HCG 5000iu ye

▎ HCG ka baarakɛcogo

▎ HCG ka ɲininiw

hCG ka ɲininiw kɛcogo ye mun ye?

hCG jɔyɔrɔ ka bon bangekɔlɔsi furakɛli la, i n’a fɔ kɔnɔmaya joona marali ani ka kɔnɔmaya bila bangekɔlɔsi fɛɛrɛw la minnu bɛ dɛmɛ. hCG nafama bɛ bɔ fɔlɔ musokɔnɔmaw ka sugunɛ na, o bɛ dantigɛli jira a sɔrɔli ni saniya sabatili la. O tɛ se ka kɛnɛyaso ka ɲininiw dafa minnu bɛ ka bonya, o bɛ kɛ sababu ye ka hCG sintetiki dilan walasa ka fura sɔrɔyɔrɔ sabatilen ni dannaya bɛ se ka da min kan.

Ɲɛtaa minnu kɛra jamu sɛgɛsɛgɛli fɛɛrɛbɔ la, olu kɛra sababu ye ka hCG jamu kɛcogo caman kɛ ani k’a jira, o ye fɛɛrɛ jusigilan sigi hCG sintetiki ɲinini na. Ni hCG jamu donna jatigila selilɛriw kɔnɔ i n’a fɔ yezu walima Sinuwa hamster ovary (CHO) selilɛriw, hCG jirali bɛ se ka kɛ ɲɔgɔn fɛ. hCG sintetiki bɛ misali saniyalenw di walasa ka sigida ni baarakɛcogo kalanw kɛ, o bɛ a ka baarakɛcogo faamuyali jugu nɔgɔya ani ka furakɛli kɛcogo ɲumanw yiriwa. Ka fara o kan, hCG sintetiki bɛ se ka kɛ ka banakisɛfagalanw labɛn, ka kɔnɔmaya sɛgɛsɛgɛli kɛcogo ɲuman sabati ani ka banaw kɔlɔsi minnu bɛ tali kɛ ɲɔgɔn na.

HCG ka baarakɛcogo ye mun ye?

Fɛɛrɛ min bɛ kɛ kɔnɔmaya sabatili la : hCG bɛ sɔrɔ fɔlɔ sinsitiyɔtrofoblasi selilɛriw fɛ minnu tɛ kelen ye, wa a bɛ kɛ denw ka taamasiɲɛ nafamaba ye min nafa ka bon kɔnɔmaya sabatili la. A bɛ taamasiɲɛ caman kɛ ni a sirili ye luteinizing hormone/human chorionic gonadotropin receptor (LHCGR) la. Nwabuobi C ka ɲininiw y’a jira ko jɛɲɔgɔnya tilennen walima jɛɲɔgɔnya tilennen tɛ ni transforming growth factor beta receptor (TGFβR) ye, a bɛ denba ka taamasiɲɛw siraw baara i n’a fɔ Smad2, protein kinase C (PKC), ani/walima protein kinase A (PKA). Denso kɔnɔnatumuw ka joli-sira-funu sabatili la, hCG bɛ dɛmɛ ka balo ni oksizɛni bɛrɛbɛrɛ di den ka yiriwali ma; Denso kɔnɔnatumuw lafiyali sabatili la, a bɛ denso kɔnɔna sabatilen dɔ dilan min bɛ denso doncogo ni a yiriwali dɛmɛ; Banakisɛfagalanw labɛnni sabatili la denba ni den cɛsira la, hCG bɛ denba ka farikolo tangacogo sɛmɛntiya walasa ka den bali ka ban, o bɛ kɔnɔta ɲɛtaa ^sabati.

Fɛɛrɛ min bɛ kɛ ka kɔnɔbara minɛcogo ɲɛ : Kɔrɔbɔli minnu kɛra in vivo kɔnɔ ni denw doncogo jugumanba (EID) sogo modɛli ye ani hadamaden kɔnɔbara basigilen selilɛriw (EEC) y’a jira ko hCG bɛ kɔnɔbara minɛcogo ɲɛ EID sogow la. hCG bɛ miR-126-3p/PIK3R2 aksidan labɛn ni miR-126-3p jirali sabatili ye ani ka PIK3R2 bali, ka sɔrɔ miR-126-3p bɛ PIK3R2 laɲini. EEC caya cayara hCG furakɛli kɔfɛ nka a balila ni miR-126-3p jiginna. Kɔrɔbɔli minnu kɛra in vivo ani in vitro fila bɛɛ la olu y’a jira ko hCG bɛ kɔnɔbara minɛcogo ɲɛ ani ka denw donli nɔgɔya ni PI3K/Akt/eNOS sira baara ye miR-126-3p/PIK3R2 axis fɛ^, .

Jaa 1 hCG ye kɔnɔbara basigilen minɛcogo ɲɛ EID sogow la ^[2]..

Glycosylation nɔ min bɛ ɔrimɔni fɛɛrɛw la : Kɔlɔsili minnu kɛra hCG yɔrɔ glycosylées kan, olu y’a jira ko ni sukaro tolen suguya wɛrɛw bɔra hCG bɔlenw na, o bɛ nɔ bila u sirili seko la ni sosow ka Leydig selilɛriw ye ani u ka se ka testosterone ni cyclic AMP (cAMP) sɛnɛcogo lawuli. Ni asidi siyaliki, galakɔtɔsi, N-asetiliglukozamini ani manɔsi tolenw bɔra ɲɔgɔn kɔ, ɔrimɔni hakɛ nafama min ka kan ka kɛ walasa ka stɛroyi bɔli lawuli, o cayara dɔɔni dɔɔni, ka sɔrɔ seko min bɛ cAMP dalajɛli lawuli, o dɔgɔyara kosɛbɛ. Ɔrimɔni bɔlenw minnu furakɛra ni glycosidase hakɛ dɔgɔman ye, olu ye farali nɔ jira ni u sɛgɛsɛgɛra ni hCG ye u seko la ka tetarasikilini sɔrɔli lawuli. Nka, o bɔlen ninnu tun ye hCG ka cAMP dalajɛli balilan barikamaw ye, o b’a jira ko glycosylation bɔli bɛ nɔba bila ɔrimɔni ni selilɛri sirili la ka sɔrɔ ka dɔ bɔ ɔrimɔni sirilenw seko la ka adenylate cyclase baara. O bɛ glycosylation jɔyɔrɔba jira ka t’a fɛ taamasiɲɛw cili la hCG baarakɛcogo kɔnɔ ^{[3] .}.

hCG baarakɛcogo ye mun ye?

Kɔnɔmaya sɛgɛsɛgɛli joona : hCG dilannen bɛ kɛ ka banakisɛfagalanw labɛn. Dɔgɔtɔrɔso la, kɔnɔmaya bɛ dɔn ni hCG hakɛ sumani ye muso sugunɛ walima a joli la. Tile 6–7 ɲɔgɔn kɔnɔmaya kɔfɛ, trofoblaste selilɛriw bɛ hCG bɔli daminɛ. Ni kɔnɔmaya bɛ taa ɲɛ, hCG hakɛ bɛ wuli joona joli ni sugunɛ fila bɛɛ la. Baara kɛli ni hCG sintetiki ye i n’a fɔ sariya, o bɛ kɛ sababu ye ka kuru jɔnjɔn dɔ sigi sen kan tigitigi dɔnnifɛnw na, o bɛ se ka kɛ sababu ye ka hCG hakɛ jateminɛ tigitigi kɛ misaliw kɔnɔ. Misali la, kɔnɔmaya sɛgɛsɛgɛli sɛbɛnw minnu bɛ kɛ tuma caman na, olu bɛ u jigi da immunochromatography fɛɛrɛ kan, banakisɛfagalanw minnu dilannen don ni hCG dilannen ye, olu bɛ siri kɛrɛnkɛrɛnnenya la hCG la sugunɛ na, ni kulɛri kɛcogo dɔ bɛ kɔnɔmaya cogoya jira. A ka c’a la, waati tɛmɛnen kɔfɛ, musow bɛ se ka baara kɛ ni o fɛɛrɛ suguw ye kɔnɔmaya jateminɛ fɔlɔ la, o bɛ kɛ sababu ye ka bangekɔlɔsi ladonni ni furakɛli ^kɔfɛ.

