Cocer Peptides fɛ 
a bɛ tile 15 bɔ
BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, U BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.
Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *glasi kɔnɔ*, o kɔrɔ ye gilasi kɔnɔ) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki ka dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.
Bonya hormone (GH) jɔyɔrɔ ka bon farikolo taabolo caman na, i n’a fɔ bonya, yiriwali ani farikoloɲɛnajɛ ɲɛnabɔli fɛnɲɛnama ɲɛnamaw la. A bɔli bɛ ɲɛnabɔ ka ɲɛ ni farikolojidɛsɛbanakisɛ gɛlɛn dɔ ye, wa Peptides (Péptides de Releasing Hormone de Growth Hormone (GHRP)) ye fɛn suguya dɔ ye min bɛ bonya hormone bɔli lawuli, o bɛ ɲininikɛlaw hakili sama kosɛbɛ. Ipamorelin, n’o ye GHRP denbaya kɔnɔmɔgɔ ye, o bɛ bɔ kɛnɛ kan a ka jɔcogo kɛrɛnkɛrɛnnen n’a seko jiralen fɛ ka bonya hormones bɔli sabati.
Ni an y’a lajɛ ni kemikaliya jɔcogo ye, Ipamorelin ye pentapeptide sintetiki ye. O jɔcogo in b’a to a bɛ ɲɔgɔndɛmɛba di a ma ni Growth Hormone-Releasing Peptide Receptor (GHRP-R) ye, o b’a to a bɛ se ka a minɛbaga baara ka ɲɛ ani ka taamasiɲɛw sira caman daminɛ selilu kɔnɔ, o la, a bɛ bonya hormone bɔli sabati.
Ni i ye a suma ni bonya hormone-Releasing Hormone (GHRH) ye, Ipamorelin bɛ nafa caman lase mɔgɔ ma minnu tɛ kelen ye. GHRH bɛ baara kɛ fɔlɔ GHRH minɛbagaw kan minnu bɛ bonya hormone cellules sanfɛ pituitaire gland ɲɛfɛ walasa ka bonya hormone dilanni n’a bɔli lawuli. Ipamorelin tɛ baara kɛ dɔrɔn pituitaire glande kan, nka a bɛ bonya hormone bɔli ɲɛnabɔ cogo la min tɛ ɲɛ, a kɛtɔ ka baara kɛ hypothalamus ni yɔrɔ wɛrɛw la, o bɛ wale sira suguya caman di. Ipamorelin bɛ sugandili caman jira ka ɲɛsin bonya hormone bɔli ma, a bɛ wulicogo jira ka caya bonya hormone bɔli la ka sɔrɔ a tɛ nɔba bila joli la joli la hormone wɛrɛw la i n’a fɔ hormone follicules (FSH), hormone luteinizing (LH), prolactin (PRL), ani hormone stimulant thyroïde (TSH).
Baganw ka kɔrɔbɔliw la, Ipamorelin y’a jira ko a bɛ se ka bonya hormone bɔli sabati baganw ka misali suguya caman na, i n’a fɔ sosow, donsokɛw, sagaw ani wuluw. Sogow ka kɔrɔbɔliw la, Ipamorelin tali kɔfɛ, dɔ farala teliya la joli la bonya hormone hakɛ kan, o bɛ jɛɲɔgɔnya jira min bɛ bɔ a tata hakɛ la. O b’a jira ko Ipamɔrilini bɛ se ka bonya hormone bɔli ɲɛnabɔ ka ɲɛ, ka dalilu barikamaw di k’a lajɛ a kɛcogo kan baganw ka bonya baarakɛcogo ɲɛnabɔli la ani bana minnu bɛ tali kɛ ɲɔgɔn na, olu furakɛli la.
Jaa 1 Tablo 1 Pentapɛtidi kura dɔw ka sigicogo ni baarakɛcogo cɛsiraw GH bɔli kan sosow ka pituitaire selilɛriw la in vitro – a ni GHRP-1, GHRP-2, GHRP-6, ani GHRH bɛ tali kɛ ɲɔgɔn na. Jateminɛw jiralen don i n’a fɔ kɔrɔlenw ± SEM (n = 3–6 danfaralenw).
Ipamorelin ka baara kɛcogo ka ɲɛsin bonya hormone bɔli ma
Jɛɲɔgɔnya ni pepitiri minɛbaga ye min bɛ bonya hormone bɔ
Ipamorelin jɔyɔrɔ fɔlɔ jɔnjɔn min bɛ bonya hormone bɔli sabatili la, o ye a sirili kɛrɛnkɛrɛnnen ye bonya hormone-releasing peptide receptor (GHRP-R) la. GHRP-R bɛ G protein-coupled receptor superfamily kɔnɔ, wa a bɛ jɛnsɛn kosɛbɛ pituitaire ɲɛfɛla la, hypothalamus la ani farikolo yɔrɔ wɛrɛw la. Ipamorelin ka pentapeptide jɔcogo b’a to a bɛ se ka baara kɛ tigitigi ni GHRP-R ka ligand-binding pocket ye, o bɛ kɛ sababu ye ka conformational changement kɛ a minɛbaga la. O cogoya caman caman cili bɛ kɛ i n'a fɔ 'switch' walasa ka taamasiɲɛw cili daminɛ selilu kɔnɔ, o bɛ a to GHRP-R ka se ka jɛɲɔgɔnya kɛ ni G poroteyiniw ye minnu bɛ duguma ani ka u baara.
GHRP-R min bɛ baara kɛ, o bɛ guanosine nukilitɔnw ɲɔgɔn falen-falen sabati G poroteyini α yɔrɔ fitinin na min faralen don a kan, ni GDP bɛ bila GTP nɔ na, o bɛ kɛ sababu ye ka G poroteyini α yɔrɔ fitinin faranfasi ka bɔ G poroteyini βγ dimɛri la. G poroteyini α yɔrɔ min faralen don ɲɔgɔn kan ani G poroteyini βγ dimɛri bɛ se ka jiginɛ taamasiɲɛw cili sira danfaralenw baara ka taa a fɛ, ka ɲɛnamaya kɛcogo caman lawuli selilu kɔnɔ, o laban bɛ na ni bonya hormone bɔli caya ye.
CJC-1295, i n’a fɔ bonya hormone synthétique analogique, a bɛ dɛmɛ don farikolo girinya dɔgɔyali la, farikolo fanga bonya la, fari la kɛnɛyali la, sunɔgɔ la, ani joginda kɛnɛyali la. Ipamorelin ye pentapetidi dilannen ye min bɛ bonya hormone bɔli pepitiriw (secretagogues) kulu dɔ la. A bɛ bonya hormone bɔli lawuli ani ka nɔ bila farikolo taabolo suguya caman na, i n’a fɔ kɔnɔbara lankolonya teliya, ka banakɔtaa balili taamasiɲɛw ɲɛ opereli kɔfɛ, ka insuline bɔli lawuli, ani ka glucocorticoïdes ka catabolic nɔw kɛlɛ kolotugudaw ni kolo la. Nin furakisɛ fila ninnu ka jɛɲɔgɔnya nɔw sɛgɛsɛgɛli bɛ se ka kɛ sababu ye ka ɲɛtaa kura sɔrɔ kɛnɛyako la, farikoloɲɛnajɛ furakɛli la ani banaw furakɛli la minnu bɛ tali kɛ o la.
Jaa 2 GH hakɛw joli la ka kɛɲɛ ni waati ye donsokɛw la ipamorelin hakɛ danfaralenw tali kɔfɛ iv.
Selilu kɔnɔ taamasiɲɛw cili siraw baarakɛli
Fosfolipazi C - poroteyini kinase C sira (PLC - PKC sira): G poroteyini α yɔrɔ fitinin min bɛ baara kɛ, o bɛ se ka fosfolipazi C (PLC) baara, o min bɛ fosifatidilinɔsitɔli-4,5-bisifositɛri (PIP2) jilama kɛ selilɛri kan ka kɛ ciden filanan nafama fila ye: inositɔli-1,4,5-trisfosfate (IP3) ani diyakiligiliserɔli (DAG). IP3 bɛ jɛnsɛn ka don sitoplasma kɔnɔ, ka siri IP3 minɛbagaw la endoplasme reticulum kan, ka kalisiyɔmu ion (Ca bɔli sabati 2+ ) endoplasme reticulum kɔnɔ, o bɛ kɛ sababu ye ka Ca 2+ hakɛ caya teliya la selilu kɔnɔ. DAG bɛ to selilɛri kan ani poroteyini kinase C (PKC) min bɛ baara kɛ. PKC bɛ se ka jɛnɛya minnu bɛ tali kɛ ɲɔgɔn na, olu jirali labɛn ni duguma-ji-yɔrɔ-poroteyini caman fosforilasi ye, i n’a fɔ sɛbɛnnikɛlanw, o la, a bɛ bonya hormone (hormone) sɔrɔli ni a bɔli sabati. Ca⊃2;+ hakɛ cayalenba selilɛri kɔnɔ, o fana bɛ se ka baara kɛ ka ɲɛsin gundolafɛnw ma walasa ka bonya hormone bɔli sabati.
Mitogène-activé proteine kinase sira (MAPK sira): Ka fara PLC-PKC sira kan, Ipamorelin bɛ mitogène-activé proteine kinase sira baara GHRP-R baarakɛlen kɔfɛ walasa ka bonya hormone bɔli sabati. G poroteyini βγ dimɛri bɛ guanine nucleotide exchange factor (GEF) baara, o min bɛ GDP sirilen Ras poroteyini jiginni sabati ka kɛ GTP ye, o bɛ Ras poroteyini baara. Ras poroteyini min bɛ baara kɛ, o bɛ Raf poroteyini baara ka t’a fɛ, o min bɛ fosforilasi kɛ ka mitojeni-activé proteine kinase kinase (MEK) baara. O kɔfɛ, MEK bɛ fosiforila ka sɔrɔ ka kinase extracellular signal-regulated (ERK) baara. ERK donlen kɔ selilu kɔnɔ, a bɛ fosforilasi kɛ sɛbɛnnikɛlan caman na, i n’a fɔ Elk-1, o bɛ jɛnɛya jiracogo ɲɛnabɔ min bɛ tali kɛ bonya hormone dilanni ni a bɔli la, o bɛ bonya hormone dilanni n’a bɔli sabati.
Hypothalamuse-pituitaire axis (yɔrɔ min bɛ wele ko hypothalamuse-pituitaire) labɛnni
Hypothalamic-pituitaire axis jɔyɔrɔ ka bon kosɛbɛ bonya hormone bɔli labɛnni na. Ipamorelin tɛ baara kɛ dɔrɔn ka ɲɛsin bonya hormone selilɛriw ma minnu bɛ ɲɛgɛnɛsira ɲɛfɛ walasa ka bonya hormone bɔli sabati nka a bɛ nɔ bila fana bonya hormone bɔli la cogo la min tɛ ɲɛ, ka kɛɲɛ ni hypothalamus labɛnni ye. GHRH ni somatostatin (SST) minnu bɛ bɔ hipotalamus fɛ, olu bɛ nɔ bila bonya ni balili la bonya hormone bɔli la. Ipamorelin bɛ se ka bonya hormones bɔli ɲɛnabɔ cogo la min tɛ ɲɛ, a kɛtɔ ka GHRH ni SST dilanni ni u bɔli sɛmɛntiya hipotalamus neurones kɔnɔ. Ipamorelin bɛ se ka SST senfagabana baara bali hipotalamus kɔnɔ, ka SST bɔli dɔgɔya, o la, SST ka balili nɔ bɛ nɔgɔya bonya hormone bɔli la. Ipamorelin bɛ se fana ka GHRH senfagabana nisɔndiya bonya, ka GHRH bɔli sabati, ani ka bonya hormones bɔli lawuli ka taa a fɛ. Nin sariya fila in bɛ kɛ sababu ye ka Ipamorelin dɛmɛ ka bonya hormone bɔli hakɛ labɛn.
Ipamorelin jɔyɔrɔ ka ɲɛsin bonya hormone bɔli ma
Ka bonya ni yiriwali sabati
Baganw ka bonya ni u yiriwali waati la, bonya hormone jɔyɔrɔ ka bon kosɛbɛ ɲɛnabɔli la, wa Ipamorelin bɛ nɔ ɲuman bila baganw ka bonya ni u ka yiriwali la, a kɛtɔ ka bonya hormone bɔli sabati. Bagan denmisɛnninw na, Ipamorelin tali bɛ dɔ fara u bonya hakɛ kan kosɛbɛ. Ni aw ye sosow ta ka kɛ misali ye, Ipamorelin hakɛ bɛnnen dilen kɔfɛ, sosow bɛ girinya teliya jira, ka kolotugudaw caya ni u danfara bonya, ani kolo janya bɛ bonya. O bɛ se ka kɛ sababu ye ka bonya hormone (banakisɛfagalan) bɛ inisɔndiya-like growth factor-1 (IGF-1) sɔrɔli lawuli farikolo yɔrɔw la i n’a fɔ sugunɛ. IGF-1 bɛ yaala joli fɛ ka taa farikolo yɔrɔw la i n’a fɔ kolo, o bɛ kolotugudaw caya ani ka u faranfasi, o bɛ kolo falen nɔgɔya. Ipamorelin bɛ bonya hormone bɔli sabati, a bɛ dɔ fara IGF-1 bɔli kan cogo la min tɛ ɲɛ, o bɛ kolo bonya ni a yiriwali teliya.
Ipamorelin fana bɛ farikolo yiriwali sabati. Bonya hormone bɛ farikolojɔli dumuniw sɔrɔli sabati, ka farikolojɔli dumuniw tiɲɛni bali, ani ka dɔ fara farikolo fanga kan. Baganw ka kɔlɔsiliw la, Ipamorelin tali kɔfɛ, baganw ye farikolojidɛsɛbanakisɛw jira ani ka farikolo fanga bonya.
Labɛnni nɔ minnu bɛ sɔrɔ farikoloɲɛnajɛ la
Glucose metabolism regulation : Ipamorelin bɛ bonya hormone bɔli sabati, a bɛ nɔ dɔ bila glucose metabolisme la. Bonya hormone jɔyɔrɔ fila bɛ sukaro sɛnɛcogo la. Farikolo ta fan fɛ, bonya hormone bɛ insuline bɔli lawuli, ka sukaro tali ni a baara sabati, ani ka sukaro hakɛ dɔgɔya joli la. Ni a hakɛ ka ca, bonya hormone bɛ insuline kɛlɛli nɔ jira, ka farikolo yɔrɔw sukaro tali ni a baara bali, o la, a bɛ dɔ fara joli sukaro hakɛ kan. Ipamorelin bɛ nɔ bila sukaro farikoloɲɛnajɛ balansi la cogo la min tɛ ɲɛ, a kɛtɔ ka bonya hormone bɔli ɲɛnabɔ. Bagan minnu ka kɛnɛ, Ipamorelin hakɛ bɛnnenw bɛ se ka joli sukaro to a cogo la min tɛ sabati, o bɛ se ka kɛ sababu ye a ka bonya hormone bɔli sabati, o min bɛ inisɔndiya bɔli lawuli fo ka se hakɛ dɔ ma, o la, a bɛ joli sukaro hakɛ labɛn. Sukarodunbanabagatɔ baganw ka misaliw la, Ipamorelin nɔw ka gɛlɛn ka tɛmɛ; a bɛ se ka inisɔndiya kunbɛncogo ɲɛ ni a bɛ bonya hormones bɔli labɛn, o la, a bɛ nɔ ɲuman bila joli sukaro kɔlɔsili la.
Tumu sɛnɛcogo ɲɛnabɔli : Bonya hormone bɛ tulumafɛnw tiɲɛni sabati, ka dɔ fara asidi fatɔw ka oksidan kan walasa ka fanga sɔrɔ, ani ka tulumafɛnw dalajɛli dɔgɔya. Ipamorelin bɛ bonya hormone bɔli sabati, o la a bɛ a ka ɲɛnabɔli nɔ bila tulumafɛnw falenni na. Baganw ka kɔlɔsiliw la, Ipamorelin tali kɔfɛ, tulu hakɛ min bɛ baganw fari la, o dɔgɔyara, kɛrɛnkɛrɛnnenya la yɔrɔw la i n’a fɔ kɔnɔbara. O bɛ kɛ barisa bonya hormone bɛ lipase hormone-sensitive (HSL) baara tulumafɛnw kɔnɔ, o bɛ triglycérides jilamali sabati ka kɛ asidi fatɔw ni glycérol ye. O kɔfɛ, asidi fatɔw bɛ don mitokondriyaw la walasa ka β-oxydation sɔrɔ walasa ka fanga dilan. Bonya hormone fana bɛ tulumafɛnw danfara bali, ka dɔ bɔ u hakɛ la ani ka farikolo tulu hakɛ dɔgɔya ka taa a fɛ. Ipamorelin, ni a bɛ bonya hormone bɔli sabati, a jɔyɔrɔ ka bon tulumafɛnw falenfalenni labɛnni na ani farikolo girinya kɔlɔsili la.
A bɛ nɔ minnu bila farikolo yɔrɔw dilancogo ni u lasegincogo la
Bonya hormone jɔyɔrɔ ka bon farikolo yɔrɔw dilancogo ni u lasegincogo la. Ipamorelin, ni a bɛ bonya hormone bɔli sabati, o bɛ cogoya ɲumanw di farikolo yɔrɔw dilancogo ni u lasegincogo kura ma. Farikolo tiɲɛnenw na, bonya hormone bɛ se ka farikolokisɛw caya ani ka u faranfasi, ka farikolo yɔrɔw kɔkanfɛnw dilanni sabati i n’a fɔ kolajɛ, ani ka joginda kɛnɛyali teliya. Fari jogincogo misaliw la, Ipamorelin tali kɔfɛ, fiɲɛbanakisɛw caya joginda yɔrɔ la, o bɛ teliya, kolajɛni bɔli bɛ caya, ani joginda kɛnɛyali waati bɛ surunya. O bɛ se ka kɛ sababu ye ka bonya hormone (banakisɛfagalan) min bɛ sitokiniw bɔli ɲɛ fibroblaste (fibroblaste) la i n’a fɔ transforming growth factor-β (TGF-β), o bɛ fibroblaste (fibroblaste) caya ni kolajɛni (kolagen) sɔrɔli lawuli ka taa a fɛ. Bonya hormone fana bɛ joli siraw kɔnɔnatumuw caya ni u ka taa yɔrɔ wɛrɛw la, o bɛ joli sira kuraw dilancogo nɔgɔya walasa ka balo ni oksizɛni bɛrɛbɛrɛ di farikolo yɔrɔ tiɲɛnenw ma, o la, farikolo yɔrɔw dilancogo bɛ teliya. Ipamorelin jɔyɔrɔ min bɛ farikolo yɔrɔw dilancogo ni u lasegincogo sabatili la, o b’a kɛ mɔgɔ ye min bɛ layidu ta, min bɛ se ka kɛ ka ɲɛsin joginda furakɛli ma, opereli plastiki la, ani baara wɛrɛw la.
Ipamorelin tali ka ɲɛsin bonya hormone bɔli ma
Baara minnu bɛ se ka kɛ furakɛli siratigɛ la
Bonya hormone dɛsɛ furakɛli : Bonya hormone dɛsɛ ye bana ye min bɛ sɔrɔ bonya hormone bɔli fɛ ka ɲɛ, a bɛ sɔrɔ a janya ka surun ani a bonya ni a yiriwali bɛ mɛn. Ni i ye a suma ni laadala bonya hormone sinsinni furakɛli ye, Ipamorelin bɛ kɔnɔna na bonya hormone bɔli lawuli, ka kɔlɔlɔ dɔw bali minnu bɛ sɔrɔ bonya hormone kɛnɛman tali kuntaalajan na. Dɔgɔtɔrɔso ka sɛgɛsɛgɛliw y’a jira ko banabagatɔ dɔw la, minnu ka bonya hormone dɛsɛ bɛ u la, Ipamorelin tali bɛ dɔ fara u ka bonya hormone hakɛ kan kosɛbɛ, ka u janya teliya, ani ka u ka ɲɛnamaya kɛcogo ɲɛ.
Kɔrɔya kɛlɛli furakɛli : Ni mɔgɔw bɛ kɔrɔbaya, bonya hormones bɔli bɛ dɔgɔya dɔɔni dɔɔni, o bɛ tali kɛ farikolo la fɛn caman na minnu bɛ sɔrɔ kɔrɔya fɛ. Ipamorelin, min bɛ bonya hormones bɔli sabati, jɔyɔrɔ dɔ bɛ a la kɔrɔya kɛlɛli siratigɛ la. Ni Ipamorelin bɛ dɔ fara bonya hormones hakɛ kan, a bɛ se ka farikolo labɛncogo ɲɛ mɔgɔkɔrɔbaw la, ka farikolo fanga bonya, ka tulu dalajɛli dɔgɔya, ka koloci caya, ani ka fari lamagacogo ɲɛ. Kɛnɛyaso sɛgɛsɛgɛliw y’a jira ko mɔgɔkɔrɔba minnu bɛ Ipamorelin ta hakɛ bɛnnen na, olu farikolo baara, u muɲuli ani u hakili cogoya bɛ ɲɛtaa sɔrɔ.
Joginda kɛnɛyali sabatili : Ipamorelin bɛ farikolo yɔrɔw dilancogo ni u lasegincogo sabati ni a bɛ bonya hormone bɔli lawuli. Furakɛcogo la, joginda dɔw bɛ banabagatɔ minnu na, i n’a fɔ jeninida walima kari, Ipamorelin tali bɛ se ka joginda kɛnɛyali teliya ani ka dɔ bɔ gɛlɛyaw sɔrɔli la. Jeninida banabagatɔw la, Ipamorelin bɛ se ka joginda sanfɛla sɔgɔsɔgɔninjɛ sabati ani ka dɔ bɔ joginda sɔrɔli la; karibagatɔw la, a bɛ se ka kolotugudaw sɔrɔli sabati ani ka karilenw kɛnɛyali teliya. O bɛ furakɛli dɛmɛnan kura di joginda furakɛli ma, min bɛ se ka furakɛli kɔlɔlɔw ɲɛ.
Baarakɛcogo minnu bɛ Kɛ Spor furakɛli la
K’a sababu kɛ a seko ye ka bonya hormone bɔli lawuli, a bɛ se ka dɔ fara farikolo fanga kan, ka farikoloɲɛnajɛ kɛcogo ɲɛ, ani ka farikoloɲɛnajɛ kɔfɛ kɛnɛya teliya. Fɛnɲɛnɛmakɛlaw minnu bɛ degeliw kɛ ni fanga ye, Ipamorelin bɛ se k’u dɛmɛ ka farikolo fanga sɔrɔ joona, ka farikolo sɛgɛn dɔgɔya, ani ka joginni farati dɔgɔya. Muɲuli farikoloɲɛnajɛla minnu bɛ muɲu, Ipamorelin bɛ se ka farikoloɲɛnajɛ muɲuli sabati ni a bɛ tulumafɛnw falenfalenni sabati; fanga farikoloɲɛnajɛla la, a bɛ se ka dɔ fara farikolo fanga ni fanga kan.
Kuncɛli
Kuma surun na, i n’a fɔ pentapɛtidi min bɛ bonya hormone bɔli sabati, Ipamorelin bɛ jɔyɔrɔba jira bonya ni yiriwali la, farikoloɲɛnajɛ labɛnni na, farikolo yɔrɔw dilancogo la, ani a kɛcogo suguya wɛrɛw la.
Sosow (Sɔrɔyɔrɔw).
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Fɛn min bɛ sɔrɔ ɲininiw dɔrɔn kama:
