Na Cocer Peptides bin rayt am 
1 mɔnt dɔn pas
ƆL DI ATIKUL ƐN PRODƆKT INFƆMƐSHƆN WE DƐN GI NA DIS WƐBSAYT NA FƆ ƆL FƆ DI INFƆMƐSHƆN ƐN FƆ EDYUKESHƆN.
Di prɔdak dɛn we dɛn gi na dis wɛbsayt na fɔ in vitro risach nɔmɔ. in vitro risach (Latin: *in glas*, we min insay glas) dεn de du am ausayd mכtalman bכdi. Dɛn prɔdak ya nɔto mɛrɛsin, dɛn nɔ gɛt di aprɔval frɔm di US Food and Drug Administration (FDA), ɛn dɛn nɔ fɔ yuz dɛn fɔ protɛkt, trit, ɔ mɛn ɛni mɛrɛsin, sik, ɔ sik. Di lɔ nɔ gri fɔ mek dɛn put dɛn tin ya insay mɔtalman ɔ animal bɔdi ɛni we.
1. Ɔvaviu
Kisspeptin na nyuropεptida we di Kiss1 jin de kכd, we de εksprεs fכs insay di arcuate nyuklios εn prεoptik εria na di haypothalamus. i de ple wan kכl rol fכ rεgεl di rεprכdaktiv fכnshכn εn i de wok as imכtant כpstrim rεgεlεt fכ di haypothalamic-pituitary-gonadal (HPG) aks. kisspeptin de biεn di G protin-kכpl rεsεpכta 54 (GPR54), we de aktibכt wan siriכs signal path fכ rεgεl rεprכdaktiv fכnshכn. wan pan di mak dεm we de sho se di pikin bigin fכ bכn na di pulsatile sekreshכn fכ gonadotropin-rilis כmon (GnRH) bay di haypothalamic GnRH nyuron dεm, εn kisspeptin de wok as krichכl כpstrim rεgεdyushכn kכmכpכnt fכ di GnRH nyuron dεm, we de ple wan kכl rol fכ machכ di rεprכdaktiv aks.
Figure 1 Sεlyul akshכn mεkanism fכ kisspeptin.
2. Fɔnkshɔn
rεgulεshכn fכ di pikin we de bigin fכ bכn: insay mami dεm, di εksprεshכn fכ kisspeptin εn in rεsεpכta GPR54 de inkrεs bכku bכku wan bifo di puberty bigin. i de aktibכt GnRH nyuron dεm, we de protεkt pulsatile GnRH rilis εn dat de initiate puberty. insay mכtalman εn כda mami dεm, di absכns fכ kisspeptin signal de mek di haypogonadism bikoz fכ insufisεnt gonadotropin sekreshכn, we de mek di nכmal we fכ bigin fכ bכn.
rεgulεshכn fכ di rεprכdaktiv כmon sekreshכn: Kisspeptin de mek di antεriכr pituitary gland fכ sekret gonadotropin dεm, inklud fכlikul-stimulεt כmon (FSH) εn luteinizing כmon (LH). dis de apin bay we di GnRH sekreshכn de inkrεs, we in tכn de mek di antεriכr pituitary sεl dεm fכ sכntez εn rilis FSH εn LH, we de rεgεl di gonadal fכnshכn, protεkt di sεntesis fכ gonadal stεroyd כmon dεm, εn fεsilit di divεlכpmεnt fכ di jεm sεl dεm.
fכ infכlכ di rεprכdaktiv saykl: insay uman animal dεm, kisspeptin de tek pat fכ rεgεl di mεnstral saykl כ di εstrous saykl. di tεm we di mεnstrual saykl de, di kisspeptin nyuron dεm kin rili sεnsitiv to fכdbכk rεguleshכn bay εstrojen. we di εstrojen lεvεl dεm go כp, di kisspeptin nyuron aktiviti de inkrεs, we de mek GnRH rilis mכr, we de mek LH sכj, εn we de mek ovuleshכn. insay animal dεm we de brid insay sizin lεk ship, di εksprεshכn εn aktiviti fכ Kisspeptin nyuron dεm de chenj wit sizin vεryushכn, we de afekt GnRH sekreshכn εn dat de rεgεl di brid sizin.
patisipeshכn insay rεprכdaktiv-rεlatεd fysiolojikal prכsεs dεm: Kisspeptin nכ de כnli infכmeshכn di gonadal aks dεm dεn wan bכt i de tek pat pan כda riprodaktiv-rεlatεd fysiolojikal prכsεs dεm. insay di ovaria dεm, di εksprεshכn fכ Kisspeptin εn in rεsεpכta dεm de kכl fכ divεlכpmεnt, machכ, εn ovuleshכn. i de infכlכw fכlikul growth εn stεroyd כmon sεntesis bay we i de rεgεl lokal εndokrin εn parakrin signal dεm na di ovaria dεm. insay di tεsti, Kisspeptin kin tek pat bak pan di rεguleshכn fכ di sεl dεm εn di tεstostεron sekreshכn.
3. Aplikeshɔn dɛn
Tritmεnt fכ uman infεliti: Insay di tritmεnt fכ uman infεliti, Kisspeptin dכn sho pכtεnshal aplikεshכn valyu. fכ di sik pipul dεm we gεt ovulatory abnכmaliti כ insufisεnt gonadotropin sekreshכn bikoz fכ di haypothalamic-pituitary dysfunction, εksojen administreshכn fכ Kisspeptin כ in analכg dεm kin mek di nכmal ovulatory fכnshכn bak bay we i de stimulate GnRH εn gonadotropin sekreshכn. fכ egzampl, insay sכm klinik stכdi dεm, dεn fכnshכn se tritmεnt wit Kisspeptin analכg dεm pan pasεn dεm we gεt fכnshכnal haypothalamic amenorrhea de indyuz inkrεs sekreshכn fכ LH εn FSH, wit sכm pasεnshכn dεm we de gεt ovuleshכn εn mεnstrual saykl dεm bak.
fכ impruv man riprodaktiv fכnshכn: Insay di fild fכ man riprodaktiv hεlth, Kisspeptin de ol prכmis aplikεshכn dεm bak. fכ man pasεnshכn dεm we gεt oligoasthenozoospermia כ haypogonadism we kכz fכ insufisεnt gonadotropin sekreshכn, Kisspeptin tεrapi kin impruv di sεl kwaliti εn kwantiti bay we i de promuot di rilis fכ GnRH εn gonadotropins, we de mek di tεstostεron sekreshכn go כp. stכdi dεm we dεn du pan animal dεn sho se if dεn gi Kisspeptin i kin mek di tεstostεron lεvεl dεm na man animal dεm, i kin mek di sεl dεm we dεn kכl sεl dεm, εn i kin mek di rεprכdaktiv kεpasiti go כp.
εsist riprodaktiv tεknכlכji: insay di in vitro fεtilayzεshכn-εmbriyo tכnfכs (IVF-ET) prכsεs, prεsis kכntrכl fכ uman ovulεshכn εn כmon lεvεl dεm na imכtant. Kisspeptin kin sav as nyu dכg tכgεt fכ optimiz ovulεshכn indukshכn protכkכl dεm. bay we dεn de rεgεl di Kisspeptin signal path, i kin pכsibul fכ kכntro di fכlikul divεlכpmεnt εn ovuleshכn mכr prεsis, impruv di eg rεtrival rεt εn εmbriyo kwaliti, we de mek di sakses rεt fכ IVF-ET bכku.
4. Fɔ dɔn
fכ sכmari, Kisspeptin de gi nyu we fכ εnhans riprodaktiv fכnshכn insay hכman fεtiliti tritmεnt.
Sos dɛn we dɛn pul
[1] Szeliga A, Męczekalski B. Kisspeptin Mכdulεshכn כf rεprכdaktiv Fכnshכn[J]. Ɛndokrin, 2022. https://api.semanticscholar.org/CorpusID:250228276, di wan dɛn we de stɔdi bɔt di Baybul.
[2] Rt AKUK, Kuru M, Başer O. M., ɛn ɔda pipul dɛn. Kisspeptin: Rol in Fεmεl Infεrtiliti[J]. Riprodaktiv Ɔmon dɛn, 2020. https://api.semanticscholar.org/CorpusID:229493075, di wan dɛn we de stɔdi bɔt di Baybul.
[3] Smit J. T., Hawken P. R., Lehman M. N., ɛn ɔda pipul dɛn. di rol we kisspeptin de ple fכ rεprכdaktiv fכnshכn na di εw[J]. Bayosayntifik Prosiding, 2019. Di https://api.semanticscholar.org/KɔpɔsID:85961626. Di wan dɛn we de stɔdi bɔt di Baybul.
[4] Clarke H, Dhillo WS, Jayasena C N. Komprεhεnsiv Rivyu pan Kisspeptin εn in Rol in Riprodaktiv Dizכrd[J]. Ɛndokrinɔlɔji ɛn Mɛtabolism, 2015,30(2):124-141.DOI:10.3803/EnM.2015.30.2.124.
Prodak we de fɔ yuz fɔ risach nɔmɔ:
