Cocer Peptides fɛ 
a bɛ kalo 1 bɔ
BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, U BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.
Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *glasi kɔnɔ*, o kɔrɔ ye gilasi kɔnɔ) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki ka dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.
1. Kuma bɛɛ lajɛlen
Kisspeptin ye neuropeptide ye min kofɔlen don Kiss1 jamu fɛ, a bɛ sɔrɔ fɔlɔ hypothalamus nucléaire arcuate ani preoptic yɔrɔ la. A jɔyɔrɔ ka bon bangekɔlɔsi baarakɛcogo ɲɛnabɔli la, wa a bɛ kɛ sanfɛla labɛnbaga nafama ye hipotalamu-pituitaire-gonadal (HPG) axis la. Kisspeptin bɛ siri G protein-coupled receptor 54 (GPR54) la, o bɛ taamasiɲɛw sira caman baara walasa ka bangekɔlɔsi baara ɲɛnabɔ. Furucɛya daminɛ taamasiɲɛ dɔ ye gonadotropin-releasing hormone (GnRH) bɔli ye ni wulikan ye GnRH senkɔniw fɛ, wa kisspeptin bɛ kɛ GnRH senfagabana sanfɛla labɛnni yɔrɔ koloma ye, a jɔyɔrɔ ka bon bangekɔlɔsi fɛɛrɛ kɔgɔli la.
Jaa 1 Kisspeptin ka baarakɛcogo selilɛriw la.
2. Baarakɛcogo
Furuɲɔgɔnmaya daminɛcogo ɲɛnabɔli : Baganw na, kisspeptin ni a minɛbaga GPR54 jirali bɛ caya kosɛbɛ sani cɛya ni musoya ka daminɛ. A bɛ GnRH senfagabana baara, ka GnRH bɔli sabatili sabati ani o cogo la ka cɛya ni musoya daminɛ. Hadamadenw ni bagan wɛrɛw la, ni kisspeptin taamasiɲɛ tɛ yen, o bɛ na ni gonadisimu dɔgɔyali ye ka a sababu kɛ gonadotropin bɔli dɔgɔyali ye, o bɛ kɛ sababu ye ka cɛya ni musoya daminɛcogo ɲuman tiɲɛ.
Bangekɔlɔsi hormone bɔli ɲɛnabɔli : Kisspeptin bɛ ɲɛgɛnɛsira ɲɛfɛla bila ka gonadotropins bɔ, i n’a fɔ hormone follicules stimulant (FSH) ani hormone luteinizing (LH). O bɛ sɔrɔ ni GnRH bɔli caya ye, o min bɛ kɛ sababu ye ka ɲɛgɛnɛsira ɲɛfɛla selilɛriw lawuli walasa u ka FSH ni LH labɛn ani ka u bɔ, o bɛ kɛ sababu ye ka gonadali baara ɲɛnabɔ, ka gonadal stɛroyi ɔrimɔni sɔrɔli yiriwa, ani ka banakisɛfagalanw yiriwali nɔgɔya.
Ka nɔ bila bangekɔlɔsi la : Bagan musomanw na, kisspeptin bɛ a sen don kalolabɔ walima musoya waati labɛnni na. Koli waati, kisspeptin (kisspeptin) senfagabana bɛ se ka jaabiw labɛn kosɛbɛ ositorojɛni fɛ. Ni ɔrimɔni hakɛ wulila, kisspeptin senfagabana baara bɛ bonya, o bɛ GnRH bɔli sabati ka taa a fɛ, ka LH wulicogo daminɛ, ani ka kɔnɔmaya bila mɔgɔ la. Bagan minnu bɛ balo waati kɔnɔ i n’a fɔ sagaw, Kisspeptin senkɔniw jiracogo n’u baara bɛ Changé ni waati caman ɲɔgɔnna ye, o bɛ nɔ bila GnRH bɔli la, o la, a bɛ bange waati labɛn.
Ka a sen don bangekɔlɔsi fɛɛrɛw la minnu bɛ tali kɛ bangekɔlɔsi fɛɛrɛw la : Kisspeptin tɛ nɔ bila dɔrɔn ka ɲɛsin musoya ma, nka a bɛ a sen don fana bangekɔlɔsi fɛɛrɛw la minnu bɛ tali kɛ farikoloɲɛnajɛ la. O kɔnɔbara la, Kisspeptin ni a minɛbagaw jirali bɛ tali kɛ kosɛbɛ fogonfogon yiriwali la, a kɔgɔli la ani a bɔli la. A bɛ nɔ bila folikɛlanw falenni na ani stɛroyi ɔrimɔni sɔrɔli la ni a bɛ sigida endocrine ni paracrine taamasiɲɛw labɛn kɔnɔbara la. Kɔnɔbara la, Kisspeptin fana bɛ se ka kɛ cɛya ni musoya bɔli ni tetarasikilini bɔli labɛnni na.
3. Baarakɛcogo
Muso ka bangekɔlɔsi furakɛli : Muso ka bangekɔlɔsi furakɛli la, Kisspeptin y’a jira ko a bɛ se ka kɛ a tali la. Banabagatɔ minnu ka kɔnɔbara basigilen tɛ walima minnu ka gonadotropin bɔli tɛ se ka kɛ ka a sababu kɛ hipotalamus-pituitaire baarakɛbaliya ye, Kisspeptin walima a ɲɔgɔnnaw tali kɛnɛma bɛ se ka kɔnɔbara basigilen baara cogo lasegin ni GnRH ni gonadotropin bɔli ye. Misali la, kɛnɛyaso ka sɛgɛsɛgɛli dɔw la, a jirala ko furakɛli ni Kisspeptin analoziw ye banabagatɔw la minnu ka kɔnɔboli bɛ baara la, o bɛ kɛ sababu ye ka LH ni FSH bɔli caya, banabagatɔ dɔw bɛ kɔnɔmaya ni kalolabɔ sɔrɔ kokura.
Cɛw ka bangeko baara ɲɛtaa : Cɛw ka bangekɔlɔsi kɛnɛya siratigɛ la, Kisspeptin fana bɛ baarakɛcogo layidu ta. Banabagatɔ cɛman minnu ka oligoasthenozoospermie walima hypogonadisme bɛ u la, o bɛ sɔrɔ gonadotropini bɔli dafalen fɛ, Kisspeptin furakɛli bɛ se ka cɛya jogo ni a hakɛ ɲɛ ka taa a fɛ ni GnRH ni gonadotropinw bɔli ye, o bɛ dɔ fara tetarasikilini bɔli kan. Baganw ka sɛgɛsɛgɛliw y’a jira ko Kisspeptin tali bɛ se ka dɔ fara tetarasikilini hakɛ kan bagan cɛmanw na, ka cɛya sɔrɔcogo ɲɛ, ani ka bange seko bonya.
Bangekɔlɔsi fɛɛrɛ dɛmɛnan : Bangekɔlɔsi-denmisɛnninw cili in vitro (IVF-ET) kɛcogo la, muso ka kɔnɔmaya ni ɔrimɔni hakɛ kɔlɔsili tigitigi nafa ka bon kosɛbɛ. Kisspeptin bɛ se ka kɛ fura kura laɲini ye walasa ka ovulation induction protocoles (ovulation induction protocoles) ɲɛ. Ni Kisspeptin taamasiɲɛw sira labɛnna, a bɛ se ka kɛ ka ɲɛgɛnɛsiraw falenni ni kɔnɔbara bɔli kɔlɔsi ka ɲɛ, ka kɔnɔbara bɔli hakɛ ni denw cogoya ɲɛ, o la, ka FIV-ET ɲɛtaa hakɛ caya.
4. Kuncɛli
Kuma surun na, Kisspeptin bɛ fɛɛrɛ kuraw di walasa ka bangekɔlɔsi baarakɛcogo ɲɛ hadamadenw ka bange furakɛli la.
Sosow (Sɔrɔyɔrɔw).
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[4] Clarke H, Dhillo WS, Jayasena C N. Seginkanni bɛɛ lajɛlen Kisspeptin kan ani a jɔyɔrɔ bangeko gɛlɛyaw la[J]. Endocrinologie ani metabolisme, 2015,30(2):124-141.DOI:10.3803/EnM.2015.30.2.124.
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