Research Umuringa-cu Ubushakashatsi
Ni ubuhe bushakashatsi bwakozwe muri Copper-cu?
Mu myaka ya za 70, abahanga mu bya siyansi b'Abanyamerika bakora ubushakashatsi ku ngaruka za plasma y'abantu ku ngingo zo mu byiciro bitandukanye bakoze ubushakashatsi. Iyo plasma yaturutse ku rubyiruko yongewe ku mwijima w’umwijima ku bantu bakuze, inyama zumwijima zashaje zatangiye gukora neza poroteyine zihariye nkiz'umubiri muto. Nyuma yisesengura ryimbitse, mu 1973, yatandukanije neza Umuringa-cu na serumu yabantu. Uru ruganda rukorwa na tripeptide igizwe na glycine, histidine, na lysine ihambiriye cyane kuri ion y'umuringa. Ubushakashatsi bwakozwe bwerekanye ko Umuringa-cu ubaho muburyo bwimikorere yabantu mumacandwe, mumaraso, ninkari. Urwego rwo kwibandaho rufitanye isano cyane nimyaka: igera kuri 200ng / mL muri plasma yimyaka 20, ariko igabanuka cyane kugera kuri 80ng / mL kumyaka 60.
Ubushakashatsi bwakurikiyeho bukomeje kwagura imipaka yo gusobanukirwa Umuringa-cu. Mu ntangiriro ya za 1980, intiti zavumbuye ko umubiri wumuntu urekura GHK ahakomeretse, bashira amanga bashidikanya uruhare rwayo nkikimenyetso cyambere cyo gusana uruhu. Kuva icyo gihe, ubushakashatsi bwimbitse bwibanze ku ruhare rwa Copper-cu mu guhindura imyenda, cyane cyane mu kuvugurura uruhu. Umuringa-cu utera synthesis ya kolagen, elastine, na glycosaminoglycans mugihe ugenga ibikorwa bya metalloproteinase hamwe na inhibitor zabo. Iragira ingaruka nziza mukurwanya anti-inflammation, anti -xydeant defence, na angiogenez, buhoro buhoro ihinduka ingingo yubushakashatsi mubice byinshi birimo ibinyabuzima, dermatologiya, nubuvuzi bushya.
Nubuhe buryo bwo gukora kumuringa-cu?
Guteza imbere gukira ibikomere
Gukwirakwiza Akagari no Kwimuka: Umuringa-cu utera ikwirakwizwa no kwimuka kwingirabuzimafatizo zitandukanye, harimo fibroblast y'uruhu na selile endothelia. Kurugero, ahantu hakomeretse uruhu, byihutisha synthesis yibice bya matrice idasanzwe nka collagen na elastin na fibroblast, bitanga ubufasha bwuburyo bwo gukira ibikomere. Icyarimwe, ikurura ingirabuzimafatizo kugirango yimuke yerekeza ku gikomere, itera imiyoboro mishya y'amaraso. Ibi bitanga intungamubiri nyinshi na ogisijeni ku gikomere, byihutisha inzira yo gukira [1].
Kugena Ibintu Gukura: Uru ruganda ruhindura imvugo no kurekura ibintu byinshi bikura, nko guhindura ibintu bikura-β (TGF-β) hamwe niterambere ryimitsi iva mu mitsi (VEGF). Dufashe nk'urugero rwa VEGF, Umuringa-cu utera ururenda rwarwo, ari nawo utera ingirabuzimafatizo ya endoteliyale ikwirakwira hamwe na angiogenezi - inzira ikomeye yo gukira ibikomere [1].
Ingaruka zo kurwanya inflammatory
Kubuza abunzi batera umuriro: Umuringa-cu uhagarika umusaruro no kurekura abunzi benshi batera umuriro, harimo ikibyimba cya nekrosis-α (TNF-α) na interleukin-1β (IL-1β). Aba bahuza bafite uruhare runini mubisubizo byokongeza. Muguhagarika imvugo yabo, Umuringa-cu ugabanya ubukana nigihe cyo gutwika, bityo bikagabanya kwangirika kwinyama [2].
Guhindura ingirabuzimafatizo z'umubiri: Itegeka kandi imikorere y'uturemangingo. Muguhindura macrophage polarisiyasi yerekeza kuri macrophage anti-inflammatory, igabanya irekurwa ryabunzi batera umuriro kandi igatera gusana ingirangingo [2].
Gusana ADN
Gukora inzira zo gusana: Umuringa-cu ukora inzira yo gusana ADN idasanzwe. Iyo selile zangijwe nibintu bitandukanye bya endogenous cyangwa exogenous, zitangiza urukurikirane rwuburyo bwo gusana ADN. Umuringa-cu uteza imbere gusana ADN yangiritse muguhuza ibikorwa byimisemburo ijyanye nayo yo gusana, nka ADN polymerase na ligase, bityo bikagumana ituze rya genomic [2].
Kurinda Antioxydeant: Ifite ubushobozi bwa antioxydeant, igabanya ubwoko bwa ogisijeni ikora (ROS) -yangiza ADN. ROS irashobora gutuma ADN imeneka hamwe na okiside yibanze. Mugukata ROS, Umuringa-cu urinda mu buryo butaziguye ADN kwangirika, bigatuma habaho uburyo bwiza bwo gusana ADN [1].
Kugenga Metabolism
Guteza imbere Metabolism yingufu: Kubijyanye ningufu zingirabuzimafatizo, umuringa-cu urashobora guhindura imikorere ya mito-iyambere. Mitochondria ikora nk'ingufu za selile, kandi Umuringa-cu urashobora kongera ingufu z'umusemburo wa selile muguhuza ibikorwa byimisemburo ifitanye isano na mitochondrial-nk'abagize uruhare mu kuzunguruka aside tricarboxylic na fosifori ya okiside - bityo bikuzuza ingufu zikenewe mu ngirabuzimafatizo nko gukura no gusana [2].
Kugenga Ibintu Byuzuzanya: Umuringa-cu uhindura kandi synthesis yibintu byingenzi byimitsi. Nkuko byavuzwe haruguru, iteza imbere synthesis yibigize matrice idasanzwe nka collagen na elastin. Byongeye kandi, bigira ingaruka kuri synthesis hamwe na metabolism yibintu bigize ingirangingo nka proteyine na lipide, bityo bikagumana imikorere isanzwe ya selile ya selile [2].
Ni ubuhe buryo bukoreshwa mu muringa-cu?
Gukiza ibikomere: Umuringa-cu ufite ubushobozi bwo guteza imbere gukira ibikomere. Itera angiogenez, itanga intungamubiri nyinshi na ogisijeni ahakomeretse, bityo byihutisha gusana no kuvugurura. Umuringa-cu ushyigikira kandi imikorere ya fibroblast ya dermal, uteza imbere synthesis ya kolagen, elastine, na glycosaminoglycans. Ibi bifasha mukubaka matrise nziza idasanzwe kandi byihutisha inzira yo gukira ibikomere. Mu bushakashatsi bwa Pickart L ku bijyanye no gukomeretsa uruhu, kuvura hamwe n’umuti urimo umuringa-cu byihutishije cyane umuvuduko wo gukira ibikomere no kunoza ubuvuzi bwiza [2].
Ingaruka zo kurwanya inflammatory: Igabanya ibisubizo byumuriro muguhagarika inzira zerekana ibimenyetso. Muri lipopolysaccharide (LPS) -yatewe nimbeba yimbeba ikaze yibihaha (ALI) ndetse no mubushakashatsi bwa vitro hamwe na macrophage ya RAW 264.7, kuvura umuringa-cu byagabanije ubwoko bwa ogisijeni ikora (ROS), byongera ibikorwa bya superoxide (SOD), kandi bigabanya ibisekuruza byabunzi batera indwara nkibibyimba bya IL-6) na TNF-α) NF-κB p65 na p38 MAPK yerekana inzira. Rero, Umuringa-cu werekana ubushobozi bwo kuvura indwara ziterwa no gutwika nka ALI / Acute Respiratory Distress Syndrome (ARDS) [3].
Kurinda selile: Yerekana ingaruka nyinshi zo kurinda selile. Indwara idakira ifata ibihaha (COPD), irinda kandi igasana ingirangingo y'ibihaha mugihe igarura imikorere ya fibroblast ya COPD. Irabuza kandi molekile nka NFκB, zizera ko zihutisha indwara zisaza, zikerekana ubushobozi bwo kurwanya gusaza. Byongeye kandi, irerekana ibikorwa byo kurwanya amaganya, analgesic, no kurwanya ibitero, kandi ikora ibikorwa byogusukura selile ikoresheje sisitemu ya proteasome, itanga uburinzi bwuzuye bwa selile [2] .
Gusana ADN: Umuringa-cu ugira uruhare mubikorwa byo gusana ADN idasanzwe, bifasha kubungabunga ituze rya genoside no kugabanya indwara ya selile nibibazo byo gusaza biterwa no kwangirika kwa ADN. Ibi bifasha mu gukumira no kuvura indwara ziterwa na ADN [2].
Umwanzuro
Nka endogenous tripeptide-umuringa, umuringa-cu ugaragaza ibikorwa byibinyabuzima byinshi. Mugukoresha inzira yerekana inzira nka PI3K / Akt na MAPK / ERK, iteza ikwirakwizwa rya fibroblast, angiogenez, hamwe na synthesis ya matrix idasanzwe, bigira uruhare runini mugukiza ibikomere. Irerekana kandi ibikorwa byo kurwanya inflammatory, antioxydeant, na immunomodulatory, bigabanya kwangirika kwinyama no gufasha mu gusana ihahamuka no gutabara indwara.
Ibyerekeye Umwanditsi
Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.
Umwanditsi w'ikinyamakuru
Loren Pickart yari umuhanga mu binyabuzima uzwi cyane akaba yarashinze Skin Biology Inc., inzobere mu kwiga peptide y'umuringa no kuyikoresha mu buzima bw'uruhu no gusaza. Yavumbuye umuringa peptide Umuringa-cu mu 1973 ubwo yakoraga ubushakashatsi bwa dogiteri muri kaminuza ya Californiya, San Francisco. Ubu buvumbuzi bwatumye habaho iterambere ry’uruhu rwitwa peptide yumuringa ndetse n’ishyirwaho rya Skin Biology Inc. mu 1994. Ibikorwa bye byagize uruhare runini mu gusobanukirwa n’ibinyabuzima by’uruhu ndetse no guteza imbere imiti igabanya ubukana. Ubushakashatsi bwa Pickart bukomeje kugira ingaruka kubijyanye na dermatology nubuvuzi bushya. Loren Pickart yanditse murutonde rwerekana [2].