Kɔnɔmaya bɛ tali kɛ bana minnu na, olu kɔlɔsili : Kɔnɔmaya waati, denba ka hCG hakɛ caman caman cili bɛ dɛmɛ ka kɔnɔmaya bana suguya caman sɛgɛsɛgɛ ani k’u kɔlɔsi. Misali la, kɔnɔmaya kɔfɛ, kɔnɔbara basigilen bɛ don yɔrɔ minnu na denso kɔkan, trophoblastic cellules bɛ yiriwa cogo la min tɛ bɛn. O bɛ na ni hCG bɔli dɔgɔyali ye ni a bɛ tali kɛ kɔnɔmaya la min bɛ kɛ cogo la ani ka waati jan kɛ siɲɛ fila. Ni aw bɛ to ka joli kɔnɔ hCG hakɛ kɔlɔsi, ni o farala ɲɔgɔn kan ni ultrasound sɛgɛsɛgɛliw ye, o bɛ kɔnɔta kɔkanna dɔnni nɔgɔya joona. O bɛ kɛ sababu ye ka dɛmɛ don a la ani ka furakɛli kɛ waati bɛnnen na, ka gɛlɛya jugumanw bali. Ka fara o kan, trophoblastic banaw la i n’a fɔ hydatidiform mole, a ka ca a la hCG hakɛ bɛ wulicogo jugu jira. Furakɛli kɔfɛ, hCG kɔlɔsili min bɛ to senna, o bɛ se ka furakɛli nafa jateminɛ ani ka seginkanni dɔn. Ni hCG hakɛ bɛ to ka wuli walima ka wuli, o b’a jira ko bana tolen bɛ se ka sɔrɔ walima ka segin a kan, o bɛ kɛ sababu ye ka sɛgɛsɛgɛli wɛrɛw kɛ ani ka fɛɛrɛ tigɛ ^{[1] .}.

Ɲɛtaa jumɛnw kɛra k’a lajɛ ka ɲɛsin hCG ma?

Bangekɔlɔsi boloci minnu dilannen don ni hCG ka β-subunit dafalen ye i n’a fɔ farikolo tangalan ani asidi aminiki 37 pepitiri yɔrɔ (C-terminus 109-145) i n’a fɔ farikolo tangalan, olu tɛmɛna baga ni lakana sɛgɛsɛgɛliw ɲɛfɛ ka kɔn kɛnɛyaso ɲɛ ani ka Fasa I ni Fase II kɛnɛyaso sɛgɛsɛgɛliw dafa. Fasa fɔlɔ kɛnɛyako sɛgɛsɛgɛli dɔ la min kɛra ni muso 116 ye minnu tun ye tubabufura siri, boloci suguya saba minnu sinsinnen bɛ β-hCG kan, olu sɛgɛsɛgɛra. Jateminɛw y’a jira ko muso bolocilenw bɛɛ ye farikolo tangalanw sɔrɔ hCG ni tetanɔsi la, o b’a jira ko nin boloci ninnu bɛ hadamaden farikolo tangacogo lawuli kosɛbɛ ^{[4] .}.

Walasa ka bangekɔlɔsi fɛɛrɛw sɔrɔ ani ka banaw furakɛ minnu bɛ sɔrɔ ɔrimɔni fɛ, ɲininikɛlaw ye bolociw labɛn minnu ɲɛsinnen bɛ hCG ma. Banakisɛfagalanw labɛnna ni pepitiri sintetikiw sirili ye minnu bɛ hCG β-subunit ka sigicogo fɔlɔ dabɔlen jira ni farikolojɔlifɛnw tabaga ye. Yiriwali waati la, ɲininikɛlaw ye pepitiri caman dilan minnu janya tɛ kelen ye, minnu sugandira ka bɔ β yɔrɔ fitinin C-terminal yɔrɔ la, ka u seko kɔrɔbɔ ka farikolojɔlifɛnw bila minnu bɛ se ka kɛ ni hCG ye ani k’a baara kɛ fɛn ye min tɛ se ka kɛ in vivo. A laban na, asidi aminiki 37 pepitiri yɔrɔ min bɛ β yɔrɔ fitinin C-terminal yɔrɔ jira, o sugandira ka kɛ boloci antijeni ye. Dipthéria toxoïde sugandira ka kɛ a tabaga ye, o kɛra sababu ye ka boloci fɔlɔ labɛnni kɛ. Kɔrɔbɔliw kɔfɛ suguya caman kan, nin boloci in ye farikolo tangalan hakɛ caman bila hCG kɛlɛli la ka ɲɛ, wa bangekɔlɔsi dɔgɔyara kosɛbɛ baganw bolocilenw na. O ye hakilina kuraw di ani fɛɛrɛ minnu bɛ se ka kɛ hadamadenw ka bangekɔlɔsi fɛɛrɛw la ani banaw furakɛli minnu bɛ tali kɛ o la ^{[5] .}.

Kuncɛli

I n’a fɔ glycoprotéine hormone jɔnjɔn, hCG jɔyɔrɔ ka bon kosɛbɛ bangekɔlɔsi fɛɛrɛw la: musow la, a bɛ baara kɛ ni a sirili ye luteinizing hormone/ chorionic gonadotropin receptor (LHCGR) la walasa ka kɔnɔmaya daminɛ na (a bɛ luteal progesterone bɔli dɛmɛ ani ka denso lamini sabatilen dilan), ka kɔnɔbara basigilen ni kɔnɔbara basigilen sabati, ani ka a bonya kɔnɔbara basigilen sɔrɔli walasa ka denw donli nɔgɔya. Cɛw la, a bɛ Leydig selilɛriw lawuli u ka tetarasikilini dilan ani k’a bɔ, o bɛ bangekɔlɔsi fɛɛrɛw yiriwali ni cɛya sɔrɔli dɛmɛ.

A sɛbɛnbaga ko la

Fɛn minnu kofɔlen dòn san fɛ, olu bɛɛ ɲinini Kɛra, k’u Labɛn ani k’u Lajɛ Cocer Peptides fɛ.

Dɔnniya gafe sɛbɛnbaga

Nwabuobi C ye ɲininikɛla ye min sinsinnen bɛ hadamadenw ka gonadotropin (hCG) kalanni kan. U ka ɲininiw sinsinnen bɛ kosɛbɛ hCG ka ɲɛnamaya baarakɛcogo sɛgɛsɛgɛli kan ani k’a ni kɛnɛyaso baarakɛcogo cɛsiraw sɛgɛsɛgɛ. Nwabuobi C ka teli ka kɔrɔbɔli fɛɛrɛw faralen ɲɔgɔn kan i n’a fɔ molekiyɔmu biologi fɛɛrɛw ani kɛnɛyaso misali sɛgɛsɛgɛli walasa ka ɲinini kuncɛlenw kɛ, k’a laɲini ka hCG farikoloɲɛnajɛ kɛcogo faamuyali juguya ani a nafa waleyali kɛnɛyako siratigɛ la. Nwabuobi C tɔgɔ sɛbɛnnen bɛ citation référence kɔnɔ [1].

▎ Sɛbɛn minnu bɛ tali kɛ o la

[1] Nwabuobi C, Arlier S, Schatz F, Guzeloglu-Kayisli O, Lockwood C. J., Kayisli U. A. (2006) Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew. hCG: Biologique baarakɛcogo ani a kɛcogo kɛnɛyaso la. Duniya kɔnɔ, fɛnɲɛnɛma dɔnniyaw ka gafe 2017; 18(10).DOI: 10.3390/ijms18102037. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.

[2] Wang W, Ge L, Zhang L. L., ani mɔgɔ wɛrɛw. Adamaden ka gonadotropin chorionic ka fɛɛrɛ kɔnɔbara basigilen na miR-126-3p/PI3K/Akt/eNOS axis fɛ. Kaohsiung ka dɔgɔtɔrɔso dɔnniya gafe 2023; 39(5): 468-477.DOI: 10.1002/kjm2.12672. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.

[3] Moyle WR, Bahl OP, März L. Hadamaden ka gonadotropin chorionic ka witaminiw jɔyɔrɔ ɔrimɔni baarakɛcogo la. Journal of Biologique Chimie 1975; 250(23): 9163-9169. Bamako, Mali.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Sɔrɔ&db=pubmed&dopt=Abstract&list_uids=172504&query_hl=1.

[4] Talwar G. P., Hingorani V., Kumar S., ani a ɲɔgɔnnaw. Fasa fɔlɔ kɛnɛyaso sɛgɛsɛgɛliw ni hadamadenw ka gonadotropin koloci suguya saba ye. Bangekɔlɔsi fɛɛrɛw 1990; 41(3): 301-316.DOI: 10.1016/0010-7824(90)90071-3.. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.

[5] Sitiwɛn V. C.. Pepitidi dilannenw kɛli i n’a fɔ farikolo tangalanw walasa ka hadamadenw ka gonadotropini (gonadotropin chorionic) boloci kɛ. Ciba Sɔrɔla Simp 1986; 119: 200-225.DOI: 10.1002/9780470513286.ch12. Bamako, Mali.

BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, olu BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.  

Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *glasi kɔnɔ*, o kɔrɔ ye gilasi kɔnɔ) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki ka dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.