▎ ọla kọpa-cu Nchọpụta
Kedu ihe ndabere nyocha nke Copper-cu?
N'afọ ndị 1970, ndị ọkà mmụta sayensị America na-enyocha mmetụta plasma mmadụ na anụ ahụ sitere na afọ dị iche iche mere nleba anya nke ọma. Mgbe agbakwunyere plasma sitere na ndị na-eto eto na anụ ahụ imeju site n'aka ndị agadi, anụ ahụ imeju merela agadi malitere ịmịpụta protein dị iche iche dị ka nke anụ ahụ na-eto eto. Mgbe nyochachara miri emi, na 1973, o wepụrụ Copper-cu nke ọma na serum mmadụ. A na-emepụta mgbagwoju a site na tripeptide nke nwere glycine, histidine, na lysine jikọtara ya na ion ọla kọpa. Nnyocha ndị ọzọ gosiri na Copper-cu na-adị n'ụdị ọdịdị mmadụ n'ime mmiri, ọbara, na mmamịrị. A na-ejikọta ọkwa ntinye uche ya na afọ: na-eru ihe dị ka 200ng / ml na plasma nke ndị dị afọ 20, ma na-agbada nke ọma na gburugburu 80ng / ml site na afọ 60.
Nnyocha na-esote na-aga n'ihu na-agbasawanye oke nghọta nke Copper-cu. Na mmalite 1980s, ndị ọkà mmụta chọpụtara na ahụ mmadụ na-ahapụ GHK na saịtị mmerụ ahụ, na-eji obi ike kwupụta ọrụ ya dị ka ihe mgbaàmà mbụ maka nrụzi akpụkpọ ahụ. Kemgbe ahụ, nyocha siri ike elekwasịla anya na ọrụ Copper-cu na-arụzigharị anụ ahụ, karịsịa na mmeghari akpụkpọ ahụ. Copper-cu na-akpali njikọ nke collagen, elastin na glycosaminoglycans ka ọ na-achịkwa ọrụ metalloproteinase na ndị na-egbochi ha. Ọ na-arụ ọrụ dị mma na mgbochi mkpali, nchebe antioxidant, na angiogenesis, jiri nwayọọ nwayọọ na-aghọ isiokwu nke nyocha n'ọtụtụ mpaghara gụnyere biochemistry, dermatology, na nkà mmụta ọgwụ.
Kedu usoro eji arụ ọrụ maka Copper-cu?
Na-akwalite ọgwụgwọ ọnya
Mgbasa Cell na Mbugharị: Copper-cu na-eme ka mmụba na ịkwaga mkpụrụ ndụ dị iche iche, gụnyere fibroblasts akpụkpọ anụ na sel endothelial. Dịka ọmụmaatụ, na saịtị ọnya akpụkpọ ahụ, ọ na-eme ka njikọ nke matrix extracellular dị ka collagen na elastin site na fibroblasts, na-enye nkwado nhazi maka ọgwụgwọ ọnya. N'otu oge ahụ, ọ na-adọta mkpụrụ ndụ endothelial ịkwaga n'ọnya ahụ, na-akwalite nhazi arịa ọbara ọhụrụ. Nke a na-ebunye ọtụtụ nri na oxygen na ọnya ahụ, na-eme ka usoro ọgwụgwọ dị ngwa ngwa [1].
Iwu nke ihe ndị na-eto eto: mgbagwoju anya a na-eme ka nkwupụta na ntọhapụ nke ọtụtụ ihe na-eto eto, dị ka ihe na-agbanwe uto-β (TGF-β) na vascular endothelial growth factor (VEGF). N'iji VEGF dịka ọmụmaatụ, Copper-cu na-akwalite nzuzo ya, nke n'aka nke ya na-akpali mgbasa sel endothelial vaskụla na angiogenesis - usoro dị mkpa maka ọgwụgwọ ọnya [1].
Mmetụta mgbochi mkpali
Mgbochi nke ndị mgbasa ozi na-egbuke egbuke: Copper-cu na-egbochi mmepụta na ntọhapụ nke ọtụtụ ndị mgbasa ozi mkpali, gụnyere tumor necrosis factor-α (TNF-α) na interleukin-1β (IL-1β). Ndị ogbugbo a na-arụ ọrụ dị mkpa na nzaghachi mkpasu iwe. Site na igbochi okwu ha, Copper-cu na-ebelata ike na ogologo oge nke mbufụt, si otú ahụ na-ebelata mmebi anụ ahụ [2].
Mgbanwe nke Selụ Immune: Ọ na-achịkwa ọrụ cell nke na-alụso ọrịa ọgụ. Site n'ịgbanwe macrophage polarization na mgbochi mkpali macrophages, ọ na-ebelata ntọhapụ nke ndị ogbugbo mkpali ma na-akwalite mmezi anụ ahụ [2].
Ndozi DNA
Nkwalite ụzọ mmezi: Copper-cu na-eme ka ụzọ ndozi DNA intracellular rụọ ọrụ. Mgbe sel dị iche iche mebiri emebi site na ihe dị iche iche nke endogenous ma ọ bụ exogenous, ha na-amalite usoro nhazi DNA. Copper-cu na-akwalite nrụzi DNA mebiri emebi site na ịhazi ọrụ nke enzymes nrụzi metụtara ya, dị ka DNA polymerase na ligase, si otú a na-ejigide nkwụsi ike nke genomic [2].
Nchekwa Antioxidant: Ọ nwere ikike antioxidant, na-ebelata ụdị oxygen na-emeghachi omume (ROS) mebiri DNA. ROS nwere ike ịkpata nkwụsị DNA strand na oxidation base. Site n'ịchọgharị ROS, Copper-cu na-echebe DNA n'ezoghị ọnụ site na mmebi, na-eke ọnọdụ dị mma maka nrụzi DNA [1].
Na-achịkwa metabolism cellular
Na-akwalite Metabolism Energy: Banyere cellular ume metabolism, Copper-cu nwere ike imetụta ọrụ mitochondrial. Mitochondria na-eje ozi dị ka ụlọ ọrụ cellular, na Copper-cu nwere ike ịkwalite nrụpụta ike nke cell site na ịhazi ọrụ nke enzymes metụtara mitochondrial-dị ka ndị na-etinye aka na usoro tricarboxylic acid na phosphorylation oxidative-si otú ahụ na-egbo mkpa ume n'oge usoro cellular dị ka uto na nrụzi [2].
Ịchịkọta ihe nchịkọta: Copper-cu na-agbanwekwa njikọ nke ihe dị mkpa intracellular. Dị ka e kwuru na mbụ, ọ na-akwalite njikọ nke extracellular matrix components dị ka collagen na elastin. Na mgbakwunye, ọ na-emetụta njikọ na metabolism nke ihe intracellular dị ka protein na lipids, si otú a na-ejigide ọrụ physiological cellular nkịtị [2]..
Kedu ihe bụ ngwa nke Copper-cu?
Ọgwụgwọ ọnya: Copper-cu nwere ikike ịkwalite ọgwụgwọ ọnya. Ọ na-akpali angiogenesis, na-enye ezigbo nri na oxygen na saịtị ọnya ahụ, si otú a na-eme ka nrụzi anụ ahụ dịkwuo elu na ịmaliteghachi. Copper-cu na-akwadokwa ọrụ nke fibroblasts dermal, na-akwalite njikọ nke collagen, elastin, na glycosaminoglycans. Nke a na-enyere aka n'ịmepụta matrix extracellular dị mma ma na-eme ka usoro ọgwụgwọ ọnya dị ngwa ngwa. N'ime ọmụmụ Pickart L banyere mmerụ ahụ akpụkpọ ahụ, ọgwụgwọ na usoro nwere Copper-cu mere ka ọ dị ngwa ngwa ọgwụgwọ ọnya yana mma ọgwụgwọ dị mma [2].
Mmetụta mgbochi mkpali: Ọ na-ebelata nzaghachi mkpali site na igbochi ụzọ mgbaàmà metụtara mbufụt. N'ime ma lipopolysaccharide (LPS) na-akpata nnukwu mmerụ ahụ nku ume (ALI) na nnwale in vitro na RAW 264.7 macrophages, ọgwụgwọ ọla kọpa na-ebelata mmepụta oxygen (ROS), mụbara ọrụ superoxide dismutase (SOD), ma belata ọgbọ nke ndị mgbasa ozi mkpali dị ka -αr-NF (Intercrosis). (IL-6), nwetara site na igbochi NF-κB p65 na p38 MAPK ụzọ akara. Ya mere, ọla kọpa-cu na-egosipụta ike ọgwụgwọ maka ọrịa ndị metụtara mbufụt dị ka ALI/Acute Respiratory Distress Syndrome (ARDS) [3].
Nchekwa ekwentị: Na-egosipụta ọtụtụ mmetụta nchebe cellular. Na ọrịa na-adịghị ala ala obstructive pulmonary (COPD), ọ na-echebe ma na-edozi anụ ahụ ngụgụ mgbe ọ na-eweghachi ọrụ fibroblast COPD. Ọ na-egbochikwa ụmụ irighiri ihe dị ka NFκB, nke a kwenyere na ọ na-eme ka ọrịa ịka nká dịkwuo elu, na-egosipụta ikike mgbochi ịka nká. Na mgbakwunye, ọ na-egosipụta mgbochi nchegbu, analgesic, na mgbochi ime ihe ike, ma na-arụ ọrụ nhicha cellular site na usoro proteasome, na-enye nchebe cellular zuru oke [2]. .
Ndozi DNA: Copper-cu na-ekere òkè na usoro nrụzi DNA intracellular, na-enyere aka ịnọgide na-enwe nkwụsi ike nke genomic na ibelata pathology cellular na ịka nká nke sitere na mmebi DNA gbakọtara. Nke a na-akwado mgbochi na ọgwụgwọ ọrịa ndị metụtara mmebi DNA [2].
Mmechi
Dị ka mgbagwoju trieptide-ọla kọpa endogenous, Copper-cu na-egosipụta ọrụ ndụ multidimensional. Site n'ịgbalite ụzọ mgbaàmà dị ka PI3K/Akt na MAPK/ERK, ọ na-akwalite mmụba fibroblast, angiogenesis, na njikọ matrix extracellular, na-arụ ọrụ dị mkpa na ọgwụgwọ ọnya. Ọ na-egosipụtakwa mgbochi mkpali, antioxidant, na ọrụ immunomodulatory, na-ebelata mmebi nke anụ ahụ ma na-enyere aka n'ịrụzi trauma na ọrịa na-egbu egbu.
Banyere Onye dere ya
Ihe niile a kpọtụrụ aha n'elu bụ Cocer Peptides na-enyocha, dezie ma chịkọta ya.
Onye ode akwụkwọ akụkọ sayensị
Loren Pickart bụ onye ama ama na biochemist na onye guzobere Skin Biology Inc., ọkachamara na ọmụmụ nke peptides ọla kọpa na ngwa ha na ahụike anụ ahụ na ịka nká. Ọ chọtara ọla kọpa peptide Copper-cu na 1973 n'oge nyocha nke doctoral na Mahadum California, San Francisco. Nchọpụta a mere ka e nwee mmepe nke peptides ọla kọpa na-eme ka akpụkpọ anụ na-eme ka akpụkpọ anụ na-eme ka ọkpụkpụ na-emepụta Skin Biology Inc. na 1994. Ọrụ ya nyere aka n'ụzọ dị ukwuu na nghọta nke usoro ihe ọmụmụ akpụkpọ anụ na mmepe nke ọgwụgwọ ịka nká. Nchọpụta Pickart na-aga n'ihu na-emetụta ngalaba nke dermatology na ọgwụ na-emegharị ahụ. Edepụtara Loren Pickart na ntụaka ntụaka [2].
