Cocer Peptides ye 
ŋlɔe ɣleti 1 enye sia
NYATAKAKAWO KPLE NUSIWO WOTSƆ ƑE NYATAKAKA SIWO KAtã WOÐO LE NYATAKAKADZRAÐOƑE SIA ME LA KPLE NYATAKAKAWO kaka KPLEE NUFIAFIA ƑE TAÐOÐOWO KO.
Wotrɔ asi le atike siwo wona le nyatakakadzraɖoƒe sia ŋu na numekuku le vitro ɖeɖeko. Wowɔa numekuku le vitro (Latingbe me: *le ahuhɔ̃e me*, si gɔmee nye le ahuhɔ̃e me) le amegbetɔ ƒe ŋutilã godo. Atike siawo menye atikewo o, United States ƒe Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) meda asi ɖe wo dzi o, eye mele be woazã wo atsɔ axe mɔ ɖe atikewɔwɔ, dɔléle, alo dɔléle aɖeke nu, adae, alo adae o. Se de se vevie be woatsɔ atike siawo ade amegbetɔ alo lãwo ƒe ŋutilã me le mɔ ɖesiaɖe nu.
Le atikewɔwɔ kple nugbagbeŋutinunya me la, dɔdzẽ ƒe ŋuɖoɖo nye ŋutilã ƒe ametakpɔkpɔ ƒe nuwɔna sesẽ aɖe ɖe nu vovovo siwo doa abi ame ŋu. Dɔdzẽ ƒe ŋuɖoɖo si gbɔ eme alo esi dzi womeɖu o ate ŋu agblẽ nu le ŋutilãa ŋu eye wòahe dɔléle vovovowo vɛ. Vilon, abe nusi ƒe wɔwɔme kple dɔwɔwɔ ƒe nɔnɔme tɔxɛwo le ene, ɖe akpa tɔxɛ siwo wòwɔna kple eŋudɔwɔwɔ ƒe ŋutete fia le dɔlékuiwutikewo ƒe ŋusẽkpɔɖeamedziwo me.
Nɔnɔmetata 1 Dɔlékuiwutikewo ƒe dɔwɔwɔ.
Vilon ƒe Dzɔtsoƒewo Kple Eƒe Dɔwɔɖoɖo
Vilon nye peptide si wɔa dɔ le nugbagbewo me si ƒe ŋkɔ bliboa nye L-Lys-L-Glu. Wotue ɖe atike si nye Thymogen dzi, si me dipeptide L-Glu-L-Trp si me dɔlélenutsiŋutete ƒe dɔwɔwɔ trɔna le. Le ƒe 1991 me la, Morozov kple Khavinson ɖe Naturalthymic factors (NTFs) ɖe vovo tso nyitsu ƒe thymus me, eye emegbe woto atike si nye Thymalin si wotu ɖe NTFs dzi vɛ, si wozãna le atikewɔnyawo me tsɔ xea mɔ na dɔlélenutsiŋutete ƒe dɔmawɔmawɔ nyuie kple wo dada. Emegbe wozã reverse-phase liquid chromatography tsɔ ɖe Thymogen si me dipeptide vevitɔ le la ɖe vovo tso Thymalin me, eye woganɔ te ɖe esia dzi gawɔ Vilon. Dzɔdzɔmenuwo ɖeɖeɖa afɔɖeɖe siae ɖo gɔmeɖoanyi na Vilon ƒe dɔ tɔxɛ si tsia dɔdzẽ nu. Amino acid ƒe ɖoɖo tɔxɛ aɖee le eme, eye L-Lys (lysine) kple L-Glu (glutamic acid) do ƒome kple peptide ƒe kadodo. Dɔwɔwɔ sia nana Vilon te ŋu wɔa dɔ kple lãmenugbagbeviwo ƒe yame xɔlawo alo lãmenugbagbeviwo me moleculewo, si wɔnɛ be wòdzea dɔlékuiwutikewo ƒe dɔwɔwɔ ɖe wo nɔewo yome gɔme.
Vilon ƒe ɖoɖowɔwɔ ƒe ŋusẽkpɔɖeamedzi ɖe dɔdzẽ ƒe lãmenugbagbeviwo kple dɔdzẽ ƒe nuwɔna dzi
Ŋusẽkpɔɖeamedzi ɖe macrophages dzi: Macrophages nye lãmenugbagbevi vevi siwo le dɔdzẽ ƒe ŋuɖoɖo me. Le dɔdzẽɣi la, macrophages wɔa dɔ eye woɖea nu vovovo siwo doa alɔ dɔdzẽ kple dɔdzẽ ƒe domenɔlawo ɖe go. Vilon kpɔa ŋusẽ ɖe nusiwo doa alɔ dɔdzẽ IL-1β kple TNF-α, kpakple dɔdzẽ ƒe domenɔla NO, ƒe dodo dzi vevie to sisiblisi ƒe dɔgbo me macrophages siwo kpɔa gome le dɔdzẽ ƒe ŋuɖoɖoa me dzi. Esi wozã LPS-activated mouse primary cultured peritoneal macrophages abe alesi woawɔ akpɔ egbɔ nyuie ene, ne wodo mouse peritoneal macrophages ɖekae kple Vilon le agbɔsɔsɔ si nye 0.1 μg/mL, 1 μg/mL, kple 10 μg/mL, kple LPS le 1 μg/mL me la, Vilon ɖe dodoɖeŋgɔ ƒe ŋusẽkpɔɖeamedzi si dze ƒã fia ɖe IL-1β kple NO ƒe dodo dzi to LPS-activated mouse peritoneal macrophages, kple ƒomedodo si nɔ te ɖe agbɔsɔsɔme si wozã dzi. Esia ɖee fia be ne Vilon ƒe agbɔsɔsɔ le dzidzim ɖe edzi la, ŋutete si le esi be wòado nu siawo siwo do ƒome kple dɔdzẽ ƒe dodo ɖe ŋgɔ to macrophages dzi hã dzina ɖe edzi. Tsɔ kpe ɖe eŋu la, Vilon do IL-1β, TNF-α, kple iNOS mRNA ƒe ɖeɖefia hã ɖe ŋgɔ.
Esia fia be Vilon ate ŋu aɖɔ dɔdzẽ ƒe nuwɔna ɖo le domenyiŋusẽfianu ƒe nuŋɔŋlɔ ƒe ɖoɖo nu, si ana wòakpɔ ŋusẽ ɖe dɔdzẽ ƒe ŋuɖoɖo ƒe ŋgɔyiyi dzi. Togbɔ be edze abe Vilon doa dɔlékuiwutikewo ƒe dodo ɖe ŋgɔ ene hã la, dodoɖeŋgɔ ƒe ŋusẽkpɔɖeamedzi sia ate ŋu anye ɖoɖowɔwɔ ƒe mɔnu le dɔdzẽ ƒe ŋuɖoɖo siwo sesẽ la me. Le kpɔɖeŋu me, dɔdzẽ ƒe nusiwo dona le lãme na ame le mɔ si sɔ nu kpena ɖe ame ŋu wòdzea ŋutilãa ƒe dɔlélenutsiŋutete takpɔkpɔ ƒe mɔnuwo gɔme be wòaɖe dɔlékuiwo kple nu bubu siwo gblẽa nu le ame ŋu ɖa, eye Vilon ate ŋu aɖɔ dɔlékui siawo ƒe dodo ƒe agbɔsɔsɔme ɖo pɛpɛpɛ be wòanɔ agbɔsɔsɔ si ana dɔdzẽ ƒe ŋgɔyiyi si sɔ la nanɔ bɔbɔe evɔ magblẽ nu le ŋutilãa ŋu fũu akpa o.
