▎ Vilon Ŋuti Numekuku
Nukae nye numekuku si Vilon wɔ?
1. Hiahiã Kpata be Woawɔ Numekuku le Tsitsi Kple Dɔlélewo Ŋu
Esi xexeame katã ƒe amewo ƒe tsitsi le kabakaba ta la, nya vovovo siwo ku ɖe tsitsi ŋu, abe lãmenugbagbeviwo ƒe tsitsi, lãmenugbagbeviwo ƒe dɔwɔwɔ dzi ɖeɖe kpɔtɔ, kple ame tsitsiwo ƒe dɔlélewo ƒe dzɔdzɔ fũ ene, va zu atikewɔwɔ me kuxi siwo gbɔ wòle be woakpɔ kpata. Lãmenugbagbeviwo ƒe tsitsi kpena ɖe ŋutete si bu vivivi be woalé lãmeka siwo gblẽ la me ɖe asi ahadzra wo ɖo, si wɔe be ele vevie ŋutɔ be woadi nusiwo ate ŋu ahe lãmenugbagbeviwo ƒe tsitsi ƒe ɖoɖoa ɖe megbe eye wòana lãmenugbagbeviwo ɖɔɖɔɖo ƒe dɔwɔwɔ nanyo ɖe edzi.
Le ɣeyiɣi ma ke me la, dɔléle gãwo abe kansa, lãmenugbagbeviwo ƒe dɔwɔwɔ, dzitodzito me dɔlélewo, kple aklãdɔlélewo dea amegbetɔ ƒe lãmesẽ afɔku me vevie. Seɖoƒe aɖewo li na atikewɔwɔmɔnu xoxowo le dɔléle siawo gbɔ kpɔkpɔ me, eye ehiã kpata be woato atikewɔwɔmɔnu kple atike yeyewo vɛ. Le kpɔɖeŋu me, kansadɔnɔ tsitsiwo melɔ̃a keklẽŋusẽdɔdamɔnu kple atikewɔmɔnu nyuie o, eye atikewɔwɔ ƒe ŋusẽkpɔɖeamedzia medzea ame ŋu o. Ele kpata be woadi atikewɔwɔmɔnu siwo le dedie eye wowɔa dɔ nyuie. Le nɔnɔme sesẽ sia tɔgbe me la, dzɔdzɔmeŋutinunyalawo trɔ woƒe susu ɖe bioactive peptides ŋu, kple mɔkpɔkpɔ be yewoakpɔ ŋgɔyiyi aɖe, eye numekuku si wowɔ tso Vilon ŋu va do.
2. Numekuku Siwo Wowɔ le Bioactive Peptides Ŋu ƒe Ŋgɔyiyi Sesẽ
Peptide-nu siwo le nugbagbewo me bɔ eye wokpɔa gome le ŋutilã ƒe dɔwɔwɔ vevi geɖe me, abe lãmenugbagbeviwo ƒe dzesiwo nana, dɔlélenutsiŋutete ƒe ɖoɖowɔwɔ, kple lãmenugbagbeviwo ƒe dɔwɔwɔ nyuie ene. Le ƒe ʋɛ siwo va yi me la, esi mɔ̃ɖaŋununyawo abe molecule biology kple biochemistry ene va le ŋgɔ yim kabakaba ta la, wowɔ ŋgɔyiyi gã aɖe le numekuku si wowɔ tso bioactive peptides ŋu me.
Dzɔdzɔmeŋutinunyalawo ate ŋu awɔ peptide vovovowo wòade pɛpɛpɛ wu, aɖe wo ɖe vovo, ahade dzesi wo, eye woaku woƒe dɔwɔwɔ ƒe mɔnuwo me tsitotsito. Numekuku gbogbo aɖewo ɖee fia be nugbagbeŋusẽ ƒe dɔwɔwɔ vovovowo le peptide siwo ƒe wɔwɔme to vovo, si he mɔkpɔkpɔ yeye vɛ be woakpɔ lãmesẽ kple dɔléle ƒe kuxiwo gbɔ. Le ɖoɖo sia me la, numekulawo srɔ̃ nu tso peptide gbogbo aɖewo ŋu to mɔnuwo abe dodokpɔ si me wowɔa dɔ nyuie le kple dɔwɔwɔ ƒe kpeɖodzinana ene dzi. Vilon, abe dipeptide si ƒe wɔwɔme le etɔxɛ eye wòate ŋu awɔ dɔ ene la, va le amewo ƒe susu me vivivi.
3. Lãmetsiwo Dzadzraɖo Kple Wo Gbugbɔgadzɔ ƒe Mɔnuwo Ŋuti Numekuku Deto
Lãmetsiwo dzadzraɖo kple wo gbugbɔgadzɔ nye nu vevi siwo ana nugbagbewo ƒe ŋutilã ƒe dɔwɔwɔ nyuie nalé ɖe te eye wowɔa nu ɖe abixɔxɔ ŋu. Gake dometsotso geɖe gakpɔtɔ le ɖoɖo sia gɔmesese fifia me, eye alesi woado lãmenugbagbeviwo ɖɔɖɔɖo kple wo gbugbɔgawɔ nyuie wu ɖe ŋgɔe va zu nusi ŋu numekukuwo ku ɖo. Lãmenugbagbeviwo wɔa akpa vevi aɖe le lãmenugbagbeviwo ɖɔɖɔɖo kple wo gbugbɔgadzɔ me, eye wolé ŋku ɖe numekuku siwo wowɔ tso woƒe dɔwɔwɔ, woƒe dzidziɖedzi, kple woƒe vovototodedeameme ƒe mɔnuwo ŋu vevie.
Tsɔ kpe ɖe eŋu la, nusiwo nye lãmenugbagbeviwo godo ƒe matriki ƒe wɔwɔme kple eƒe gbegblẽ kple lãmenugbagbeviwo dome dzesiwo hã kpɔa ŋusẽ vevi aɖe ɖe lãmenugbagbeviwo ƒe dzadzraɖo dzi. Esi numekulawo le lãmenugbagbeviwo ɖɔɖɔɖo kple wo gbugbɔgadzɔ ƒe mɔnuwo me dzrom la, wokpɔe be peptide aɖewo ate ŋu aɖɔ dɔwɔwɔ vevi siawo ɖo. Wonɔ te ɖe esia dzi le numekuku si wowɔ tso peptide siwo ate ŋu aɖɔ lãmenugbagbeviwo ƒe ɖɔɖɔɖo kple woƒe gbugbɔgadzɔ ɖo ŋu la de to ɖe edzi ɣesiaɣi. Vilon va zu numekuku vevi aɖe le go sia me le ŋusẽ si wòate ŋu akpɔ le kpekpeɖeŋu nana lãmenugbagbeviwo ƒe dɔwɔwɔ kple woƒe dzidziɖedzi kpakple fibroblast ƒe dɔwɔwɔ dzi kpɔkpɔ ta.
Nukae nye Vilon ƒe dɔwɔwɔ ƒe mɔnu?
1. Ŋusẽkpɔɖeamedzi ɖe Dzɔdzɔmeŋusẽŋununya Kple Domenyiŋusẽfianu ƒe Nyaɖeɖefia Dzi
Heterochromatin ƒe Ʋuʋu Dodo Ðe Ŋgɔ: Numekukuwo ɖee fia be Vilon ate ŋu ana heterochromatin bliboa ƒe ʋuʋu (deheterochromatization) naɖe le ame tsitsiwo ƒe ʋumenugbagbevi dzĩ siwo wode agble me [1] . Esia fia be ateŋu awɔ dɔ na ribosomal domenyiŋusẽfianuwo ƒe wɔwɔme si tso nucleolar organizing region ƒe deheterochromatization gbɔ eye wòaɖe asi le domenyiŋusẽfianu siwo woxe mɔ na le euchromatin nutoa ƒe condensation ta be woawɔ facultative heterochromatin. Le ɣeyiɣi ma ke me la, Vilon menaa heterochromatin si nye constitutive heterochromatin la ʋuʋuna ƒoa xlã centromere la o. Nusiwo do tso eme ɖee fia be Vilon awɔ facultative heterochromatin (deheterochromatization) dɔ vivivi ne ame tsi [1]..
2. Akpa Siwo Wowɔna Le Dɔlélewo Dada Me
Dɔdamɔnu Blibo na Kansa Dɔnɔwo: Le kansadɔnɔ tsitsiwo dada me la, wotsɔa Vilon dea atikewɔwɔ ƒe ɖoɖoa me abe dɔlélenutsiŋutete ƒe mɔxenu ene. Numekuku gbãtɔwo ɖee fia be Vilon zazã ate ŋu ana dɔnɔwo ƒe agbetsitsi ƒe 2 nanyo ɖe edzi, axe mɔ ɖe dɔwɔwɔ vɔ megbe kuxiwo, kuxi siwo le didiƒe, eƒe gbugbɔgadzɔ, kple dɔdzẽ ƒe kaka nu, eye wòana agbenɔnɔ nanyo ɖe edzi le atikewɔwɔ vevie megbe [2]..
Dɔlékuiwutike ƒe Ŋusẽkpɔɖeamedzi: Dodokpɔ siwo wowɔ le vitro me la, Vilon kpɔa ŋusẽ ɖe dɔdzẽ ƒe lãmenugbagbevi ƒomevi etɔ̃ ƒe tsitsi dzi le agbɔsɔsɔme si wozãna nu, siwo nye amegbetɔ ƒe dɔdzẽ si le dɔgboa me LOVO, amegbetɔ ƒe dɔgbo me kansa MKN45, kple amegbetɔ ƒe aklã me dɔdzẽ QGY7703, gake mekpɔa ŋusẽ si dze ƒã be wòaxe mɔ ɖe amegbetɔ ƒe ʋumenugbagbevi ɣi siwo sɔ dzi o [3] . Dodokpɔ siwo wowɔ tsɔ xe mɔ ɖe dɔdzẽ nu le agbe me ɖee fia be Vilon kpɔa ŋusẽ ɖe sisiblisi ƒe aklã me kansa H22 ƒe tsitsi dzi, eye agbɔsɔsɔ si wɔa dɔ nyuie enye 15mg・Kg-1. Ne wozã 30mg・Kg-1 ƒe agbɔsɔsɔ gã la, dɔdzẽ ƒe mɔxexe ɖe dɔdzẽ ƒe aklã me dɔdzẽ H22 si wodo na miawo me ƒe agbɔsɔsɔ si wu 60% [3] ..
Ŋusẽkpɔɖeamedzi ɖe Suklidɔlélawo Dzi: Le suklidɔ ƒomevi I ƒe dɔnɔ tsitsiwo gome la, Vilon, abe atikewɔwɔ bliboa ƒe akpa aɖe ene, ate ŋu ana ʋumenugbagbeviɣidɔ kple ʋu ƒe sisi ƒe dɔwɔwɔ nanyo ɖe edzi, si dzena abe dzɔdzɔmetike siwo tsia ʋumenugbagbeviɣidɔ nu (antithrombin III kple protein C) ƒe dzidziɖedzi kple fibrinolysis ƒe ʋuʋu ene [4] . Le ɣeyiɣi ma ke me la, zi geɖe la, Vilon ate ŋu aɖe insulin ƒe agbɔsɔsɔ si hiã be wòana carbohydrate ƒe asitɔtrɔ nali ke hã dzi akpɔtɔ. Tsɔ kpe ɖe eŋu la, ate ŋu aɖe T kpeɖeŋutɔ lãmenugbagbeviwo, NK lãmenugbagbevi siwo nɔa te ɖe T dzi kple esiwo menɔa te ɖe T dzi o ƒe agbɔsɔsɔ dzi akpɔtɔ hã, ana T ʋumenugbagbevi siwo le dɔ wɔm, B ʋumenugbagbevi dzĩwo, kple IgA ƒe agbɔsɔsɔ nasɔ ɖe ɖoɖo nu, eye wòakpɔ ŋusẽ ɖe dɔlélenutsiŋutete kple ʋu ƒe sisi ƒe dɔwɔwɔ dzi wòali ke [4]..
3. Ŋusẽkpɔɖeamedzi ɖe Lãmenugbagbeviwo Kple Ŋutilãwo ƒe Dɔwɔwɔ Dzi
Aklãmenugbagbeviwo ƒe Gbugbɔgadzɔ ƒe Dɔwɔna: Le aklã me ʋu ƒe sisi si carbon tetrachloride ƒe aɖi hena vɛ ƒe kpɔɖeŋu si wowɔ le sisiblisiwo me la, Vilon kpɔa ŋusẽ aɖe ɖe aklã me lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dɔwɔwɔ ƒe hayahaya kple aklã ƒe gbugbɔgadzɔ dzi le sisiblisi siwo ŋu aklãdɔ le me. Kwasiɖa eve le atike sia zazã megbe la, glucose-6-phosphatase (G6P) ƒe dɔwɔwɔ le sisiblisi siwo ŋu aklãdɔ le ƒe aklã me dzi ɖena kpɔtɔna, eye Vilon ate ŋu adzii ɖe edzi. Le sisiblisi siwo womewɔ atike na o gome la, glycogen bliboa kple eƒe akpa siwo le eme kpakple G6P ƒe dɔwɔwɔ gakpɔtɔ le alesi wònɔ do ŋgɔ na ʋumenugbagbeviɣidɔ. Le dodokpɔa katã me la, vovototo aɖeke mele glycogen phosphorylase (GP) kple glycogen synthase (GS) ƒe dɔwɔwɔ le sisiblisi siwo ŋu aklãdɔléle le ƒe aklã me le hatsotso eveawo siaa me kple dzidzenu siwo dzi woɖu la dome o. Vilon kpɔa ŋusẽ si gbɔdzɔ si doa ŋusẽ aklã le aklã ƒe gbugbɔgadzɔ le sisiblisi siwo ŋu aklãdɔléle le me, si dzena abe protein ƒe agbɔsɔsɔ bliboa kple ploidy ƒe agbɔsɔsɔ le aklãmenugbagbevi siwo le sisiblisiwo ƒe hatsotso evelia me la sɔ gbɔ wu 4.7% kple 11.5% wu esiwo le hatsotso gbãtɔ me [5]..
Dɔ si wòkpɔna ɖe ŋutinu siwo sea keklẽŋusẽ dzi: Vilon doa ŋusẽ thymocytes ƒe dzidziɖedzi ƒe dɔwɔwɔ eye wòdoa dɔgboa me lãmenugbagbeviwo ƒe dzidziɖedzi ƒe ŋutete ɖe ŋgɔ, si wɔnɛ be ŋutinu veviwo gahaya le keklẽŋusẽ megbe. Le kpɔɖeŋu me, numekuku siwo wowɔ le sisiblisi siwo me gblẽ o kple sisiblisi siwo wotsɔ gamma-ray keklẽ ɖeka (6Gy) na ŋutilã bliboa ŋu la ɖee fia be Vilon kpɔa ŋusẽ ɖe thymus, spleen, kple duodenum ƒe dɔwɔwɔ ƒe nɔnɔme dzi [6]..
4. Akpa Siwo Wowɔna le Molekyulãwo ƒe Dzidzenu
Mɔnu si Ate Ŋu Awɔ Abla Ðe Lãmetsiŋusẽ Ŋu: Molecular dynamics trajectory numekukuwo ɖee fia be Vilon (lysylglutamic acid dipeptide) kple thymopoietin (Glu-Trp) siaa me dze tɔdzisasrã siwo le molecule me le woƒe wɔwɔmewo me, si ɖea woƒe nɔnɔme ƒe asitɔtrɔ dzi kpɔtɔna. Le Lys ƒe axadzikɔsɔkɔsɔ si nye aliphatic ta la, Vilon te ŋu trɔna bɔbɔe wu. Wodo mɔnu aɖe si ate ŋu ato dipeptide la ƒe ligand-receptor bla ɖe lãkusi si doa dzidzɔ na ame ŋu, si fia be wòabla to nitrogen kple oxygen atɔm siwo wɔa dze ƒe tɔdzisasrãa dzi [7] ..
Ŋusẽkpɔɖeamedzi ɖe Protein ƒe ɖeɖefia dzi le Nucleolar Organizing Region: Vilon doa ŋusẽ AIDS proteinwo ƒe ɖeɖefia le nucleolar ɖoɖowɔha ƒe nuto siwo le serum tissue kple epithelial cell nuclei me eye wòxea mɔ na wo, eye wònaa ribosomes ƒe wɔwɔme, woƒe ƒoƒo ƒu, kple woƒe tsɔtsɔ yi cytoplasm me alo ɖea wo dzi kpɔtɔna, si wɔnɛ be protein ƒe wɔwɔme sesẽna le lãmenugbagbevi siawo me. Tsɔ kpe ɖe eŋu la, peptide sia doa thymocytes ƒe tɔtrɔ ɖe blast cells siwo le dzidzim ɖe edzi hã ɖe ŋgɔ [8] ..
Nukae nye Vilon ƒe dɔwɔwɔ?
1. Tsitretsitsi ɖe tsitsi ŋu
Wobua vilon be enye peptide si ate ŋu atsi tsitsi nu si ate ŋu ahe lãmenugbagbeviwo ƒe tsitsi ɖe megbe to dɔgbo ƒe dɔwɔwɔ nyuie wu, enzyme ƒe dɔwɔwɔ dodo ɖe ŋgɔ, kple nunyiamewo ƒe xɔxlɔ̃ dodo ɖe ŋgɔ me. Tsɔ kpe ɖe eŋu la, wokpɔe hã be Vilon te ŋu naa ŋutigbalẽ me kolagen ƒe ɖeɖefia nanyo ɖe edzi eye wòɖea ŋutigbalẽ ƒe tsitsi ƒe dzesiwo dzi kpɔtɔna. Numekukuwo ɖee fia be peptide KE (Lys-Glu, Vilon) ate ŋu ana collagen 1 ƒe ɖeɖefia ƒe teƒe nadzi ɖe edzi le ŋutigbalẽ me fibroblast siwo tsi wu ƒe dekɔnuwo me 83%; edzia sirtuin 6 ƒe ɖeɖefia ƒe teƒe hã ɖe edzi le ŋutigbalẽ ƒe fibroblasts ɖeviwo kple tsitsiwo ƒe dekɔnuwo me zi gbɔ zi 1.6 kple 2.6 [11] ..
2. Lãmetsiwo Dzadzraɖo Kple Wo Gbugbɔgadzɔ
Vilon ɖea ŋutete gã aɖe fiana le lãmenugbagbeviwo ɖɔɖɔɖo kple wo gbugbɔgawɔ me. Ate ŋu ado alɔ lãmenugbagbeviwo ƒe dɔwɔwɔ kple woƒe dzidziɖedzi, ana abi nahaya kabakaba eye wòana lãmenugbagbeviwo naɖɔ ɖo. Numekukuwo ɖee fia hã be Vilon ate ŋu ado ŋutigbalẽ, dɔgbo, kple lãkusi bubuwo dzadzraɖo ɖe ŋgɔ to fibroblast ƒe dɔwɔwɔ dzi kpɔkpɔ me. Numekukuwo ɖee fia be wotsɔ dipeptide si wowɔ si nye Vilon de explant culture medium me tso sisiblisi siwo xɔ ƒe vovovowo gbɔ. Nusiwo do tso eme ɖee fia be Vilon ateŋu ana lãmenugbagbeviwo ƒe nɔnɔme nali ke, ana lãmenugbagbeviwo ƒe gbugbɔgadzɔ kple dɔwɔwɔ nawɔ dɔ, eye wòakpɔ ŋusẽ ɖe sisiblisi tsitsiwo ƒe explants dzi vevie wu, si fia be ŋutete le Vilon ŋu le lãmenugbagbeviwo ɖɔɖɔɖo me [9]..
3. Dzitodzitowo Kple Ayikuwo Takpɔkpɔ
Vilon kpɔa ŋusẽ nyui ɖe dzitodzito kple ayiku ƒe lãmesẽ hã dzi. Ate ŋu ana dzitodzitowo ƒe dɔwɔwɔ nanyo ɖe edzi to domenyiŋusẽfianu ƒe ɖeɖefia ƒe ɖoɖo tɔtrɔ me eye wòana ʋuka suewo ƒe gege ɖe lãme na ame le ayikudɔlélewo me nanyo ɖe edzi, si ana ʋu ƒe sisi nyuie wu.
4. Dɔwɔwɔ le Kansa Dada Me
Dɔdamɔnu Blibo na Kansa Dɔnɔ Tsitsiwo: Le kansadɔnɔ tsitsiwo dada me la, wotsɔa Vilon dea atikewɔwɔ ƒe ɖoɖoa me abe dɔlélenutsiŋutete ƒe mɔxenu ene. Le kpɔɖeŋu me ..
Dɔnɔwo ƒe hatsotsowo me toto na kansa geɖewo: Nyatakaka ƒe vovototo si wotsɔ tsaka Layers of Networks algorithm (ViLoN) si Vilon xɔ la nye mɔnu yeye si wotu ɖe network dzi si woate ŋu azã atsɔ aƒo molecule ƒe anyigbatata geɖewo nu ƒu. Le dɔnɔwo ƒe hatsotsowo me toto gome la, woɖo kpe mɔnu sia dzi le nyatakaka ƒomevi vovovo siwo wotsɔ ƒo ƒui (domenyiŋusẽfianu ƒe ɖeɖefia, methylation, kɔpi xexlẽme), eye wòkpɔa ŋusẽ ɖe dɔnɔwo ƒe hatsotsowo me toto dzi ŋutɔ, eye hoʋiʋli ƒe ŋutete nɔa esi ɣesiaɣi le nɔnɔmeawo katã me. Le hatsotso suewo me (rectal adenocarcinoma: 90, esophageal cancer: 180), dɔwɔwɔ ŋuti sidzedze do ŋgɔ (KEGG, GO) dede eme le vevie ŋutɔ be woakpɔ emetsonu nyuiwo [10]..
5. Dɔwɔwɔ le Aklãdɔlélewo Dada me
Dɔwɔwɔ ɖe sisiblisi siwo ŋu aklãdɔ le ƒe aklã dzi: Wosrɔ̃ nu tso ŋusẽ si dipeptide dzadzraɖo 'Vilon' kpɔna ɖe aklã me lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe hayahaya kple aklã ƒe gbugbɔgadzɔ le sisiblisi siwo ŋu aklãdɔ le me ŋu. Wona Vilon (microgram 1.7/kg) sisiblisi siwo ŋu aklãdɔ si carbon tetrachloride ƒe aɖi hena vɛ hena ɣleti 4 eye wodo atike na wo gbesiagbe hena ŋkeke 5. Nusiwo do tso eme ɖee fia be le kwasiɖa eve le atike la zazã megbe la, glucose-6-phosphatase (G6P) ƒe dɔwɔwɔ, si dzi ɖe kpɔtɔ zi gbɔ zi 1.2 le aklãdɔ me la, dzi ɖe edzi le Vilon ƒe dɔwɔwɔ me. Vilon kpɔa ŋusẽ si gbɔdzɔ si doa ŋusẽ aklã le aklã ƒe gbugbɔgadzɔ le sisiblisi siwo ŋu aklãdɔléle le me, si dzena abe protein ƒe agbɔsɔsɔ bliboa kple ploidy ƒe agbɔsɔsɔ le aklãmenugbagbevi siwo le sisiblisiwo ƒe hatsotso evelia me la sɔ gbɔ wu 4.7% kple 11.5% wu esiwo le hatsotso gbãtɔ me [5]..
6. Dɔwɔwɔ le Lãmetsiŋusẽ ƒe Dɔdamɔnu Me
Ŋusẽkpɔɖeamedzi ɖe Suklidɔléla Tsitsiwo Dzi: Wozãa Vilon, abe thymic mimetic ene, abe atike kpeɖeŋutɔ ene le suklidɔ ƒomevi I ƒe dɔnɔ tsitsiwo dada bliboe me. Nusiwo do tso eme ɖee fia be Vilon zazã naa ʋumenugbagbeviɣidɔ kple ʋu ƒe sisi ƒe dɔwɔwɔ nyona ɖe edzi, si dzena abe dzɔdzɔme atike siwo tsia ʋumenugbagbeviɣidɔ nu (antithrombin III kple protein C) ƒe dzidziɖedzi kple fibrinolysis ƒe ʋuʋu me. Zi geɖe la, Vilon ɖea insulin ƒe agbɔsɔsɔ si hiã be wòana carbohydrate ƒe asitɔtrɔ nali ke dzi kpɔtɔna. Le ɣeyiɣi ma ke me la, Vilon ɖea T kpeɖeŋutɔ lãmenugbagbeviwo, NK lãmenugbagbevi siwo nɔa te ɖe T dzi kple esiwo menɔa te ɖe T dzi o hã dzi kpɔtɔna, eye wònaa T ʋumenugbagbevi siwo le dɔ wɔm, B ʋumenugbagbevi dzĩwo, kple IgA ƒe agbɔsɔsɔ nɔa ɖoɖo nu, si ɖee fia be Vilon kpɔa ŋusẽ ɖe dɔlélenutsiŋutete kple ʋumenugbagbeviɣidɔ ƒe dɔwɔwɔ dzi be wòali ke [4]..
7. Dɔwɔwɔ le Kekeli ƒe Nuveviwɔame ƒe Atikewɔwɔ me
Ŋusẽ si wòkpɔna ɖe ŋutinu siwo sea keklẽŋusẽ dzi: Wosrɔ̃ nu tso ŋusẽ si vilon kple epithalon kpɔna ɖe thymus, spleen, kple duodenum ƒe dɔwɔwɔ ƒe nɔnɔme dzi le sisiblisi kple sisiblisi siwo me gblẽ o siwo xɔ ŋutilã bliboa ƒe γ-ray keklẽ ɖeka si nye 6Gy la ŋu. Nusiwo do tso eme ɖee fia be vilon doa ŋusẽ thymocytes ƒe dzidziɖedzi ƒe dɔwɔwɔ eye wòdoa dɔgbo ƒe lãmenugbagbeviwo ƒe dzidziɖedzi ƒe ŋutete ɖe ŋgɔ, si wɔnɛ be ŋutinu veviwo ƒe hayahaya le keklẽŋusẽ megbe [6] ..
Le nyataƒoƒo me la, abe dipeptide tɔxɛ ene la, Vilon ate ŋu ana dɔgbo ƒe dɔwɔwɔ nanyo ɖe edzi, ahe tsitsi ɖe megbe, akpe ɖe lãmenugbagbeviwo ɖɔɖɔɖo kple wo gbugbɔgadzɔ ŋu, eye wòalé dzitodzito kple ayiku ƒe lãmesẽ me ɖe asi. Ekpɔa ŋusẽ nyui ɖe kansa, aklãdɔ, lãmenugbagbeviwo ƒe dɔwɔwɔ, kple keklẽŋusẽ ƒe abi dada hã dzi.
Le Agbalẽŋlɔla La Ŋu
Nusiwo míeyɔ ɖe etame la katã nye esiwo ŋu Cocer Peptides wɔ numekuku le, trɔ asi le wo ŋu eye woƒo wo nu ƒu.
Dzɔdzɔmeŋutinunya ƒe Nyadzɔdzɔgbalẽŋlɔla Kańduła MM nye numekula si do ƒome kple dɔwɔƒe xɔŋkɔ geɖewo, siwo dometɔ aɖewoe nye Janssen Atikewɔƒe, BOKU Yunivɛsiti, BOKU Vienna, Boston Yunivɛsiti, kple Johannes Kepler Yunivɛsiti Linz. Eƒe numekukua ku ɖe dɔ vovovowo ŋu, si ɖe eƒe nunya le nusɔsrɔ̃ vovovowo me fia. Le Biochemistry & Molecular Biology me la, ewɔ akpa aɖe le lãmenugbagbeviwo ƒe dɔwɔwɔ kple molecule ƒe kadodo gɔmesese dodo ɖe ŋgɔ me.
Dɔ si wòwɔ le Lãmenugbagbeviwo Ŋuti Nunya me bia be wòasrɔ̃ nu tso lãmenugbagbeviwo ƒe wɔwɔme kple dɔwɔwɔ ŋu, si le vevie ŋutɔ na atikewɔwɔmɔnu yeyewo toto vɛ. Le Biotechnology & Applied Microbiology me la, Kańduła MM ku mɔnu yeyewo me hena nugbagbevi suewo ƒe ɖoɖowo zazã atsɔ akpɔ kuxi ŋutɔŋutɔwo gbɔ. Eƒe numekuku le Life Sciences & Biomedicine - Other Topics me ɖee fia be eƒo eɖokui ɖe mɔnu kple mɔ̃ɖaŋununya deŋgɔ siwo ƒo dzɔdzɔmeŋutinunya ƒe liƒo xoxowo ta. Gakpe ɖe eŋu la, dɔ si wòwɔ le Mɔ̃ɖaŋuŋutinunya me ɖe ŋutete si le esi be wòatsɔ dzɔdzɔmeŋutinunya ƒe gɔmeɖosewo ade dɔwɔwɔ ŋutɔŋutɔ me fia. Kańduła MM to eƒe numekuku si me wòto le go geɖe me la, ewɔ akpa vevi aɖe le dzɔdzɔmeŋutinunyalawo ƒe habɔbɔa me, eye wòkpɔ ŋusẽ ɖe nukpɔsusu ƒe ŋgɔyiyiwo kple wo zazã ŋutɔŋutɔ siaa dzi le atikewɔwɔ kple nugbagbeŋutinunya me. Woŋlɔ Kańduła MM ŋkɔ ɖe nyayɔyɔ ƒe nyatakaka me [10].
