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GLP-3 30 mg

GLP-3 yog cov tshuaj peptide tshiab thiab triple receptor agonist ua haujlwm ntawm GLP-1, GIP, thiab glucagon receptors. Nws pab txo qhov hnyav los ntawm kev tswj kev qab los noj mov, txhim kho satiety, thiab nce kev siv hluav taws xob. GLP-3 kuj tseem txhim kho cov kab mob plawv-metabolic xws li ntshav siab, HbA1c, yoo mov qabzib, insulin, roj cholesterol, thiab triglycerides. Tsis tas li ntawd, nws muaj txiaj ntsig zoo rau cov neeg mob uas tsis muaj dej cawv fatty siab kab mob los ntawm normalizing daim siab rog. Tsis zoo li ib leeg lossis ob tus agonists, GLP-3's triple action mechanism muaj cov txiaj ntsig zoo hauv metabolic, ua rau nws zoo dua rau kev poob phaus, txo cov rog hauv siab, thiab ntshav qab zib normalization. GLP-3 yog ib qho kev cog lus tshiab kev kho mob rau cov neeg rog rog thiab hom 2 mob ntshav qab zib, tshwj xeeb tshaj yog cov tsis teb rau cov kev kho mob tam sim no.

Cov peptide yuav muab ua lyophilized hmoov kom muaj kev ruaj ntseg siab tshaj plaws.

Nqe: $ 430

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1 khoom (10Vials)

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GLP-3 Txheej txheem cej luam

GLP-3 Structure

GLP-3 Kev Tshawb Fawb

Kev Citations

▎ GLP-3 Txheej txheem cej luam

GLP-3 yog tshuaj peptide tshiab. Raws li triple receptor agonist, nws ua haujlwm ntawm glucagon-zoo li peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), thiab glucagon receptors ib txhij. Nws pab cov tib neeg poob phaus los ntawm kev tswj hwm kev qab los noj mov, txhim kho satiety, suppressing tshaib plab, thiab nce kev siv zog.

Tsis tas li ntawd, GLP-3 tuaj yeem txhim kho ntau yam kev pheej hmoo ntawm cov hlab plawv, xws li ntshav siab, glycated hemoglobin, ceev cov ntshav qabzib, insulin, tag nrho cov roj cholesterol, qis lipoprotein cholesterol, thiab triglycerides. Nws kuj tseem muaj txiaj ntsig zoo rau cov neeg mob uas tsis muaj dej cawv fatty siab kab mob, ua rau lub siab rog cov ntsiab lus ntawm feem ntau cov neeg tuaj koom rov qab los.

Piv nrog rau ib leeg lossis ob tus agonists, GLP-3 tswj cov ntshav qabzib, lub cev hnyav, thiab lwm yam los ntawm ntau qhov ntev los ntawm kev ua kom peb lub receptors ntawm GLP-1, GIP, thiab glucagon (GCG). Raws li txoj cai, nws tuaj yeem txhim kho cov kab mob metabolic ntau dua thiab muaj qhov zoo tshwj xeeb hauv cov khoom xws li kev poob phaus, txo qis hepatic steatosis, thiab normalization ntawm cov ntshav qabzib.

Kev sib koom ua ke ntawm ntau lub receptors ntawm GLP-3 ua rau nws muaj txiaj ntsig zoo dua li GLP-1 receptor agonists uas twb muaj lawm lossis dual receptor agonists hauv kev tswj ntshav qab zib thiab tswj lub cev hnyav, muab kev kho tshiab rau cov neeg mob rog rog thiab hom 2 mob ntshav qab zib mellitus.

▎ GLP-3 Structure

1 GLP-3

Source: PubChem

Sequence: YA⊃1;QGTFTSDYSI-L⊃2;LDKK⁴AQA⊃1;AFIEYLLEGGPSSGAPPPS⊃3;

Molecular Formula: C ₂₂₁H ₃₄₂N ₄₆O₆₈

Molecular Luj: 4731 g / mol

CAS Nr .: 2381089-83-2

PubChem CID: 171390338

Cov ntsiab lus: LY3437943

▎ GLP-3 Kev Tshawb Fawb

Dab tsi yog qhov kev tshawb fawb keeb kwm ntawm GLP-3?

Kev rog rog tau dhau los ua ib qho ntawm cov teeb meem kev noj qab haus huv tseem ceeb hauv zej zog niaj hnub no. Nws tuaj yeem ua rau muaj teeb meem kev noj qab haus huv ntau yam xws li hom 2 metabolism mellitus, kab mob plawv, ntshav siab, dyslipidemia, thiab kab mob tsis muaj dej cawv fatty siab. Nrog rau kev nce ntxiv ntawm qhov tshwm sim ntawm kev rog rog, muaj qhov xav tau ceev ceev rau cov kev kho tshiab uas tuaj yeem tswj hwm lub cev hnyav thiab txhim kho kev noj qab haus huv ^[1]. Txawm hais tias kev cuam tshuam hauv kev ua neej, xws li kev ua kom lub cev muaj zog thiab tswj kev noj zaub mov, yog qhov tseem ceeb rau kev ntsuas qhov hnyav, nws nyuaj heev rau ntau tus neeg mob rog rog kom tswj tau qhov hnyav mus ntev.

GLP-3, raws li tus tshiab triple receptor agonist, tuaj yeem ua rau ntawm glucagon-zoo li peptide-1 receptor (

GLP-1R), glucose-dependent insulinotropic polypeptide receptor (GIPR), thiab glucagon receptor (GCGR). Qhov no multi-receptor mechanism ntawm kev nqis tes ua endows nws nrog cov txiaj ntsig tseem ceeb hauv kev poob phaus. Piv nrog rau cov tshuaj poob phaus uas ua rau tsuas yog ib qho receptor, GLP-3 tuaj yeem tswj hwm lub cev cov txheej txheem metabolic ^[1]. GLP-3 ua tiav qhov poob phaus los ntawm kev tswj hwm ntau cov tshuaj hormones receptors, tsis yog tsuas yog qhia tau hais tias muaj txiaj ntsig zoo, tab sis kuj muaj cov kev mob tshwm sim me me hauv plab hnyuv. Tsis tas li ntawd, raws li triple receptor agonist, GLP-3 muaj zog dua qhov hnyav dua thiab ntau dua ntawm cov neeg siv tau piv nrog rau lwm cov tshuaj poob phaus.

GLP-3 yog dab tsi?

GLP-3 yog ib qho tshiab ntev-ua yeeb yam glucagon-zoo li peptide-1 (GLP-1) receptor agonist. Nws tau hloov kho thiab ua kom zoo raws li cov qauv ntawm ntuj GLP-1, thiab nws tuaj yeem khi rau thiab ua kom lub GLP-1 receptor, ua haujlwm lub cev zoo ib yam li cov natural GLP-1, xws li txhawb cov insulin secretion, inhibiting glucagon secretion, qeeb plab hnyuv plab, txo qab los noj mov, thiab lwm yam.

GLP-3 mechanism ntawm kev txiav txim yog dab tsi?

Lub mechanism ntawm kev txiav txim ntawm GLP-3 stems los ntawm nws agonistic teebmeem ntawm ntau receptors. Ua ntej, nws cov nyhuv agonistic ntawm glucagon-zoo li peptide-1 receptor (GLP-1R) tuaj yeem ua rau kom cov tshuaj insulin tso tawm, inhibit glucagon secretion, txo cov ntshav qabzib, thiab tib lub sijhawm ncua kev ua pa ntawm lub plab, nce satiety, thiab txo cov zaub mov noj ^[2]. Qhov thib ob, nws cov nyhuv agonistic ntawm cov piam thaj-dependent insulinotropic polypeptide receptor (GIPR) tuaj yeem txhawb nqa cov tshuaj insulin secretion, txhim kho kev siv cov piam thaj, thiab cuam tshuam rau cov roj metabolism, inhibiting lipolysis thiab txhawb kev rog rog ^[2]. Ntxiv mus, cov nyhuv agonistic ntawm GLP-3 ntawm glucagon receptor (GCGR) feem ntau txhawb nqa glycogenolysis thiab gluconeogenesis hauv daim siab, ua rau cov ntshav qabzib nce ntxiv. Txawm li cas los xij, nyob rau hauv qhov kev txiav txim ntawm GLP-3, qhov kev txhawb nqa cov piam thaj no tau raug cuam tshuam los ntawm cov teebmeem ntawm ob lub receptors, thaum txhawb lipolysis thiab txo cov rog rog ^[2]. Qhov ntau hom phiaj ntawm qhov kev txiav txim no tuaj yeem ua tau zoo dua hauv kev kho mob rog dua li ib leeg receptor agonists.

Los ntawm tib lub sijhawm ua rau peb cov receptors no, GLP-3 tuaj yeem siv ntau yam kev tswj hwm cov metabolism thiab tsim cov teebmeem kev noj qab haus huv ntawm kev rog thiab cov kab mob ntsig txog. Nyob rau hauv cov nqe lus ntawm kev tswj cov ntshav qabzib, txij li kev ua kom GLP-1R thiab GIPR txhawb nqa cov tshuaj insulin secretion thiab inhibits glucagon secretion, thiab kev ua haujlwm ntawm GCGR yog offset los ntawm cov teebmeem ntawm ob receptors, GLP-3 tuaj yeem tswj cov ntshav qabzib ntau, uas yog qhov tseem ceeb rau kev kho mob hom 2, metabolism ^mellitus. Nyob rau hauv cov nqe lus ntawm kev txo cov rog tsub zuj zuj, qhov ua rau ntawm GCGR txhawb lipolysis thiab txo cov rog tsub kom, thaum lub activation ntawm GLP-1R tsub kom satiety thiab txo cov zaub mov noj, ntxiv txo cov rog synthesis ^[1]. Tsis tas li ntawd, GLP-3 kuj tseem muaj kev txhim kho ntawm cov kab mob uas tsis yog-alcoholic fatty siab. Nws tuaj yeem txo cov rog hauv daim siab thiab txhim kho daim siab ua haujlwm.

HbA1c, lub cev hnyav, ntshav siab, thiab lipids Cov ntaub ntawv yog qhov tsawg tshaj plaws-squares txhais tau tias (nrog cov kab yuam kev uas qhia SEs) los ntawm kev tsom xam cov txiaj ntsig, tshwj tsis yog sau tseg.

Source: PubMed ^[4]

GLP-3 qhia txog qhov cuam tshuam li cas?

GLP-3 nthuav tawm cov teebmeem tseem ceeb hauv ntau yam

Kev poob ceeb thawj tseem ceeb: GLP-3 tau ua kom pom qhov hnyav hnyav hauv ntau qhov kev sim tshuaj. Piv txwv li, hauv kev tshawb fawb soj ntsuam nrog rau 338 tus neeg laus (Jastreboff AMM, 2023), cov neeg mob tau kho nrog cov koob tshuaj sib txawv ntawm GLP-3 tau ntsib qhov hnyav poob ntawm 48 lub lis piam. Ntawm lawv, cov neeg mob hauv pawg koob tshuaj 12mg poob 24.2% ntawm lawv lub cev hnyav, thiab feem ntau ntawm cov neeg mob tau poob phaus mus rau qhov sib txawv. Piv txwv li, ntawm cov neeg mob tau txais koob tshuaj 4mg, 8mg, thiab 12mg, 92%, 100%, thiab 100% ntawm cov neeg mob, raws li, poob 5% lossis ntau dua ntawm lawv lub cev hnyav. Hauv lwm txoj kev tshawb fawb ^[3], ob qhov kev sim tswj kev sib tw nrog 353 tus neeg mob uas muaj hom 2 metabolism hauv cov ntshav qhia tau tias piv nrog cov placebo, GLP-3 tuaj yeem txo lub cev hnyav ntawm cov neeg mob los ntawm 11.89kg, thiab tseem txo glycated hemoglobin (HbA1C). Tsis tas li ntawd, hauv kev sim ntawm cov neeg laus uas muaj kev rog rog yam tsis muaj cov metabolism, GLP-3 ua rau 24.2% poob rau cov neeg mob, thiab 83% ntawm cov neeg mob poob 15% lossis ntau dua ntawm lawv lub cev hnyav ntawm 48 lub lis piam. Cov txiaj ntsig no qhia tau tias GLP-3 muaj peev xwm loj hauv kev poob phaus.

Kev kho mob ntawm hom 2 metabolism mellitus: GLP-3 kuj qhia tau qee yam muaj peev xwm hauv kev kho mob ntawm hom 2 metabolism mellitus. Hauv qee qhov kev sim tshuaj, GLP-3 tau pom tias txo qis hauv glycated hemoglobin (HbA1c) thiab kev poob phaus raws li koob tshuaj. Piv txwv li, hauv ib txoj kev tshawb fawb, hauv cov neeg mob uas muaj hom 2 metabolism hauv mellitus, GLP-3 pom tau tias muaj kev cuam tshuam cov ntshav qabzib tseem ceeb. Piv nrog rau cov placebo, glycated hemoglobin poob los ntawm 1.64% ^[3]. Tsis tas li ntawd, nyob rau hauv randomized, ob-dig muag, placebo thiab active-tswj parallel-paj pawg theem 2 mus sib hais, tsiaj cov qauv nrog hom 2 metabolism mellitus, tom qab tau txais kev kho GLP-3, pom qhov txo qis hauv glycated hemoglobin qib, thiab lawv lub cev hnyav kuj txo qis hauv kev siv tshuaj ntau npaum li cas ^[4]. Qhov no tuaj yeem raug ntaus nqi los ntawm cov txiaj ntsig zoo ntawm cov tshuaj ntawm GLP-1, GCGR, thiab GIPR, uas txhim kho cov piam thaj metabolism thiab lub zog sib npaug.

