Eddagala lya adipotide 10mg

▎ ya Adipotide Enzimba

▎ bulwadde bwa Adipotide Okunoonyereza ku

Ensibuko y’okunoonyereza ku Adipotide eri etya?

Mu nsi yonna, omugejjo gweyongedde okufuuka ekizibu eky’amaanyi. Okunoonyereza ku ndwadde okuva mu 2008 kulaga nti abantu abakulu nga 33.9% mu Amerika batawaanyizibwa omugejjo. Omugejjo si kugejja kwokka; kikwatagana nnyo n’ensonga nnyingi ez’amaanyi ez’ebyobulamu, omuli puleesa, omusaayi omungi, obulwadde bw’okukyusakyusa emmere, ssukaali atasinziira ku insulini, obubenje bw’emisuwa gy’obwongo, okuzimba emisuwa gy’omutima, ne kookolo ow’enjawulo. Okugatta ku ekyo, amasavu mu lubuto galeeta obulabe bungi eri obulamu okusinga amasavu mu bitundu by’omubiri ebya wansi oba mu bisambi olw’emirimu gyago egy’okusengejja amasavu amangi.

Mu kusooka yakolebwa ng’eddagala erijjanjaba kookolo, Adipotide yagenderera okusalako omusaayi ogugenda mu butoffaali bwa kookolo, okubufa enjala y’ebiriisa n’okuyimiriza okukula. Abanoonyereza baakizuula mu ngeri ey’ekimpowooze nti eddagala lino bwe likola ku butoffaali bw’amasavu mu musaayi, mu ngeri y’emu libufa enjala, ne liwaliriza obutoffaali bw’amasavu okufa ne buddamu okuyingizibwa omubiri. Abanoonyereza basuubira nti enkola ya Adipotide ey’enjawulo ejja kuwa abantu abagejjulukuka obujjanjabi obupya.

Adipotide ekola etya?

Okuleeta apoptosis mu butoffaali bw’emisuwa egy’amasavu amazungu

Ekikolwa ekigendereddwamu: Adipotide etunuulira nnyo emisuwa egy’omusaayi munda mu bitundu by’amasavu ebyeru. Kizuula bulungi era ne kikola ku misuwa egyetoolodde ebifo eby’amasavu amazungu. Barnhart KF ne banne. yalaga nti okutunuulira kuno kusobozesa Adipotide okukola butereevu ku misuwa gy’amasavu amazungu awatali kukosa nnyo nkola ya misuwa mu bitundu by’omubiri ebirala ^[1,2,3]..

Triggering Apoptosis: Adipotide bw’ekwatagana n’emisuwa gy’omusaayi egy’amasavu, ereeta apoptosis mu butoffaali obuli mu misuwa gino. Apoptosis nkola ya kufa kw’obutoffaali etegekeddwa nga yeetaagibwa okukuuma ensengekera y’ebitundu ebya bulijjo n’okukola mu mbeera z’omubiri. Wabula apoptosis ereetebwa adipotide etunuuliddwa nnyo emisuwa gy’omusaayi egy’ebitundu by’amasavu. Oluvannyuma lw’okufa kw’obutoffaali bw’emisuwa gy’amasavu, obulungi bw’emisuwa buba mu kabi, ekivaako okukendeeza ku bungi bw’omusaayi mu bitundu by’amasavu. Kino kisala bulungi 'payipu y'okutuusa ebiriisa' eri ebitundu by'amasavu, ekimalako obutoffaali bw'amasavu ebiriisa ebimala ne omukka gwa oxygen. N’olwekyo, obutoffaali bw’amasavu tebusobola kuyimirizaawo nkyukakyuka ya bulijjo n’okukula, okukkakkana nga bufa oba okukendeera, bwe kityo ne kituuka ku kukendeera kw’ebitundu by’amasavu ^[3,5]..

Ekifaananyi 1 Okukebera omubiri gw’enkima nnya eza rhesus ezigejjulukuka ezajjanjabwa n’eddagala lya adipotide eryeyongera (0.10, 0.25, 0.43, ne 0.75 mg/kg) ^[3]..

Ekivaako okugejja

Okukendeeza ku masavu: Adipotide ereeta apoptosis mu misuwa gy’amasavu, ekivaako okukendeera mpolampola kw’amasavu amazungu olw’okukendeera kw’omusaayi (ischemia) n’obutaba na mukka gwa mukka. Amasavu amazungu ge gakola ng’ekifo ekikulu eky’okutereka amasavu mu mubiri gw’omuntu. Okukendeera kwayo okw’amaanyi kwavaamu butereevu okugejja. Mu kugezesa okwali kuzingiramu enkima ennene, obukodyo bw’okukuba ebifaananyi nga magnetic resonance imaging (MRI) ne dual-energy X-ray absorptiometry (DXA) bwakakasa nti enkima ennene ennyo ezajjanjabwa adipotide zaayoleka okukendeera okw’amaanyi mu bitundu by’amasavu ebyeru, ekivaako okukendeera amangu mu buzito. Enkola eno ekiikirira okukendeera okwa nnamaddala kw’amasavu agaterekeddwa —si kufiirwa mazzi gokka oba okwonoona ebinywa —okuwa omusingi omunywevu ogw’omubiri ogw’okukendeeza ku buzito ^[4,5]..

Biki ebikozesebwa mu kukozesa eddagala lya Adipotide?

Obujjanjabi bw'omugejjo

Induction of Adipose Tissue Vascular Apoptosis: Okunoonyereza mu nkimye z’ensi enkadde ezigejjulukuka kwalaga nti Adipotide ereeta apoptosis egenderere munda mu nkola y’emisuwa gy’ebitundu by’amasavu ebyeru. Amasavu amazungu gakola kinene nnyo mu kutereka amaanyi n’okutereeza enkyukakyuka mu mubiri, era okukuŋŋaanyizibwa kw’amasavu amazungu ekisusse kye kisinga okuvaako omugejjo. Nga etumbula apoptosis mu misuwa gy’amasavu amazungu, Adipotide etaataaganya enkola y’omusaayi mu bitundu by’amasavu, ekivaako obutoffaali bw’amasavu okuyita mu apoptosis olw’obutabeera na biriisa bimala. Kino kituukiriza ekigendererwa ky’okukendeeza ku masavu amazungu n’okutumbula okugejja. Mu kunoonyereza kwa Barnhart KF, enkima ennene ennyo ezajjanjabwa n’eddagala lya Adipotide zafuna okugejja amangu, ekiraga nti zikola bulungi mu kujjanjaba omugejjo ^[3]..

Okulongoosa mu kuziyiza insulini: Omugejjo gutera okuwerekerwako okuziyiza insulini. Adipotide takoma ku kukendeeza ku buzito bw’omubiri wabula era alongoosa obuziyiza bwa insulini. Okuziyiza insulini kitegeeza embeera ng’ebitundu ebigendereddwamu biraga okukendeeza ku buwulize eri ebikolwa bya insulini, ekitegeeza nti dose za insulini eza bulijjo zikola okuddamu kw’ebiramu okutali kulungi. Kino kivaako glucose mu musaayi okulinnya era ne kireetawo obuzibu obuwerako mu nkyukakyuka y’emmere. Enkola Adipotide gy’eyamba okulongoosa obuziyiza bwa insulini eyinza okuzingiramu okukendeeza ku bitundu by’amasavu ebyeru, okulongoosa okufulumya adipokine, n’okulungamya amakubo agalaga obubonero bwa insulini. Mu kunoonyereza kwa Barnhart KF ku nkimye ezigejjulukuka, okuziyiza insulini kwatereera oluvannyuma lw’okuweebwa Adipotide ^[3]..

Nga Prototype for Obesity Therapeutics: Olw’enjawulo mu biramu wakati w’ebiwuka n’ebisolo ebiyitibwa primates, okuvvuunula enkola z’okulwanyisa omugejjo ezizuuliddwa oba ezaakolebwa mu biwuka mu bujjanjabi obulungi obw’abantu kyolekagana n’ebizibu ebinene. Obuwanguzi bwa Adipotide mu kunoonyereza ku primate (okugeza, enkima ezigejjulukuka) bugiteeka nga prototype for a novel class of therapeutic candidates ^[3]..

Mu bufunzi

Nga ligand-directed peptidomimetic, Adipotide eraga ebikolwa eby’enjawulo mu kunoonyereza ku primate: mu ngeri ey’enjawulo ereeta apoptosis mu misuwa gy’amasavu amazungu, ekendeeza okukuŋŋaanyizibwa kw’amasavu okutuuka ku kugejja, n’okulongoosa okuziyiza insulini okwekuusa ku mugejjo, bwe kityo n’ewa obusobozi obw’obujjanjabi obw’obujjanjabi bw’omugejjo.

Ebikwata ku Muwandiisi

Ebintu ebyogeddwako waggulu byonna binoonyerezeddwako, birongooseddwa era ne bikung’aanyizibwa kkampuni ya Cocer Peptides.

Omuwandiisi wa Scientific Journal

Kirstin F. Barnhart munoonyereza mukugu mu by’eddagala lya molekyu n’okukola eddagala. Abadde n’okunoonyereza okukolagana n’abawandiisi nga essira balitadde ku nteekateeka n’okwekenneenya ebirungo ebiyitibwa peptidomimetic compounds okukozesebwa mu bujjanjabi. Omulimu gwe guyamba okutumbula enkola z’okutuusa eddagala ezigendereddwamu n’okutegeera ebikosa mu bikolwa eby’okusooka okujjanjaba. Kirstin F. Barnhart awandiikiddwa mu kiwandiiko ekijuliziddwa [3].

▎ Ebiwandiiko Ebikwatagana

[1] Christianson D, Kolonin M, Hulvat J, Chan L, Arap W, Pasqualini R. Okuddamu okuteesa ku 'Eddagala lya Peptidomimetic erigenderera amasavu amazungu lireeta okugejja n'okulongoosa okuziyiza insulini mu nkimye ezigejjulukuka'. Sayansi Eddagala ly’okuvvuunula 2012; 4: 131lr2.DOI: 10.1126/eyakyusiddwa.3004103.

[2] Fiaschi T. Enkola z’Ekikolwa kya Adiponectin. Ekitabo ky’ensi yonna ekya Sayansi wa Molekyulu 2019; 20(12).DOI: 10.3390/ijms20122894.

[3] Barnhart KF, Christianson D. R., Hanley P. W., n’abalala. Enkola ya peptidomimetic egenderera amasavu amazungu ereeta okugejja n’okulongoosa obuziyiza bwa insulini mu nkimye ezigejjulukuka. Sayansi Eddagala ly’okuvvuunula 2011; 3(108): 108ra112.DOI: 10.1126/eyavvuunuddwa.3002621.

[4] Lalumiere R, Kalivas P. Omuze gwa cocaine: Enkola z’okukola. Ebitabo by’eby’obulamu bw’emitwe 2008; 38: 252-258.

[5] Criscione L. Comment on 'peptidomimetic egenderera amasavu amazungu ereeta okugejja n'okulongoosa okuziyiza insulin mu nkimye ezigejjulukuka'. Sayansi Eddagala ly’okuvvuunula 2012; 4 (131): 131le2, 131l-132l.DOI: 10.1126/scitranslmed.3003760.

EBINTU BYONNNA N’AMAWULIRE GW’EBINTU EBIweereddwa KU MUTINDO GUNO BIKOZESEBWA KU KUSASANYA AMAWULIRE N’EBIKOLWA BY’OKUSOMESA.  

Ebintu ebiweereddwa ku mukutu guno bigendereddwamu kunoonyereza mu kisenge (in vitro research) byokka. Okunoonyereza mu vitro (Olulattini: *mu ndabirwamu*, ekitegeeza mu bikozesebwa mu ndabirwamu) kukolebwa ebweru w’omubiri gw’omuntu. Ebintu bino si bya ddagala, tebikkiriziddwa kitongole kya Amerika ekivunaanyizibwa ku by’emmere n’eddagala (FDA), era tebirina kukozesebwa kuziyiza, kujjanjaba oba kuwonya mbeera yonna ya bujjanjabi, bulwadde oba bulwadde. Kikugirwa nnyo mu mateeka okuyingiza ebintu bino mu mubiri gw’omuntu oba ebisolo mu ngeri yonna.