By Cocer Peptides 
Watanni 1 da suka gabata
DUKKANIN LABARI DA BAYANIN KYAUTATAWA DA AKE BAYAR A WANNAN SHAFIN KAWAI DOMIN WATSA BAYANI NE DA MANUFOFIN ILIMI.
Kayayyakin da aka bayar akan wannan gidan yanar gizon an yi niyya ne kawai don binciken in vitro. Binciken in vitro (Latin: *a cikin gilashi*, ma'ana a cikin gilashin gilashi) ana gudanar da shi a wajen jikin mutum. Waɗannan samfuran ba magunguna ba ne, Hukumar Abinci da Magunguna ta Amurka (FDA) ba ta amince da su ba, kuma dole ne a yi amfani da su don hanawa, magani, ko warkar da kowane yanayi na likita, cuta, ko cuta. Doka ta haramta shigar da waɗannan samfuran cikin jikin mutum ko dabba ta kowace hanya.
1. Bayani
Kisspeptin wani neuropeptide ne wanda aka sanya shi ta hanyar Kiss1 gene, da farko an bayyana shi a cikin arcuate nucleus da preoptic area na hypothalamus. Yana taka muhimmiyar rawa wajen daidaita aikin haifuwa kuma yana aiki a matsayin mai mahimmanci mai daidaitawa na axis hypothalamic-pituitary-gonadal (HPG). Kisspeptin yana ɗaure ga mai karɓar furotin mai haɗin GPR54 (GPR54), yana kunna jerin hanyoyin sigina don daidaita aikin haihuwa. Ɗaya daga cikin alamomin farkon balaga shine fitowar pulsatile na hormone mai sakin gonadotropin (GnRH) ta hanyar hypothalamic GnRH neurons, kuma kisspeptin yana aiki a matsayin mahimmancin tsari mai mahimmanci na GnRH neurons, yana taka muhimmiyar rawa a cikin girma na axis na haihuwa.
Hoto 1 Tsarin aikin salula na kisspeptin.
2. Aiki
Ka'idojin farawa na balaga: A cikin dabbobi masu shayarwa, furcin kisspeptin da mai karɓar sa GPR54 yana ƙaruwa sosai kafin fara balaga. Yana kunna jijiyoyi na GnRH, yana haɓaka sakin GnRH mai bugun jini kuma ta haka yana fara balaga. A cikin mutane da sauran dabbobi masu shayarwa, rashin siginar kisspeptin yana haifar da hypogonadism saboda rashin isasshen ƙwayar gonadotropin, wanda hakan ya haifar da matsala na farko na balaga.
Ka'idojin fitar da sinadarai na haifuwa: Kisspeptin yana motsa glandon pituitary na baya don ɓoye gonadotropins, gami da hormone mai motsa jiki (FSH) da hormone luteinizing (LH). Ana samun wannan ne ta hanyar haɓaka siginar GnRH, wanda hakan ke haifar da ƙwayoyin pituitary na baya don haɗawa da sakin FSH da LH, ta haka ne ke daidaita aikin gonadal, haɓaka haɓakar hormones na gonadal steroid, da sauƙaƙe haɓakar ƙwayoyin ƙwayoyin cuta.
Tasirin sake zagayowar haihuwa: A cikin dabbobin mata, kisspeptin yana shiga cikin daidaita yanayin haila ko hawan haila. Lokacin zagayowar haila, kisspeptin neurons suna da matukar damuwa ga ka'idojin amsa ta hanyar isrogen. Lokacin da matakan isrogen ya tashi, aikin kisspeptin neuron yana ƙaruwa, yana ƙara haɓaka sakin GnRH, haifar da haɓakar LH, da haifar da ovulation. A cikin dabbobin kiwo na lokaci-lokaci irin su tumaki, magana da ayyukan jijiyoyi na Kisspeptin suna canzawa tare da bambance-bambancen yanayi, suna shafar ɓoyewar GnRH kuma ta haka ne ke daidaita lokacin kiwo.