Kev txhim kho ntawm cov kab mob plawv: GLP-3 tuaj yeem tsis tsuas yog txo lub cev hnyav xwb tab sis kuj tseem txhim kho cov kab mob plawv, xws li cov ntshav lipid profile thiab glycated hemoglobin qib. Qhov no qhia txog kev sib txuas ntawm pathophysiological ze ntawm kev rog thiab cov kab mob plawv, thiab GLP-3 tuaj yeem txhim kho cov hlab plawv kev noj qab haus huv ntawm cov neeg mob rog dhau los ntawm ntau txoj hauv kev. Piv txwv li, txo qis HDL-C, apoB, thiab LDLP qib tuaj yeem txo qhov kev pheej hmoo ntawm atherosclerosis; txo glycated hemoglobin qib tuaj yeem txhim kho cov ntshav qabzib tswj hauv cov neeg mob nrog cov metabolism, yog li txo qis kev pheej hmoo ntawm cov teeb meem plawv ^{[3, 5, 6]}.

Kev kho mob ntawm cov kab mob uas tsis yog-alcoholic fatty siab (NAFLD): GLP-3 yog ib qho tshiab triple receptor agonist peptide uas tsom rau glucagon receptor (GCGR), qabzib-dependent insulinotropic polypeptide receptor (GIPR), thiab glucagon-zoo li peptide-1 receptor (GLP-1R). Cov kev tshawb fawb tau pom tias GLP-3 muaj peev xwm kho tau cov kab mob uas tsis yog-alcoholic fatty siab. Hauv ib txoj kev tshawb fawb, ib qho kev sib tw, ob qhov muag tsis pom kev, kev sim tshuaj placebo tau ua rau 48 lub lis piam rau cov neeg koom nrog metabolic dysfunction-associated fatty siab kab mob thiab lub siab rog cov ntsiab lus ntawm ≥10%. Cov txiaj ntsig tau pom tias ntawm 24 lub lis piam, qhov nruab nrab txheeb ze hloov pauv hauv daim siab rog los ntawm cov hauv paus hauv paus hauv cov neeg koom nrog kev kho mob sib txawv ntawm GLP-3 (1mg, 4mg, 8mg, thiab 12mg) yog -42.9%, -57.0%, -81.4%, thiab -82.4%, feem, thaum nyob hauv pawg placebo yog +0.3% ^[7] Qhov no qhia tau hais tias GLP-3 tuaj yeem muaj kev kho mob tseem ceeb ntawm cov kab mob tsis muaj dej cawv fatty siab.

Hauv kev xaus, raws li tus tshiab triple receptor agonist, GLP-3 qhia tau hais tias muaj peev xwm loj hauv kev kho mob rog thiab lwm yam kab mob. Nws tuaj yeem tswj hwm tib neeg cov metabolism los ntawm ntau qhov ntev los ntawm kev ua kom cov glucagon receptor, qabzib-nyob ntawm insulinotropic polypeptide receptor, thiab glucagon-zoo li peptide-1 receptor, txhim kho ntshav qabzib tswj, txo lub cev hnyav, thiab tswj lipid metabolism. Qhov tshwm sim ntawm GLP-3 tau coj cov kev kho mob tshiab rau cov neeg mob rog rog, hom 2 metabolism mellitus, thiab lwm yam. Nws xav tias yuav tawg los ntawm cov kev txwv ntawm ib txwm siv tshuaj receptor agonist, muab riam phom muaj zog dua rau kev daws cov teeb meem loj zuj zus ntawm kev rog rog thiab cov kab mob metabolic, txhawb kev txhim kho ntxiv ntawm kev kho mob, txhim kho lub neej zoo ntawm cov neeg mob, thiab txo cov kev mob nkeeg.

Hais Txog Tus Sau

Cov ntaub ntawv hais saum toj no yog txhua yam tshawb fawb, kho thiab sau los ntawm Cocer Peptides.

Scientific Journal Author

Rosenstock J yog tus kws tshawb fawb muaj txiaj ntsig zoo hauv kev kho mob, sib koom tes nrog cov koom haum xws li University of Texas Southwestern Medical Center thiab University of Texas Dallas. Nws kuj ua kev tshawb fawb ntawm cov chaw xws li Canadian VIGOR Center thiab Veloc Clin Res Ctr Med City.

Nws txoj kev tshawb fawb nthuav dav endocrinology thiab cov metabolism, cov hlab plawv thiab cov hlab plawv, pharmacology, thiab kev sim tshuaj, nrog rau kev tsom mus rau cov metabolism, rog rog, thiab lwm yam kev kho mob thiab kev txhim kho tshuaj. J Rosenstock tau ua tiav cov txiaj ntsig tseem ceeb hauv cov tshuaj kho mob, tau raug hu ua Tus Kws Tshaj Lij Tshaj Lij Tshaj Lij Tshaj Lij los ntawm 2017 txog 2024. Qhov no qhia txog qhov cuam tshuam loj thiab kev lees paub dav ntawm nws txoj haujlwm. Los ntawm kev koom tes nrog ntau lub koom haum tshawb fawb, nws tau ua tiav cov txiaj ntsig kev tshawb fawb hauv kev tshawb fawb hauv kev siv tshuaj kho mob, tau txais txiaj ntsig zoo rau cov neeg mob metabolic thiab kab mob plawv thiab nce qib kev kho mob. Rosenstock J tau teev nyob rau hauv kev siv ntawm cov ntaub ntawv pov thawj [4].

▎ Cov Lus Qhia Tseem Ceeb

[1] Kaur M, Misra S. Kev tshuaj xyuas cov tshuaj tshawb nrhiav GLP-3, tus neeg sawv cev tshiab triple agonist rau kev kho mob rog rog [J]. European Journal of Clinical Pharmacology, 2024,80(5):669-676.DOI:10.1007/s00228-024-03646-0.

[2] Jastreboff AM, Kaplan LM, Frias JP, et al. Triple-hormone-Receptor Agonist GLP-3 rau Obesity - Theem 2 Trial [J]. New England Journal of Medicine, 2023,389(6):514-526.DOI:10.1056/NEJMoa2301972.

[3] Lopez DC, Pajimna JT, Milan MD, et al. 7792 Kev Ua Tau Zoo ntawm GLP-3 rau Kev Txom Nyem thiab Nws Cov Teebmeem Cardiometabolic Ntawm Cov Neeg Laus: Kev Ntsuam Xyuas Txheej Txheem thiab Meta-Analysis[J]. Phau ntawv Journal of the Endocrine Society, 2024,8(1):163-749.DOI:10.1210/jendso/bvae163.749.

[4] Rosenstock J, Frias J, Jastreboff AM, et al. GLP-3, GIP, GLP-1 thiab glucagon receptor agonist, rau cov neeg uas muaj hom 2 metabolism: ib qho randomised, ob-dig muag, placebo thiab active-tswj, parallel-pab pawg, theem 2 sim ua nyob rau hauv teb chaws USA [J]. Lancet, 2023,402(10401):529-544.DOI:10.1016/S0140-6736(23)01053-X.

[5] Nicholls S, Pirro V, Lin Y, et al. Triple-hormone receptor agonist GLP-3 txhim kho lipoprotein thiab apolipoprotein profiles hauv cov neeg koom nrog rog lossis rog [J]. European Heart Journal, 2024,45.DOI:10.1093/eurheartj/ehae666.1501.

[6] Ray A. GLP-3: triple incretin receptor agonist rau kev tswj kev rog [J]. Cov Lus Qhia Txog Kev Tshawb Fawb Txog Tshuaj, 2023,32(11): 1003-1008.DOI: 10.1080/13543784.2023.2276754.

[7] Sanyal AJ, Kaplan LM, Frias JP, et al. Triple hormone receptor agonist GLP-3 rau metabolic dysfunction-associated steatotic daim siab kab mob: ib theem randomized 2a sim [J]. Nature Medicine, 2024,30(7):2037-2048.DOI:10.1038/s41591-024-03018-2.

Tag nrho cov kab lus thiab cov ntaub ntawv ntawm cov khoom lag luam muab rau ntawm lub vev xaib no tsuas yog rau cov ntaub ntawv tshaj tawm kev tshaj tawm thiab cov hom phiaj kev kawm.

Cov khoom muab rau hauv lub vev xaib no yog npaj tshwj xeeb rau kev tshawb fawb hauv vitro. Kev tshawb fawb hauv vitro (Latin: * hauv iav *, lub ntsiab lus hauv iav) yog ua los ntawm tib neeg lub cev. Cov khoom no tsis yog tshuaj, tsis tau txais kev pom zoo los ntawm US Food and Drug Administration (FDA), thiab yuav tsum tsis txhob siv los tiv thaiv, kho, lossis kho txhua yam mob, kab mob, lossis mob. Nws raug txwv nruj raws li txoj cai los qhia cov khoom no rau hauv tib neeg lossis tsiaj lub cev hauv txhua daim ntawv.

Yam khoom

GLP-3 30 mg

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