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1kits （10Ibikoresho）
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Ucture Imiterere ya Glutathione
Inkomoko: PubChem |
Urukurikirane: XCG Inzira ya molekulari: C 10H 17N 3O 6S. Uburemere bwa molekuline: 307.33g / mol Umubare CAS: 70-18-8 PubChem CID: 124886 Synonyme: L-Glutathione |
Research Ubushakashatsi bwa Glutathione
Ni ubuhe bushakashatsi bwakozwe na Glutathione?
Kuvumbura no kugena imiterere ya glutathione
Glutathione yavumbuwe bwa mbere mu musemburo mu 1888. Mu 1921, abahanga bakomeje kumenya imiterere y’imiti. Glutathione ni tripeptide ikorwa na kanseri ya glutamic, sisitemu, na glycine binyuze mu mitsi ya peptide.
Kumenya uruhare runini rwibinyabuzima
Kuva mu 1930, abantu bamenye buhoro buhoro ko glutathione ifite imirimo itandukanye yibinyabuzima. Ifite uruhare muri redox reaction muri selile, igira uruhare runini mukubungabunga umutekano wibidukikije byimitsi no kurinda selile kwangirika kwa okiside. Hagati aho, igira kandi uruhare runini mubikorwa bya physiologiya nko gutwara aside amine no kugenzura ibikorwa bya enzyme. Ibyavuye mu bushakashatsi byashyizeho urufatiro rwo gukoresha glutathione mu rwego rwubuvuzi.
Ubushakashatsi ku nkomoko yabyo busabwa nubuvuzi busaba ubuvuzi
Hamwe nubushakashatsi bwimbitse bwimikorere ya physiologique ya glutathione, agaciro kayo gashobora gukoreshwa mubuvuzi kamaze kugaragara. Ikoreshwa mu kuvura indwara zitandukanye, nk'indwara z'umwijima n'indwara z'amaso, kandi irashobora no kuba antioxydeant. Kugira ngo glutathione ikenewe cyane mu mavuriro, abashakashatsi batangiye kwibanda ku gushakisha isoko nziza kandi ihamye ya glutathione, ibyo bikaba byaratumye ubushakashatsi bwimbitse ku nkomoko yabyo.
Ni ubuhe buryo bwo gukora bwa Glutathione?
Ingaruka ya Antioxydeant
Glutathione (GSH) ni antioxydeant igira uruhare muri sisitemu yo kwirinda antioxydeant muri selile. Irashobora kwitwara neza nubwoko bwa ogisijeni ikora (ROS) nka hydrogen peroxide (H₂O₂) ikabigabanya mubintu bitagira ingaruka [1, 2] . Kurugero, binyuze muri glutathione redox cycle, glutathione ifata H₂O₂ ikayihindura mumazi, bityo ikarinda selile kwangirika kwa okiside. Muri ubu buryo, glutathione ihindurwamo okiside glutathione (GSSG), ariko kugabanuka kwa glutathione mu kagari birashobora kugabanya GSSG gusubira muri GSH, bikagumana ubushobozi bwa antioxydeant ya selile. Byongeye kandi, glutathione irashobora kandi kurinda amatsinda -SH kuri selile ya selile, igira uruhare runini mugutwara cation no gutembera neza. Mugukomeza kugabanuka kwa membrane -SH matsinda, glutathione ifasha kugumya gutuza no gukora bisanzwe mumikorere ya selile [1].
Ingaruka zo kwangiza
Glutathione igira uruhare runini mugikorwa cyo kwangiza. Irashobora guhuza uburozi kugirango ikore ibintu bidafite uburozi cyangwa uburozi buke, byorohereza gusohoka mu mubiri. Kurugero, mu mwijima, glutathione ihuza ibintu bitandukanye byangiza kandi isohoka binyuze mu mara cyangwa inkari, ikarinda ingirabuzimafatizo umwijima kwangiza uburozi. Umwijima ningingo nyamukuru yangiza umubiri wumuntu, kandi uruhare rwa glutathione muri rwo ni ingenzi.
Ingaruka kuri sisitemu yumubiri
Glutathione ifite imirimo yingenzi mu ngirabuzimafatizo. Kurugero, muri macrophage, selile yica naturel, na T selile, irashobora kugenga imikorere ya selile, metabolism, kurekura cytokine ikwiye, ibikorwa bya redox, hamwe nurwego rwubusa [3] . Ingirabuzimafatizo zigira uruhare runini mu kurwanya indwara ziterwa na virusi no kubungabunga ubuzima bw'umubiri. Glutathione yongerera umubiri ubushobozi bwo kwirinda indwara igenga imikorere y'utugingo ngengabuzima. Glutathione irashobora guhagarika ibikorwa bya redox, guhindura umwirondoro wa cytokine werekeza kubisubizo byubwoko bwa Th1, kandi bikongera imikorere ya lymphocytes T, bityo bikagira uruhare runini mugutunganya ubudahangarwa no kwirinda antioxydeant [3] . Ubwoko bwa cytokine Th1 bugira uruhare runini mubisubizo byubudahangarwa bw'umubiri birwanya virusi nka virusi, bagiteri, na selile. Glutathione yongerera umubiri ubushobozi bwo kwirinda indwara igenga uburinganire bwa cytokine.
Ingaruka kuri sisitemu yimyororokere
Glutathione igira uruhare runini mu tugingo ngengabuzima tw’igitsina gabo n’umugore ndetse no mu ntangiriro yo gukura kwa emboro. Mu mikino y'abagabo n'abagore, GSH igira uruhare mu kurinda utugingo ngengabuzima kwangiza [4] . Kurugero, mugihe cya spermatogenezesi, kwibumbira hamwe kwa glutathione bigenda bigabanuka buhoro buhoro, mugihe mugihe cyo gukura kwa oocyte, synthesis ya glutathione igengwa na gonadotropine, kandi kwibanda kwayo nabyo birahinduka. Glutathione nayo ifitanye isano no kubungabunga morphologie ya meiotic spindle ya oocyte. Nyuma yo gusama, igira uruhare runini mu mikorere ya pronucleus yumugabo no gukura kwa urusoro rwo hambere kugeza kuri bastocyst. Mubyongeyeho, selile cumulus nayo igira uruhare runini muguhuza glutathione.
Inkomoko: Byatangajwe [9]
Ni ubuhe buryo bukoreshwa na Glutathione?
Gushyira mu bikorwa indwara y'umwijima
Indwara y'umwijima w'inzoga (ALD) n'indwara ikomeye irangwa no guhangayika cyane. Kunywa inzoga zidakira birashobora gutera okiside no gutwika, byangiza ingirabuzimafatizo. Glutathione (GSH), tripeptide igizwe na γ-glutamylcysteineglycine kandi irimo itsinda rya sulfhydryl, igira uruhare mu myitwarire ya redox kandi ni yo miyoboro nyamukuru ya radical scavenger mu ngirabuzimafatizo. Mu mwijima, ubukana bwa GSH buri hejuru cyane, ariko kubarwayi barwaye ALD, urwego rwa endogenous rugabanuka, bikabije. Kwiyongera kwa GSH kwerekanye ibisubizo byiza kubarwayi barwaye ALD, bashoboye kunoza imikorere yumwijima no kugabanya ibimenyetso bya fibrosis [5].
Uruhare mugutinda gusaza
Mu buryo butemewe, buhumye-buhumyi, bugenzurwa na placebo, bubangikanye, ubushakashatsi bwamaboko atatu yubuzima bwiza bwigitsina gore, indangagaciro ya melanin hamwe nuduce twa ultraviolet mumaso no mumaboko yibintu bifata GSH cyangwa GSSG akenshi byari munsi ugereranije nibyitsinda rya placebo. Mu turere tumwe na tumwe, iminkanyari yibintu bifata GSH yagabanutse cyane, kandi ugereranije nitsinda rya placebo, ubworoherane bwuruhu rwamatsinda ya GSH na GSSG bwerekanaga uburyo bwo kwiyongera. Ubu bushakashatsi bwerekana ko glutathione igira ingaruka nziza mugutinda gusaza kwuruhu [6].
Gushyira mu bikorwa indwara ya Parkinson
Indwara ya Parkinson (PD) ni indwara yo mu mutwe. Ubushakashatsi bwerekanye ko glutathione (GSH) ishobora kugira ingaruka zo kuvura kuri PD. Binyuze mu bushakashatsi butunganijwe bwububiko bwinshi hamwe na meta-isesengura, byagaragaye ko hari itandukaniro rinini ry’imibare muri Unified Parkinson's Disease Rating Scale (UPDRS) III hagati ya GSH nitsinda rishinzwe kugenzura, kandi hari itandukaniro rikomeye muri glutathione peroxidase. Ariko, nta tandukanyirizo rishingiye ku mibare ryari hagati yaya matsinda yombi mu manota ya UPDRS I na UPDRS II kimwe n’ingaruka mbi. Byongeye kandi, isesengura ryitsinda ryerekanye ko igipimo (300mg na 600mg) cyari ikintu cyagize ingaruka kuri UPDRS III. Ibi byerekana ko GSH ishobora kuzamura gato amanota ya moteri ya PD itiriwe yongeraho ibintu bibi [7].
Gushyira mu bikorwa indwara z'umutima
Kwirinda indwara zifata umutima
Indwara z'umutima-damura nka coronari arteriire, indwara z'umutima ukabije, hamwe na stroke, indwara nyinshi z'umutima-dameri zitera imiterere ya stress ya okiside mugihe cyiterambere ryabo, bigatuma imiterere yabarwayi yangirika, ibyo bikaba bifitanye isano no gukora ubwoko bwa ogisijeni ikora (ROS) nubwoko bwa azote (RNS). Kugabanya glutathione (GSH), nka antioxydeant ikomeye, irashobora kugira uruhare mukurwanya okiside yibi bintu byangiza. GSH ikomatanyirizwa mu mutima no mu mwijima kandi ifite akamaro kanini mu gukumira cyangwa kugabanya ingaruka mbi za ROS mu ndwara zifata umutima [8].
Indwara z'umutima
Urwego rwo hasi rwa glycine rufitanye isano n'indwara z'umutima n'imitsi (CVD). Ubushakashatsi bwerekanye ko ibura rya glycine rishobora kongera iterambere rya aterosklerose, mu gihe inyongera ya glycine ishobora kuyigabanya. DT-109, ibice bishingiye kuri glycine hamwe na lipide ebyiri zigabanya / glucose-igabanya, bifite ingaruka zikomeye zo kurinda indwara ya aterosklerose. Ubushakashatsi bwakozwe ku barwayi barwaye indwara z'umutima, imbeba za atherosklerotike, na macrophage zerekanye ko glycine igira uruhare mu gutera indwara ya aterosklerose, kandi ubuvuzi bushingiye kuri glycine bushobora kugabanya aterosklerozose binyuze mu ngaruka za antioxydeant itera glutathione biosynthesis [9].
Gukoresha mukurinda no kuvura indwara zamaso
Kwirinda no kuvura cataracte
Mubuvuzi bw'amaso, glutathione irashobora gukoreshwa mugukumira no kuvura cataracte. Ubushakashatsi bwerekanye ko kuba cataracte ifitanye isano rya bugufi no kwangiza okiside mu lens. Nka antioxydants, glutathione irashobora kugabanya ingaruka ziterwa na okiside kuri selile kandi ikagumana imikorere isanzwe yinzira. Kurugero, mubushakashatsi bwakozwe, hagaragaye ikoreshwa ryibitonyanga byamaso birimo glutathione mukuvura abarwayi ba cataracte kugirango bigabanye urugero rwa lens opacite no kunoza icyerekezo kurwego runaka [10].
Kwirinda no kuvura retinopathie
Retinopathie ni indwara y'amaso ikunze kugaragara, kandi kuba bibaho bifitanye isano nibintu nka stress ya okiside ndetse no gusubiza umuriro. Glutathione irashobora, binyuze mu ngaruka zayo za antioxydeant, kugabanya kwangirika kwa okiside kwingirangingo zumwijima, bikabuza kwifata, bityo bikarinda ingirabuzimafatizo. Byongeye kandi, glutathione irashobora kandi guteza imbere imikorere ya metabolike yingirabuzimafatizo no kongera ubushobozi bwo kwikosora bwa retina ..
Gukoresha muri sclerose nyinshi
Muri sclerose nyinshi, kwangirika kwa neuronal bifitanye isano na stress ya okiside. Dimethyl fumarate (DMF) nuburyo bwiza bwo kuvura umunwa kandi byagaragaye ko bigabanya ibikorwa byindwara niterambere ryaba barwayi bafite sclerose nyinshi. DMF irashobora gukora ibintu byandikirwa ibintu bya kirimbuzi erythroide 2 ifitanye isano na 2 (NRF2), biganisha ku kwiyongera kwa synthesis ya antioxydeant selile glutathione (GSH) kandi ifite ingaruka zikomeye za neuroprotective muri vitro. Ubushakashatsi bwerekanye ko DMF itera glutathione reductase (GSR), ikongera ikoreshwa rya glutathione itera GSR [6].
