Cocer Peptides fɛ 
a bɛ kalo 1 bɔ
BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, U BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.
Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *in glass*, o kɔrɔ ye gilasi minɛnw na) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.
1. Kuma bɛɛ lajɛlen
Kisspeptin ye neuropeptide ye min kodeli bɛ Kiss1 jamu fɛ, a bɛ sɔrɔ fɔlɔ hypothalamus nucléaire arcuate ani preoptic yɔrɔ la. A jɔyɔrɔ ka bon bangekɔlɔsi baarakɛcogo ɲɛnabɔli la, wa a bɛ kɛ sanfɛla labɛnbaga nafama ye hipotalamu-pituitaire-gonadal (HPG) axis la. Kisspeptin bɛ siri G protein-coupled receptor 54 (GPR54) la, o bɛ taamasiɲɛw sira caman baara walasa ka bangekɔlɔsi baara ɲɛnabɔ. Furuɲɔgɔnmaya daminɛ taamasiɲɛ dɔ ye gonadotropin-releasing hormone (GnRH) bɔli ye ni wulikan ye GnRH sɔgɔsɔgɔninjɛ fɛ, wa kisspeptin bɛ kɛ GnRH senfagabana sanfɛla labɛnni yɔrɔba ye, min jɔyɔrɔ ka bon bangekɔlɔsi fɛɛrɛ kɔgɔli la.
Jaa 1 Kisspeptin ka baarakɛcogo selilɛriw la.
2. Baarakɛcogo
Furuɲɔgɔnmaya daminɛcogo ɲɛnabɔli : Baganw na, kisspeptin ni a minɛbaga GPR54 jirali bɛ caya kosɛbɛ sani cɛya ni musoya ka daminɛ. A bɛ GnRH senfagabana baara, ka GnRH bɔli sabatili sabati ani o la ka cɛya ni musoya daminɛ. Hadamadenw ni bagan wɛrɛw la, ni kisspeptin taamasiɲɛ tɛ yen, o bɛ na ni gonadisimu dɔgɔyali ye ka a sababu kɛ gonadotropin bɔli dɔgɔyali ye, o bɛ cɛya ni musoya daminɛcogo ɲuman tiɲɛ.
Bangekɔlɔsi hormone bɔli ɲɛnabɔli : Kisspeptin bɛ ɲɛgɛnɛsira ɲɛfɛla bila ka gonadotropins bɔ, i n’a fɔ hormone follicules (FSH) ani hormone luteinizing (LH). O bɛ sɔrɔ ni GnRH bɔli caya ye, o min bɛ kɛ sababu ye ka ɲɛgɛnɛsira ɲɛfɛla seliluw lawuli walasa u ka FSH ni LH labɛn ani ka u bɔ, o bɛ kɛ sababu ye ka gonadali baara ɲɛnabɔ, ka gonadal stɛroyi ɔrimɔni sɔrɔli sabati, ani ka banakisɛfagalanw yiriwali nɔgɔya.
Ka nɔ bila bangekɔlɔsi la : Bagan musomanw na, kisspeptin bɛ a sen don kalolabɔ walima musoya waati labɛnni na. Koli waati, kisspeptin senfagabana bɛ se ka jaabiw labɛn kosɛbɛ ositorojɛni fɛ. Ni ɔrimɔni hakɛ wulila, kisspeptin senfagabana baara bɛ bonya, o bɛ GnRH bɔli sabati ka taa a fɛ, ka LH wulicogo daminɛ, ani ka kɔnɔmaya bila mɔgɔ la. Bagan minnu bɛ balo waati kɔnɔ i n’a fɔ sagaw, Kisspeptin senkɔniw jiracogo n’u baara bɛ Changé ni waati caman ɲɔgɔnna ye, o bɛ nɔ bila GnRH bɔli la, o la, a bɛ bange waati labɛn.
Ka a sen don bangekɔlɔsi fɛɛrɛw la minnu bɛ tali kɛ bangekɔlɔsi fɛɛrɛw la : Kisspeptin tɛ nɔ bila dɔrɔn ka ɲɛsin gonadal axis ma, nka a bɛ a sen don fana bangekɔlɔsi fɛɛrɛw la minnu bɛ tali kɛ bangekɔlɔsi fɛɛrɛw la. Ovariw la, Kisspeptin ni a minɛbagaw jirali bɛ tali kɛ kosɛbɛ folikɛw yiriwali la, u kɔgɔli la ani u bɔli la. A bɛ nɔ bila folikɛlanw falenni na ani stɛroyi ɔrimɔni sɔrɔli la ni a bɛ sigida endocrine ni paracrine taamasiɲɛw labɛn kɔnɔbara la. Tɔgɔso la, Kisspeptin fana bɛ se ka kɛ cɛya ni musoya bɔli ni tetarasikilini bɔli labɛnni na.
3. Baarakɛcogo minnu bɛ kɛ
Muso ka bangekɔlɔsi furakɛli : Muso ka bangekɔlɔsi furakɛli la, Kisspeptin y’a jira ko a bɛ se ka kɛ a tali la. Banabagatɔ minnu ka kɔnɔbara basigilen tɛ walima minnu ka gonadotropin bɔli tɛ se ka kɛ ka a sababu kɛ hipotalamus-pituitaire baarakɛbaliya ye, Kisspeptin walima a ɲɔgɔnnaw tali kɛnɛma bɛ se ka kɔnɔbara basigilen baara cogo lasegin ni GnRH ni gonadotropin bɔli ye. Misali la, kɛnɛyaso ka sɛgɛsɛgɛli dɔw la, a jirala ko furakɛli ni Kisspeptin analogues ye banabagatɔw la minnu ka kɔnɔboli bɛ baara la, o bɛ kɛ sababu ye ka LH ni FSH bɔli caya, banabagatɔ dɔw bɛ kɔnɔmaya ni kalolabɔ sɔrɔ kokura.
Cɛw ka bangeko baara ɲɛtaa : Cɛw ka bangekɔlɔsi kɛnɛya siratigɛ la, Kisspeptin fana bɛ baarakɛcogo layidu ta. Banabagatɔ cɛman minnu ka oligoasthenozoospermie walima hypogonadisme bɛ u la, o bɛ sɔrɔ gonadotropini bɔli dafalen fɛ, Kisspeptin furakɛli bɛ se ka cɛya jogo ni a hakɛ ɲɛ ka taa a fɛ ni GnRH ni gonadotropinw bɔli ye, o bɛ dɔ fara tetarasikilini bɔli kan. Baganw ka sɛgɛsɛgɛliw y’a jira ko Kisspeptin tali bɛ se ka dɔ fara tetarasikilini hakɛ kan bagan cɛmanw na, ka cɛya sɔrɔcogo sabati, ani ka bange seko bonya.
Bangekɔlɔsi fɛɛrɛ dɛmɛnan : Bangekɔlɔsi-denmisɛnninw cili in vitro (IVF-ET) kɛcogo la, muso ka kɔnɔmaya ni ɔrimɔni hakɛ kɔlɔsili tigitigi nafa ka bon kosɛbɛ. Kisspeptin bɛ se ka kɛ fura kura laɲini ye walasa ka ovulation induction protocoles (ovulation induction protocoles) ɲɛ. Ni Kisspeptin taamasiɲɛw sira labɛnna, a bɛ se ka kɛ ka ɲɛgɛnɛsiraw falenni ni kɔnɔbara basigilen kɔlɔsi ka ɲɛ, ka kɔnɔbara bɔli hakɛ ni denw cogoya ɲɛ, o la, ka FIV-ET ɲɛtaa hakɛ caya.
4. Kuncɛli
Kuma surun na, Kisspeptin bɛ fɛɛrɛ kuraw di walasa ka bangekɔlɔsi baarakɛcogo ɲɛ hadamadenw ka bange furakɛli la.
Sosow (Sɔrɔyɔrɔw).
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[3] Smith J. T., Hawken P. R., Lehman M. N., ani a ɲɔgɔnnaw. Kisspeptin jɔyɔrɔ bangeko baara la sagaden na[J]. Bioscientifica ka baarakɛnafolo, san 2019. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.
[4] Clarke H, Dhillo WS, Jayasena C N. Seginkanni bɛɛ lajɛlen Kisspeptin kan ani a jɔyɔrɔ bangeko gɛlɛyaw la[J]. Endocrinologie ani sukarodunbana, 2015,30(2):124-141.DOI:10.3803/EnM.2015.30.2.124.
Fɛn min bɛ sɔrɔ ɲininiw dɔrɔn kama:
