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1kits （10Ibikoresho）
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Imiterere ya Kisspeptin Structure
Inkomoko: PubChem |
Urukurikirane: GTSLSPPPESSGSRQQPGLSAPHSRQIPAPQGAVLVQREKDLPNYNWNSFGLRF Inzira ya molekulari: C 258H 401N 79O.78 Uburemere bwa molekuline: 5857 g / mol PubChem CID ： 71306396 Synonyme: Protein KISS-1 ； Kisspeptins |
Kisspeptin Research Ubushakashatsi
Ni ubuhe bushakashatsi bwakozwe na Kisspeptin?
Mu mpera z'ikinyejana cya 20, hamwe n’iterambere ryakozwe mu bushakashatsi bwakozwe ku ngirabuzimafatizo ya metastasis suppressor, abahanga mu bya siyansi bavumbuye gene ya KiSS-1 mu ngirabuzimafatizo ya melanoma bakoresheje imvange ya subtractive Hybridisation mu 1996. Mu 1999, imbeba G proteine ihujwe na reseptor GPR54 yaramenyekanye, maze mu 2001, ubushakashatsi bwemeza ko umusaruro wa gene ya KiSS-1 witwa Lissand ya GPRpeptin. Mu ikubitiro hagaragajwe imiterere yacyo yibibyimba metastasis-suppressive, iyi neuropeptide yaje gusanga ikora nkibyingenzi byingenzi bigenga imiterere ya hypothalamic-pitoitar-gonadal axis, bigira uruhare runini mugutunganya neuroendocrine igenga iterambere ryimyororokere. Ifite kandi uruhare mubikorwa byinshi byimyororokere nkimyitwarire yimyororokere, kugenzura imiterere, gukura kwa metabolisme, hamwe n imyitwarire yo kugaburira. Ubuvumbuzi n'ubushakashatsi bukora kuri Kisspeptin bitanga urufatiro rukomeye rwo gushakisha uburyo bwo kugenzura imikorere ya neuroendocrine no kuvura indwara zifitanye isano.
Nubuhe buryo bwo gukora bwa Kisspeptin?
Uburyo bwo kugenzura imyororokere
Amabwiriza ya Hypothalamic-Pitoitar-Gonadal (HPG) Axis: Kisspeptin igira uruhare runini mugutunganya imyororokere, cyane cyane binyuze muguhindura umurongo wa HPG. Mu nyamaswa z’inyamabere, Kisspeptin itera ururenda rwa hormone irekura gonadotropine (GnRH). By'umwihariko, Kisspeptin ikora ururenda rwa pulsatile ya selile ya GnRH ikoresheje uburyo bwa poroteyine G ikoresheje reseptor GPR54. Kurugero, mugihe cyo gutangira ubwangavu, kongera ibikorwa bya hypothalamic Kisspeptin neuron bitera ururenda rwa GnRH, ari nako bitera glande ya pitoito gusohora gonadotropine (nka hormone itera imisemburo FSH na luteinizing hormone LH). Iyi misemburo ikora kuri gonad kugirango iteze imbere iterambere rya gonadal no gusohora imisemburo ya hormone, bityo bigatangira gukura . .
Ingaruka Zitaziguye kuri Gonadi: Usibye kugenzura mu buryo butaziguye imyororokere binyuze mu murongo wa HPG, Kisspeptin inagira ingaruka zitaziguye kuri gonad. Ubushakashatsi bwakozwe kuri oocytes ziva mu ntama za anestrous Tan, nk'urugero, bwerekanye ko Kisspeptin itezimbere cyane igipimo cyo gukura kwa vitro oocytes yintama ya Tan kandi igatera gukura kwa oocyte muguhuza imvugo ya gene. Ibi birerekana ko Kisspeptin ishobora kugira uruhare rutaziguye mu kugenzura iterambere ryimitsi muri gonad.
Ni ubuhe buryo bwa Kisspeptin bwo gukora?
Imikoranire nizindi Neuropeptide: Muri hypothalamic arcuate nucleus, hariho icyiciro cya neuron ya Kisspeptin ifatanya glutamate, neurokinin B (NKB), na dynorphine (Dyn). Izi neuron zigaragaza ibikorwa byigihe kimwe kugirango bigabanye imisemburo ya pulsatile [2] . Ubushakashatsi bwakozwe ku mbeba z’abagore bwerekanye ko guhuza ubwonko bwa ARN ^ {KISS} neurons biterwa cyane no kwanduza glutamate binyuze mu byakira AMPA no kwanduza neurokinin B, mu gihe kubuza kwakira NMDA no kwakira κ-opioid nta ngaruka bigira ku gipimo cyo guhuza [3] . Imbeba zabagabo, guhuza ARN ^ {KISS} neuron bituruka kubikorwa byurusobe bitunguranye byabaturage mubaturage, biterwa cyane na glutamate-AMPA yerekana ibimenyetso, hamwe na neurokinin B yongerera imbaraga glutamate iterwa na syncronisation, mugihe dynorphin-κ-opioid tone murusobe ikora nkuburyo bwo gutangiza ibikorwa. Ibi byerekana imiyoboro ihuza imikoranire hagati ya neuron ya Kisspeptin nizindi neuropeptide mugutunganya neuroendocrine, hamwe igenga imisemburo ya pulsatile [2].
Igicapo 1 Histogramu yerekana ijanisha ryibigeragezo aho ibintu bya calcium byabayeho byabaye hagati ya ARN ^ {KISS} neuron mugice cyubwonko mubihe bitateganijwe kandi nyuma yumurongo muke hamwe no gukurura inshuro nyinshi za neuron imwe mugihe udahari kandi uhari wa CNQX cyangwa reseptor ya neurokinin (NKR).
Inkomoko: Byatangajwe [3].
Ni ubuhe buryo bwo gukora ubushakashatsi ku mavuriro kuri Kisspeptin mu kuvura indwara ziterwa na metabolike?
Kisspeptin na Diyabete yo mu bwoko bwa 2 (T2DM)
Amabwiriza ya Glucose Metabolism: Ibintu by'ingenzi bigize T2DM harimo kurwanya insuline, gusohora insuline bidahagije, hamwe na glucose yamaraso. Ubushakashatsi bwerekana ko Kisspeptin ishobora kugenga glucose metabolism binyuze munzira nyinshi. Ku ruhande rumwe, Kisspeptin irashobora guhindura insuline; kurundi ruhande, irashobora gukora kumikorere ya pancreatic islet cell-selile imikorere kugirango igire ingaruka kuri insuline.
Kisspeptin n'umubyibuho ukabije
Kugena ingufu zingana no gufata ibiryo: Umubyibuho ukabije akenshi ujyana no kutaringaniza ingufu bitewe no gufata ingufu nyinshi no kugabanya gukoresha ingufu. Kisspeptin igenga imbaraga zingirakamaro hamwe nigaburo ryimyitwarire muri sisitemu yo hagati. Kwiyongera kwa Kisspeptin bishobora kugabanya gufata ibiryo mu nyamaswa, mugihe imvugo yagabanutse ishobora kwiyongera, byerekana ko Kisspeptin ikora nk'ingenzi mu kugenzura ingufu zifata umubyibuho ukabije.
Indwara y'umwijima Kisspeptin n'inzoga zitari inzoga (NAFLD)
Ingaruka kuri Hepatic Metabolism: NAFLD n'indwara y'umwijima ifitanye isano rya bugufi no kurwanya insuline na syndrome de metabolike, irangwa no gushira amavuta menshi ya hepatike. Kisspeptin igira uruhare mu kugenzura imiterere ya hepatike. Mu bushakashatsi bw’inyamaswa, kwifashisha Kisspeptin byagaragaye ko bihindura metabolisme ya lipide, ibisubizo bitera umuriro, hamwe na stress ya okiside mu mwijima. Irashobora kugabanya ikwirakwizwa ryamavuta ya hepatike muguhuza ibikorwa byimisemburo yingenzi igira uruhare muri synthesis ya fatty acide no kumeneka. Byongeye kandi, Kisspeptin irashobora guhindura inzira ya hepatike yerekana inzira kugirango igabanye umuriro kandi itinde iterambere rya NAFLD.
Indwara ya Kisspeptin na Polycystic Ovary Syndrome (PCOS)
Amabwiriza abiri y’imyororokere ya Endocrinology na Metabolism: PCOS ni indwara isanzwe ya endocrine na metabolic disorder irangwa n’imyororokere idasanzwe ya endocrine idasanzwe ndetse n’indwara ya glucose-lipide ihindagurika ku barwayi benshi. Kisspeptin igira uruhare runini muri PCOS. Hagati, igenga hypothalamic-pitoitar-gonadal axis kugirango igire ingaruka kumyororokere yimyororokere kubarwayi ba PCOS. Hagati aho, igira uruhare mu guhinduranya metabolike irimo insuline, leptine, na adiponectine, byerekana ko ari ikintu cy'ingenzi mu mikorere mibi ya metabolike muri PCOS.
Ni ubuhe buryo bukoreshwa na Kisspeptin?
Kuvura indwara yimyororokere
Iterambere ridasanzwe ryimyororokere: Kisspeptin ningirakamaro mugutangira ubwangavu. Ubushakashatsi bwerekana ko ihinduka ryimiterere muri sisitemu ya Kisspeptin-GPR54 rishobora gutuma ubukererwe butinda cyangwa hypogonadism. Imiyoborere idasanzwe ya Kisspeptin irashobora gukurura HPG kugirango iteze imbere ururenda rwa GnRH na gonadotropine, isezeranya kuvura indwara ziterwa no kubyara. Kurugero, kubarwayi barwaye hypogonadism bitewe na Kisspeptin yerekana inenge, kongerwaho na Kisspeptin cyangwa ibigereranyo byayo birashobora kugarura iterambere ryimyanya myibarukiro [4, 5].
Indwara ya Ovulation: Muri sisitemu yimyororokere yumugore, Kisspeptin igenga ukwezi kwintanga ngore. Ifite ubushobozi bwo kuvura indwara ya ovulation nka PCOS. Mugutegeka gusohora kwa GnRH pulsatile, Kisspeptin irashobora guhindura irekurwa rya gonadotropine kugirango itezimbere imisemburo na ovulation. Ubushakashatsi ku mavuriro bwerekana ko Kisspeptin itera uburyo bwo gusohora umubiri wa gonadotropine ya physiologique ku barwayi bamwe na bamwe barwaye indwara ya ovulation, bikazamura igipimo cya ovulation [5, 6].
Imikorere ya Hypothalamic Amenorrhea (FHA): FHA iterwa no gusohora bidasanzwe kwa GnRH pulsatile muri hypothalamus. Nkurwego rwo hejuru rwa GnRH, Kisspeptin ningirakamaro mukuvura FHA. Ubushakashatsi bwerekana ko imiyoborere ya Kisspeptin-54 ku barwayi ba FHA itera neza ururenda rwa gonadotropine (FSH, LH), ikagira amasezerano yo kugarura ukwezi no kubyara. Ibi bitanga ingamba nshya zo kuvura FHA [6].
Kuvura indwara za metabolike
Indwara Yumwijima Utarimo Inzoga (NAFLD): Ubushakashatsi buherutse gukorwa bwerekanye ko gukora reseptor ya Kisspeptin 1 (KISS1R) byerekana inzira bigira ingaruka zo kuvura NAFLD. Muburyo bwamavuta agaburirwa nimbeba yimbeba, knockout ya hepatike Kiss1r yongera umwijima wa hepatike, mugihe imbaraga za KISS1R zirinda imbeba zo mubwoko bwa steatose kandi bikagabanya fibrosis ya hepatike mumirire iterwa nimbeba iterwa na alcool ya steatohepatitis (NASH). Ubushakashatsi bwakozwe bwerekana ko ibimenyetso bya hepatike KISS1R biteza imbere iterambere rya NAFLD ukoresheje AMPK, molekile yingenzi igenga ingufu, kugirango igabanye lipogenezi. Byongeye kandi, kwiyongera kwa hepatike KISS1 / KISS1R hamwe na plasma Kisspeptin ku barwayi ba NAFLD hamwe nimbeba zigaburirwa amavuta menshi byerekana uburyo bwo kwishyura indishyi zigabanya synthesis ya triglyceride, bigatuma KISS1R iba intego nshya yo kuvura NASH [7].
Umuti wa Osteoporose: Osteoporose ni indwara isanzwe yo mu magufwa ya metabolike aho imisemburo yimyororokere igira uruhare runini mu mikurire yamagufwa no kuyitaho cyane. Ubushakashatsi bwerekana ko Kisspeptin itera itandukaniro rya osteoblast kandi ikabuza osteoclasts, itanga ubushobozi bwo kuvura osteoporose. Ubu buryo bushobora kuba bukubiyemo kugenzura amagufwa ya metabolism ajyanye n'inzira zerekana ibimenyetso, nk'inzira ya Wnt na sisitemu ya RANKL-OPG, kugira ngo iteze imbere amagufwa, ibuze amagufwa, kongera ubwinshi bw'amagufwa, no kuzamura ubuzima bw'amagufwa ku barwayi ba osteoporose.
Umwanzuro
Nubwo ubushakashatsi ku mavuriro kuri Kisspeptin mu kuvura indwara ziterwa na metabolike bwateye imbere, ingaruka zabwo zirimo ibintu byinshi birimo glucose metabolism, kuringaniza ingufu, metabolisme ya hepatike, no kugenzura kabiri endocrinology yimyororokere na metabolism.
Ibyerekeye Umwanditsi
Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.
Umwanditsi w'ikinyamakuru
Guzman, S ni intiti izwi cyane mu bijyanye n'ubuvuzi n'ubumenyi bw'ubuzima, ifatanije n'ibigo byinshi bizwi nka Sisitemu ya kaminuza ya Rutgers, Ikigo cyita ku buzima bw'abana cya New Jersey, na Sisitemu yo mu mujyi wa New York (CUNY). Ubushakashatsi bwe bwibanze kuri Gastroenterology & Hepatology, Biologiya Cell, Biologiya Imyororokere, na Obstetrics & Gynecology. Ibi bice byubushakashatsi bifite akamaro kanini mugutezimbere amahame yubuvuzi nubuvuzi, bikagaragaza ubuhanga bwe bwumwuga n’uruhare runini mu bushakashatsi bw’ubuvuzi .. Guzman, S yashyizwe ku rutonde rwavuzwe [7].