Gushyira mu bikorwa indwara ya Alzheimer
Mu ndwara ya Alzheimer, amyloide β-peptide (Aβ) ifatwa nk'imwe mu mpamvu zingenzi zitera indwara ya Alzheimer (AD). Ferroptose ni uburyo bushya bwo kumenyekanisha okiside ya selile ifitanye isano na AD. Tetrahydroxystilbene glucoside (TSG) ni ingirakamaro mu kugabanya imyigire no kwibuka muri AD hamwe na moderi yimbeba ishaje. Ubushakashatsi bwerekanye ko TSG irwanya urupfu rwa neurotoxique yingirabuzimafatizo zatewe na Aβ muguhindura poroteyine na ferime ziterwa na ferroptose mu mbeba za APP / PS1, bikagabanya imihangayiko ya okiside ya selile no kwangirika kw’umuriro, kandi bigateza imbere imikorere ya GSH / GPX4 / ROS na Keap1 / Nrf2 / ARE byerekana inzira. Byongeye kandi, TSG igabanya kandi ibimenyetso byerekana ibimenyetso bifitanye isano na ferroptose kandi ikongerera ubushobozi bwo kurwanya imbaraga za okiside [11].
Kuvura indwara zubuhumekero
Kuvura indwara zidakira zidakira (COPD)
Ku barwayi bafite indwara zidakira zifata ibihaha, gutwika umwuka no guhagarika umutima ni ibintu by'ingenzi biganisha ku gutera imbere. Glutathione irashobora kugabanya gucana umwuka no kunoza imikorere yubuhumekero binyuze muri antioxydeant. Irashobora gusibanganya radicals yubusa mumuyaga, kugabanya kwangirika kwingutu ya okiside itera selile epithelial selile, bityo bikagabanya uburibwe bwumwuka. Byongeye kandi, glutathione irashobora kandi kugenzura imikorere yubudahangarwa no kongera umubiri kurwanya indwara ziterwa na virusi ..
Gukoresha indwara zirwa
Ku barwayi bafite indwara zo mu kirwa hamwe n’abarwayi ba diyabete ya serumu, hasuzumwe glutathione reductase na glutathione peroxidase. Ubushakashatsi bwerekanye ko muri iyi ndwara, ubusumbane buri mu kigereranyo cya okiside na antioxydants bishobora kuba bifitanye isano n’imiterere [13].
Nka compound tripeptide igizwe na aside glutamic, cysteine, na glycine, glutathione igira uruhare runini mubinyabuzima, nkibikorwa bya antioxydeant, kwangiza, kugenzura ubudahangarwa, no kugira ingaruka kumyororokere. Kuva yavumburwa, hamwe n’ubushakashatsi bwimbitse, agaciro kayo gakoreshwa mu rwego rw’ubuvuzi karakomeje kugaragara, kigaragaza ingaruka nziza mu kuvura cyangwa gukumira indwara zitandukanye, zirimo indwara y’umwijima w’inzoga, indwara ya Parkinson, indwara zifata umutima n’indwara z’amaso. Nubwo uburyo bwa porogaramu zimwe na zimwe hamwe n’ingaruka z’ingaruka zabwo mu ndwara zimwe na zimwe bikomeje gushakishwa, glutathione ifite akamaro kanini mu kubungabunga ubuzima bw’umubiri no gukumira no kuvura indwara.
Ibyerekeye Umwanditsi
Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.
Umwanditsi w'ikinyamakuru
Rom O ni umushakashatsi w'umuhanga ukorana n’ibigo byinshi bizwi, birimo ikigo cy’ubumenyi cy’ubuzima cya kaminuza ya Leta ya Louisiana i Shreveport, Sisitemu ya kaminuza ya Leta ya Louisiana, Kaminuza ya Pittsburgh, na kaminuza ya Michigan. Ibikorwa bye byahujwe n’ibigo bizwi nka Lsuhs Shreveport na Michigan Med, byerekana uruhare yagize mu masomo akomeye y’ubuvuzi n’ubuvuzi.
Ubushakashatsi bwa Rom O bushingiye kumurongo mugari wibyiciro. Ubuhanga bwe buri mubice bya Cardiovascular System & Cardiology, Hematology, Endocrinology & Metabolism, Biochemistry & Molecular Biology, na Gastroenterology & Hepatology. Hamwe n'umwuga wibanze kuri izi nzego zigoye zo kwiga, yagize uruhare mu guteza imbere ubumenyi no gusobanukirwa muri aya mashami akomeye ya siyanse yubuvuzi.yashyizwe ku rutonde rwavuzwe [9].
