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1 kits (10 Vials)
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▎ MOTS-c Tsarin
Source: PubChem |
Jeri: MRWQEMGYIFYPRKLR Tsarin kwayoyin halitta: C101H152N28O22S2 Nauyin Kwayoyin: 2174.6g/mol Lambar CAS: 1627580-64-6 Kamfanin CID na PubChem: 146675088 Synonyms: UNII-A5CV6JFB78 |
▎ MOTS-c Bincike
Menene asalin bincike na MOTS-c?
Mitochondion wuri ne mai mahimmanci don samar da makamashi a cikin sel. Na dogon lokaci, masana kimiyya sun gudanar da bincike mai zurfi da zurfi kan tsari da aikin mitochondria. A cikin wannan tsari, an gane a hankali cewa mitochondria ba wai kawai yana taka muhimmiyar rawa wajen samar da makamashi ba amma yana iya shiga cikin wasu hanyoyin ilimin lissafin jiki na sel ta wasu hanyoyin da ba a sani ba.
Tare da ci gaba da ci gaban fasahar bincike, musamman haɓakar ilimin halittu da fasahohin haɓaka, ya zama mai yiwuwa a gano sabbin ƙwayoyin cuta masu alaƙa da mitochondria. MOTS-c (mitochondrial bude karatun firam na 12S rRNA-c) peptide ne wanda aka samo daga mitochondria wanda yankin 12S rRNA na kwayar halittar mitochondrial ne [1].
Ta hanyar zurfafa bincike na kwayar halittar mitochondrial, masana kimiyya sun gano wasu ƙananan buɗaɗɗen firam ɗin karatu (sORFs), waɗanda za su iya ɓoye wasu peptides tare da takamaiman ayyuka. Bayan ƙarin bincike da tabbatarwa, an gano MOTS-c. Nazarin ya gano cewa MOTS-c an bayyana shi a cikin nau'ikan kyallen takarda a cikin mutane da dabbobi. Yafi yin aiki akan tsokoki na kwarangwal ta hanyar jini, yana haɓaka haɓakawa da amfani da glucose, don haka inganta juriya na insulin da daidaita ma'aunin metabolism [2]..
Tare da zurfafa bincike, an gano cewa canje-canje a cikin maganganun MOTS-c suna da alaƙa da abubuwan da suka faru da ci gaban tsufa da cututtukan da suka shafi shekaru. Misali, matakin MOTS-c a cikin plasma yana raguwa da shekaru (Zheng Y, 2013). A lokaci guda, MOTS-c an tabbatar da cewa yana da amfani ga cututtukan da suka shafi shekaru, gami da ciwon sukari, cututtukan zuciya, osteoporosis, kiba bayan menopause, da cutar Alzheimer [3].
Menene tsarin aikin MOTS-c?
Sarrafa maganganun kwayoyin halitta:
MOTS-c na iya aiwatar da ayyukanta na ilimin lissafi ta hanyar daidaita maganganun kwayoyin halitta. Misali, yana iya daidaita maganganun kwayoyin halitta kamar GLUT4, STAT3, da IL-10. MOTS-c galibi yana aiwatar da tasirin sa ta hanyar kunna hanyar siginar AICAR-AMPK da tarwatsa tsarin folate-methionine a cikin sel [4].
Inganta juriya na insulin:
MOTS-c na iya rage juriya na insulin kuma ya hana nau'in ciwon sukari na 2. Hanyar aikinta na iya kasancewa da alaƙa da hanawa na myostatin. Nazarin ya gano cewa matakin MOTS-c na plasma yana da alaƙa da mummunan alaƙa da matakin myostatin a cikin jikin mutum. MOTS-c na iya inganta haɓakar insulin ta hanyar hana ayyukan FOXO1 na sama da kuma rage matakin myostatin [5].
Inganta bambancin tsoka:
A cikin ƙwayoyin tsoka, MOTS-c yana hulɗa tare da STAT3 ta hanyar maɓalli mai ɗaure SH2 a cikin yankin YIFY, yana rage ayyukan rubutu na STAT3, don haka haɓaka haɓakar myotube. Nau'in-nau'in MOTS-c peptide na daji na iya haɓaka haɓakar myotube na ɗan adam (LHCN-M2) da linzamin kwamfuta (C2C12) sel masu haɓaka tsoka da kuma kare ƙwayoyin tsoka daga raguwar tabon myogenin na nukiliya wanda ya haifar da interleukin-6 (IL-6) [6].
Gudanar da aikin mitochondrial:
MOTS-c na iya daidaita metabolism na mitochondrial. Nazarin ya nuna cewa zalunta kwayoyin dabbobi masu shayarwa tare da MOTS-c na iya ƙara matakan furotin na mitochondrial biogenesis alamomi TFAM, COX4, da NRF1, amma nazarin cytometry na gudana ya nuna cewa yawan mitochondria ya ragu sosai bayan jiyya na MOTS-c. Ci gaba da bincike ya gano cewa MOTS-c na iya aiki tare tare da haɗin gwiwar mitochondrial tare da haɓaka matakan furotin na GTPases guda biyu, OPA1 da MFN2, waɗanda ke da mahimmanci don haɗakar mitochondria na mammalian. Hana waɗannan GTPases guda biyu ko buga MFN2 ta hanyar siRNA zai kawar da ikon MOTS-c don haɓaka fassarar GLUT4 da ɗaukar glucose [7].
MOTS-c shine yuwuwar manufa ta warkewa don cututtukan da suka shafi tsufa da yawa, gami da neurodegeneration, osteoporosis, cututtukan zuciya, atherosclerosis, sarcopenia, nau'in ciwon sukari na 2, da kiba.
Source:PubMed [8]
Menene aikace-aikacen MOTS-c?
Inganta cututtukan da suka shafi shekaru
Dangantaka da tsufa:
MOTS-c shine peptide wanda aka samo daga mitochondria, kuma canje-canje a cikin maganganunsa yana da alaƙa da abin da ya faru da ci gaban tsufa da cututtukan da suka shafi shekaru. Yayin da mutane ke tsufa, matakin MOTS-c yana raguwa. Nazarin ya gano cewa motsa jiki yana da tasiri mai mahimmanci akan maganganun MOTS-c, kuma MOTS-c na iya daidaita tasirin tsufa na motsa jiki [3].
Ciwon sukari:
MOTS-c na iya inganta glucose na jiki da metabolism na lipid, inganta aikin mitochondrial a cikin sel, da kuma rage amsawar kumburi na tsarin. Ga masu ciwon sukari, matakin MOTS-c a cikin plasma yana raguwa. MOTS-c na iya daidaita yanayin homeostasis na rayuwa ta hanyar haɓaka haɓakar glucose da haɓaka haɓakar insulin, kuma yana da tasiri mai kyau akan hana nau'in ciwon sukari na 2 [8].
Cututtukan zuciya:
Gyara tsarin tsarin zuciya da rashin aiki sune matsalolin gama gari na ciwon sukari, galibi suna haifar da mummunan al'amuran zuciya na jijiyoyin jini. MOTS-c na iya inganta aikin endothelial na jijiyoyin jini kuma shine sabon makasudin warkewa don rikice-rikice na zuciya da jijiyoyin jini na ciwon sukari. Nazarin ya nuna cewa MOTS-c na iya gyara lalacewar mitochondrial na myocardial a cikin berayen masu ciwon sukari da kuma kare systolic na zuciya da ayyukan diastolic [9].
Osteoporosis: MOTS-c na iya inganta haɓakawa, bambance-bambance, da kuma ma'adinai na osteoblasts, hana ƙwayar osteoclast, da daidaita tsarin kasusuwa da gyaran kashi. Motsa jiki na iya daidaita ma'anar MOTS-c yadda ya kamata, amma takamaiman hanyar da motsa jiki ke tsara MOTS-c a cikin ƙasusuwa har yanzu ba a sani ba [10].
Sauran cututtuka
Fibrosis na huhu:
Fibrosis na huhu shine mummunar cutar huhu tare da rashin hangen nesa, kuma har yanzu ba a san ilimin abubuwan da ke haifar da cutar ba. Tsarin karatun mitochondrial na 12S rRNA-c (MOTS-c) peptide ne wanda aka sanya shi ta hanyar genome na mitochondrial, wanda ke da tasiri mai kyau akan glucose da lipid metabolism, salon salula da mitochondrial homeostasis, da raguwar amsawar kumburin tsarin, kuma yana iya zama yuwuwar motsa jiki mimetic. Wannan bita yana nufin cikakken nazarin wallafe-wallafen da ake da su game da yuwuwar rawar MOTS-c don inganta haɓakar fibrosis na huhu da kuma gano takamaiman takamaiman hanyoyin warkewa don dabarun jiyya na gaba [11].
Duchenne muscular dystrophy:
MOTS-c shine peptide bioactive na mitochondria wanda aka samu tare da abubuwan da ke haifar da tsoka, wanda zai iya haɓaka haɓakar glycolytic da ƙarfin samar da kuzari na tsokoki na dystrophic a cikin vitro da vivo, don haka haɓaka haɓakawa da ayyukan phosphonodiamidite morpholino oligomers (PMO) a cikin mdxx. Gudanar da maimaitawa na dogon lokaci na MOTS-c da PMO na iya haifar da bayyanar da matakan warkewa na dystrophin a cikin tsokoki na gefe, inganta aikin tsoka da ilimin cututtukan ƙwayoyin cuta na berayen mdx, kuma ba shi da wani takamaiman guba [12].
Kiba da tsoka atrophy:
Kiba da nau'in ciwon sukari na 2 sune cututtuka na rayuwa sau da yawa hade da sarcopenia da rashin aikin tsoka. MOTS-c, a matsayin hormone na tsarin, yana shiga cikin homeostasis na rayuwa. Nazarin ya gano cewa matakin MOTS-c na plasma yana da alaƙa da mummunan alaƙa da matakin myostatin a cikin jikin mutum. MOTS-c na iya hana palmitic acid-induced atrophy na daban-daban C2C12 myotubes da kuma rage myostatin matakin a cikin plasma na rage cin abinci-jawo kiba mice. Ta hanyar hana myostatin, MOTS-c na iya zama mai yuwuwar magani don atrophy na kwarangwal wanda ya haifar da juriya na insulin da sauran ƙwayoyin atrophy na tsoka ciki har da sarcopenia [5].
Hadarin cututtuka na rayuwa a cikin masu tsira da ciwon nono:
Matan da suka sami maganin cutar kansar nono suna cikin haɗarin kamuwa da cututtukan zuciya, ciwon sukari, da kiba, kuma motsa jiki na iya rage waɗannan illolin. MOTS-c yana da aikin kwaikwayon motsa jiki kuma yana da tasiri mai amfani akan metabolism da ƙarfin motsa jiki. Nazarin ya gano cewa aikin motsa jiki na mako-mako na 16 na motsa jiki da juriya na iya kara yawan matakin MOTS-c a cikin wadanda ba su da ciwon nono na Hispanic, amma ba shi da wani tasiri mai mahimmanci a kan masu ciwon nono na Hispanic. Haɓakawa a matakin MOTS-c wanda motsa jiki ya haifar a cikin waɗanda ba na Hispanic ciwon nono ba na iya kasancewa da alaƙa da haɓaka haɓakar insulin, don haka rage haɗarin haɗuwa [13].
A ƙarshe, a matsayin 16-amino acid polypeptide wanda aka sanya shi ta hanyar genome na mitochondrial, MOTS-c yana taka muhimmiyar rawa a cikin tsarin tsarin rayuwa na jiki, kare danniya, da rigakafin cututtuka da magani. Yana iya inganta homeostasis na glucose da lipid metabolism, haɓaka haɓakar insulin, da hana bayyanar myostatin, yadda ya kamata yana rage nau'in ciwon sukari na 2, kiba, da atrophy na tsoka mai alaƙa. A lokaci guda, ta hanyar daidaita mitochondrial biogenesis da fusion, MOTS-c yana haɓaka iyawar antioxidant ta tantanin halitta kuma yana hana amsawar kumburi, yana nuna yiwuwar warkewar cututtukan cututtukan cututtukan cututtukan zuciya kamar cututtukan zuciya, osteoporosis, da fibrosis na huhu. Musamman mahimmanci, a matsayin mai shiga tsakani mai mahimmanci na sadarwar mitochondria-nucleus, MOTS-c na iya kwatanta tasirin motsa jiki da jinkirta tsarin tsufa. Matsayinsa yana da alaƙa da alaƙa da cututtukan da ke da alaƙa da shekaru, kuma ƙari na waje zai iya juyar da rikice-rikice na rayuwa kuma yana hana kwafi. An san shi da 'hormone mitochondrial'.
Game da Marubuci
Abubuwan da aka ambata a sama duk bincike ne, gyara su kuma Cocer Peptides ne suka haɗa su.
Mawallafin Jaridar Kimiyya
Dieli-Conwright CM ƙwararren masani ne wanda ke da tasiri mai mahimmanci a cikin tsaka-tsakin fannin ilimin oncology da kimiyyar motsa jiki. A halin yanzu tana aiki a matsayin abokiyar farfesa a fannin likitanci a Makarantar Kiwon Lafiya ta Harvard da Cibiyar Ciwon daji ta Dana-Farber kuma tana da matsayi na aboki a cikin Sashen Abinci a Harvard TH Chan Makarantar Kiwon Lafiyar Jama'a. Binciken Dr. Dieli-Conwright ya mayar da hankali ne kan gano tasirin motsa jiki ga masu ciwon daji, musamman yadda motsa jiki zai iya inganta aikin ilimin lissafi, lafiyar kashi, da kuma ingancin rayuwar masu ciwon daji. Ilimin iliminta ya ƙunshi fannoni da yawa kamar ilmin halitta, kinesiology, lafiyar jama'a, da ilimin halittu. Ta kammala karatunta a cibiyoyi kamar Jami'ar Jihar California, Northridge, da Jami'ar Kudancin California kuma ta kammala karatun digirinta a Cibiyar Kiwon Lafiya ta Kasa ta City of Hope. Dokta Dieli-Conwright ta nasarorin binciken da aka buga a ko'ina cikin mujallu na ilimi daban-daban, kuma aikinta ya ƙunshi fannoni da yawa kamar lafiyar jama'a, abinci mai gina jiki, tsarin zuciya da jijiyoyin jini, da ilimin zuciya, yana ba da shaida mai mahimmanci na kimiyya don gyarawa da kula da lafiyar masu ciwon daji. An jera Dieli-Conwright CM a cikin ambaton ambaton [13].
