MOTS-c 10mg ƒe dɔwɔwɔ

▎ MOTS-c Dɔwɔɖoɖo

Dzɔtsoƒe: PubChem

Nusiwo kplɔ wo nɔewo ɖo: MRWQEMGYIFYPRKLR Molekyulãwo ƒe Mɔfiame: C101H152N28O22S2 Molekyulã ƒe Kpekpeme: 2174.6g/mol CAS ƒe xexlẽdzesi: 1627580-64-6 PubChem ƒe CID: 146675088 Nya siwo sɔ kple wo nɔewo: UNII-A5CV6JFB78

▎ MOTS-c Numekuku

Nukae nye numekuku si wowɔ le MOTS-c ŋu?

Mitochondrion nye teƒe vevi aɖe si ŋusẽ ƒe asitɔtrɔ le lãmenugbagbeviwo me le. Ɣeyiɣi didi aɖee nye sia si dzɔdzɔmeŋutinunyalawo wɔ numekuku deto si de to le mitochondria ƒe wɔwɔme kple dɔwɔwɔ ŋu. Le ɖoɖo sia me la, wokpɔe dze sii vivivi be menye ɖeko mitochondria wɔa akpa vevi aɖe le ŋusẽ wɔwɔ me ko o, ke ate ŋu akpɔ gome le lãmenugbagbeviwo ƒe ŋutilã ƒe dɔwɔwɔ bubuwo hã me to mɔnu aɖewo siwo womenya o dzi.

Esi numekuku mɔ̃ɖaŋununyawo le ŋgɔ yim ɖaa, vevietɔ domenyiŋusẽfianu kple proteomics mɔ̃ɖaŋunuwo ƒe ŋgɔyiyi ta la, wova ke ɖe molecule yeye siwo do ƒome kple mitochondria ŋu. MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) nye peptide si wokpɔ tso mitochondria me si woŋlɔ ɖe mitochondria ƒe domenyiŋusẽfianu ƒe 12S rRNA nuto me ^[1]..

To mitochondrial domenyiŋusẽfianu me dzodzro tsitotsito me la, dzɔdzɔmeŋutinunyalawo ke ɖe nuxexlẽ ƒe ɖoɖo sue aɖewo siwo le ʋuʋu ɖi (sORF) ŋu, siwo ate ŋu aŋlɔ peptide aɖewo siwo wɔa dɔ tɔxɛwo. Le numekuku bubuwo kple kpeɖodzinana megbe la, wode dzesi MOTS-c. Numekukuwo ɖee fia be MOTS-c dzena le lãmenugbagbevi vovovowo me le amegbetɔwo kple lãwo me. Ewɔa dɔ ɖe ƒunukpeƒeŋusẽwo dzi koŋ to ʋukawo me, si wɔnɛ be sukli ƒe xɔxlɔ̃ kple eŋudɔwɔwɔ dzina ɖe edzi, si wɔnɛ be insulin ƒe dɔlélenutsiŋutete nyona ɖe edzi eye wònaa lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dadasɔ ^{[2] .}.

Esi numekukuwo le goglom ɖe edzi la, wokpɔe be tɔtrɔ siwo va le MOTS-c ƒe ɖeɖefia me do ƒome kplikplikpli kple tsitsi kple dɔléle siwo do ƒome kple tsitsi ƒe dzɔdzɔ kple woƒe dzɔdzɔ. Le kpɔɖeŋu me, MOTS-c ƒe agbɔsɔsɔ le ʋumenugbagbevi dzĩ me dzi ɖena kpɔtɔna ne ame tsi (Zheng Y, 2013). Le ɣeyiɣi ma ke me la, wokpɔe be MOTS-c ɖea vi na dɔléle siwo do ƒome kple tsitsi, siwo dometɔ aɖewoe nye suklidɔ, dzitodzito me dɔlélewo, ƒumeŋuɖui, lolo akpa le dzinukpɔkpɔ megbe, kple Alzheimer dɔléle ^[3]..

Nukae nye MOTS-c ƒe dɔwɔwɔ ƒe mɔnu?

Domenyiŋusẽfianu ƒe ɖeɖefia dzi kpɔkpɔ: 

MOTS-c ate ​​ŋu awɔ eƒe ŋutilã ƒe dɔwɔwɔwo to domenyiŋusẽfianu ƒe ɖeɖefia dzi kpɔkpɔ me. Le kpɔɖeŋu me, ate ŋu aɖɔ domenyiŋusẽfianuwo abe GLUT4, STAT3, kple IL-10 ene ƒe ɖeɖefia ɖo. MOTS-c wɔa eƒe ŋusẽkpɔɖeamedzi koŋ to AICAR-AMPK ƒe dzesimɔa ƒe dɔwɔwɔ kple folate-methionine ƒe tsatsam le lãmenugbagbeviwo me ƒe tɔtɔ me ^[4]..

Insulin ƒe dɔlélenutsiŋutete ƒe nyonyo: 

MOTS-c ate ​​ŋu aɖe insulin ƒe dɔlélenutsiŋutete dzi akpɔtɔ eye wòaxe mɔ ɖe suklidɔ ƒomevi evelia nu. Alesi wòwɔa dɔe ate ŋu ado ƒome kple myostatin ƒe mɔxexeɖedɔléle nu. Numekukuwo ɖee fia be MOTS-c ƒe agbɔsɔsɔ le ʋumenugbagbevi dzĩ me do ƒome gbegblẽ kple myostatin ƒe agbɔsɔsɔ le amegbetɔ ƒe ŋutilã me. MOTS-c ate ​​ŋu ana insulin ƒe dɔwɔwɔ nanyo ɖe edzi to mɔxexe ɖe dzigbe nuŋɔŋlɔ ƒe akpa si nye FOXO1 ƒe dɔwɔwɔ nu kple myostatin ƒe agbɔsɔsɔ dzi ɖeɖe kpɔtɔ me ^[5]..

Lãmetsiwo ƒe vovototodedeameme dodo ɖe ŋgɔ: 

Le lãmeka ƒe lãmenugbagbeviwo me la, MOTS-c wɔa nu kple STAT3 to SH2 ƒe kadodo ƒe nɔnɔme si wosusu le YIFY nutoa me dzi, si ɖea STAT3 ƒe nuŋɔŋlɔ ƒe dɔwɔwɔ dzi kpɔtɔna, si wɔnɛ be myotube ƒe wɔwɔme dzina ɖe edzi. Gbemelã ƒomevi MOTS-c peptide ateŋu adzi amegbetɔ (LHCN-M2) kple sisiblisi (C2C12) lãmeka ƒe ŋgɔgbe lãmenugbagbeviwo ƒe myotube wɔwɔ ɖe edzi eye wòakpɔ lãmeka lãmenugbagbeviwo ta tso nuklia myogenin ƒe amadede si interleukin-6 (IL-6) hena vɛ dzi ɖeɖe kpɔtɔ me ^[6]..

Mitochondria ƒe dɔwɔwɔ dzi kpɔkpɔ: 

MOTS-c ate ​​ŋu aɖɔ mitochondria ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ɖo. Numekukuwo ɖee fia be ne wotsɔ MOTS-c da dɔ na no me lãmenugbagbeviwo ate ŋu ana protein ƒe agbɔsɔsɔ nadzi ɖe edzi le mitochondrial biogenesis markers TFAM, COX4, kple NRF1 me, gake flow cytometry numekuku ɖee fia be mitochondria ƒe xexlẽme dzi ɖena kpɔtɔna ŋutɔ le MOTS-c zazã vɔ megbe. Numekuku bubuwo ɖee fia be MOTS-c ate ​​ŋu ana mitochondria ƒe fusion nawɔ dɔ le ɣeyiɣi ɖeka me eye wòana protein ƒe agbɔsɔsɔ si le GTPase eve, OPA1 kple MFN2, siwo le vevie ŋutɔ na no me lãwo ƒe mitochondria ƒe fusion nadzi ɖe edzi. Mɔxexe ɖe GTPase eve siawo nu alo MFN2 ƒe anyidzedze to siRNA dzi aɖe ŋutete si le MOTS-c ŋu be wòado GLUT4 ƒe ʋuʋu kple sukli ƒe xɔxlɔ̃ ɖe ŋgɔ la ɖa ^[7]..

MOTS-c nye atike si woate ŋu azã atsɔ ada dɔléle geɖe siwo do ƒome kple tsitsi, siwo dometɔ aɖewoe nye ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie, ƒumeŋuɖui, dzitodzito me dɔléle, ʋukawo ƒe ʋuʋu, sarcopenia, suklidɔ ƒomevi evelia, kple lolo akpa.

Dzɔtsoƒe:PubMed ^{[8] .}

Nukae nye MOTS-c ƒe dɔwɔwɔ?

Dɔléle siwo tso tsitsi gbɔ ƒe nyonyo

Ƒomedodo si le ame kple tsitsi dome: 

MOTS-c nye peptide si wokpɔna tso mitochondria me, eye tɔtrɔ siwo va le eƒe ɖeɖefia me do ƒome kplikplikpli kple tsitsi kple dɔléle siwo do ƒome kple tsitsi ƒe dzɔdzɔ kple woƒe dzɔdzɔ. Ne amewo le tsitsim la, MOTS-c ƒe agbɔsɔsɔ dzi ɖena kpɔtɔna. Numekukuwo ɖee fia be kamedede kpɔa ŋusẽ gã aɖe ɖe MOTS-c ƒe ɖeɖefia dzi, eye MOTS-c ate ​​ŋu anye domenɔla na kamedede ƒe ŋusẽkpɔɖeamedzi si tsia tsitsi nu ^[3]..

Suklidɔ: 

MOTS-c ate ​​ŋu ana ŋutilãa ƒe sukli kple ami ƒe asitɔtrɔ nanyo ɖe edzi, ado mitochondria ƒe dɔwɔwɔ ɖe ŋgɔ le lãmenugbagbeviwo me, eye wòaɖe dɔdzẽ ƒe ŋuɖoɖo si nɔa anyi didi si le ɖoɖo nu dzi akpɔtɔ. Le suklidɔlélawo gome la, MOTS-c ƒe agbɔsɔsɔ le ʋumenugbagbevi dzĩ me dzi ɖena kpɔtɔna. MOTS-c ateŋu aɖɔ lãmenugbagbeviwo ƒe homeostasis ɖo to sukli ƒe xɔxlɔ̃ kabakaba kple insulin ƒe dɔwɔwɔ nyuie wu me, eye ekpɔa ŋusẽ nyui ɖe mɔxexe ɖe suklidɔ ƒomevi evelia nu dzi ^[8]..

Dzitodzito me dɔlélewo: 

Dzi ƒe wɔwɔme ƒe tɔtrɔ kple eƒe dɔmawɔmawɔ nyuie nye suklidɔ ƒe kuxi siwo bɔ, eye zi geɖe la, wohea dzitodzito me dɔléle sesẽwo vɛ. MOTS-c ate ​​ŋu ana ʋukawo ƒe dɔwɔwɔ nanyo ɖe edzi eye wònye atikewɔwɔ ƒe taɖodzinu yeye na suklidɔ ƒe dzitodzito me kuxiwo. Numekukuwo ɖee fia be MOTS-c ate ​​ŋu adzra dzitodzito me mitochondria ƒe gbegblẽ ɖo le suklidɔléla siwo le sisiblisi siwo ŋu suklidɔ le me eye wòakpɔ dzitodzito me ʋu ƒe sisi kple dzitodzito ƒe dɔwɔwɔ ta ^[9]..

Ƒumeŋuɖui: MOTS-c ate ​​ŋu ado ƒumeŋuɖuiwo ƒe dzidziɖedzi, vovototodedeameme, kple mineralization ɖe ŋgɔ, axe mɔ na ƒumeŋuɖuiwo ƒe dzɔdzɔ, eye wòana ƒu ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ kple ƒu ƒe gbugbɔgaɖɔɖo naɖɔ ɖo. Kamedede ate ŋu ana MOTS-c ƒe ɖeɖefia nadzi ɖe edzi nyuie, gake mɔnu tɔxɛ si dzi kamedede tona ɖɔa MOTS-c ɖo le ƒuwo me la me mekɔ haɖe o ^{[10] .}.

Dɔléle bubuwo

Aklã me lãkusi ƒe dɔléle: 

Aklãdɔ nye aklãdɔléle sesẽ aɖe si ƒe ŋgɔdonya menyo o, eye womenya nusi gbɔ wòtso kple alesi wòdzɔna haɖe o. Mitochondrial open reading frame of 12S rRNA-c (MOTS-c) nye peptide si mitochondrial genome ŋlɔ, si kpɔa ŋusẽ nyui ɖe sukli kple lipid ƒe asitɔtrɔ, lãmenugbagbeviwo kple mitochondrial homeostasis, kple ɖoɖowɔɖi ƒe dɔdzẽ ƒe ŋuɖoɖo dzi ɖeɖe kpɔtɔ dzi, eye ate ŋu anye kamedede ƒe kpɔɖeŋu si ate ŋu adzɔ. Totoɖeme sia ƒe taɖodzinue nye be woaku agbalẽ siwo li ku ɖe akpa si MOTS-c ate ​​ŋu awɔ le aklã me ʋu ƒe sisi ƒe ŋgɔyiyi me ŋu tsitotsito eye woade dzesi atikewɔwɔ ƒe taɖodzinu tɔxɛwo na atikewɔwɔmɔnu siwo woazã le etsɔme ^[11]..

Duchenne ƒe lãmekawo ƒe dɔmawɔmawɔ nyuie: 

MOTS-c nye mitochondria-si wokpɔ tso bioactive peptide si si dzɔdzɔmeŋusẽ si ɖoa taɖodzinu na lãmekawo le, si ate ŋu ana glycolytic flux kple ŋusẽ wɔwɔ ƒe ŋutete nadzi ɖe edzi le dystrophic lãmekawo me le vitro kple in vivo, si ana phosphonodiamidite morpholino oligomers (PMO) ƒe xɔxlɔ̃ kple dɔwɔwɔ nadzi ɖe edzi le mdx mice me. MOTS-c kple PMO dodo enuenu ɣeyiɣi didi ate ŋu ana dystrophin ƒe atikewɔwɔ ƒe agbɔsɔsɔ nadze le lãmeka siwo le gota gome, ana mdx mice ƒe lãmekawo ƒe dɔwɔwɔ kple dɔléle nanyo ɖe edzi, eye aɖi aɖeke si dze ƒã mele eme o ^[12]..

Lolo akpa kple lãmekawo ƒe tsɔtsrɔ̃: 

Lolo akpa kple suklidɔ ƒomevi evelia nye lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dɔléle siwo do ƒome kple sarcopenia kple lãmekawo ƒe dɔmawɔmawɔ nyuie zi geɖe. MOTS-c, abe lãmetsi si le ɖoɖo nu ene, kpɔa gome le lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe homeostasis me. Numekukuwo ɖee fia be MOTS-c ƒe agbɔsɔsɔ le ʋumenugbagbevi dzĩ me do ƒome gbegblẽ kple myostatin ƒe agbɔsɔsɔ le amegbetɔ ƒe ŋutilã me. MOTS-c ate ​​ŋu axe mɔ ɖe C2C12 myotubes siwo to vovo ƒe atrophy si palmitic acid hena vɛ nu eye wòaɖe myostatin ƒe agbɔsɔsɔ si le mice lolo akpa siwo nuɖuɖu hena vɛ ƒe ʋumenugbagbeviɣi dzi akpɔtɔ. To mɔxexe ɖe myostatin nu me la, MOTS-c ateŋu anye atike si ateŋu anye ƒumeŋuɖui ƒe lãmekawo ƒe tsɔtsrɔ̃ si tso insulin ƒe dɔlélenutsiŋutete kple lãmekawo ƒe tsɔtsrɔ̃ ƒe nɔnɔme bubu siwo dome sarcopenia hã le gbɔ ^[5]..

Afɔku si le lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dɔlélewo me le amesiwo tsi agbe le no me dɔdzẽ me ŋu: 

Nyɔnu siwo xɔ no me dɔdzẽ ƒe dɔdamɔnu la ate ŋu axɔ dzitodzito me dɔlélewo, suklidɔ, kple lolo akpa, eye kamedede ate ŋu aɖe nugbegblẽ le ame ŋu siawo dzi akpɔtɔ. MOTS-c ƒe dɔwɔwɔ srɔ̃a kamedede eye wòkpɔa ŋusẽ nyui ɖe lãmenugbagbeviwo ƒe dɔwɔwɔ kple kamedede ƒe ŋutete dzi. Numekukuwo ɖee fia be kwasiɖa 16 ƒe kamedede si me ya kple tsitretsitsi le ate ŋu ana MOTS-c ƒe agbɔsɔsɔ nadzi ɖe edzi le amesiwo menye Hispaniatɔwo o siwo tsi agbe le no me dɔdzẽ me, gake mekpɔa ŋusẽ gã aɖeke ɖe Hispaniatɔ siwo tsi agbe le no me dɔdzẽ me dzi o. MOTS-c ƒe agbɔsɔsɔ si kamedede hena vɛ le amesiwo tsi agbe le no me dɔdzẽ me siwo menye Hispaniatɔwo o ate ŋu atso insulin ƒe dɔwɔwɔ nyuie wu gbɔ, si ana woaɖe dɔléle siwo kpe ɖe eŋu ƒe afɔkua dzi akpɔtɔ ^[13]..

Le nyataƒoƒo me la, abe amino acid 16 ƒe polypeptide si mitochondrial genome ŋlɔna ene la, MOTS-c wɔa akpa vevi aɖe le ŋutilã ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ dzi kpɔkpɔ, nuteɖeamedzi takpɔkpɔ, kple dɔlélewo nu tsitsi kple edada me. Ate ŋu ana sukli kple ami ƒe asitɔtrɔ le lãme na ame ƒe homeostasis nanyo ɖe edzi ŋutɔ, ana insulin ƒe dɔwɔwɔ nanyo ɖe edzi, eye wòaxe mɔ ɖe myostatin ƒe ɖeɖefia nu, si aɖe suklidɔ ƒomevi evelia, lolo akpa, kple lãmekawo ƒe tsɔtsrɔ̃ si do ƒome kplii dzi akpɔtɔ nyuie. Le ɣeyiɣi ma ke me la, to mitochondrial biogenesis kple fusion dzi kpɔkpɔ me la, MOTS-c doa ŋusẽ lãmenugbagbevi ƒe antioxidant ŋutete eye wòxea mɔ na dɔdzẽ ƒe ŋuɖoɖo, si ɖea atikewɔwɔ ƒe ŋutete fiana na dɔléle siwo nɔa anyi didi abe dzitodzito me dɔlélewo, ƒumeŋuɖui, kple aklã me fibrosis ene. Vevietɔ wu la, esi MOTS-c nye domenɔla vevi aɖe le mitochondria kple nucleus dome kadodo me ta la, ate ŋu awɔ kamedede ƒe ŋusẽkpɔɖeamedziwo ƒe kpɔɖeŋu eye wòahe tsitsi ƒe ɖoɖoa ɖe megbe. Eƒe agbɔsɔsɔ do ƒome gbegblẽ kple dɔléle siwo do ƒome kple tsitsi, eye kpeɖeŋutɔ tso gota ate ŋu atrɔ lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe kuxiwo eye wòaxe mɔ ɖe dɔlékuiwo ƒe dzidziɖedzi nu. Woyɔe be 'mitochondrial hormone'.

Le Agbalẽŋlɔla La Ŋu

Nusiwo míeyɔ ɖe etame la katã nye esiwo ŋu Cocer Peptides wɔ numekuku le, trɔ asi le wo ŋu eye woƒo wo nu ƒu.

Dzɔdzɔmeŋutinunya ƒe Agbalẽŋlɔla

Dieli-Conwright CM nye agbalẽnyala si kpɔ ŋusẽ gã aɖe ɖe dɔdzẽŋutinunya kple kamedede ŋuti dzɔdzɔmeŋutinunya ƒe akpa vovovowo me. Fifia enye atikewɔwɔ ŋuti nufialagã kpeɖeŋutɔ le Harvard Atikewɔwɔ Suku kple Dana-Farber Kansa Dɔwɔƒe eye wòle nufialagã ƒe kpeɖeŋutɔ ƒe ɖoƒe le Nuɖuɖu Ŋuti Dɔwɔƒe le Harvard T. H. Chan Dukɔa ƒe Lãmesẽnyawo Gbɔkpɔƒe. Ðɔkta Dieli-Conwright ƒe numekukua ku ɖe ŋusẽ si kamedede kpɔna ɖe kansadɔnɔwo dzi la me dzodzro ŋu, vevietɔ alesi kamedede ate ŋu ana kansadɔnɔwo ƒe ŋutilã ƒe dɔwɔwɔ, ƒu ƒe lãmesẽ, kple agbenɔnɔ nanyo ɖe edzii. Eƒe sukudede ku ɖe nu vovovowo abe nugbagbeŋutinunya, ʋuʋudediŋutinunya, dukɔa ƒe lãmesẽnyawo, kple nugbagbewo ƒe dɔwɔwɔ ŋuti nunya ŋu. Ewu eƒe nusɔsrɔ̃ nu le dɔwɔƒewo abe California Dukɔa ƒe Yunivɛsiti, Northridge, kple Southern California Yunivɛsiti ene eye wòwu eƒe ɖɔktanyenye megbe numekuku nu le City of Hope Dukɔa ƒe Atikewɔƒe. Wota Ðɔkta Dieli-Conwright ƒe numekuku me dzidzedzekpɔkpɔwo ɖe agbalẽ vovovowo me le agbalẽ vovovowo me, eye eƒe dɔa ku ɖe nusɔsrɔ̃ vovovowo abe dukɔa ƒe lãmesẽ, nunyiame, dzitodzito, kple dzidɔ ene ŋu, si na dzɔdzɔmeŋutinunya me kpeɖodzi veviwo le kansadɔnɔwo ƒe gbugbɔgaɖɔɖo kple woƒe lãmesẽnyawo gbɔ kpɔkpɔ ŋu. Woŋlɔ Dieli-Conwright CM ŋkɔ ɖe nyayɔyɔ ƒe nyatakaka me [13].

▎ Nyayɔyɔ Siwo Sɔ

[1] Zheng Y, Wei Z, Wang T. MOTS-c: Peptide si wokpɔ tso mitochondrial me si ŋugbe wodo na atikewɔwɔ me zazã[J]. Liƒowo le Endocrinology, 2023,14.DOI: 10.3389 / fendo.2023.1120533.

[2] Boyu Y. Kamedede kple MOTS-c dzia mitochondrial-si wokpɔ tso peptide MOTS-c ƒe ɖeɖefia ɖe edzi eye wònaa insulin ƒe tsitretsitsi nyona ɖe edzi to AMPK/PGC-1α mɔ dzi[D]. Atikewɔwɔ Yunivɛsiti, 2019.10.27652/d.cnki.gzyku.2019.001531.

[3] Mohtashami Z, Singh MK, Salimiaghdam N, kple ame bubuwo. MOTS-c, si nye Peptide si Wokpɔ tso Mitochondrial Me Nyitsɔ Laa le Amegbetɔ ƒe Tsitsi Kple Dɔléle Siwo Do Ƒome Kple Tsitsi [J]. Dukɔwo Dome Molekyulãŋutinunya ƒe Agbalẽ, 2022,23 (19).DOI: 10.3390 / ijms231911991.

[4] Gao Y, Wei X, Wei P, kple ame bubuwo. MOTS-c Xɔa Mɔ Ðe Lãmetsiŋusẽ ƒe Dɔlélewo Nu le Dɔwɔwɔ Me[J]. Nusiwo wotsɔna ɖɔlia nu, 2023, 13 (1).DOI: 10.3390 / metabo13010125.

[5] Kumagai H, Coelho A. R., Wan J., kple ame bubuwo. MOTS-c ɖea myostatin kple lãmekawo ƒe tsɔtsrɔ̃ ƒe dzesiwo dzi kpɔtɔna[J]. Amerikatɔwo ƒe Nyadzɔdzɔgbalẽ si Ku Ðe Lãmesẽŋutinunya-Dɔlékuiwutikewo Kple Lãmetsiŋusẽŋununya Ŋu, 2021,320 (4): E680-E690.DOI:10.1152/ajpendo.00275.2020.

[6] Garcia Benlloch S, Francisco R. R., Rafael Blesa J, kple ame bubuwo. MOTS-c doa lãmekawo ƒe vovototodedeameme ɖe ŋgɔ le vitro[J]. Peptides, 2022,155.DOI: 10.1016 / j.peptidewo.2022.170840.

[7] Bhullar K. S., Shang N., Kerek E., kple ame bubuwo. Mitofusion hiã na MOTS-c ƒe GLUT4 ƒe ʋuʋu[J]. Dzɔdzɔmeŋutinunya ƒe Nyatakakawo, 2021, 11 (1).DOI: 10.1038 / s41598-021-93735-2.

[8] Kong BS, Lee C, Cho Y M. Mitochondrial-Encoded Peptide MOTS-c, Suklidɔ, Kple Dɔléle Siwo Do Ƒome Kple Tsitsi[J]. Suklidɔ & lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe agbalẽ, 2023,47 (3): 315-324.DOI: 10.4093 / dmj.2022.0333.

[9] Wang M, Wang G, Pang X, kple ame bubuwo. MOTS-c dzraa dzitodzito ƒe nugbegblẽ ɖo to mɔxexe ɖe CCN1/ERK1/2/EGR1 mɔ nu le suklidɔlélawo ƒe sisiblisiwo me[J]. Liƒowo le Nunyiame me, 2023,9.DOI: 10.3389/fnut.2022.1060684.

[10] Yi X, Hu G, Yang Y, kple ame bubuwo. Akpa si MOTS-c wɔna le ƒu ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ dzi kpɔkpɔ me[J]. Liƒowo le Dzɔdzɔmeŋusẽŋununya, 2023,14.DOI: 10.3389 / fphys.2023.1149120.

[11] Zhang Z, Chen D, Du K, kple ame bubuwo. MOTS-c: Nusi ate ŋu atsi aklã me fibrosis nu si wokpɔ tso mitochondria gbɔ[J]. Mitochondrion, 2023, 71: 76-82.DOI: 10.1016 / j.mito.2023.06.002.

[12] Ran N, Lin C, Leng L, kple ame bubuwo. MOTS-c doa phosphorodiamidate morpholino oligomer ƒe xɔxlɔ̃ kple eƒe dɔwɔwɔ ɖe ŋgɔ le dystrophic mice me[J]. Embo Molekyul Atikewɔwɔ, 2021, 13 (2).DOI: 10.15252 / emmm.202012993.

[13] Dieli-Conwright C. M., Nathalie S., K. N. M., kple ame bubuwo. Dɔ si aerobic kple tsitretsitsi ƒe kamedede kpɔna ɖe mitochondrial peptide MOTSc dzi le Hispaniatɔwo kple amesiwo menye Hispaniatɔwo o siwo tsi agbe le no me dɔdzẽ me.[J]. Kansa Ŋuti Numekuku, 2021,81 (13).

NYATAKAKAWO KPLE NUSIWO WOTSƆ ƑE NYATAKAKA SIWO KAtã WOÐO LE NYATAKAKADZRAÐOƑE SIA ME LA KPLE NYATAKAKAWO kaka KPLEE NUFIAFIA ƑE TAÐOÐOWO KO.  

Wotrɔ asi le atike siwo wona le nyatakakadzraɖoƒe sia ŋu na numekuku le vitro ɖeɖeko. Wowɔa numekuku le vitro (Latingbe me: *le ahuhɔ̃e me*, si gɔmee nye le ahuhɔ̃e me) le amegbetɔ ƒe ŋutilã godo. Atike siawo menye atikewo o, United States ƒe Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) meda asi ɖe wo dzi o, eye mele be woazã wo atsɔ axe mɔ ɖe atikewɔwɔ, dɔléle, alo dɔléle aɖeke nu, adae, alo adae o. Se de se vevie be woatsɔ atike siawo ade amegbetɔ alo lãwo ƒe ŋutilã me le mɔ ɖesiaɖe nu.