By Cocer Peptides 
1 ọnwa gara aga
Edemede na ozi ngwaahịa niile enyere na webụsaịtị a bụ naanị maka mgbasa ozi na ebumnuche mmụta.
Ngwaahịa ndị enyere na webụsaịtị a bụ naanị maka nyocha in vitro. A na-eme nyocha in vitro (Latin: * na iko *, nke pụtara na ihe eji enyo) na mpụga ahụ mmadụ. Ngwaahịa ndị a abụghị ọgwụ, ndị US Food and Drug Administration (FDA) akwadoghị ya, ha agaghịkwa eji ya gbochie, gwọọ, ma ọ bụ gwọọ ọnọdụ ahụike ọ bụla, ọrịa, ma ọ bụ ọrịa. Iwu amachibidoro nke ọma iwebata ngwaahịa ndị a n'ime ahụ mmadụ ma ọ bụ anụmanụ n'ụdị ọ bụla.
1. Nchịkọta
Kisspeptin bụ neuropeptide nke mkpụrụ ndụ Kiss1 kpuchiri, nke egosipụtara nke ọma na mpaghara arcuate na mpaghara preoptic nke hypothalamus. Ọ na-arụ ọrụ dị mkpa n'ịhazi ọrụ ịmụ nwa ma na-eje ozi dị ka onye na-ahụ maka elu elu nke axis hypothalamic-pituitary-gonadadal (HPG). Kisspeptin na-ejikọta na G protein-coupled receptor 54 (GPR54), na-arụ ọrụ usoro nke ụzọ mgbaàmà iji mezie ọrụ ọmụmụ. Otu n'ime ihe ama ama nke mmalite mmalite bụ pulsatile secretion nke gonadotropin na-ahapụ hormone (GnRH) site na hypothalamic GnRH neurons, na kisspeptin na-eje ozi dị ka akụkụ dị mkpa nke usoro nchịkwa GnRH neurons, na-ekere òkè dị mkpa na ntozu oke nke axis ọmụmụ.
Ọgụgụ 1 Usoro ọrụ cellular nke kisspeptin.
2. Ọrụ
Iwu nke mmalite mmalite: N'ime ụmụ anụmanụ, ngosipụta kisspeptin na onye na-anabata ya GPR54 na-abawanye nke ukwuu tupu mmalite ntozu. Ọ na-arụ ọrụ neurons GnRH, na-akwalite ntọhapụ GnRH pulsatile ma si otú ahụ na-amalite ntozu okè. N'ime mmadụ na anụmanụ ndị ọzọ, enweghị akara ngosi kisspeptin na-eduga na hypogonadism n'ihi ụkọ gonadotropin ezughi oke, si otú ahụ na-emebi mmalite mmalite nke ntozu okè.
Iwu nke mmepụta homonụ nke ịmụ nwa: Kisspeptin na-akpali gland pituitary nke dị n'ihu iji zoo gonadotropins, gụnyere hormone na-akpali akpali (FSH) na hormone luteinizing (LH). A na-enweta nke a site na ịba ụba nke nzuzo GnRH, nke na-eme ka mkpụrụ ndụ pituitary dị n'ihu na-emepụta ma hapụ FSH na LH, si otú ahụ na-achịkwa ọrụ gonadal, na-akwalite njikọ nke gonadal steroid hormones, na-eme ka mmepe nke mkpụrụ ndụ germ.
Na-emetụta usoro ọmụmụ: N'ime ụmụ anụmanụ nwanyị, kisspeptin na-ekere òkè n'ịchịkwa oge ịhụ nsọ ma ọ bụ okirikiri estrous. N'oge okirikiri nsọ nsọ, akwara kisspeptin na-enwe mmetụta nke ukwuu maka nhazi nzaghachi site na estrogen. Mgbe ọkwa estrogen na-ebili, ọrụ kisspeptin neuron na-abawanye, na-akwalite ntọhapụ GnRH, na-akpalite mmụba LH, na ịkpata ovulation. N'ime anụmanụ na-azụlite n'oge dị ka atụrụ, okwu na ọrụ Kisspeptin neurons na-agbanwe site na mgbanwe oge, na-emetụta nzuzo GnRH ma si otú a na-ahazi oge ọmụmụ.
Isonye na usoro ọmụmụ gbasara ọmụmụ physiological: Kisspeptin abụghị naanị na-emetụta axis gonadal kamakwa na-ekere òkè na usoro ọmụmụ physiological ndị ọzọ metụtara ọmụmụ. N'ime ovaries, okwu Kisspeptin na ndị na-anabata ya nwere njikọ chiri anya na mmepe follicle, maturation, na ovulation. Ọ na-emetụta uto follicle na njikọ homonụ steroid site n'ịchịkwa endocrin mpaghara na akara paracrine na ovaries. Na testes, Kisspeptin nwekwara ike isonye na nhazi nke spermatogenesis na testosterone secretion.
3. Ngwa
Ọgwụgwọ nke ịmụ nwa: N'ọgwụgwọ nke ịmụ nwa, Kisspeptin egosipụtara uru ngwa ngwa. Maka ndị ọrịa nwere ọrịa ovulatory ma ọ bụ gonadotropin ezughi oke n'ihi dysfunction hypothalamic-pituitary, nchịkwa exogenous nke Kisspeptin ma ọ bụ analogues ya nwere ike iweghachi ọrụ ovulatory nkịtị site na ịkpali GnRH na secretion gonadotropin. Dịka ọmụmaatụ, na ụfọdụ ọmụmụ ụlọ ọgwụ, a hụrụ ọgwụgwọ Kisspeptin analogues na ndị ọrịa nwere hypothalamic amenorrhea na-arụ ọrụ na-ebute mmụba nke nzuzo nke LH na FSH, ebe ụfọdụ ndị ọrịa na-enwetaghachi ovulation na oge ịhụ nsọ.
Imelite ọrụ ịmụ nwa nwoke: N'ihe gbasara ahụike ọmụmụ nwoke, Kisspeptin na-ejikwa ngwa ndị na-ekwe nkwa. Maka ndị ọrịa nwoke nwere oligoasthenozoospermia ma ọ bụ hypogonadism kpatara site na ụkọ gonadotropin ezughi oke, ọgwụgwọ Kisspeptin nwere ike imeziwanye ogo spam na ọnụ ọgụgụ ya site n'ịkwalite ntọhapụ nke GnRH na gonadotropins, si otú ahụ na-amụba secretion testosterone. Ọmụmụ anụmanụ egosila na nchịkwa Kisspeptin nwere ike ịbawanye ọkwa testosterone n'ime ụmụ anụmanụ nwoke, kwalite spermatogenesis, na ịkwalite ikike ịmụ nwa.
Nkà na ụzụ ịmụ nwa na-enyere aka: N'ime usoro in vitro fatịlaịza-embrayo nyefe (IVF-ET), njikwa kpọmkwem nke ịmụ nwa na ọkwa hormone dị oke mkpa. Kisspeptin nwere ike ije ozi dị ka ebumnuche ọgwụ ọhụrụ maka ịkwalite protocol induction ovulation. Site n'ịhazi ụzọ akara Kisspeptin, ọ ga-ekwe omume ijikwa nke ọma mmepe follicle na ovulation, kwalite ọnụego iweghachi akwa na ogo ẹmbrayo, si otú ahụ na-eme ka ọnụọgụgụ IVF-ET na-aga nke ọma.
4. Nkwubi okwu
Na nchịkọta, Kisspeptin na-enye ụzọ ọhụrụ maka ịkwalite ọrụ ịmụ nwa na ọgwụgwọ ọmụmụ mmadụ.
Isi mmalite
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[2] Rt AKUK, Kuru M, Başer OM, et al. Kisspeptin: Ọrụ na-amụghị nwa[J]. Hormones ịmụ nwa, 2020. https://api.semanticcholar.org/CorpusID:229493075.
[3] Smith JT, Hawken PAR, Lehman MN, et al. Ọrụ kisspeptin na ọrụ ọmụmụ n'ime atụrụ [J]. Usoro Bioscientifica, 2019. https://api.semanticscholar.org/CorpusID:85961626.
[4] Clarke H, Dhillo WS, Jayasena C N. Nleba anya zuru oke na Kisspeptin na ọrụ ya na nsogbu ọmụmụ[J]. Endocrinology na Metabolism, 2015,30 (2): 124-141.DOI: 10.3803 / EnM.2015.30.2.124.
Ngwaahịa dị maka naanị nyocha:
