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▎ MOTs-CSstructure
Isi mmalite: PubChem |
Usoro: MRWQEMGYIFYPRKLR Ụdị ihe omimi: C101H152N28O22S2 Ibu molekụla: 2174.6g/mol Nọmba CAS: 1627580-64-6 PubChem CID: 146675088 Okwu ndị yiri: UNII-A5CV6JFB78 |
▎ MOTS-C Nchọpụta
Kedu ihe ndabere nyocha nke MOTS-C?
Mitochondion bụ ebe dị mkpa maka ọrịa shuga ike n'ime sel. Ruo ogologo oge, ndị ọkà mmụta sayensị emeela nchọpụta dị ukwuu na nke miri emi banyere nhazi na ọrụ nke mitochondria. N'ime usoro a, a na-amata nke nta nke nta na mitochondria ọ bụghị nanị na-ekere òkè dị mkpa na mmepụta ume kamakwa ọ nwekwara ike isonye na usoro physiological ndị ọzọ nke mkpụrụ ndụ site na usoro ụfọdụ amaghị.
Site na ọganihu na-aga n'ihu nke teknụzụ nyocha, karịsịa mmepe nke genomics na teknụzụ proteomics, ọ na-ekwe omume ịchọta ụmụ irighiri ihe ọhụrụ metụtara mitochondria. MOTs-C (mitochondrial mepere emepe nke 12S rRNA-c) bụ peptide sitere na mitochondria sitere na mpaghara 12S rRNA nke genome mitochondrial [1].
Site na nyocha miri emi nke genome mitochondrial, ndị ọkà mmụta sayensị achọpụtala ụfọdụ obere okpokolo agba emeghe (sORF), nke nwere ike itinye ụfọdụ peptides nwere ọrụ ụfọdụ. Ka emechara nyocha na nkwenye ọzọ, MOTS-C chọpụtara. Nnyocha achọpụtala na MOTS-C na-egosipụta n'ụdị anụ ahụ dị iche iche na mmadụ na anụmanụ. Ọ na-emekarị na akwara skeletal site na ọbara, na-abawanye nnabata na itinye n'ọrụ nke glucose, si otú a na-eme ka nguzogide insulin dịkwuo elu ma na-ahazi nguzozi nke metabolic [2]..
Site na omimi nke nyocha, achọpụtara na mgbanwe na nkwupụta nke MOTs-C nwere njikọ chiri anya na omume na mmepe nke ịka nká na ọrịa ndị metụtara afọ. Dịka ọmụmaatụ, ọkwa MOTS-C na plasma na-ebelata ka afọ (Zheng Y, 2013). N'otu oge ahụ, MOTs-C egosila na ọ bara uru maka ọrịa ndị metụtara afọ, gụnyere ọrịa shuga, ọrịa obi, osteoporosis, oke ibu postmenopausal, na ọrịa Alzheimer [3].
Gịnị bụ usoro omume nke MOTS-C?
Na-ahazi okwu mkpụrụ ndụ ihe nketa:
MOTS-C nwere ike ịrụ ọrụ ya site n'ịhazi okwu mkpụrụ ndụ ihe nketa. Dịka ọmụmaatụ, ọ nwere ike ịhazi okwu nke mkpụrụ ndụ ihe nketa dịka GLUT4, STAT3, na IL-10. MOTs-C na-arụ ọrụ ya site n'ịgbalite ụzọ akara AICAR-AMPK na imebi usoro folate-methionine na sel [4].
Na-akwalite nguzogide insulin:
MOTS-C nwere ike ibelata nguzogide insulin ma gbochie ụdị ọrịa shuga 2. Usoro ya nwere ike jikọta ya na mgbochi nke myostatin. Nnyocha achọpụtala na ọkwa MOTs-C nke plasma na-adịghị mma na ọkwa myostatin dị na ahụ mmadụ. MOTS-C nwere ike imeziwanye mmetụta insulin site na igbochi ọrụ nke ihe ntụgharị ederede FOXO1 na ibelata ọkwa myostatin [5].
Na-akwalite ọdịiche nke akwara:
N'ime mkpụrụ ndụ akwara, MOTs-C na STAT3 na-emekọrịta ihe site na ntinye SH2 na-ejikọta motif na mpaghara YIFY, na-ebelata ọrụ ederede nke STAT3, si otú a na-eme ka nhazi myotube dịkwuo elu. Ụdị anụ ọhịa MOTs-C peptide nwere ike ime ka myotube guzobe nke mmadụ (LHCN-M2) na òké (C2C12) sel progenitor muscle ma na-echebe mkpụrụ ndụ akwara site na mbelata nke myogenin myogenin nke na-ebute site na interleukin-6 (IL-6) [6].
Na-ahazi ọrụ mitochondrial:
MOTs-C nwere ike ịhazi ọrịa shuga mitochondrial. Nnyocha egosiwo na ịgwọ mkpụrụ ndụ mammalian na MOTs-C nwere ike ịbawanye ọkwa protein nke mitochondrial biogenesis markers TFAM, COX4, na NRF1, mana nyocha nke cytometry na-egosi na ọnụ ọgụgụ nke mitochondria na-ebelata nke ọma mgbe ọgwụgwọ MOTs-C gasịrị. Nnyocha ndị ọzọ achọpụtala na MOTs-C nwere ike imekọrịta mmekọrịta mitochondrial fusion wee bulie ọkwa protein nke GTPase abụọ, OPA1 na MFN2, nke dị oke mkpa maka njikọta nke mitochondria mammalian. Igbochi GTPases abụọ a ma ọ bụ ịkụda MFN2 site na siRNA ga-ewepụ ikike MOTs-C iji kwalite ntụgharị GLUT4 na nnabata glucose [7].
MOTs-C bụ ebumnuche ọgwụgwọ maka ọtụtụ ọrịa metụtara ịka nká, gụnyere neurodegeneration, osteoporosis, ọrịa obi, atherosclerosis, sarcopenia, ụdị 2 ọrịa shuga mellitus, na oke ibu.
Isi mmalite: PubMed [8]
Kedu ihe bụ ngwa MOTS-C?
Ịkwalite ọrịa ndị metụtara afọ
Mmekọrịta ya na ịka nká:
MOTs-C bụ peptide sitere na mitochondria, na mgbanwe na okwu ya nwere njikọ chiri anya na omume na mmepe nke ịka nká na ọrịa ndị metụtara afọ. Ka ndị mmadụ na-aka nká, ọkwa MOTS-C na-ebelata. Nnyocha achọpụtala na mmega ahụ nwere mmetụta dị ukwuu na nkwupụta nke MOTs-C, na MOTs-C nwere ike mebie mmetụta mgbochi ịka nká nke mmega ahụ [3]..
ọrịa shuga:
MOTs-C nwere ike imeziwanye glucose nke anụ ahụ na ọrịa shuga lipid, kwalite ọrụ mitochondrial na sel, ma belata mmeghachi omume mkpali na-adịghị ala ala. Maka ndị ọrịa nwere ọrịa shuga, ọkwa MOTS-C na plasma na-ebelata. MOTs-C nwere ike ịhazi metabolism homeostasis site n'ịkwalite nnabata glucose na imeziwanye mmetụta insulin, ọ na-enwekwa mmetụta dị mma na igbochi ụdị ọrịa shuga 2 ..
Ọrịa obi:
Mgbanwe nhazi nke obi na arụrụ ọrụ bụ nsogbu nkịtị nke ọrịa shuga, na-ebutekarị ihe omume obi siri ike. MOTs-C nwere ike imeziwanye ọrụ endothelial vaskụla ma bụrụ ebumnuche ọgwụgwọ ọhụrụ maka nsogbu obi obi nke ọrịa shuga. Nnyocha egosiwo na MOTs-C nwere ike ịrụzi mmebi mitochondrial myocardial na oke ọrịa shuga ma chebe systolic obi na ọrụ diastolic [9].
Osteoporosis: MOTs-C nwere ike ịkwalite mmụba, ọdịiche, na mineralization nke osteoblasts, gbochie osteoclast genesis, ma na-achịkwa ọrịa shuga ọkpụkpụ na nhazi ọkpụkpụ. Mmega ahụ nwere ike imeziwanye nkwupụta nke MOTs-C nke ọma, mana usoro a kapịrị ọnụ nke mmega ahụ na-achịkwa MOT-C n'ọkpụkpụ ka amabeghị [10].
Ọrịa ndị ọzọ
Fibrosis nke akpa ume:
Fibrosis pulmonary bụ ọrịa ngụgụ siri ike nke na-enwechaghị amụma amụma, na etiology ya na pathogenesis ka amabeghị. Oghere ọgụgụ ọgụgụ mitochondrial mepere emepe nke 12S rRNA-c (MOTs-C) bụ peptide nke genome nke mitochondrial, nke nwere mmetụta dị mma na glucose na ọrịa shuga lipid, cellular na mitochondrial homeostasis, yana mbelata nzaghachi mkpali sistemu, ma nwee ike bụrụ mmega ahụ mimetic. Nyocha a na-achọ iji nyochaa akwụkwọ ndị dị ugbu a na ọrụ MOTs-C nwere ike ime iji melite mmepe nke fibrosis pulmonary ma chọpụta kpọmkwem ọgwụgwọ ọgwụgwọ maka usoro ọgwụgwọ n'ọdịnihu [11].
Dystrophy muscular nke Duchenne:
MOTs-C bụ peptide bioactive nke sitere na mitochondria nwere ihe na-akpachapụ anya akwara, nke nwere ike ịbawanye mmụba nke glycolytic na ike mmepụta ike nke akwara dystrophic na vitro na in vivo, si otú ahụ na-ebuli elu na ọrụ nke phosphonodiamidite morpholino oligomers (PMO) na md. Nlekọta ogologo oge nke MOTs-C na PMO nwere ike ime ka ngosipụta nke usoro ọgwụgwọ nke dystrophin n'ime akwara dị n'akụkụ, kwalite ọrụ ahụ ike na pathology nke ụmụ oke mdx, na enweghị nsi doro anya [12].
Ibu na atrophy muscle:
Oke ibu na ụdị ọrịa shuga 2 bụ ọrịa metabolic na-ejikọta ya na sarcopenia na arụ ọrụ akwara. MOTS-C, dị ka homonụ sistemu, na-ekere òkè na homeostasis metabolic. Nnyocha achọpụtala na ọkwa MOTs-C nke plasma na-adịghị mma na ọkwa myostatin dị na ahụ mmadụ. MOTs-C nwere ike igbochi atrophy nke palmitic acid kpatara C2C12 myotubes dị iche iche ma belata ọkwa myostatin na plasma nke oke oke nri na-ebute. Site na igbochi myostatin, MOTs-C nwere ike ịbụ ọgwụgwọ nwere ike ịgwọ ọrịa atrophy nke anụ ahụ skeletal kpatara site na nguzogide insulin na anụ ahụ ndị ọzọ atrophy phenotypes gụnyere sarcopenia [5].
Ihe ize ndụ nke ọrịa metabolic na ndị lanarịrị ọrịa ara ara:
Ụmụ nwanyị ndị natara ọgwụgwọ ọrịa kansa ara nọ n'ihe ize ndụ dị ukwuu nke ọrịa obi, ọrịa shuga, na oke ibu, na mmega ahụ nwere ike ibelata mmetụta ndị a. MOTS-C nwere ọrụ nṅomi mmega ahụ ma nwee mmetụta bara uru na ọrịa shuga na ike mmega ahụ. Nnyocha achọpụtala na mmega ahụ nke ikuku ikuku na izu 16 na mmegide mmega ahụ nwere ike ịbawanye ọkwa MOTs-C na ndị na-anwụghị na ọrịa ara ara na-abụghị ndị Hispanic, ma ọ nweghị mmetụta dị ịrịba ama na ndị lanarịrị ọrịa ara ara Hispanic. Mmụba nke ọkwa MOTs-C na-ebute site na mmega ahụ na ndị lanarịrị ọrịa ara ara na-abụghị ndị Hispanic nwere ike jikọta ya na mmụba nke mmetụta insulin, si otú ahụ belata ihe ize ndụ nke comorbidities [13]..
