Icyiciro cyibicuruzwa

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Sangira kuri:

CagriSema 10mg (Kuvanga)

Cagrilintide ni Amylin-Calcitonin Receptor Agonist (DACRA) yo kugenzura metabolike.
Semaglutid ni GLP-1 yakira reseptor agonist ikoreshwa mukuvura metabolism yo mu bwoko bwa 2.
Iyo bihujwe, birwanya neza umubyibuho ukabije na metabolisme mu kugabanya ubushake bwo kurya no kuzamura ubuzima bwa metabolike. Gukoresha kwabo hamwe kunoza ibisubizo byubuvuzi kandi bigabanya ingaruka zumutima. Ibi bituma bagirira akamaro kanini abarwayi bafite metabolike, batanga ubuzima bwiza no kugabanya ingaruka ziterwa nindwara. Bagaragaje imbaraga nyinshi mu gucunga umubyibuho ukabije no guhindura metabolisme mu bigeragezo bivura, bagaragaza amasezerano yabo mu kuvura indwara ziterwa na metabolike.

Peptide izatangwa nkifu ya lyofilize kugirango ihamye neza.

Igiciro: $ 240

Icyitegererezo:
1kits （10Ibikoresho）

Kuboneka:

Mbere:

Ibikurikira:

Cagrilintide ni iki?

Semaglutid ni iki?

Incamake

Imirongo ijyanye

C Cagrilintide ni iki?

Cagrilintide ni Dual Amylin-Calcitonin Receptor Agonist (DACRA) yateguwe hashingiwe ku miterere ya molekile ya amylin. Mugihe kimwe cyo kwibasira no gukora reseptor ya amylin hamwe na reseptor ya calcitonine, irerekana ubushobozi bwo kugenzura ibipimo byinshi byerekana ibipimo bya metabolike, harimo nuburyo bwibikorwa nko gucunga ibiro, kubungabunga amaraso glucose homeostasis, no kugaburira ibyifuzo. Igitekerezo cyubushakashatsi niterambere ryacyo biva mubisesenguye byimbitse kumikorere ya physiologique ya amyline karemano: nka hormone isohorwa na selile pancreatic β selile, amylin naturel igira uruhare mukugenzura metabolisme yamaraso murwego rwinshi, nko kugenzura guhaga, kubuza gusohora glucagon, no gutinda gusohora gastric. Ariko, ivuriro ryayo rigarukira kubuzima buke (hafi iminota 20), bisaba ubuyobozi kenshi.

Cagrilintide yongerera igice cya kabiri cyiminsi 7 kugeza 8 binyuze mumihindagurikire ya molekile, bityo bikagabanya cyane inshuro zubuyobozi no kunoza cyane amavuriro. Iki gishushanyo kimaze igihe kinini nticyorohereza gusa uburyo bwo gutanga ibiyobyabwenge ahubwo kigera no kubikorwa byigihe kirekire mubibazo byo guhindagurika kwa metabolike mukomeza gukora amylin na calcitonine. By'umwihariko, Cagrilintide ifatanya kugira uruhare mu kubungabunga amaraso glucose homeostasis mu guhagarika ururenda rwa glucagon nyuma yo gutangira, gutinda gusohora gastrica, no kongera guhaga. Muri icyo gihe, imikorere yacyo ya reseptor ya calcitonine irusheho kunoza imikorere yo kurinda amagufwa no kugenzura ubushake bwo kurya. Ubu buryo bugamije guhuza byinshi butanga amahirwe menshi yo kuvura umubyibuho ukabije, ubwoko bwa 2 metabolism mellitus n'ingorane zabwo, kandi butanga ingamba zo kuvura uburyo bushya bwo gucunga neza syndrome de metabolike.

Sem Semaglutid ni iki?

Semaglutid, nka glucagon ikora nka peptide-1 (GLP-1) reseptor agonist, yakoreshejwe cyane mubuvuzi bwa metabolism mellitus yo mu bwoko bwa 2. Mu kwigana imikorere ya physiologique ya GLP-1 karemano, uyu muti utera uburyo bwinshi bwo kugenzura metabolike nyuma yo gukora reseptor ya GLP-1, harimo no kongera imisemburo ya insuline iterwa na glucose, kugabanya irekurwa rya glucagon, gutinda kw'igabanuka ry’igifu, hamwe n’ingaruka zo guhagarika ubushake bwo kurya, bityo bikagera ku ngaruka zifatika zo kugenzura neza amaraso ya glucose no gucunga ibiro. Imiterere yihariye ya pharmacokinetic itanga ubuzima bwigice cyubuzima bwiminsi 7, igashyigikira gahunda yo gutera inshinge rimwe mubyumweru cyangwa uburyo bwo kuyobora umunwa burimunsi, ibyo bikaba byoroshya cyane uburambe bwo kuvura abarwayi kandi bikanonosora imiti.

Igeragezwa ry’amavuriro ryerekana ko semaglutide ishobora kugabanya cyane urwego rwa glycated hemoglobine (HbA1c) kugera kuri 1.8%, kandi indwara ziterwa na hypoglycemic ziri hasi cyane, ibyo bikaba biha inyungu idasanzwe mu micungire y’amaraso glucose. Byongeye kandi, ingaruka zo gukingira umutima n’umutima w’ibi biyobyabwenge zaragenzuwe neza, zishobora kugabanya ibyago by’indwara zikomeye zifata umutima n’amaraso ku kigero cya 26%, bigatanga izindi nyungu zo kuvura abarwayi ba diyabete bafite indwara zifata umutima. Usibye kuvura metabolism, semaglutide irashobora gukoreshwa mugucunga igihe kirekire cyumubyibuho ukabije kandi yerekanye agaciro kavura mubushakashatsi bwamavuriro ku ndwara nka steatohepatite idafite inzoga n'indwara ya Alzheimer.

Ubu buryo bwo kuvura intego nyinshi bushingiye kubikorwa bya GLP-1 ntabwo byorohereza gusa ibipimo bya metabolike mu kunoza ibyiyumvo bya insuline, kubuza gusohora glucagon ikabije, no kugenzura ikigo gishinzwe kuringaniza ingufu, ariko kandi gitanga uburyo bushya bwo kuvura uburyo bunoze bwo gucunga neza indwara ziterwa na metabolike zidakira binyuze mu ngaruka zo gukingira umutima n’umutima. Ubushobozi bwayo bukoreshwa mubice byinshi byindwara birashimangira kandi umwanya wingenzi wa GLP-1 reseptor agonist nkuburyo bwibanze bwo kuvura mubuvuzi bwa kijyambere.

Incamake

Ihuriro rya Cagrilintide na Semaglutid (Cagrisema) ryerekana ingaruka zikomeye zo kuvura umubyibuho ukabije hamwe nubwoko bwa 2 metabolism mellitus. Ubu buryo bwo kuvura bugera ku byiciro byinshi byo kurya, glucose glucose metabolism, hamwe no gucunga ibiro icyarimwe byibasira reseptor ya amylin na GLP-1. Cagrilintide igenga binyuze mu gutinda gusiba gastrica no kugenzura guhaza hagati, mugihe Semaglutid ibuza gusohora glucagon kandi ikongera insuline. Ingaruka ya synergiste yibi byombi byongera cyane ingaruka zo kugabanya ibiro no kugenzura glucose yamaraso.

Igeragezwa ry’amavuriro ryerekana ko Cagrisema (ikomatanya rya Cagrilintide 2.4mg na Semaglutid 2.4mg) itera kugabanuka ku kigereranyo cya 9.07% (gutakaza ibiro rwose 9.11kg) mugihe cyo kuvura ibyumweru 20 kugeza 32, bikaba byiza cyane kuruta uburyo bwo kuvura bwo gukoresha Semaglutide 2.4mg rimwe mu cyumweru wenyine ^[1]. Mugihe cyibyumweru 32, multicenter, impumyi ebyiri, icyiciro cya 2 cyamavuriro, gutakaza ibiro byabarwayi bavuwe na CagriSema byari byinshi cyane ugereranije nabarwayi bavuwe na Semaglutid cyangwa Cagrilintide bonyine.

Kugabanuka ibiro mu itsinda rya CagriSema byari -15,6%, ko mu itsinda rya Semaglutid byari -5.1%, naho mu itsinda rya Cagrilintide byari -8.1% ^[2]. Byongeye kandi, Cagrisema nayo ikora neza mukugabanya glycated hemoglobine (HbA1c) no kunoza ibipimo byerekana ingaruka z'umutima-damura, mugihe ibyago byo kurwara hypoglycemia ari bike cyane. Binyuze muburyo butandukanye, ubu buryo bwo kuvura ntibuhindura gusa ibipimo byimikorere ahubwo binagabanya cyane ibyago byindwara zifata umutima, bitanga uburyo bunoze bwo kuvura abarwayi bafite umubyibuho ukabije hamwe nubwoko bwa 2 metabolism mellitus.

Ibyerekeye Umwanditsi

Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.

y'Ibyingenzi Imirongo

[1] Dutta D, Nagendra L, Harish BG, n'abandi. Ingaruka n'umutekano bya Cagrilintide Wenyine kandi Ufatanije na Semaglutid (Cagrisema) nk'imiti igabanya umubyibuho ukabije: Isubiramo rifatika hamwe na Meta-Isesengura [J]. Ikinyamakuru cyo mu Buhinde cya Endocrinology na Metabolism, 2024,28: 436-444.DOI: 10.4103 / ijem.ijem_45_24.

[2] Frias JP, Deenadayalan S, Erichsen L, n'abandi. Imikorere n'umutekano byafatanyirijwe hamwe rimwe mu cyumweru cagrilintide 2 · 4 mg hamwe na semaglutide rimwe mu cyumweru 2 · 4 mg muburyo bwa 2 metabolism: multicentre, randomized, impumyi ebyiri, igenzurwa cyane, igeragezwa ryicyiciro cya 2 [J]. Lancet, 2023,402 (10403): 720-730.DOI: 10.1016 / S0140-6736 (23) 01163-7.

INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.

Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.

Icyiciro cyibicuruzwa

CagriSema 10mg (Kuvanga)

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