▎ Kɔpa-cu Risach
Wetin na di risach bakgrɔn fɔ Kɔpa-ku?
Insay di 1970 dɛm, Amɛrikan sayɛnsman dɛm we bin de invɛstigat di ifɛkt dɛm we mɔtalman plasma gɛt pan di tisu dɛm frɔm difrɛn ej grup dɛm bin rili wach. We dɛn ad plasma frɔm yɔŋ pipul dɛn to di liva tisu frɔm ol pipul dɛn, di ol liva tisu bigin fɔ prodyuz spɛshal prɔtin dɛn fayn fayn wan lɛk di wan we yɔŋ tisu gɛt. Afta dip analisis, insay 1973, i bin saksesful fɔ aylɔlɔ Kɔpa-cu frɔm mɔtalman sɛrum. dis komplex de fכm bay wan tripεptida we kכmכp fכ glycine, histidine, εn lysine we tayt wan to wan kכpa ayכn. כda risach sho se Kכpa-cu de nכmal fכ de insay mכtalman fysiolojikal prכsεs dεm insay saliva, bכdi, εn urine. di kכnsantreshכn lεvεl dεm we i gεt de kכlכs wit di ej: i de rich lεk 200ng/mL insay di plasma fכ 20 ia ol pipul dεm, bכt i de dכn shap to arawnd 80ng/mL we i rich 60 ia.
Risach we dɛn du afta dat de kɔntinyu fɔ mek di bɔda dɛn fɔ ɔndastand Kɔpa-cu. Insai di erli 1980s, masta sabi bukman dεm dכn fכ no se di mכtalman bכdi de rilis GHK na di say dεm we injuri, boldly hypothεsis in pכtεnshal rol as wan εli ki signal fכ skin ripa. Frɔm da tɛm de, bɔku risach dɔn de pan di wok we Kɔpa-ku de du fɔ mek di tisu dɛn rimɔdelin, mɔ fɔ mek di skin kam bak. kכpa-cu de mek di sεntez fכ kolagen, εlastin, εn glycosaminoglycans we i de rεgεl di aktiviti fכ mεtaloproteinases εn dεn inhibito dεm. I de du fayn fayn tin dɛn pan anti-inflammation, antioxidant difens, ɛn angiogenesis, smɔl smɔl i de bi sɔbjɛkt fɔ risach akɔdin to bɔku fild dɛn we inklud bayɔkemistri, dɛmatɔlɔji, ɛn rijeneretiv mɛrɛsin.
Wetin na di mɛkanism fɔ akshɔn fɔ Kɔpa-ku?
Fɔ mek di wund dɛn wɛl
Sεl Proliferashכn εn Maygrεshכn: Kכpa-cu de mek difrεn sεl dεm proliferashכn εn maygrεshכn, inklud di skin fibroblast dεm εn εndoteyl sεl dεm. fכ egzampl, na di say dεm we di wund dεm na di skin, i de aksεlεrayt di sεntesis fכ di εkstrasεlula matris kכmכpכnεnt dεm lεk kolagen εn εlastin bay fכblas, we de gi strכkchכral sכpכt fכ wund hεl. di sem tεm, i de atrak di εndoteyl sεl dεm fכ muv to di wund, we de mek nyu bכdi vεsul dεm fכm. dis de gi bכku tin dεm εn כksijεn to di wund, we de mek di wund hεl kwik kwik wan [1] ..
rεgulεshכn fכ di gכt fכktכ dεm: dis kכmpleks de mכdulet di εksprεshכn εn rilis fכ mכltipכl gכt fכktכ dεm, lεk transfכm gכt fכktכ-β (TGF-β) εn vaskulεr εndoteyl grכw fכktכ (VEGF). we wi tek VEGF as egzampl, Kכpa-cu de protεkt in sekreshכn, we in tכn de mek di vaskulεr εndoteyl sεl proliferashכn εn angiojεnεsis—krichכl prכsεs dεm fכ wund hεl [1]..
Ifɛkt dɛn we de mek pɔsin nɔ gɛt inflammatory
inhibishכn fכ Inflammatory Mεdiate dεm: kכpa-cu de sכpres di prodyushכn εn rilis fכ mכltipכl inflammatory mεdiate dεm, inklud tכmכro nεkrכsis fכktכ-α (TNF-α) εn intalyukin-1β (IL-1β). dis mεdiate dεm de ple ki rol dεm na inflammatory rεspכns dεm. bay we i de inhibit dεn εksprεshכn, Kכpa-cu de ridyus di intensiti εn di tεm we di inflameshn de tek, we de mek di tisu dεm dεm we de pwεl bכku [2] ..
mכduleshכn fכ di imyun sεl dεm: i de rεgεl bak di imyun sεl dεm fכ wok. bay we i de mכdulet di makrofag polarizeshכn tכwכd di anti-inflammatory makrofag dεm, i de ridyus di rilis fכ inflammatory mεdiate dεm εn i de protεkt di tisu ripa [2] ..
DNA Ripair
Aktibכshכn fכ di Ripa Pathways: Kכpa-cu de aktibכt intasεlulyar DNA ripa path dεm. we difrεn εndojεnik כ εksojen fכktכ dεm de pwεl di sεl dεm, dεn de initiate wan siriכs DNA ripa mεkanism. kכpa-cu de protεkt di ripa fכ di dεmεj DNA bay we i de rεgεl di aktvכti fכ di rilayt ripa εnzym dεm, lεk DNA polimεrayz εn ligase, we de mek i de mεnten di jεnomik stεbiliti [2] ..
Antioksidant Protεkshכn: I gεt antioksidant kapasiti, we de ridyus di riaktiv כksijεn spεs (ROS)-indyus DNA dεmεj. ROS kin mek DNA strεn brok εn bays כksidεshכn. bay we i de skavenj ROS, Kכpa-cu de protεkt DNA indaykt wan frכm damej, we de mek fayn kכndishכn fכ DNA ripa [1]..
Rigulεt Sεlyul Mεtabolism
fכ protεkt εnεji mεtabolism: we i kam pan sεlyul εnεji mεtabolism, Kכpa-cu kin infכlכw di maytochכndrial fכnshכn. di maytochכndria dεm de wok lεk sεl pawa hכus dεm, εn Kכpa-cu kin εnhans di sεl εnεji prodakshכn efyushכn bay we i de rεgεl di aktiviti fכ di maytochכndrial-asכsiet εnzym dεm—lεk dεn wan dεm we de involv insay di trikarbכksilik asid saykl εn כksidεtiv fכsfכrayleshכn—dεn de mit di enεji dimand dεm we di sεl dεm de du lεk fכ gro εn ripa [2] ..
rεgεlεt sכbstans sεntesis: kכpa-cu de mכdulet di sεntesis fכ imכtant intasεlulyar sכbstans dεm bak. as wi bin dכn no, i de protεkt di sεntesis fכ εkstrasεlula matris kכmכpכnεnt dεm lεk kolagen εn εlastin. apat frכm dat, i de infכlכ di sεntesis εn mεtabolism fכ di intasεlulyar sכbstans dεm lεk protin dεm εn lipid dεm, we de mek i de mεnten nכmal sεlyul fysiolojikal fכnshכn dεm [2]..
Wetin na di aplikeshɔn dɛn fɔ Kɔpa-cu?
Wund Hiling: Kɔpa-cu gɛt di abiliti fɔ mek wund wɛl. i de mek di angiojεnεsis, i de gi bכku nyutriεnt dεm εn כksijεn to di say we di wund de, we de mek di tisu ripa εn rigεnεreshכn aksεlεrat. kכpa-cu de sכpכt bak di fכnshכn fכ di dεmal fכblast dεm, we de protεkt di sεntesis fכ kolagen, εlastin, εn glycosaminoglycans. dis de εp fכ kכnstrכkt wan hεlty εkstrasεlula matris εn i de mek di wund hεlכ prכsεs kwik kwik wan. Insay Pickart L in stכdi pan skin injuri, tritmεnt wit Kכpa-cu-kכntεn fכmulashכn dεm sכmtεm aksεlεrayt wund hεl spid εn impruv hεlin kwaliti [2]..
Anti-inflammatory Effects: I de mitigate inflammatory rispכns bay we i de inhibit inflammatory-related signaling pathways. In ɔl tu wan lipopolysaccharide (LPS)-indyus akyu lכng injuri (ALI) maws mכdel εn in vitro εkspεriεns wit RAW 264.7 makrofag, Kכpa-cu tritmεnt rεdכks riaktiv כksijεn spεs (ROS) prodakshכn, inkrεs supεrכksayd dismutase (SOD) aktiviti, εn dεkrεs di jεnereshכn כf inflammatory mεdiate lεk nεkrכsis fכktכ -α (TNF-α) εn intalyukin-6 (IL-6), we dεn achy bay we dεn de inhεbit NF-κB p65 εn p38 MAPK signal path dεm. So, Kכpa-cu de sho di tεrapi pכtεnshal fכ inflameshn-rεlatεd sik dεm lεk ALI/Acute Respiratory Distress Syndrome (ARDS) [3]..
Sεlyul Protεkshכn: I de sho plεnti sεl protεktiv ifekt dεm. insay kronik obstruktiv pulmonari sik (COPD), i de protεkt εn ripa di lכng tisu we i de mek di COPD fibroblast fכ wok bak. i de inhεbit mכlikul dεm lεk NFκB bak, we dεn biliv se de aksεlεrayt sik dεm fכ ol, we de sho anti-aging pכtεnshal. apat frכm dat, i de sho anti-anxiety, analgesic, εn anti-aggression aktiviti dεm, εn i de aktibכt sεlyul klinכp fכnshכn dεm tru di proteasome sistεm, we de gi kכmprεhεnsiv sεl protεkshכn [2]. .
DNA Ripa: Kכpa-cu de tek pat pan intasεlulyar DNA ripa prכsεs dεm, we de εp fכ mεnten di jεnomik stεbiliti εn rεdכks sεlyul patכlayzm εn ol εj εshyu dεm we kכz fכ akumulet DNA dεmεj. Dis de sɔpɔt fɔ mek dɛn nɔ gɛt ɛn trit sik dɛn we gɛt fɔ du wit DNA we dɔn pwɛl [2] ..
Dɔn
as εndojεnik tripεptida-kכpa kכmpleks, Kכpa-cu de sho mכltidimεnshכnal bayolojikal aktiviti. bay we i de aktibכt signal path dεm lεk PI3K/Akt εn MAPK/ERK, i de promuot fכ blast proliferashכn, angiojεnεsis, εn εkstrasεlula matris sεntesis, we de ple imכtant rol fכ wund hεl. i de sho bak anti-inflammatory, antioxidant, εn immunomodulatory fכnshכn dεm, we de mek di tisu inflammatory damej εn εp fכ ripa trauma εn inflammatory disease intavεnshכn.
Bɔt di pɔsin we rayt di buk
Di tin dɛn we wi dɔn tɔk bɔt, na ɔl di tin dɛn we Cocer Peptides dɔn du risach, ɛdit ɛn kɔmpilayt.
Sayɛns Jɔnal Author
Loren Pickart na bin wan bigman pan bayɔkemist ɛn na bin di wan we mek Skin Biology Inc., we spɛshal fɔ stɔdi bɔt kɔpa peptide ɛn aw fɔ yuz dɛn fɔ mek di skin gɛt wɛlbɔdi ɛn fɔ ol. I bin fɛn di kɔpa peptide Copper-cu insay 1973 we i bin de du in dɔktɔral risach na di Yunivasiti ɔf Kalifɔnia, San Fransisko. Dis diskכvri bin mek dεn divεlכp di skin rεjuvenating kכpa pεptida dεm εn dεn establish Skin Biology Inc. insay 1994. In wok dεn bin rili kכntribyut fכ כndastand di skin bayoloji εn divεlכpmεnt fכ anti-aging tritmεnt dεm. Pickart in risach de kɔntinyu fɔ inflɔws di fild fɔ dɛmatɔlɔji ɛn rijeneretiv mɛrɛsin. Loren Pickart de na di list insay di rɛfrɛns fɔ saytayshɔn [2].
