Na Cocer Peptides 
ukwezi gushize
INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.
Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.
1. Incamake
Kisspeptin ni neuropeptide igizwe na gene ya Kiss1, igaragara cyane cyane muri arcuate nucleus na preoptic ya hypothalamus. Ifite uruhare runini mugutunganya imikorere yimyororokere kandi ikora nkibyingenzi byingenzi bigenga hypothalamic-pituitar-gonadal (HPG) axis. Kisspeptin ihuza G proteine ihujwe na reseptor 54 (GPR54), ikora urukurikirane rw'inzira zerekana ibimenyetso bigenga imikorere yimyororokere. Kimwe mu bimenyetso biranga ubwangavu ni ugusohora kwa pulsatile ya hormone irekura gonadotropine (GnRH) na neuron ya hypothalamic GnRH, kandi kisspeptin ikora nkibintu byingenzi bigenga imitekerereze ya GnRH, bigira uruhare runini mu gukura kwimyororokere.
Igishushanyo 1 Uburyo bwibikorwa bya selile ya kisspeptin.
2. Imikorere
Amabwiriza yo gutangira ubwangavu: Mu nyamaswa z’inyamabere, imvugo ya kisspeptin hamwe na reseptor yayo GPR54 iriyongera cyane mbere yubugimbi. Ikora neurone ya GnRH, igatera pulsatile GnRH kurekura bityo igatangira ubwangavu. Mu bantu no ku yandi matungo y’inyamabere, kutagira ibimenyetso bya kisspeptin biganisha kuri hypogonadisme kubera gusohora kwa gonadotropine idahagije, bityo bikabangamira gutangira bisanzwe byubugimbi.
Kugena imisemburo yimyororokere yimyororokere: Kisspeptin itera glande yimbere ya pitoito kugirango isohore gonadotropine, harimo imisemburo itera imisemburo (FSH) na hormone ya luteinizing (LH). Ibi bigerwaho hongerwa ururenda rwa GnRH, narwo rukangurira ingirabuzimafatizo za pitoito imbere guhuza no kurekura FSH na LH, bityo bikagenga imikorere ya gonadal, bigateza imbere imisemburo ya gonadal steroid, kandi bikorohereza iterambere rya selile.
Kugira ingaruka ku myororokere: Mu nyamaswa z’abagore, kisspeptin igira uruhare mu kugenzura ukwezi cyangwa estrous cycle. Mugihe cyimihango, kisspeptin neuron yunvikana cyane kubitekerezo bya estrogene. Iyo urugero rwa estrogene ruzamutse, ibikorwa bya kisspeptin neuron byiyongera, bikarushaho guteza imbere irekurwa rya GnRH, bigatera LH kwiyongera, no gutera intanga. Mu bworozi bwigihe cyigihe nkintama, imvugo nigikorwa cya neuron ya Kisspeptin ihinduka hamwe nibihe bitandukanye, bigira ingaruka kumyanya ya GnRH bityo bikagenga igihe cyubworozi.
Uruhare mubikorwa byimyororokere bijyanye nimyororokere: Kisspeptin ntabwo igira ingaruka gusa muburyo bwa gonadal ahubwo inagira uruhare mubindi bikorwa byimyororokere bijyanye na physiologique. Muri ovaries, imvugo ya Kisspeptin hamwe niyakirwa ryayo bifitanye isano rya bugufi niterambere ryumusemburo, gukura, na ovulation. Ihindura imikurire ya hormone hamwe na hormone ya steroid muguhindura ibimenyetso bya endocrine yaho hamwe na paracrine muri ovaries. Mu bizamini, Kisspeptin irashobora kandi kugira uruhare mugutunganya intanga ngabo na testosterone.
3. Porogaramu
Kuvura ubugumba bw'umugore: Mu kuvura ubugumba bw'umugore, Kisspeptin yerekanye agaciro gashoboka. Ku barwayi bafite ovulatory idasanzwe cyangwa gusohora kwa gonadotropine idahagije kubera imikorere mibi ya hypothalamic-pituito, imiyoborere idasanzwe ya Kisspeptin cyangwa ibisa nayo irashobora kugarura imikorere isanzwe yintanga itera GnRH na gonadotropine. Kurugero, mubushakashatsi bumwe na bumwe bwubuvuzi, kuvura hamwe na Kisspeptin bigereranya abarwayi bafite hypothalamic amenorrhea ikora byagaragaye ko bitera ururenda rwinshi rwa LH na FSH, hamwe nabarwayi bamwe bagarura intanga ngore.
Kunoza imikorere yimyororokere yumugabo: Mubyerekeranye nubuzima bwimyororokere yumugabo, Kisspeptin nayo ifite ibyifuzo byiza. Ku barwayi b'igitsina gabo barwaye oligoasthenozoospermia cyangwa hypogonadism iterwa no gusohora kwa gonadotropine idahagije, ubuvuzi bwa Kisspeptin bushobora kuzamura ubwiza bw'intanga n'ubwinshi mu guteza imbere irekurwa rya GnRH na gonadotropine, bityo bikongera ururenda rwa testosterone. Ubushakashatsi bw’inyamaswa bwerekanye ko imiyoborere ya Kisspeptin ishobora kongera urugero rwa testosterone mu nyamaswa z’abagabo, igatera intanga ngabo, kandi ikongera ubushobozi bw’imyororokere.
Tekinoroji yimyororokere ifashwa: Mubikorwa bya vitro ifumbira-isoro ryoherezwa (IVF-ET), kugenzura neza intanga ngore n’urwego rwa hormone ni ngombwa. Kisspeptin irashobora kuba intego nshya yibiyobyabwenge mugutezimbere ovulation induction protocole. Mugutegeka inzira yerekana inzira ya Kisspeptin, birashoboka cyane kugenzura neza neza iterambere ryumusemburo hamwe nintanga ngore, kunoza igipimo cyo kugarura amagi hamwe nubwiza bwa urusoro, bityo bikazamura intsinzi ya IVF-ET.
4. Umwanzuro
Muri make, Kisspeptin itanga uburyo bushya bwo kuzamura imikorere yimyororokere mu kuvura uburumbuke bwabantu.
Inkomoko
[1] Szeliga A, Męczekalski B. Kisspeptin Guhindura imikorere yimyororokere [J]. Endocrines, 2022. https://api.semanticscholar.org/CorpusID:250228276.
[2] Rt AKUK, Kuru M, Başer OM, n'abandi. Kisspeptin: Uruhare mu Kutabyara kw'Abagore [J]. Imisemburo yimyororokere, 2020. https://api.semanticscholar.org/CorpusID:229493075.
[3] Smith JT, Hawken PAR, Lehman MN, n'abandi. Uruhare rwa kisspeptin mumikorere yimyororokere muri ewe [J]. Ibikorwa bya Bioscientifica, 2019. https://api.semanticscholar.org/CorpusID:85961626.
[4] Clarke H, Dhillo WS, Jayasena C N. Isubiramo ryuzuye kuri Kisspeptin n'uruhare rwayo mu myororokere [J]. Endocrinology na Metabolism, 2015,30 (2): 124-141.DOI: 10.3803 / EnM.2015.30.2.124.
Ibicuruzwa biboneka mubushakashatsi bukoreshwa gusa:
