CagriSema 10mg (Kuvanga)

Sem Semaglutid ni iki?

Semaglutid, nka glucagon ikora nka peptide-1 (GLP-1) reseptor agonist, yakoreshejwe cyane mubuvuzi bwa diyabete yo mu bwoko bwa 2. Mu kwigana imikorere ya physiologique ya GLP-1 karemano, uyu muti utera uburyo bwinshi bwo kugenzura metabolike nyuma yo gukora reseptor ya GLP-1, harimo no kongera imisemburo ya insuline iterwa na glucose, kugabanya irekurwa rya glucagon, gutinda kw'igabanuka ry’igifu, hamwe n’ingaruka zo guhagarika ubushake bwo kurya, bityo bikagera ku ngaruka zifatika zo kugenzura neza amaraso ya glucose no gucunga ibiro. Imiterere yihariye ya pharmacokinetic itanga ubuzima bwigice cyubuzima bwiminsi 7, igashyigikira gahunda yo gutera inshinge rimwe mubyumweru cyangwa uburyo bwo kuyobora umunwa burimunsi, ibyo bikaba byoroshya cyane uburambe bwo kuvura abarwayi kandi bikanonosora imiti.

Igeragezwa ry’amavuriro ryerekana ko semaglutide ishobora kugabanya cyane urwego rwa glycated hemoglobine (HbA1c) kugera kuri 1.8%, kandi indwara ziterwa na hypoglycemic ziri hasi cyane, ibyo bikaba biha inyungu idasanzwe mu micungire y’amaraso glucose. Byongeye kandi, ingaruka zo gukingira umutima n’umutima w’ibi biyobyabwenge zaragenzuwe neza, zishobora kugabanya ibyago by’indwara zikomeye zifata umutima n’amaraso ku kigero cya 26%, bigatanga izindi nyungu zo kuvura abarwayi ba diyabete bafite indwara zifata umutima. Usibye kuvura diyabete, semaglutide irashobora gukoreshwa mu gucunga igihe kirekire cy’umubyibuho ukabije kandi yerekanye agaciro ko kuvura mu bushakashatsi bw’amavuriro ku ndwara nka steatohepatite itari inzoga n'indwara ya Alzheimer.

Ubu buryo bwo kuvura intego nyinshi bushingiye kubikorwa bya GLP-1 ntabwo byorohereza gusa ibipimo bya metabolike mu kunoza ibyiyumvo bya insuline, kubuza gusohora glucagon ikabije, no kugenzura ikigo cy’ingufu zingana, ariko kandi gitanga uburyo bushya bwo kuvura uburyo bunoze bwo gucunga neza indwara ziterwa na metabolike zidakira binyuze mu ngaruka zo gukingira umutima ndetse n’inyungu zishobora guterwa na sisitemu yo hagati y’imitsi. Ubushobozi bwayo bukoreshwa mubice byinshi byindwara birashimangira kandi umwanya wingenzi wa GLP-1 reseptor agonist nkuburyo bwibanze bwo kuvura mubuvuzi bwa kijyambere.

Incamake​

Ihuriro rya Cagrilintide na Semaglutid (Cagrisema) ryerekana ingaruka zikomeye zo kuvura umubyibuho ukabije na diyabete yo mu bwoko bwa 2. Ubu buryo bwo kuvura bugera ku byiciro byinshi byo kurya, glucose glucose metabolism, hamwe no gucunga ibiro icyarimwe byibasira reseptor ya amylin na GLP-1. Cagrilintide igenga binyuze mu gutinda gusiba gastrica no kugenzura guhaza hagati, mugihe Semaglutid ibuza gusohora glucagon kandi ikongera insuline. Ingaruka ya synergiste yibi byombi byongera cyane ingaruka zo kugabanya ibiro no kugenzura glucose yamaraso.

Igeragezwa ry’amavuriro ryerekana ko Cagrisema (ikomatanya rya Cagrilintide 2.4mg na Semaglutid 2.4mg) itera kugabanuka ku kigereranyo cya 9.07% (gutakaza ibiro rwose 9.11kg) mugihe cyo kuvura ibyumweru 20 kugeza 32, bikaba byiza cyane kuruta uburyo bwo kuvura bwo gukoresha Semaglutide 2.4mg rimwe mu cyumweru wenyine ^[1] . Mugihe cyibyumweru 32, multicenter, impumyi ebyiri, icyiciro cya 2 cyamavuriro, gutakaza ibiro byabarwayi bavuwe na CagriSema byari byinshi cyane ugereranije nabarwayi bavuwe na Semaglutid cyangwa Cagrilintide bonyine. 

Kugabanuka ibiro mu itsinda rya CagriSema byari -15,6%, ko mu itsinda rya Semaglutid byari -5.1%, naho mu itsinda rya Cagrilintide byari -8.1% ^[2] . Byongeye kandi, Cagrisema nayo ikora neza mukugabanya glycated hemoglobine (HbA1c) no kunoza ibipimo byerekana ingaruka z'umutima-damura, mugihe ibyago byo kurwara hypoglycemia ari bike cyane. Binyuze muburyo butandukanye, ubu buryo bwo kuvura ntibuhindura gusa ibipimo bya metabolike ahubwo binagabanya cyane ibyago byindwara zifata umutima, bitanga uburyo bunoze bwo kuvura abarwayi bafite umubyibuho ukabije na diyabete yo mu bwoko bwa 2.

Ibyerekeye Umwanditsi

Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.

y'Ibyingenzi Imirongo

[1] Dutta D, Nagendra L, Harish BG, n'abandi. Ingaruka n'umutekano bya Cagrilintide Wenyine kandi Ufatanije na Semaglutid (Cagrisema) nk'imiti igabanya umubyibuho ukabije: Isubiramo rifatika hamwe na Meta-Isesengura [J]. Ikinyamakuru cyo mu Buhinde cya Endocrinology na Metabolism, 2024,28: 436-444.DOI: 10.4103 / ijem.ijem_45_24.

[2] Frias JP, Deenadayalan S, Erichsen L, n'abandi. Imikorere n'umutekano byafatanije rimwe mu cyumweru cagrilintide 2 · 4 mg hamwe na semaglutide rimwe mu cyumweru 2 · 4 mg muri diyabete yo mu bwoko bwa 2: multicentre, randomisme, impumyi ebyiri, igenzurwa cyane, igeragezwa ryicyiciro cya 2 [J]. Lancet, 2023,402 (10403): 720-730.DOI: 10.1016 / S0140-6736 (23) 01163-7.

INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.  

Ibicuruzwa bitangwa kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorerwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.