeostasis ta hanyar hana zubar da ciki da kuma samar da glucose na hanta bayan haihuwa, a ƙarshe yana rage jujjuyawar glucose na jini [4] . Bugu da ƙari, amylin na iya jinkirta zubar da ciki, yana hana peristalsis na gastrointestinal fili ta hanyar tsarin juyayi na tsakiya, kuma ya tsawaita lokacin zama na abinci a cikin gastrointestinal tract, don haka yana hana karuwa mai sauri a cikin glucose na jini.
Duk da haka, amylin yana da ɗan gajeren rabin rayuwa, wanda ke hana aikace-aikacen asibiti. Bincike ya nuna cewa analog na amylin na yanzu, pramlintide, a matsayin magani na maganin ciwon sukari, yana buƙatar gudanarwa sau uku a rana. Wannan ba kawai yana haifar da damuwa ga marasa lafiya ba amma har ma yana rage yarda da su [5] . Don magance matsalar ɗan gajeren rabin rayuwar amylin na halitta, Cagrilintide an haɓaka shi azaman analog mai tsayi. Ci gaban Cagrilintide yana dogara ne a cikin zurfin fahimtar ayyukan ilimin lissafi na amylin na halitta. Yana da nufin yin kwaikwayon tsarin aikin amylin yayin haɓaka kwanciyar hankali da kaddarorin magunguna na dogon lokaci don biyan buƙatun jiyya na asibiti.
Abubuwan Yiwuwa da Abubuwan Magunguna na Cagrilintide
Cagrilintide sabon labari ne na amylin analogue mai tsayi mai tsayi tare da yuwuwar yuwuwar, yana nuna babban tasiri a cikin kula da kiba da ciwon sukari. Yana da lipidated kuma yana da tsayayyen halaye na dogon lokaci [5] . Amylin wani hormone ne wanda aka haɗa tare da ƙwayoyin β na pancreatic tare da insulin, wanda ke haifar da satiety ta hanyar yin aiki akan yankunan homeostatic da hedonic na kwakwalwa. A matsayin analog na amylin, Cagrilintide na iya kwaikwayon wannan tasirin, haifar da satiety kuma don haka yana taimakawa wajen sarrafa nauyi. Bugu da ƙari, Cagrilintide shine amylin dual amylin da calcitonin agonist mai karɓa, wanda aka samo daga kashin baya na amylin, yana ba shi wata hanyar aiki na musamman a cikin tsarin rayuwa.
Ci gaban Nazarin Clinical akan Cagrilintide
A cikin gwaje-gwaje na asibiti, Cagrilintide ya ba da sakamako mai ban sha'awa wajen haifar da asarar nauyi. Alal misali, a cikin multicenter, bazuwar, makafi biyu, mai sarrafa wuribo, da kuma aiki mai sarrafa lokaci 2 gwajin neman kashi, mahalarta da aka bi da su tare da Cagrilintide sun nuna hasara mai mahimmanci idan aka kwatanta da waɗanda ke karɓar placebo. Matsakaicin adadin raguwar nauyi daga tushe don duk allurai na Cagrilintide (0.3 - 4.5 MG) ya kasance mafi girma (6.0% - 10.8%) fiye da na rukunin placebo (3.0%). Rage nauyi a cikin rukunin da aka yi da 4.5 MG na Cagrilintide shima ya fi na rukunin da aka yi da 3.0 MG na liraglutide (10.8% vs. 9.0%). Waɗannan sakamakon suna ba da shawarar cewa Cagrilintide na iya zama zaɓi mai tasiri don sarrafa nauyi [6].
Cagrilintide da GLP-1 mai karɓar agonist semaglutide suna da nau'ikan ayyuka daban-daban waɗanda ke da alaƙa. Semaglutid yana haifar da tasirin sa ta hanyar yin aiki akan masu karɓar GLP-1 a cikin hypothalamus, wanda ke haifar da raguwar ci, haɓakar ƙwayar insulin, da jinkirin zubar da ciki. Sabanin haka, Cagrilintide yana ƙara kashe ci ta hanyar kunna masu karɓar amylin. Gudanar da haɗin gwiwar waɗannan wakilai guda biyu yana haifar da tasiri mai mahimmanci akan ci ta hanyar hanyoyi masu yawa, yana inganta haɓakar asarar nauyi [7] . Ganin rikitaccen yanayin kiba, haɗin gwiwar jiyya da ke niyya da ƙarshen ƙarshen pathophysiological yana wakiltar dabara mai ma'ana da inganci.
Haka kuma, Cagrilintide ya kuma nuna alamun ikon sarrafa glucose na jini a cikin marasa lafiya da ke da nau'in ciwon sukari na 2. Binciken asibiti ya nuna cewa Cagrilintide yana nuna ingantaccen kwanciyar hankali da inganci a cikin sarrafa duka kiba da nau'in ciwon sukari na 2. Misali, a cikin gwaji na asibiti da ya shafi marasa lafiya da ke da nau'in ciwon sukari na 2, hadewar Cagrilintide da GLP-1 mai karɓar agonist semaglutide sun nuna ingantaccen sarrafa glucose na jini da tasirin asara. Wannan yana nuna cewa Cagrilintide yana kula da babban matakin kwanciyar hankali a cikin aikin asibiti kuma yana da ikon aiwatar da tasirin warkewa mai dorewa. A cikin wani gwaji na asibiti, Cagrilintide, ko ana gudanar da shi kadai ko a hade tare da semaglutide, ya nuna kyakkyawan haƙuri da aminci [8] . Wannan yana ƙara tabbatar da kwanciyar hankali na Cagrilintide, kamar yadda a cikin aikace-aikacen asibiti, kwanciyar hankali na magani yana da alaƙa da juriya da aminci.
