Los ntawm Cocer Peptides 
1 month ago
Tag nrho cov kab lus thiab cov ntaub ntawv ntawm cov khoom lag luam muab rau ntawm lub vev xaib no tsuas yog rau cov ntaub ntawv tshaj tawm kev tshaj tawm thiab cov hom phiaj kev kawm.
Cov khoom muab rau hauv lub vev xaib no yog npaj tshwj xeeb rau kev tshawb fawb hauv vitro. Kev tshawb fawb hauv vitro (Latin: * hauv iav *, lub ntsiab lus hauv iav) yog ua los ntawm tib neeg lub cev. Cov khoom no tsis yog tshuaj, tsis tau txais kev pom zoo los ntawm US Food and Drug Administration (FDA), thiab yuav tsum tsis txhob siv los tiv thaiv, kho, lossis kho txhua yam mob, kab mob, lossis mob. Nws raug txwv nruj raws li txoj cai los qhia cov khoom no rau hauv tib neeg lossis tsiaj lub cev hauv txhua daim ntawv.
1. Txheej txheem cej luam
Kisspeptin yog ib qho neuropeptide encoded los ntawm Kiss1 noob, feem ntau qhia nyob rau hauv lub arcuate nucleus thiab preoptic cheeb tsam ntawm lub hypothalamus. Nws ua lub luag haujlwm tseem ceeb hauv kev tswj hwm kev ua haujlwm ntawm kev ua me nyuam thiab ua haujlwm tseem ceeb hauv kev tswj hwm ntawm hypothalamic-pituitary-gonadal (HPG) axis. Kisspeptin khi rau G protein-coupled receptor 54 (GPR54), ua kom muaj ntau txoj hauv kev los tswj cov kev ua me nyuam. Ib qho ntawm cov cim tseem ceeb ntawm kev puberty pib yog pulsatile secretion ntawm gonadotropin-tso cov tshuaj hormones (GnRH) los ntawm hypothalamic GnRH neurons, thiab kisspeptin ua haujlwm tseem ceeb hauv kev tswj hwm ntawm GnRH neurons, ua lub luag haujlwm tseem ceeb hauv kev loj hlob ntawm kev ua me nyuam axis.
Daim duab 1 Cellular action mechanism ntawm kisspeptin.
2. Muaj nuj nqi
Kev cai ntawm kev pib ua neeg laus: Hauv cov tsiaj txhu, qhov kev qhia ntawm kisspeptin thiab nws cov receptor GPR54 ua rau muaj kev nce ntxiv ua ntej pib ua tiav. Nws activates GnRH neurons, txhawb pulsatile GnRH tso tawm thiab yog li pib puberty. Hauv tib neeg thiab lwm yam tsiaj tsiaj, qhov tsis muaj qhov qhia txog kisspeptin ua rau hypogonadism vim tsis txaus gonadotropin secretion, yog li ua rau tsis zoo rau qhov pib ntawm kev puberty.
Kev tswj hwm ntawm kev tsim cov tshuaj hormones zais cia: Kisspeptin nkoos lub caj pas pituitary anterior pituitary zais cia gonadotropins, suav nrog follicle-stimulating hormone (FSH) thiab luteinizing hormone (LH). Qhov no yog ua tiav los ntawm kev nce GnRH secretion, uas nyob rau hauv lem nkoos anterior pituitary hlwb los synthesize thiab tso FSH thiab LH, yog li tswj gonadal muaj nuj nqi, txhawb lub synthesis ntawm gonadal steroid hormones, thiab pab txhawb txoj kev loj hlob ntawm cov kab mob hlwb.
Influencing lub voj voog kev ua me nyuam: Hauv cov poj niam tsiaj, kisspeptin koom nrog tswj kev coj khaub ncaws los yog lub voj voog estrous. Thaum lub sij hawm cev xeeb tub, kisspeptin neurons yog rhiab heev rau kev tawm tswv yim los ntawm cov tshuaj estrogen. Thaum cov tshuaj estrogen nce, kisspeptin neuron kev ua haujlwm nce ntxiv, txhawb GnRH tso tawm, ua rau LH surge, thiab inducing ovulation. Hauv kev yug tsiaj raws caij nyoog xws li yaj, kev qhia thiab kev ua ntawm Kisspeptin neurons hloov nrog lub caij nyoog hloov pauv, cuam tshuam rau GnRH secretion thiab yog li tswj lub caij yug me nyuam.
Kev koom tes hauv cov txheej txheem kev loj hlob ntsig txog kev yug me nyuam: Kisspeptin tsis yog tsuas yog cuam tshuam ncaj qha rau ntawm gonadal axis tab sis kuj koom nrog lwm cov txheej txheem kev loj hlob ntsig txog lub cev. Nyob rau hauv lub zes qe menyuam, qhov kev qhia ntawm Kisspeptin thiab nws cov receptors yog ze ze nrog kev loj hlob ntawm follicle, maturation, thiab ovulation. Nws cuam tshuam kev loj hlob ntawm follicle thiab steroid hormone synthesis los ntawm kev tswj hwm cov kab mob endocrine thiab paracrine hauv zes qe menyuam. Hauv cov qog ntshav, Kisspeptin kuj tseem tuaj yeem koom nrog hauv kev tswj hwm ntawm spermatogenesis thiab testosterone secretion.
3. Cov ntawv thov
Kev kho tus poj niam tsis muaj menyuam: Hauv kev kho cov poj niam tsis muaj menyuam, Kisspeptin tau pom tias muaj peev xwm siv tau. Rau cov neeg mob uas muaj ovulatory abnormality los yog tsis txaus gonadotropin secretion vim hypothalamic-pituitary dysfunction, exogenous tswj ntawm Kisspeptin los yog nws cov analogues yuav rov ua tau ib txwm ovulatory muaj nuj nqi los ntawm stimulating GnRH thiab gonadotropin secretion. Piv txwv li, hauv qee qhov kev tshawb fawb soj ntsuam, kev kho mob nrog Kisspeptin analogues hauv cov neeg mob uas muaj kev ua haujlwm hypothalamic amenorrhea tau pom tias ua rau muaj kev tso tawm ntawm LH thiab FSH, nrog qee cov neeg mob rov qab ovulation thiab kev coj khaub ncaws.
Txhim kho txiv neej kev ua haujlwm: Hauv kev ua haujlwm ntawm txiv neej kev laus, Kisspeptin tseem tuav cov ntawv cog lus. Rau cov txiv neej cov neeg mob uas muaj oligoasthenozoospermia los yog hypogonadism tshwm sim los ntawm tsis txaus gonadotropin secretion, Kisspeptin kev kho yuav txhim kho phev zoo thiab kom muaj nuj nqis los ntawm kev txhawb kev tso tawm ntawm GnRH thiab gonadotropins, yog li nce testosterone secretion. Cov kev tshawb fawb tsiaj tau pom tias kev tswj hwm ntawm Kisspeptin tuaj yeem nce qib testosterone hauv cov txiv neej tsiaj, txhawb nqa spermatogenesis, thiab txhim kho kev muaj peev xwm ntawm cov menyuam.
Kev pabcuam kev ua menyuam yaus: Hauv cov txheej txheem hauv vitro fertilization-embryo hloov chaw (IVF-ET), kev tswj hwm ntawm poj niam ovulation thiab qib tshuaj hormones yog qhov tseem ceeb. Kisspeptin tuaj yeem ua lub hom phiaj tshuaj tshiab rau kev ua kom zoo ntawm ovulation induction raws tu qauv. Los ntawm kev tswj hwm Kisspeptin txoj kev taw qhia, nws yuav ua tau kom tswj tau cov follicle loj hlob thiab ovulation, txhim kho qe retrieval nqi thiab embryo zoo, yog li pab txhawb txoj kev vam meej ntawm IVF-ET.
4. Cov lus xaus
Hauv cov ntsiab lus, Kisspeptin muaj txoj hauv kev tshiab rau kev txhim kho kev ua me nyuam hauv kev kho tib neeg fertility.
Qhov chaw
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[2] Rt AKUK, Kuru M, Başer OM, et al. Kisspeptin: Lub luag haujlwm hauv Poj Niam Infertility [J]. Kev tsim cov tshuaj hormones, 2020. https://api.semanticscholar.org/CorpusID: 229493075.
[3] Smith JT, Hawken PAR, Lehman MN, et al. Lub luag haujlwm ntawm kisspeptin hauv kev ua me nyuam hauv plab ewe [J]. Bioscientifica Proceedings, 2019. https://api.semanticscholar.org/CorpusID:85961626.
[4] Clarke H, Dhillo WS, Jayasena C N. Comprehensive Review on Kisspeptin and Its Role in Reproductive Disorders[J]. Endocrinology thiab Metabolism, 2015,30(2):124-141.DOI:10.3803/EnM.2015.30.2.124.
Cov khoom muaj rau kev tshawb fawb siv nkaus xwb:
