CagriSema 10mg (Blend)

▎ Semaglutid yog dab tsi?

Semaglutid, raws li kev ua haujlwm ntev glucagon-zoo li peptide-1 (GLP-1) receptor agonist, tau siv dav hauv kev kho mob ntawm hom 2 mob ntshav qab zib mellitus. Los ntawm kev ua raws li kev ua haujlwm ntawm lub cev ntawm lub cev GLP-1, cov tshuaj no ua rau ntau yam kev tswj hwm cov txheej txheem metabolic tom qab ua kom lub GLP-1 receptor, suav nrog kev txhim kho cov piam thaj-dependent insulin secretion, inhibitory kev tswj ntawm glucagon tso tawm, qeeb ntawm lub plab khoob, thiab lub hauv paus qab los noj mov, yog li ua tiav kev tswj cov ntshav qabzib. Nws cov khoom siv tshuaj pharmacokinetic tshwj xeeb tso cai rau nws nrog ib nrab-lub neej txog li 7 hnub, txhawb kev txhaj tshuaj subcutaneous ib zaug ib lim tiam lossis kev tswj hwm qhov ncauj txhua hnub, uas ua rau muaj txiaj ntsig zoo rau kev kho mob ntawm cov neeg mob thiab txhim kho kev ua raws li cov tshuaj.

Cov ntaub ntawv soj ntsuam kuaj pom tau tias semaglutide tuaj yeem txo qis glycated hemoglobin (HbA1c) mus txog 1.8%, thiab qhov tshwm sim ntawm cov xwm txheej hypoglycemic tsawg heev, uas ua rau nws muaj txiaj ntsig zoo hauv kev tswj ntshav qabzib. Tsis tas li ntawd, cov tshuaj tiv thaiv kab mob plawv ntawm cov tshuaj no tau raug tshawb xyuas tag nrho, uas tuaj yeem txo qhov kev pheej hmoo ntawm cov kab mob plawv loj los ntawm 26%, muab cov txiaj ntsig kho mob ntxiv rau cov neeg mob ntshav qab zib nrog cov kab mob plawv. Ntxiv nrog rau kev kho mob ntshav qab zib mellitus, semaglutide tuaj yeem siv rau kev tswj hwm kev rog mus ntev thiab tau qhia tias muaj peev xwm kho tau tus nqi hauv kev tshawb fawb soj ntsuam ntawm cov kab mob xws li tsis muaj cawv steatohepatitis thiab Alzheimer's disease.

Qhov kev kho ntau lub hom phiaj no raws li GLP-1 receptor activation tsis tsuas yog ua kom zoo dua cov metabolism hauv cov metabolism los ntawm kev txhim kho insulin rhiab heev, inhibiting ntau glucagon secretion, thiab tswj lub hauv nruab nrab lub zog tshuav nyiaj li cas, tab sis kuj muab cov tswv yim kho tshiab rau kev tswj hwm kev noj qab haus huv ntawm cov kab mob metabolic los ntawm kev tiv thaiv kab mob plawv thiab cov txiaj ntsig zoo. Nws daim ntawv thov muaj peev xwm hauv ntau thaj chaw kab mob ntxiv tau lees paub txoj haujlwm tseem ceeb ntawm GLP-1 receptor agonists raws li txoj kev kho tseem ceeb hauv cov tshuaj niaj hnub metabolic.

▎ Cov ntsiab lus

Kev sib xyaw ntawm Cagrilintide thiab Semaglutid (Cagrisema) qhia tau hais tias muaj txiaj ntsig zoo hauv kev kho mob rog thiab hom 2 mob ntshav qab zib mellitus. Qhov kev sib xyaw ua ke no ua tiav ntau qhov kev tswj hwm ntawm kev qab los noj mov, cov ntshav qabzib metabolism, thiab kev tswj qhov hnyav los ntawm tib lub hom phiaj ntawm amylin thiab GLP-1 receptors. Cagrilintide tswj hwm los ntawm kev ncua lub plab zom mov thiab kev tswj hwm lub hauv paus satiety, thaum Semaglutid inhibits glucagon secretion thiab txhim kho insulin secretion. Cov nyhuv synergistic ntawm ob qhov ua rau muaj txiaj ntsig zoo ntawm kev poob phaus thiab tswj ntshav qabzib.

Cov ntaub ntawv soj ntsuam kuaj pom tau tias Cagrisema (kev sib xyaw ntawm Cagrilintide 2.4mg thiab Semaglutid 2.4mg) ua rau qhov hnyav nruab nrab ntawm 9.07% (qhov hnyav tag nrho ntawm 9.11kg) thaum lub sijhawm kho ntawm 20 mus rau 32 lub lis piam, uas yog qhov zoo dua li kev kho mob 1 lub lis piam ntawm kev siv 2mg ib ^leeg . Hauv 32 lub lis piam, multicenter, ob-dig muag, theem 2 kev soj ntsuam kuaj, qhov hnyav ntawm cov neeg mob kho nrog CagriSema tau ntau dua li cov neeg mob kho nrog Semaglutid lossis Cagrilintide ib leeg. 

Qhov poob phaus hauv pawg CagriSema yog -15.6%, uas hauv pawg Semaglutid yog -5.1%, thiab hauv pawg Cagrilintide yog -8.1% ^[2] . Tsis tas li ntawd, Cagrisema kuj ua tau zoo hauv kev txo glycated hemoglobin (HbA1c) thiab txhim kho cov kev pheej hmoo ntawm cov hlab plawv, thaum muaj kev pheej hmoo ntawm hypoglycemia tsawg heev. Los ntawm kev siv ntau lub hom phiaj, qhov kev kho mob sib xyaw ua ke no tsis yog tsuas yog ua kom zoo rau cov kab mob metabolic tab sis kuj txo qis kev pheej hmoo ntawm cov kab mob plawv, muab kev kho mob ntau dua rau cov neeg mob rog rog thiab hom 2 mob ntshav qab zib mellitus.

Hais Txog Tus Sau

Cov ntaub ntawv hais saum toj no yog txhua yam tshawb fawb, kho thiab sau los ntawm Cocer Peptides.

▎ Cov Lus Qhia Tseem Ceeb

[1] Dutta D, Nagendra L, Harish BG, et al. Kev ua tau zoo thiab kev nyab xeeb ntawm Cagrilintide Ib leeg thiab hauv kev sib xyaw nrog Semaglutid (Cagrisema) raws li Kev Noj Qab Haus Huv Kev Noj Qab Haus Huv: Kev Ntsuam Xyuas Txheej Txheem thiab Meta-Analysis[J]. Indian Journal of Endocrinology thiab Metabolism, 2024,28:436-444.DOI:10.4103/ijem.ijem_45_24.

[2] Frias JP, Deenadayalan S, Erichsen L, et al. Kev ua tau zoo thiab kev nyab xeeb ntawm kev sib koom ua ke ib zaug ib lub lis piam cagrilintide 2·4 mg nrog ib zaug ib lub lim tiam semaglutide 2·4 mg hauv hom 2 mob ntshav qab zib: multicentre, randomised, ob-dig muag, active-tswj, theem 2 trial[J]. Lancet, 2023,402(10403):720-730.DOI:10.1016/S0140-6736(23)01163-7.

Tag nrho cov kab lus thiab cov ntaub ntawv ntawm cov khoom lag luam muab rau ntawm lub vev xaib no tsuas yog rau cov ntaub ntawv tshaj tawm kev tshaj tawm thiab cov hom phiaj kev kawm.  

Cov khoom muab rau hauv lub vev xaib no yog npaj tshwj xeeb rau kev tshawb fawb hauv vitro. Kev tshawb fawb hauv vitro (Latin: * hauv iav *, lub ntsiab lus hauv iav) yog ua los ntawm tib neeg lub cev. Cov khoom no tsis yog tshuaj, tsis tau txais kev pom zoo los ntawm US Food and Drug Administration (FDA), thiab yuav tsum tsis txhob siv los tiv thaiv, kho, lossis kho txhua yam mob, kab mob, lossis mob. Nws raug txwv nruj raws li txoj cai los qhia cov khoom no rau hauv tib neeg lossis tsiaj lub cev hauv txhua daim ntawv.