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▎ Igice cya TB4 (17-13) Imiterere
Inkomoko: PubChem |
Urukurikirane: LKKTETQ Inzira ya molekulari: C 36H 66N 10O.13 Uburemere bwa molekuline: 847.0 g / mol Numero ya CAS: 476014-70-7 PubChem CID: 10169788 Synonyme: Fequesetide ； HY-P2463 ； LKKTETQ |
▎ Igice cya TB4 (17-13) Ubushakashatsi
Ni ubuhe buryo bwo gukora bw'igice cya TB4 (17-13)?
1. Uburyo bwo guteza imbere ingirabuzima fatizo
Igice cya TB4 (17-13) kigira uruhare runini mugutezimbere ingirabuzima fatizo. Irashobora kugera kuriyi mikorere binyuze muburyo bukurikira:
Gukangura ingirabuzimafatizo no gutandukanya
Iki gice gishobora guhuza ibyakiriwe byihariye hejuru yimikorere ya selile kandi bigakora inzira yerekana ibimenyetso byerekana inzira, bityo bigatera ikwirakwizwa ryimikorere no gutandukana. Kurugero, irashobora gukora inzira yerekana ibimenyetso bijyanye no gukura kwakagari no kugabana, nka mitogen-ikora protein kinase (MAPK) n'inzira ya fosifatidilinositol 3-kinase (PI3K) / protein kinase B (Akt) inzira [1] . Gukora kwizi nzira birashobora guteza imbere iterambere ryingirabuzimafatizo, kongera umubare w'utugingo ngengabuzima, bityo bigateza imbere ingirabuzima fatizo.
Byongeye kandi, agace ka TB4 (17-13) karashobora kandi guteza imbere gutandukanya selile muguhindura imvugo ya genes yihariye. Irashobora kugira ingaruka kumikorere yibintu byandikirwa bijyanye no gutandukanya selile, bityo bikagenga itandukanyirizo ryingirabuzimafatizo mu cyerekezo runaka kandi bigatanga ubwoko butandukanye bwingirabuzimafatizo zikenewe kugirango hahindurwe ingirabuzimafatizo.
Guteza imbere angiogenez
Kuvugurura imyenda mubisanzwe bisaba gutanga amaraso ahagije, kandi angiogenezi ninzira yingenzi yo gutanga amaraso. Igice cya TB4 (17-13) kirashobora guteza imbere angiogenez mugukwirakwiza ikwirakwizwa, kwimuka, hamwe na lumen yibibyimba bigize selile endoteliyale. Irashobora gukora uburyo bwo kwerekana ibintu bifatika nka angiogenic nkimikurire yimitsi iva mu mitsi (VEGF), bityo bigatuma habaho imiyoboro mishya yamaraso [1] . Imiyoboro y'amaraso imaze gushingwa irashobora gutanga ogisijeni, intungamubiri, hamwe nibintu bikura kumubiri wangiritse, byihutisha inzira yo kuvugurura ingirangingo.
2. Uburyo bwo gukora ingaruka zo kurwanya inflammatory
Gutwika ni igisubizo kirinda umubiri gukomeretsa cyangwa kwandura, ariko igisubizo kirenze urugero gishobora gutera kwangirika kwimitsi no kudakora neza. Igice cya TB4 (17-13) gifite ingaruka zo kurwanya inflammatory, kandi uburyo bwacyo bushobora kuba bukubiyemo ibintu bikurikira:
Kubuza gukora no kwinjiza ingirabuzimafatizo
Ibisubizo bitwika mubisanzwe bikubiyemo gukora no kwinjiza ingirabuzimafatizo zitandukanye, nka neutrophile, macrophage, na lymphocytes. Igice cya TB4 (17-13) kirashobora kugabanya igisubizo cyumuriro muguhagarika gukora no kwinjiza utugingo ngengabuzima. Kurugero, irashobora kubuza imvugo ya reseptors hejuru ya selile yaka umuriro, bikagabanya igisubizo cyingirabuzimafatizo yibimenyetso byerekana umuriro; cyangwa muguhindura ibimenyetso byimuka byingirabuzimafatizo, kugabanya kwinjiza ingirabuzimafatizo zangiritse kurubuga rwangiritse [1].
Byongeye kandi, iki gice gishobora no guhindura imikorere ya metabolike yingirabuzimafatizo kandi ikabuza ibikorwa bya selile. Kurugero, irashobora kugenga ingufu za metabolisme yingirangingo zumuriro, kugabanya umusaruro wubwoko bwa ogisijeni ikora (ROS) hamwe na cytokine itera inflammatory na selile, bityo bikagabanya ibisubizo byumuriro.
Kugenga imvugo no kurekura abunzi batera umuriro
Mugihe cyo gusubiza umuriro, hakorwa abunzi batandukanye batwika, nka cytokine, chemokine, na prostaglandine. Aba bahuza b'umuriro barashobora kurushaho kongera igisubizo cyo gutwika, biganisha ku kwangirika kw'imitsi. Igice cya TB4 (17-13) gishobora kugira ingaruka zo kurwanya inflammatory muguhindura imvugo no kurekura abunzi batera umuriro. Kurugero, irashobora kubuza imvugo ya cytokine itera inflammatory, nka tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), na interleukin-6 (IL-6); kandi icyarimwe, teza imbere imvugo ya cytokine irwanya inflammatory, nka interleukin-10 (IL-10) [1].
Byongeye kandi, iki gice gishobora no kugira ingaruka kumvugo ya chemokine, kugabanya kwinjiza ingirabuzimafatizo; cyangwa kugenga synthesis ya prostaglandine, kugabanya igisubizo cyo gutwika.
3. Uburyo bwo kugera ku gusana byihuse
Uburyo bwibikorwa byigice cya TB4 (17-13) mugusana byihuse birashobora kuba bifitanye isano rya hafi ningaruka zabyo zo kuvugurura ingirabuzimafatizo no kurwanya indwara. By'umwihariko, irashobora kugera ku gusana byihuse binyuze mu ngingo zikurikira:
Kwihutisha synthesis no kuvugurura matrice idasanzwe
Matrisa idasanzwe ni igice cyingenzi cyama tissue kandi ni ngombwa mugukomeza imiterere nimikorere yinyama. Igice cya TB4 (17-13) gishobora kwihutisha gusana ingirangingo zangiritse mugutezimbere ibice bigize matrice idasanzwe, nka kolagen, elastine, na glycosaminoglycans. Irashobora gukora inzira yerekana inzira ijyanye no guhuza matrice idasanzwe, igateza imbere ingirabuzimafatizo no gusohora ibice bigize matrice idasanzwe [1].
Mubyongeyeho, iki gice gishobora kandi kugenga inzira yo guhindura matrice idasanzwe. Mugihe cyo gusana ingirabuzimafatizo, matrice idasanzwe igomba guhora ivugururwa kugirango ihuze no gukura no gusana ingirangingo. Igice cya TB4 (17-13) kirashobora kugenzura uburinganire buri hagati yo kwangirika no guhuza matrice idasanzwe mu kugenzura ibikorwa byimisemburo nka matrix metalloproteinase (MMPs), bigatera gusana byihuse ingirangingo.
Kuzamura selile yimuka hamwe nubushobozi bwo gufatira hamwe
Kwimuka no gufatira hamwe kwingirabuzimafatizo nabyo ni ingenzi cyane mugusana ingirangingo. Igice cya TB4 (17-13) gishobora kongera ubushobozi bwo kwimuka no gufatira hamwe kwingirabuzimafatizo muguhindura imvugo nigikorwa cyimikorere ya selile. Kurugero, irashobora guteza imbere imvugo ya molekules ya selile ifatika nka integin, ikongerera guhuza ingirabuzimafatizo na matrise idasanzwe; cyangwa kugenga ivugurura rya cytoskeleton, guteza imbere kwimuka kwakagari [1].
Kwimuka kwingirabuzimafatizo birashobora gutuma ingirabuzimafatizo zikikije ingirangingo zangiritse zigera vuba aha zangiritse kandi zikagira uruhare mubikorwa byo gusana ingirangingo; hamwe no gufatira ingirabuzimafatizo birashobora kwemeza ko ingirabuzimafatizo zigira uruhare runini aho zangiritse, bigateza imbere gusana byihuse.
HCD MS / MS yanditse kuri 20eV (a) na 700MHz-NMR (b) yerekanwe na TB4.
Inkomoko: Byatangajwe [1]
Nigute igice cya TB4 (17-13) kigenga sisitemu yimitsi kugirango itezimbere siporo kandi igabanye umunaniro?
Igikorwa kiziguye kuri neuron
Igice cya TB4 (17-13) kirashobora gukora kuri neuron mu buryo butaziguye, bigira ingaruka ku byishimo, kwanduza synaptic, hamwe na plastike ya neuron. Kurugero, irashobora guhuza reseptors hejuru ya neuron, igakora inzira yerekana ibimenyetso byinzira, kandi ikagenga imikorere ya neuron.
Ubushakashatsi bumwe bwerekanye ko thymosine β4 ishobora guhuza ibyakirwa bitandukanye, harimo reseptor ya integrin hamwe niyakura ryikura, bigira uruhare runini mugutezimbere no mumikorere ya sisitemu y'imitsi [1].
Kugenzura mu buryo butaziguye sisitemu y'imitsi binyuze muri sisitemu y'umubiri
Hariho imikoranire ya hafi hagati yubudahangarwa bw'umubiri na sisitemu y'imitsi. Igice cya TB4 (17-13) gishobora kugira ingaruka ku buryo butaziguye sisitemu y'imitsi igenga imikorere ya sisitemu y'umubiri. Kurugero, irashobora kugira ingaruka kumikorere no gusohora kwingirabuzimafatizo, igenga urwego rwibintu bitera umuriro, bityo bikagira ingaruka kumikorere ya sisitemu y'imitsi.
Ubushakashatsi bumwe bwerekanye ko ibintu bitera umuriro bigira uruhare runini mu ndwara zifata imitsi n'umunaniro. Igice cya TB4 (17-13) gishobora kugabanya uburyo bwo gutwika imitsi ya nervice no kunoza imikorere ya sisitemu y'imitsi igenga urwego rw'ibintu bitera umuriro [1].
Ingaruka kuri sisitemu ya neuroendocrine
Sisitemu ya neuroendocrine igira uruhare runini mugutunganya imikorere yumubiri yumubiri hamwe nigisubizo cyimyitwarire. Igice cya TB4 (17-13) gishobora kugenga ibikorwa bya sisitemu y'imitsi bigira ingaruka kumikorere ya sisitemu ya neuroendocrine. Kurugero, irashobora kugira ingaruka kumikorere ya hypothalamic-pituitar-adrenal axis, igenga imisemburo ya hormone yibibazo nka cortisol, bityo bikagira ingaruka kumikorere ya sisitemu y'imitsi.
Ubushakashatsi bumwe bwerekanye ko urwego rwimisemburo ihangayikishije cyane no kumva umunaniro no gukora siporo. Igice cya TB4 (17-13) gishobora kugabanya umunaniro no kunoza imikorere ya siporo muguhindura urwego rwimisemburo ya stress [1].
Ni izihe ngaruka z'igice cya TB4 (17-13)?
1. Gusana imyenda no kuvugurura
Gukiza ibikomere ibikomere bikaze kandi bidakira:
Ku bikomere bikaze (nk'ibisebe byo kubaga, gutwikwa) n'ibikomere bidakira (nk'ibisebe bya diyabete), igice cya TB4 (17-13) kirashobora kugabanya inkovu. Uburyo bwibikorwa byabwo bushobora kuba bujyanye no guteza imbere kolagene ikurikirana no kugenzura igisubizo kibabaza ..
Kuvugurura imyenda byerekanwe mubushakashatsi bwinyamaswa:
Mu bushakashatsi bw’inyamaswa, iki gice cya peptide kirashobora guteza imbere kuvugurura uruhu, imitsi, imitsi, na karitsiye. Kurugero, muburyo bwo gukomeretsa uruhu, agace ka TB4 (17-13) gashobora gutera kwimuka no gukwirakwira kwa keratinocytes, kwihutisha gukira ibikomere (Ho ENM, 2012). Kubikomeretsa imitsi na tendon, birashobora guteza imbere gusana ingirabuzimafatizo mugutezimbere no gukwirakwiza ingirabuzimafatizo [3] . Mu buryo bwo gukomeretsa kwa karitsiye, iki gice cya peptide gishobora guteza imbere kuvugurura karitsiye muguhindura imikorere ya metabolism na synthesis ya chondrocytes [2].
2. Kurwanya inflammatory
Mu ndwara zidakira zidakira (nka rubagimpande ya rubagimpande, indwara ya Crohn), igisubizo cyo gutwika gikomeje, bigatuma kwangirika kw'imitsi no kudakora neza kw'ingingo. Nkumuti wongeyeho, agace ka TB4 (17-13) karashobora kugabanya ibimenyetso byindwara no gutinda gutera imbere muguhagarika igisubizo kibabaza [4].
3. Kuvugurura ibikomere byimitsi
Igice cya TB4 (17-13) cyihutisha gusana imitsi, imitsi, hamwe n’imvune zo mu mitsi, bigabanya igihe cyo gusubiza mu buzima busanzwe abakinnyi. Mubuvuzi bwa siporo, ibikomere bya musculoskeletal nibibazo bisanzwe. Igice cya peptide kirashobora guteza imbere gusana ingirangingo zangiritse [3].
4. Gusana umutima
Nyuma yindwara ya myocardial, agace ka TB4 (17-13) karashobora gutera angiogenezi no kubaho kwa cardiomyocytes, kunoza imikorere yumutima. Indwara ya Myocardial ni indwara iterwa no kuziba kw'imitsi y'amaraso, biganisha kuri myocardial ischemia na hypoxia. Angiogenezi irashobora gutanga ogisijene nintungamubiri kuri myocardium yangiritse, bigatuma ubuzima bwa Cardiomyocytes bubaho kandi bugasanwa ..
Mubyitegererezo byinyamanswa, agace ka TB4 (17-13) kagabanya cyane ubunini bwa infarct kandi kongerera myocardial gusana. Uburyo bwibikorwa bushobora kuba bujyanye no guteza imbere imvugo no kurekura ibintu bikura nkimikurire yimitsi iva mu mitsi (VEGF).
5. Neuroprotection nubuzima bwubwonko
Igice cya TB4 (17-13) kibuza apoptose ya neuronal kandi kigatera ikwirakwizwa ry'uturemangingo ngengabuzima. Apoptose ya Neuronal ni bumwe mu buryo bukomeye bw’indwara z’indwara zifata ubwonko no gukomeretsa ubwonko. Igice cya peptide gishobora kubuza apoptose ya neuronal kugenzura inzira zerekana ibimenyetso. Muri icyo gihe, guteza imbere ikwirakwizwa ry'uturemangingo ngengabuzima dushobora gutanga isoko rishya ry'utugingo ngengabuzima twangiritse, bigatera gusana imitsi.
Mu bwonko, gukomeretsa ubwonko (TBI), n'indwara zifata ubwonko (nk'indwara ya Alzheimer), ingirangingo z'imitsi zangiritse ku buryo butandukanye. Igice cya TB4 (17-13) gishobora kugira uruhare mu gukira kw'abarwayi binyuze mu ngaruka zacyo zo mu mutwe no mu gusana imitsi [4].
6. Kuvura indwara zamaso
0.1% ibitonyanga by'amaso Tβ4 byakijije rwose ibikomere kandi byoroheje ibimenyetso ku barwayi 6 barwaye keratite ya neurotrophique. Neurotrophique keratitis ni indwara ya corneal iterwa no kudakora neza kwa corneal. Igice cya TB4 (17-13) kirashobora guteza imbere gukira ibikomere bya corneal mugutezimbere no kwimuka kwingirabuzimafatizo ya epiteliyale no kugenzura igisubizo kibabaza [6].
7. Kuvugurura umusatsi
Igice cya TB4 (17-13) gikora imisemburo yumusatsi kandi ikongerera icyiciro cya anagen cyo gukura kwimisatsi. Ingirabuzimafatizo yumusatsi ningirabuzimafatizo zingenzi zo kuvugurura umusatsi. Barashobora gutandukanya ubwoko butandukanye bwimisatsi yimisatsi, bigatera imikurire niterambere ryumusatsi. Iki gice cya peptide gishobora guteza imbere imisatsi muguhuza ikwirakwizwa nogutandukanya ingirangingo z'umusatsi (Pan DY, 2021).
Ubushakashatsi ku nyamaswa
Imbeba:
Iterambere ryimisatsi ryihuta. Muburyo bwimbeba, agace ka TB4 (17-13) gashobora guteza imbere imikurire niterambere ryumusatsi ukoresheje ingirabuzimafatizo yumusatsi [4].
Ihene:
Ongera umubare wimisatsi ya kabiri kandi utezimbere umusaruro wimisatsi yo hasi. Mu buryo bw'ihene, iki gice cya peptide gishobora guteza imbere imikurire yimisatsi yo hasi muguhindura imikurire yimisatsi ndetse nubwiyongere bwimisatsi [4].
Mu gusoza, agace ka TB4 (17-13) karashobora guteza imbere gusana ingirabuzimafatizo, kurwanya indwara, no kuvugurura ingirabuzimafatizo, kwihutisha gukira ibikomere, no kunoza imikorere yimitsi. Ni ingirakamaro cyane ku buvuzi bushya, buzana ibyiringiro bishya byo kuvura indwara nko gutwikwa no gukomeretsa imitsi ndetse no gukora ubushakashatsi no guteza imbere imiti igabanya ubukana, ifite amahirwe menshi yo kuyashyira mu bikorwa.
Ibyerekeye Umwanditsi
Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.
Umwanditsi w'ikinyamakuru
Choi B numushakashatsi wintangarugero numunyeshuri ufite aho ahurira nibigo bikomeye nka kaminuza ya Yonsei na kaminuza nkuru ya Seoul (SNU). Ibikorwa bye muri ibyo bigo byagize uruhare runini mu guteza imbere ibice bitandukanye by’ubushakashatsi n’ubushakashatsi.
Inyungu zubushakashatsi nubuhanga bwe murwego rwibyiciro byinshi. Harimo Microbiology, Biotechnology & Applied Microbiology, Immunology, Pharmacology & Farumasi, na Science & Technology - Izindi ngingo. Ubushakashatsi bwe bunini muri izi nzego bugaragaza ubumenyi bwe n’intererano mu bumenyi. Choi B iri kurutonde rwibisobanuro [2].