Shiga cikin tsarin ilimin halittar jiki masu alaƙa da haihuwa: Kisspeptin ba wai kawai yana rinjayar axis na gonadal ba har ma yana shiga cikin wasu hanyoyin ilimin halittar jiki masu alaƙa da haihuwa. A cikin ovaries, furcin Kisspeptin da masu karɓa yana da alaƙa da haɓakar follicle, maturation, da ovulation. Yana rinjayar ci gaban follicle da haɗin gwiwar hormone steroid ta hanyar daidaita tsarin endocrin na gida da siginar paracrine a cikin ovaries. A cikin gwaje-gwajen, Kisspeptin kuma na iya shiga cikin ƙa'idodin spermatogenesis da ɓoyewar testosterone.
3. Aikace-aikace
Maganin rashin haihuwa na mace: A cikin maganin rashin haihuwa, Kisspeptin ya nuna yiwuwar aikace-aikacen ƙima. Ga marasa lafiya da ke da cututtukan ovulatory ko rashin isasshen ƙwayar gonadotropin saboda tabarbarewar hypothalamic-pituitary, exogenous gudanar da Kisspeptin ko analogues na iya dawo da aikin ovulatory na al'ada ta hanyar motsa GnRH da ɓoyewar gonadotropin. Alal misali, a wasu nazarin asibiti, an gano jiyya tare da analogues na Kisspeptin a cikin marasa lafiya da ke da aikin hypothalamic amenorrhea don haifar da haɓakar ƙwayar LH da FSH, tare da wasu marasa lafiya sun dawo da ovulation da hawan haila.
Inganta aikin haifuwa na namiji: A fagen lafiyar haihuwa, Kisspeptin kuma yana riƙe da aikace-aikace masu ban sha'awa. Ga maza marasa lafiya da oligoasthenozoospermia ko hypogonadism lalacewa ta hanyar rashin isasshen gonadotropin mugunya, Kisspeptin far iya inganta ingancin maniyyi da yawa ta hanyar inganta sakin GnRH da gonadotropins, sabili da haka kara testosterone mugunya. Nazarin dabbobi ya nuna cewa gudanar da Kisspeptin na iya kara yawan matakan testosterone a cikin dabbobin maza, inganta spermatogenesis, da haɓaka ƙarfin haihuwa.
Fasahar Haihuwa Taimakawa: A cikin tsarin hadi-embryo (IVF-ET), daidaitaccen sarrafa kwai da matakan hormone yana da mahimmanci. Kisspeptin na iya zama sabon maƙasudin magani don inganta ƙa'idodin shigar da kwai. Ta hanyar daidaita hanyar siginar Kisspeptin, yana iya yiwuwa a ƙara sarrafa ci gaban follicle da ovulation, inganta ƙimar kwai da ingancin amfrayo, don haka haɓaka ƙimar nasarar IVF-ET.
4. Kammalawa
A taƙaice, Kisspeptin yana ba da sababbin hanyoyi don haɓaka aikin haifuwa a cikin maganin haihuwa.
Sources
[1] Szeliga A, Męczekalski B. Kisspeptin Modulation of Reproductive Action[J]. Endocrine, 2022. https://api.semanticcholar.org/CorpusID:250228276.
[2] Rt AKUK, Kuru M, Başer OM, et al. Kisspeptin: Matsayi a cikin Rashin Haihuwar Mata[J]. Hormones masu Haihuwa, 2020. https://api.semanticscholar.org/CorpusID:229493075.
[3] Smith JT, Hawken PAR, Lehman MN, et al. Matsayin kisspeptin a aikin haihuwa a cikin tunkiya[J]. Ayyukan Bioscientifica, 2019. https://api.semanticscholar.org/CorpusID:85961626.
[4] Clarke H, Dhillo WS, Jayasena C N. Cikakken Bita akan Kisspeptin da Matsayinsa a cikin Rashin Haihuwa[J]. Endocrinology da Metabolism, 2015,30 (2): 124-141.DOI: 10.3803 / EnM.2015.30.2.124.
Samfura akwai don amfani da bincike kawai:
