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1kits （10Ibikoresho）
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▎ Imiterere ya SS-31
Inkomoko: PubChem |
Urukurikirane: RXKF Inzira ya molekulari: C 32H 49N 9O.5 Uburemere bwa molekuline: 639.8g / mol Numero ya CAS: 736992-21-5 PubChem CID: 11764719 Synonyme: Elamipretide |
SS SS-31 Ubushakashatsi
Ni ubuhe bushakashatsi bwakozwe na SS-31?
SS-31 ni peptide ya opioide ikomoka kuri peptide ya feromone. Byabanje kuvumburwa mugihe cyubushakashatsi bwakozwe na peptide ya feromone, igaragaza ingaruka zikomeye zo gusesengura no kwanduza ingirabuzimafatizo nziza, bigatuma habaho kumenya antioxydeant peptide SS-311. Ubushakashatsi bwakozwe kandi bufitanye isano cyane nubushakashatsi ku ndwara zijyanye no kudakora neza kwa mitochondrial. Nka 'powerhouse ' y'akagari, imikorere mibi ya mitochondrial ifitanye isano no gutangira no gutera imbere kwindwara zitandukanye, nko gukomeretsa ischemia-reperfusion, indwara zifata ubwonko, kunanirwa k'umutima, no gusaza kw'imitsi, ibyo byose bikaba bifitanye isano na stress ya okiside iterwa n'umusemburo ukabije wubusa. SS-31 igabanya neza imbaraga za okiside kandi ikingira imikorere ya mito-iyambere.
Ni ubuhe buryo bwo gukora bwa SS-31?
Kugenzura imiterere ya membrane hejuru ya electrostatike:
SS-31 ikorana na mitochondrial membrane, ihindura imiterere ya electrostatike yubuso bwa membrane kugirango igabanye ikwirakwizwa rya ion na proteyine zifatizo kuri interineti. Ubushakashatsi bwerekanye ko SS-31 ishobora guhindura ikwirakwizwa ry’imisemburo ihwanye n’akarere ka membrane, bityo bikagabanya umutwaro w’ingufu ziterwa na calcium ya mitochondial kandi bikagumana ituze rya mitochondial [1,2].
Kugira gahunda ya lipide:
Iyi peptide irashobora gutera impinduka zidasubirwaho muburyo bwa lipide. Nubwo bidahungabanya ituze rya bilayeri ku guhuza kwinshi, birashobora kugira uruhare rutaziguye mu buryo butaziguye imikorere ya fiyologiki ya mitochondrial membrane, nk'imikorere ya poroteyine ya membrane na fluid fluid, bityo bikagira ingaruka nziza ku mikorere ya mitochondial [1,2].
Kubuza ibisubizo bitera:
Mu bushakashatsi bujyanye na sepsis, SS-31 byagaragaye ko igabanya ibintu bitera umuriro nka interleukin-6 (IL-6), interleukin-1β (IL-1β), hamwe n’ibibyimba bya niyosezi -α (TNF-α), bityo bikagabanya ibyangijwe n’ibisubizo byatewe n’ingingo n’ingingo [3].
Kugabanya imihangayiko ya okiside:
SS-31 irashobora kongera ibikorwa byimisemburo ya antioxydeant nka superoxide dismutase (SOD) na glutathione peroxidase, kugabanya urwego rwibicuruzwa byangiza nka malondialdehyde (MDA), kandi bikagabanya umusaruro wubwoko bwa ogisijeni ikora (ROS), bityo bikagabanya kwangirika kwa okiside iterwa ningirabuzimafatizo na selile . .
Kugenga imbaraga za mitochondrial dinamike:
Mu bushakashatsi bwakozwe kuri sepsis ifitanye isano na encephalopathie, SS-31 irashobora kubuza gukora cyane poroteyine ziterwa na mitochondrial nka proteine 1 (Drp1), kugabanya imitekerereze ikabije ya mitochondial, gukomeza imikorere ya mito-iyambere ya mito-iyambere, bityo bigatuma imikorere yubwenge [4] .
Igishushanyo 1. Uburyo bwo gukusanya no kurwanya antioxydeant ya Szeto-Schiller-31 (SS-31) [5].
Inkomoko: MDPI
Nibihe bikorwa nibikorwa bya SS-31?
Imikorere
Ingaruka zo gukingira selile:
Muri hydrogène peroxide (H₂O₂) yateje urugero rwa okiside itera kwangirika kwingirabuzimafatizo za ARPE-19, SS-31 irashobora kongera umuvuduko wokubaho kwingirabuzimafatizo, kugabanya ibirimo ROS yo mu nda, kugumana ubushobozi bwa mitochondrial membrane, no kugabanuka kwimpfu ziterwa na selile, bikerekana ingaruka zikomeye zo kurinda ingirabuzimafatizo zangijwe na stress ya okiside.
Kunoza imikorere yingingo
Umutima: Mubyitegererezo byinyamanswa ya myocardial ischemia-reperfusion igikomere, kwitegura hamwe na SS-31 mbere yo kwisubiraho byagabanije cyane ingano ya infoc ya myocardial, hamwe nibikorwa bifitanye isano neza nuburemere bwa ischemia myocardial; mugihe cyischemic, SS-31 yagabanije akarere katagabanuka mugace ka hypoperfused myocardial kandi byongera ubwinshi nuburemere bwa arththmias. Mu mikorere mibi ya sepsis iterwa na myocardial, SS-31 irashobora kugarura ibyangiritse byimitsi ya myocardial, ikabuza ibisubizo byokongoka, ikabura imbaraga za myocardial, igakomeza ubushobozi bwa mitochondrial membrane, kandi ikarinda umutima kwangirika [3].
Ibihaha: SS-31 irashobora kugabanya gusohora no kuribwa mu ngingo zifata ibihaha, amanota yo mu mateka y’ibihaha, kugabanya ibintu bitera umuriro hamwe n’ibipimo bifitanye isano na okiside, kandi bikanakomeretsa cyane ibihaha.
Ubwonko: Gutera inshinge za intraperitoneal ya SS-31 birashobora kunoza imikorere yubwenge nigipimo cyo kubaho mu mbeba, kugabanya uburibwe bwa hippocampal, umusaruro wa ROS, na hyperdivision ya mitochondrial. Muburyo bwimbeba yimbeba ishaje, kuvura SS-31 bitera impinduka muri proteome ya microcasculaire ya cortex yubwonko bwubwonko, bikagira ingaruka kumagambo ya poroteyine zifitanye isano na mitochondial, kandi bigira ingaruka nziza muburyo bwiza bwo guhindura imitekerereze ya mikorobe itwara imyaka mu bwonko [4,6].
Porogaramu
Indwara z'umutima n'imitsi:
Bitewe n'ingaruka zayo zo gukingira indwara ya myocardial ischemia-reperfusion hamwe na sepsis iterwa na myocardial dysfunction, SS-31 ifite agaciro gakoreshwa mugukumira no kuvura indwara z'umutima-damura, hamwe n’ubushobozi bwo gutezimbere nk'umuti mushya wo kuvura indwara ziterwa na infiyasiyo ya myocardial na sepsis iterwa na cardiomyopathie [3].
Indwara zifata ibihaha:
Ku mvune ikabije y'ibihaha iterwa na sepsis, SS-31 irashobora kuba uburyo bwiza bwo kuvura kugabanya umuriro no guhagarika umutima, bityo imikorere y'ibihaha ikanatanga uburyo bushya bwo kuvura abarwayi bafite ibikomere bikabije.
Indwara zifata ubwonko:
Muri sepsis ifitanye isano na encephalopathie n'indwara zifata ubwonko ziterwa n'imyaka, SS-31 yerekanye ubushobozi bwo kunoza imikorere yubwenge, byerekana ko ishobora gutera imbere mukuvura indwara zifata ubwonko nkindwara ya Alzheimer ndetse nubumuga bwa nyuma ya sepsis [4,6].
Atherosclerose:
Bitewe n'ingaruka zayo zo kuvura kuri ApoE gene-knockout atherosclerotic imbeba, SS-31 ifite ubushobozi bwo gukoreshwa mu kuvura indwara ziterwa na aterosklerotike mu kugabanya imihangayiko ya okiside no kudindiza indwara.
Umwanzuro
Muri make, SS-31 ni peptide ya antioxydants yibasiwe na mitochondial igenga imiterere ya electrostatike ya membrane yubutaka, ikabuza gucana, igabanya imihangayiko ya okiside, kandi igateza imbaraga za mito-iyambere. Irinda ingingo nkumutima, ibihaha, nubwonko, igabanya imvune ya ischemia-reperfusion hamwe n’ibyangiritse biterwa na sepsis, itinda gusaza kwa selile, kandi ikagira ingaruka zimwe na zimwe zo kuvura mu gukumira no kuvura indwara zifata umutima, imitsi, n’izindi ndwara zifatika, ndetse na aterosklerose.
Ibyerekeye Umwanditsi
Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.
Umwanditsi w'ikinyamakuru
Broome, Sophie C ifitanye isano na kaminuza Gatolika ya Ositaraliya na kaminuza ya Auckland. Ubushakashatsi bwe bwibanze ku bumenyi butandukanye, harimo Ubumenyi bwa Siporo, Physiologiya, Imirire & Dietetics, Biochemie & Molecular Biology, na Neurosciences & Neurology. Arakora iperereza ku ngaruka zimyitozo ngororamubiri ku mikorere y’umubiri n’ubuzima, asuzuma ibisubizo bya physiologique hamwe n’imihindagurikire y’imyitozo ngororamubiri. Broome yerekana kandi isano iri hagati yimirire nubuzima, hamwe nuburyo bukoreshwa mubinyabuzima na biyolojiya ya biologiya mubumenyi bwa siporo. Ibikorwa bye muri neuroscience na neurologiya bikomeza kutwongerera gusobanukirwa imikorere ya sisitemu yimitsi nindwara zifitanye isano nayo, itanga ubumenyi bwingirakamaro kandi bufatika mubumenyi bwa siporo nubushakashatsi bwubuzima. Broome, Sophie C yanditse murutonde rwibisobanuro [5].
