▎ Copper-cu Research
Kev tshawb fawb keeb kwm ntawm Copper-cu yog dab tsi?
Xyoo 1970, Asmeskas cov kws tshawb fawb tshawb fawb txog qhov cuam tshuam ntawm tib neeg plasma ntawm cov ntaub so ntswg los ntawm ntau pawg hnub nyoog tau ua rau kev soj ntsuam zoo. Thaum cov plasma los ntawm cov neeg hluas tau ntxiv rau daim siab cov ntaub so ntswg los ntawm cov neeg laus, cov hnub nyoog daim siab cov ntaub so ntswg pib tsim cov proteins tshwj xeeb zoo li cov ntaub so ntswg hluas. Tom qab kev tsom xam qhov tob, hauv 1973, nws tau ua tiav cais Copper-cu los ntawm tib neeg cov ntshav. Cov complex no yog tsim los ntawm tripeptide uas muaj glycine, histidine, thiab lysine nruj nreem khi rau tooj liab ion. Kev tshawb fawb ntxiv tau qhia tias tooj liab-cu ib txwm muaj nyob hauv tib neeg cov txheej txheem physiological hauv qaub ncaug, ntshav, thiab zis. Nws cov qib concentration yog sib txuas nrog lub hnub nyoog: nce mus txog kwv yees li 200ng / mL hauv cov ntshav plasma ntawm cov hnub nyoog 20 xyoo, tab sis poob qis mus txog 80ng / mL thaum muaj hnub nyoog 60 xyoo.
Cov kev tshawb fawb tom qab txuas ntxiv nthuav dav thaj tsam ntawm Copper-cu nkag siab. Thaum xyoo 1980s, cov kws tshawb fawb pom tias tib neeg lub cev tso tawm GHK ntawm qhov chaw raug mob, ua siab loj xav tias nws lub luag haujlwm tseem ceeb yog lub cim tseem ceeb rau kev kho daim tawv nqaij. Txij thaum ntawd los, kev tshawb fawb dav dav tau tsom mus rau Copper-cu lub luag haujlwm hauv kev kho cov ntaub so ntswg, tshwj xeeb tshaj yog nyob rau hauv daim tawv nqaij regeneration. Copper-cu stimulates lub synthesis ntawm collagen, elastin, thiab glycosaminoglycans thaum tswj cov kev ua ntawm metalloproteinases thiab lawv inhibitors. Nws ua rau muaj txiaj ntsig zoo hauv kev tiv thaiv kab mob, tiv thaiv antioxidant, thiab angiogenesis, maj mam dhau los ua kev tshawb fawb thoob plaws ntau yam xws li biochemistry, dermatology, thiab tshuaj kho dua tshiab.
Dab tsi yog qhov mechanism ntawm kev txiav txim rau Copper-cu?
Txhawb Txoj Kev Kho Mob
Cell Proliferation and Migration: Copper-cu stimulates proliferation and migration of various cells, including skin fibroblasts and endothelial cells. Piv txwv li, ntawm qhov chaw ntawm daim tawv nqaij, nws accelerates lub synthesis ntawm extracellular matrix Cheebtsam xws li collagen thiab elastin los ntawm fibroblasts, muab cov qauv kev txhawb nqa rau qhov txhab kho. Nyob rau tib lub sijhawm, nws nyiam cov hlwb endothelial txav mus rau qhov txhab, txhawb kev tsim cov hlab ntsha tshiab. Qhov no muab cov as-ham txaus thiab oxygen rau lub qhov txhab, ua kom cov txheej txheem kho kom zoo [1].
Txoj cai ntawm Kev Loj Hlob Factors: Qhov kev ua haujlwm no ua rau kev qhia thiab tso tawm ntawm ntau yam kev loj hlob, xws li kev hloov pauv kev loj hlob-β (TGF-β) thiab vascular endothelial kev loj hlob yam (VEGF). Noj VEGF ua piv txwv, Copper-cu txhawb nqa nws qhov zais cia, uas ua rau muaj kev cuam tshuam vascular endothelial cell proliferation thiab angiogenesis - cov txheej txheem tseem ceeb rau kev kho mob [1].
Anti-inflammatory teebmeem
Inhibition of Inflammatory Mediators: Copper-cu inhibits zus tau tej cov inflammatory mediators, xws li qog necrosis factor-α (TNF-α) thiab interleukin-1β (IL-1β). Cov neeg kho kom haum xeeb no ua lub luag haujlwm tseem ceeb hauv cov lus teb inflammatory. Los ntawm inhibiting lawv cov kev qhia, Copper-cu txo qhov kev siv thiab lub sij hawm ntawm o, li no alleviating cov ntaub so ntswg puas [2].
Modulation ntawm Immune Cells: Nws kuj tswj kev tiv thaiv kab mob hauv lub cev. Los ntawm kev hloov pauv macrophage polarization mus rau cov tshuaj tiv thaiv kab mob macrophages, nws txo qis kev tso tawm ntawm cov neeg kho mob inflammatory thiab txhawb cov ntaub so ntswg kho [2].
DNA Kho
Ua kom txoj hauv kev kho: Copper-cu activates intracellular DNA kho txoj hauv kev. Thaum cov hlwb puas los ntawm ntau yam endogenous los yog exogenous yam, lawv pib ib tug series ntawm DNA kho mechanisms. Copper-cu txhawb kev kho cov DNA puas los ntawm kev tswj cov kev ua ntawm kev kho enzymes, xws li DNA polymerase thiab ligase, yog li tswj genomic stability [2].
Kev Tiv Thaiv Antioxidant: Nws muaj peev xwm antioxidant, txo qis cov pa oxygen reactive (ROS) vim DNA puas. ROS tuaj yeem ua rau DNA strand tawg thiab lub hauv paus oxidation. Los ntawm kev khawb ROS, tooj liab-cu tsis ncaj qha tiv thaiv DNA los ntawm kev puas tsuaj, tsim kom muaj txiaj ntsig zoo rau kho DNA [1].
Tswj Cellular Metabolism
Txhawb Zog Metabolism: Hais txog cellular zog metabolism, tooj liab-cu yuav cuam tshuam mitochondrial muaj nuj nqi. Mitochondria ua haujlwm hauv cellular powerhouses, thiab Copper-cu tuaj yeem txhim kho lub zog ntawm cov cellular zog los ntawm kev tswj cov haujlwm ntawm mitochondrial-associated enzymes-xws li cov koom nrog hauv lub voj voog tricarboxylic acid thiab oxidative phosphorylation-yog li ua tau raws li kev xav tau ntawm lub zog thaum lub sij hawm cellular txheej txheem xws li kev loj hlob thiab kho [2].
Regulating Substance Synthesis: Copper-cu kuj modulates cov synthesis ntawm cov khoom tseem ceeb intracellular. Raws li yav dhau los tau sau tseg, nws txhawb nqa cov synthesis ntawm extracellular matrix Cheebtsam xws li collagen thiab elastin. Tsis tas li ntawd, nws cuam tshuam rau kev sib txuas thiab cov metabolism hauv cov khoom siv hauv lub cev xws li cov proteins thiab lipids, yog li tswj hwm cov haujlwm ntawm lub cev ntawm lub cev [2].
Dab tsi yog cov ntawv thov ntawm Copper-cu?
Kev Kho Mob: Copper-cu muaj peev xwm txhawb kev kho qhov txhab. Nws txhawb nqa angiogenesis, muab cov khoom noj muaj txiaj ntsig thiab cov pa oxygen rau qhov chaw mob, yog li ua kom cov ntaub so ntswg kho thiab rov tsim dua tshiab. Copper-cu kuj txhawb kev ua haujlwm ntawm dermal fibroblasts, txhawb cov synthesis ntawm collagen, elastin, thiab glycosaminoglycans. Qhov no pab tsim kom muaj kev noj qab haus huv extracellular matrix thiab ua kom cov txheej txheem kho qhov txhab. Nyob rau hauv Pickart L txoj kev kawm txog kev raug mob ntawm daim tawv nqaij, kev kho mob nrog tooj liab-cu-muaj cov formulations ua rau lub qhov txhab kho kom ceev thiab kho kom zoo [2].
Anti-inflammatory Effects: Nws mitigates inflammatory teb los ntawm inhibiting o-txog kev taw qhia txoj kev. Hauv ob qho tib si lipopolysaccharide (LPS)-induced mob ntsws raug mob (ALI) nas qauv thiab hauv vitro thwmsim nrog RAW 264.7 macrophages, Copper-cu kho txo qis reactive oxygen hom (ROS) ntau lawm, nce superoxide dismutase (SOD) kev ua, thiab txo cov tiam ntawm inflammatory mediators xws li qog-α-TNF (nrog rau α-TNF). (IL-6), ua tiav los ntawm inhibiting NF-κB p65 thiab p38 MAPK txoj kev taw qhia. Yog li, Copper-cu qhia txog kev kho mob rau cov kab mob o xws li ALI / Acute Respiratory Distress Syndrome (ARDS) [3].
Kev Tiv Thaiv Cellular: Tshaj tawm ntau yam kev tiv thaiv cellular. Hauv cov kab mob obstructive pulmonary (COPD), nws tiv thaiv thiab kho lub ntsws cov ntaub so ntswg thaum rov ua haujlwm COPD fibroblast. Nws kuj tseem inhibits cov molecules zoo li NFκB, uas ntseeg tau tias yuav ua kom cov kab mob aging, ua kom pom kev tiv thaiv kev laus. Tsis tas li ntawd, nws nthuav tawm kev tiv thaiv kev ntxhov siab, tshuaj loog, thiab tiv thaiv kev ua phem, thiab ua kom lub cev ntxuav tes ntawm cov kab mob proteasome, muab kev tiv thaiv cellular [2] .
Kev Kho DNA: Copper-cu koom nrog cov txheej txheem kho DNA hauv intracellular, pab tswj kev ruaj ntseg ntawm genomic thiab txo cov cellular pathology thiab cov teeb meem kev laus los ntawm kev puas tsuaj DNA ntau ntxiv. Qhov no txhawb kev tiv thaiv thiab kho cov kab mob DNA puas tsuaj [2].
Xaus
Raws li ib qho endogenous tripeptide-tooj liab complex, Copper-cu nthuav tawm ntau yam kev lom zem. Los ntawm kev ua kom cov kev taw qhia xws li PI3K / Akt thiab MAPK / ERK, nws txhawb nqa fibroblast proliferation, angiogenesis, thiab extracellular matrix synthesis, ua lub luag haujlwm tseem ceeb hauv kev kho qhov txhab. Nws kuj muaj cov tshuaj tiv thaiv kab mob, antioxidant, thiab immunomodulatory functions, alleviating cov ntaub so ntswg inflammatory puas thiab pab nyob rau hauv kev kho mob thiab inflammatory kab mob.
Hais Txog Tus Sau
Cov ntaub ntawv hais saum toj no yog txhua yam tshawb fawb, kho thiab sau los ntawm Cocer Peptides.
Scientific Journal Author
Loren Pickart yog ib tus kws tshaj lij biochemist thiab tus tsim ntawm Skin Biology Inc., tshwj xeeb hauv kev kawm txog tooj liab peptides thiab lawv cov kev siv hauv kev noj qab haus huv ntawm daim tawv nqaij thiab kev laus. Nws nrhiav pom tooj liab peptide Copper-cu hauv 1973 thaum nws tshawb fawb kws kho mob hauv University of California, San Francisco. Qhov kev tshawb pom no tau ua rau kev txhim kho ntawm daim tawv nqaij rejuvenating tooj liab peptides thiab tsim ntawm Skin Biology Inc. nyob rau hauv 1994. Nws txoj hauj lwm tau ua rau muaj txiaj ntsig zoo rau kev nkag siab ntawm daim tawv nqaij biology thiab kev txhim kho ntawm kev tiv thaiv kev laus. Pickart txoj kev tshawb fawb txuas ntxiv cuam tshuam rau thaj tsam ntawm dermatology thiab tshuaj kho dua tshiab. Loren Pickart tau teev nyob rau hauv qhov kev siv ntawm kev hais tawm [2].