N'ikpeazụ, dị ka 16-amino acid polypeptide nke mitochondrial genome, MOTs-C na-arụ ọrụ bụ isi na nhazi usoro metabolic nke anụ ahụ, nchebe nrụgide, na mgbochi ọrịa na ọgwụgwọ. Ọ nwere ike imeziwanye homeostasis nke glucose na ọrịa shuga lipid, na-eme ka mmetụta insulin dịkwuo elu, na-egbochi nkwupụta nke myostatin, na-ebelata nke ọma ụdị ọrịa shuga 2, oke ibu, na atrophy muscle metụtara ya. N'otu oge ahụ, site n'ịchịkwa mitochondrial biogenesis na ngwakọta, MOTs-C na-eme ka ikike antioxidant nke cell dịkwuo elu ma na-egbochi nzaghachi mkpali, na-egosi ike ọgwụgwọ maka ọrịa na-adịghị ala ala dịka ọrịa obi, osteoporosis, na fibrosis pulmonary. Karịsịa, dị ka onye isi ogbugbo nke nkwurịta okwu mitochondria-nucleus, MOTs-C nwere ike ime ka mmetụta nke mmega ahụ na-egbu oge usoro ịka nká. A na-ejikọta ọkwa ya na ọrịa ndị metụtara afọ na-adịghị mma, na mgbakwunye na exogenous nwere ike gbanwee nsogbu nke metabolic ma gbochie nje virus. A maara ya dị ka 'hormone mitochondrial'.
Banyere Onye dere ya
Ihe niile a kpọtụrụ aha n'elu bụ Cocer Peptides na-enyocha, dezie ma chịkọta ya.
Onye ode akwụkwọ akụkọ sayensị
Dieli-Conwright CM bụ ọkà mmụta nwere mmetụta dị ukwuu na ngalaba interdisciplinary nke oncology na sayensị mmega ahụ. Ọ na-eje ozi ugbu a dị ka onye otu prọfesọ nke ọgwụ na Harvard Medical School na Dana-Farber Cancer Institute ma na-ejide ọnọdụ ngalaba na Ngalaba Nutrition na Harvard TH Chan School of Health Public. Nchọpụta Dr. Dieli-Conwright na-elekwasị anya n'ịchọpụta mmetụta mmega ahụ na-emetụta ndị ọrịa cancer, karịsịa otú mmega ahụ nwere ike isi meziwanye ọrụ anụ ahụ, ahụike ọkpụkpụ, na ndụ ndụ nke ndị ọrịa cancer. Nzụlite agụmakwụkwọ ya na-ekpuchi ọtụtụ ngalaba dị ka bayoloji, kinesiology, ahụike ọha na biokinesiology. Ọ gụsịrị akwụkwọ na ụlọ akwụkwọ dịka California State University, Northridge, na Mahadum Southern California wee mechaa nyocha postdoctoral ya na City of Hope National Medical Center. Akwukwo nyocha nke Dr. Dieli-Conwright na-ebipụta n'ọtụtụ ebe n'akwụkwọ akụkọ agụmakwụkwọ dị iche iche, ọrụ ya gụnyere ọtụtụ usoro dịka ahụike ọha na eze, nri nri, usoro obi, na obi, na-enye ihe akaebe sayensị dị mkpa maka nhazigharị na nlekọta ahụike nke ndị ọrịa cancer. Edepụtara Dieli-Conwright CM na ntụaka nke ntụaka [13].