A ƙarshe, a cikin gwaje-gwaje na asibiti, an yi haƙuri da magani tare da cagrilintide da kyau. A cikin gwajin neman kashi na 2 na lokaci, ƙimar dakatarwar jiyya ta dindindin ta kasance daidai da ƙungiyoyin jiyya daban-daban, galibi ana danganta su ga abubuwan da ba su da kyau. Duk da haka, al'amuran da suka fi dacewa su ne cututtuka na ciki da kuma halayen wurin allura, tare da mafi yawan kasancewa masu sauƙi zuwa matsakaici a cikin tsanani. A cikin bazuwar, gwajin lokaci na 1b mai sarrafawa, jiyya na lokaci guda tare da cagrilintide da 2.4 MG na semaglutide suma sun nuna kyakkyawan haƙuri da ingantaccen bayanin martaba [9]. Gwaje-gwaje masu girma da tsayi suna da garantin nan gaba don kimanta inganci da amincin wannan haɗin gwiwar.
Samfurin Tsarin Cagrinlintide
Source:PubMed [5]
Muhimmancin Amfani da Cagrilintide
Bayyanar Cagrilintide ya kawo sabon bege ga maganin kiba da nau'in ciwon sukari na 2. Duk da karuwar tsananin matsalar kiba ta duniya, zaɓuɓɓukan da aka amince da su a halin yanzu don maganin magunguna sun kasance iyakance. A matsayin sabon labari na amylin analogue na dogon lokaci, Cagrilintide yana ba da sabon zaɓi na warkewa ga marasa lafiya masu kiba, musamman waɗanda ke da mummunan martani ga ayyukan rayuwa kuma ba su dace da tiyatar bariatric ba. Yana samun nasarar sarrafa nauyi ta hanyar tsarin aiki na musamman, yana ba da sabbin dabaru da hanyoyin magance kiba, kuma yana iya nuna ingantaccen inganci da aminci idan aka kwatanta da magungunan rigakafin kiba na gargajiya [7] . Bugu da ƙari, yanayin nasara na haɗuwa da Cagrilintide da semaglutide (CagriSema) ya nuna cewa haɗin gwiwar da ke tattare da maƙasudin ƙwayoyin cuta da yawa shine ingantacciyar dabara don haɓaka amsawar jiyya a cikin kiba [8] . Wannan ƙirar jiyya mai maƙasudi da yawa ba wai kawai yana ba da sabon salo don sarrafa kiba ba har ma yana kawo ingantaccen haɓakar rayuwa ga marasa lafiya da ke da nau'in ciwon sukari na 2.
A ƙarshe, a matsayin sabon labari na amylin analogue na dogon lokaci, Cagrilintide yana da yuwuwar yuwuwar asara mai nauyi da sarrafa glucose na jini. Yana kunna hanyar siginar satiety ta hanyar kwaikwayon aikin amylin kuma yana daidaita metabolism azaman agonist mai karɓa biyu. Gwaje-gwaje na asibiti sun nuna cewa Cagrilintide, ko dai amfani da shi kadai ko a hade tare da semaglutide, na iya rage nauyin jiki sosai kuma yana da kyau. Bugu da ƙari, ya kuma nuna kyakkyawan ikon sarrafa glucose na jini a cikin marasa lafiya da ke da nau'in ciwon sukari na 2, yana ba da sabon zaɓi don kula da kiba da ciwon sukari da kuma cike gibi a cikin tsarin jiyya da ake da su, musamman ga waɗanda marasa lafiya da ke da mummunan martani ga ayyukan rayuwa da waɗanda ba su dace da tiyata ba. Dabarun jiyya na manufa da yawa yana ba da sabbin fahimta don kula da cututtukan rayuwa.
Game da Marubuci
Abubuwan da aka ambata a sama duk bincike ne, gyara su kuma Cocer Peptides ne suka haɗa su.
Mawallafin Jaridar Kimiyya
Dr. DCW Lau farfesa ne a Makarantar Magunguna ta Cumming, Jami'ar Calgary, Kanada. Abubuwan bincikensa sun haɗa da ilimin endocrinology da metabolism, magani na gabaɗaya da na ciki, tsarin zuciya da jijiyoyin jini da cututtukan zuciya, lafiyar jama'a, lafiyar muhalli da aikin sana'a, gami da oncology. Ya kuma rike mukamai tare da Sabis na Kiwon Lafiya na Alberta (AHS) da Obesity Canada kuma yana aiki a Cibiyar Binciken Ciwon sukari na Julia McFarlane. Dokta Lau yana da kwarewa sosai a fannin binciken ciwon sukari da kuma kiba, tare da buga aikinsa a cikin mujallu na ilimi kamar Canadian Journal of Diabetes. An jera Dokta DCW a cikin ambaton ambaton [6].
