Cocer Peptides fɛ       a bɛ tile 22 bɔ

BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, U BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.  

Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *glasi kɔnɔ*, o kɔrɔ ye gilasi kɔnɔ) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.

Kuma bɛɛ lajɛlen

Timosini Alfa-1 (Tα1) ye polipɛtidi ye min maralen don kosɛbɛ, a bɛ kɛ ni asidi aminiki 28 ye min jɔyɔrɔ ka bon farikolo tangacogo labɛnni na farikolo kɔnɔ. A daminɛ na, a bɔra timisi bɔlenw na, wa a ye jɔyɔrɔba sɔrɔ farikolo tangacogo la k’a sababu kɛ a ka farikolo tangacogo kɛrɛnkɛrɛnnen ye. Banakisɛfagalanw dɛsɛ bɛ tali kɛ farikolo tangalanw ka baarakɛcogo la minnu tɛ kelen ye, o bɛ na ni banakisɛfagalanw ka se sɔrɔli dɔgɔyali ye ani ka farikolokisɛw bɔ yen minnu tɛ cogo la. Nin bana in bɛ se ka sɔrɔ fɛn caman fɛ, i n’a fɔ bangekɔlɔsi fɛɛrɛw ani fɛn sɔrɔlenw i n’a fɔ banakisɛw, dɔrɔguta, ani kuru jugumanw. Banabagatɔ minnu farikolo tangacogo ka dɔgɔn, olu ka banakisɛ sɔrɔli farati ka bon, wa banakisɛw ka teli ka kɛ sababu ye ka bana jugumanba lase u ma ani ka furakɛli gɛlɛyaw caya.

Jaa 1 Tα1 farikolo tangacogo ni a kɛcogo.

Banakisɛfagalanw ka fɛɛrɛw sɛgɛsɛgɛli kuncɛlen

T selilɛriw kɔgɔli ni u danfara labɛnni : Tα1 jɔyɔrɔ ka bon kosɛbɛ T selilɛriw kɔgɔli ni u danfara labɛnni na. Timi kɔnɔ, Tα1 bɛ se ka timi seliluw danfara lawuli, ka u jiginni sabati ka bɔ kɔrɔɲɔgɔnmaw la ka kɛ T selilɛri kɔgɔlenw ye. O kɛcogo in bɛ tali kɛ taamasiɲɛw sira caman na, i n’a fɔ ka siri fɛn kɛrɛnkɛrɛnnenw na minnu bɛ T-cellw sanfɛ, ka taamasiɲɛw cili cascades (selulu kɔnɔ taamasiɲɛw cili cascades) baara, ani ka fɛn dɔw bila seliluw jiracogo la minnu bɛ tali kɛ o la, o la, ka jamu jiracogo ɲɛnabɔ min bɛ tali kɛ T-cell yiriwali la. T-cell kɔgɔlenw jɔyɔrɔ ka bon farikolo tangacogo la farikolo tangacogo kɔnɔ, i n’a fɔ banakisɛw ni tumuw dɔnni n’u fagali. Tα1 bɛ T-cell kɔgɔli ni u danfara bonya, o la, a bɛ selilɛriw ka farikolo tangacogo barikama sigi farikolo la.

Banakisɛfagalan bangenenw ka baarakɛcogo : Tα1 fana bɛ baara kɛ ni farikolo tangalan bangenenw ye. Makrofagaw, i n’a fɔ farikolo tangalan bangenenw yɔrɔ nafamaw, olu bɛ dumunikɛ seko bonya kosɛbɛ Tα1 ka fanga kɔrɔ. Tα1 bɛ Toll-like receptors (TLRs) baara makɔrɔfagaw sanfɛ, ka jiginɛ taamasiɲɛw siraw daminɛ minnu bɛ makɔrɔfagaw bila ka sitokini suguya caman bɔ, i n’a fɔ tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), ani dɔ wɛrɛw. O sitokiniw tɛ makɔrɔfagaw yɛrɛ ka farikolo tangacogo fanga bonya dɔrɔn, nka u bɛ farikolo tangalan wɛrɛw fana ta ani k’u baara, o bɛ farikolo tangacogo caman daminɛ. Tα1 fana bɛ dɔ fara farikolo fagalanw (NK) farikolokisɛw ka sitotokisi baara kan, o b’a to u bɛ se ka banakisɛfagalanw walima tumuw dɔn ka ɲɛ ani k’u faga, o la, a bɛ farikolo tangalan fɔlɔ sigi sen kan.

Sitokiniw ka rezo balansi labɛnni : Sitokiniw bɛ baara kɛ i n’a fɔ cidenw farikolo tangalanw na, ka farikolo tangalanw ni farikolo tangalanw ka jɛɲɔgɔnyaw ɲɛnabɔ. Tα1 bɛ se ka sitokiniw ka rezo balansi labɛn tigitigi. Ni farikolo tangalanw ka dɔgɔn, Tα1 bɛ Th1 suguya sitokiniw (i n’a fɔ interferon-γ, IFN-γ) bɔli sabati, o bɛ farikolo tangalanw baara sabati. Ni farikolo tangalanw ka baara caya kojugu, Tα1 bɛ se ka banakisɛfagalan dɔw bɔli damatɛmɛ (i n’a fɔ interleukin-6, IL-6), o bɛ dɔ bɔ tiɲɛni na min bɛ sɔrɔ funu jaabiw fɛ farikolo la. Nin sira fila ɲɛnabɔli nɔ in b’a to Tα1 bɛ se ka farikolo tangalanw fanga ni u ɲɛsincogo ladilan ka kɛɲɛ ni farikolo tangacogo caman yeli ye, ka farikolo tangalanw ka homeostasis mara.

Banakisɛfagalanw ka muɲuni siraw daminɛni : Tα1 bɛ se ka triptophane kataboliki sira baara min bɛ tali kɛ farikolo tangacogo muɲuni na, a kɛtɔ ka farikolo tangalan anzimu indoleamine 2,3-dioxygenase (IDO) baara labɛn. IDO bɛ triptophane (triptophane) farikolojɔli kɛ sababu ye, o bɛ na ni triptophane hakɛ dɔgɔyali ye selilɛriw ka sigida lamini na, o la, a bɛ T-cell caya ni u baara bali, ka farikolo tangalanw muɲuni bila mɔgɔ la. Ni cogoyaw la i n’a fɔ farikolo tangalanw walima farikolo tangacogo banbaliya, Tα1 bɛ dɛmɛ ka farikolo tangacogo jugumanba tiɲɛ, a kɛtɔ ka nin sira in baara, ka farikolo tangalanw ka bana tiɲɛniw nɔgɔya, ani ka farikolo tangalanw sigida fitinin dɔ dilan min sabatilen don kosɛbɛ farikolo la.

Jɔrɔ min bɛ farikolo tangacogo dɛsɛ banaw la

Banakisɛfagalanw ka dɛsɛ bangenenw : Banakisɛfagalanw ka dɛsɛ bangenenw bɛ sɔrɔ jamu fɛ minnu bɛ na ni farikolo tangacogo dafalen ye walima a baarakɛbaliya ye. Banabagatɔ dɔw la minnu bangenen don ni T-cell farikolo tangacogo dɛsɛ ye, Tα1 furakɛli bɛ se ka T-cell baara ɲɛ kosɛbɛ. Ni farikolo tangalanw bangenen don ni timi ye, Tα1 bɛ timikisɛw danfara ni u kɔgɔli sabati, ka dɔ fara T selilɛri kɔgɔlenw hakɛ kan joli lamini na, ka farikolo tangacogo ɲɛ, ani ka banabagatɔ ka se ka banakisɛw kɛlɛ, o bɛ dɔ bɔ banakisɛw sɔrɔli caya ni a juguya la. Tα1 furakɛli waati dɔ kɔfɛ, T-cell kulu fitininw hakɛ bɛ segin a cogo kɔrɔ la dɔɔni dɔɔni, farikolo tangalanw hakɛ bɛ bonya, ani kɛnɛyaso taamasiɲɛw bɛ ɲɛ kosɛbɛ.

Banakisɛfagalan min bɛ sɔrɔ farikolo tangacogo la (SIDA): Sidabana bɛ sɔrɔ hadamaden farikolo tangalan banakisɛ (VIH) fɛ, o min bɛ CD4+ T lanposotiw de laɲini fɔlɔ, o bɛ na ni farikolo tangacogo tiɲɛni jugumanba ye. Tα1 jɔyɔrɔ ka bon kosɛbɛ sidabana furakɛli la. A bɛ se ka farikolo tangacogo sabati sidabanakisɛ bɛ mɔgɔ minnu na, ka dɔ fara CD4+ T selilɛriw hakɛ ni u baara kan, ani ka farikolo ka farikolo tangacogo segin a yɔrɔ dɔ la. Kɔlɔsiliw y’a jira ko ni Tα1 farala banakisɛfagalanw kan minnu bɛ baara kɛ kosɛbɛ (HAART), o bɛ se ka kɛ sababu ye ka CD4+ T selilɛriw hakɛ caya kosɛbɛ ani ka farikolo tangacogo kura sɔrɔ. Tα1 bɛ se fana ka sitokini balansi labɛn banabagatɔw la, ka funu jaabiw dɔgɔya, ka funu tiɲɛni basigilenw nɔgɔya sidabanakisɛ sɔrɔli fɛ ani farikolo tangacogo, ani ka banabagatɔw ka ɲɛnamaya kɛcogo ɲuman ni u ka ɲɛnamaya kɛcogo ɲɛ.

Jaa 2 Yɛlɛma donna sjTREC hakɛ la (kopiw/μ1 joli) PBMCw la ka bɔ kalan banabagatɔw la. Misaliw bɛ dannaya yɔrɔw jira 95% ani P hakɛ jatebɔlen ni Mann–Whitney U-test ye.

Farikolo tangacogo dɛsɛ min bɛ sɔrɔ tumu jugumanw fɛ : Tumu bɛ banabagatɔ minnu na, olu ka teli ka farikolo tangacogo tiɲɛ bana ka taa ɲɛ ani furakɛli kɔfɛ i n’a fɔ chimiothérapie ani radiothérapie. Tα1 bɛ se ka ɲɛtaa kɛ kosɛbɛ o siratigɛ la. A bɛ farikolo ka farikolo tangalan fanga bonya ni a bɛ farikolo tangalanw baara i n’a fɔ T-cell ani NK selilɛriw, o la u ka se ka tumuw dɔn ani k’u faga. Tα1 bɛ se ka chimiothérapie ni radiothérapie ka farikolo tangalanw dɔgɔya ani ka farikolo tangacogo seginni sabati. Banabagatɔ minnu ka fogonfogon kansɛri tɛ selilɛri fitiniw ye ani sugunɛ kansɛri minnu ye opereli kɛ ka u tigɛ, Tα1 tali furakɛli dɛmɛnanw na, o bɛ se ka ɲɛnamaya bɛɛ lajɛlen ɲɛ kosɛbɛ. Banabagatɔ minnu ka fogonfogon kansɛri bɛ sigida la, a tɛ se ka tigɛ, a tɛ se ka tigɛ, Tα1 bɛ se ka dɔ bɔ kosɛbɛ kɔlɔlɔw la i n’a fɔ farikolojidɛsɛ ni sɔgɔsɔgɔninjɛ minnu bɛ sɔrɔ chimiothérapie fɛ, wa, ŋaniya bɛ yen ka ɲɛnamaya bɛɛ lajɛlen ɲɛ.

Banakisɛfagalanw ka dɛsɛ min bɛ sɔrɔ banakisɛw fɛ : Banakisɛ jugumanw na, i n’a fɔ sepsis jugumanba, a ka ca a la farikolo bɛ don farikolo tangacogo la, o bɛ a to a ka gɛlɛn banabagatɔw ma ka banakisɛfagalan fɔlɔw kɛlɛ, ka dɔ bɔ banakisɛfagalanw tali la minnu bɛ sɔrɔ dɔgɔtɔrɔso la, ani ka dɔ fara banakisɛfagalanw seginni farati kan. A jirala ko Tα1 bɛ farikolo tangacogo segin a cogo kɔrɔ la ani ka dɛmɛ don ka dɔ bɔ banabagatɔw ka saya la minnu ka bana jugumanba bɛ u la. A bɛ o sɔrɔ ni farikolo tangalanw bangenenw baara ye ani ka T-cell baara ɲɛnabɔ walasa ka farikolo ka se ka banakisɛw saniya, ka sɔrɔ ka sitokiniw ka rezow sɛmɛntiya walasa ka tiɲɛniw nɔgɔya minnu bɛ sɔrɔ funu jaabi tɛmɛnenw fɛ, o la, banabagatɔ ka sɔrɔ bɛ ɲɛ.

Sisan kɛnɛyaso baarakɛcogo ani siniko nataw

Sisan kɛnɛyaso baarakɛcogo : Tα1 bɛ kɛ ka caya kansɛribanatɔw ni bana jugumanba bɛ minnu na, wa a kɛra teliya la ka kɛ farikolo tangalan ye ninakilibana jugumanba (SARS) ni COVID-19 banakisɛw waati. Dɔgɔtɔrɔso baarakɛcogo la, a ka ca a la, Tα1 bɛ kɛ farikolo jukɔrɔ pikiri fɛ, o bɛ muɲuli ɲuman jira, ni kalan fanba y’a jira ko sigida dimi dɔrɔn de bɛ kɛ pikiri kɛyɔrɔ la.

A faralen ɲɔgɔn kan ni furakɛlicogo wɛrɛw ye : Walasa ka furakɛli nafa bonya ka taa a fɛ, a ka ca a la, Tα1 bɛ kɛ ka fara furakɛlicogo wɛrɛw kan. Kansɛri furakɛli la, Tα1 bɛ jɛɲɔgɔnya barikama jira ni a ni chimiothérapie furaw farala ɲɔgɔn kan. A bɛ dɔ fara chimiothérapie furaw ka tumu kɛlɛli baara kan ka sɔrɔ ka u farikolo tangacogo nɔgɔya, o la, a bɛ banabagatɔw ka ɲɛnamaya kɛcogo ɲɛ. Kansɛri furakɛli la ni farikolo tangalanw ye (ICI), Tα1 fana bɛ se ka kɛ ɲɔgɔn fɛ. Tα1 bɛ se ka makɔrɔfaga M2 polarisiyɔn kɔsegin ni TLR7/SHIP1 aksidan baara ye, ka tumu kɛlɛli farikolo tangacogo ɲɛ, ka 'tumu fariganw' caman tigɛli kɛ 'tumu funtenimanw ye,' o la ka ICIw nafa ɲɛ. Tα1 fana bɛ se ka jɔyɔrɔba ta farikolo tangalanw ka kɔlɔlɔw nɔgɔyali la i n’a fɔ kɔnɔboli min bɛ sɔrɔ ICIw fɛ.

Kuncɛli

I n’a fɔ pepitiri furakɛli kura, Prostamax bɛ nafa jira ɲɛgɛnɛsira kɛnɛya siratigɛ la. K’a ta a kɛcogo kɛrɛnkɛrɛnnen na ka se a nɔba ma funu ɲɛnabɔli la, farikolo yɔrɔw jɔcogo sabatili la, ani bangekɔlɔsi baara yiriwali la, ani a kɛcogo suguya caman na kɛnɛyaso furakɛli la, banakunbɛn furakɛli la, ani furakɛli faralen ɲɔgɔn kan, a bɛ dɛmɛ don ɲɛgɛnɛsira banaw furakɛli ni u kunbɛnni na.

Sɛbɛn minnu bɛ tali kɛ o la

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[4] Stincardini C, Renga G, Villella V, ani a ɲɔgɔnnaw. Cellular proteostasis : fɛn kura min bɛ kɛ timosini α1[J] ka baara la. Dɔnnibaaw ka hakilina Biologique Therapie kan, 2018,18(sup1):43-48.DOI:10.1080/14712598.2018.1484103.

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[6] Chadwick D, Pido-Lopez J, Pires A, ani a ɲɔgɔnnaw. Sɛgɛsɛgɛli fɔlɔ min kɛra timosini alfa 1 lakanani ni a nafa kan farikolo tangacogo kura sabatili la sidabanakisɛ bɛ banabagatɔ minnu na, ni CD4 hakɛ ka dɔgɔn u la, minnu bɛ banakisɛfagalanw ta minnu bɛ baara kɛ kosɛbɛ[J Banakisɛfagalanw ka kɛnɛyako ni kɔrɔbɔli, 2003,134(3):477-481.DOI:10.1111/j.1365-2249.2003.02331.x.

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