Ŋusẽ si wòate ŋu akpɔ ɖe dɔlélenutsiŋutete ƒe lãmenugbagbevi bubuwo dzi: Tsɔ kpe ɖe macrophages ŋu la, Vilon, abe dɔlélenutsiŋutete ƒe ɖoɖowɔla si wɔa dɔ geɖe ene, ate ŋu akpɔ ŋusẽ ɖe dɔlélenutsiŋutete ƒe lãmenugbagbevi bubuwo hã dzi, eye wòakpɔ gome le dɔlékuiwutikewo ƒe dɔwɔwɔ me le mɔ si mele tẽ o nu. Le kpɔɖeŋu me, ate ŋu ado thymocytes ƒe dzidziɖedzi, dɔwɔwɔ, kple vovototodedeameme ɖe ŋgɔ. Thymus nye teƒe vevi aɖe si T lymphocytes tsina, eye Vilon ƒe ŋusẽkpɔɖeamedzi ɖe thymocytes dzi ate ŋu akpɔ ŋusẽ ɖe T lymphocytes ƒe xexlẽme kple dɔwɔwɔ dzi. T ʋumenugbagbevi dzĩwo wɔa akpa vevi aɖe le dɔlélenutsiŋutete ƒe ɖoɖowɔwɔ me le dɔdzẽ ƒe ŋuɖoɖowo me, eye T ʋumenugbagbevi sue vovovowo ɖɔa dɔdzẽ ƒe sesẽme kple ɣeyiɣi didi si wòxɔna ɖo to mɔnuwo abe cytokine ƒe dodo ene dzi. To ŋusẽkpɔkpɔ ɖe thymocytes dzi la, Vilon ate ŋu atrɔ asi le T lymphocyte ƒe dɔwɔwɔ ŋu le mɔ si mele tẽ o nu, si akplɔe ayi mɔ si tsi tre ɖe dɔdzẽ nu ŋu. Tsɔ kpe ɖe eŋu la, Vilon ate ŋu ana humoral dɔlélenutsiŋutete ƒe dɔwɔwɔ nanyo ɖe edzi le ƒunukpeƒe lãmenugbagbeviwo. Aɖuɖɔtoe nye dɔlélenutsiŋutete ƒe ŋutinu vevi aɖe le ŋutilãa me, eye aɖuɖɔtoe me lãmenugbagbeviwo kpɔa gome le dɔlélenutsiŋutete ƒe dɔwɔwɔ vovovowo me, siwo dometɔ aɖewoe nye dɔlékuiwutikewo wɔwɔ. Dɔlékuiwutikewo ƒe humoral dɔlélenutsiŋutete ƒe ŋusẽdodo kpena ɖe ŋutilãa ŋu wòwɔa nu ɖe dɔlékuiwo ƒe dɔlékuiwo ŋu nyuie wu eye wòɖea dɔdzẽ si dɔlékuiwo ƒe anyinɔnɔ ɣeyiɣi didi hena vɛ dzi kpɔtɔna. Vilon doa chemotaxis kple phagocytosis hã ɖe ŋgɔ neutrophils. Neutrophils le dɔlélenutsiŋutete ƒe lãmenugbagbevi gbãtɔ siwo va ɖoa afisi dɔdzẽa le la dome. Chemotaxis kple phagocytic ŋutete siwo dzi ɖe edzi kpena ɖe ame ŋu woɖea dɔlékuiwo kple dɔdzẽ ƒe gbeɖuɖɔwo ɖa kabakaba wu, si wɔnɛ be dɔdzẽ dzi ɖena kpɔtɔna.
Vilon Zazã ƒe Mɔkpɔkpɔwo le Dɔléle Siwo Do Ƒome Kple Dzoxɔxɔ Me
Dɔléle siwo nɔa anyi didi: Dɔléle geɖe siwo nɔa anyi didi do ƒome kplikplikpli kple dɔdzẽ ƒe ŋuɖoɖo siwo nɔa anyi ɖaa. Le aklãdɔlélewo me la, dɔdzẽ si nɔa anyi didi nye nu vevi aɖe si nana ʋumenugbagbeviɣidɔ ƒe ŋgɔyiyi. Vilon ƒe dɔlékuiwutikewo na wònye atike si ate ŋu ada aklãdɔléle siwo nɔa anyi didi abe aklãdɔléle ene. To dɔdzẽ ƒe lãmenugbagbeviwo kple domenɔlawo ƒe dodo dzi kpɔkpɔ me la, ate ŋu aɖe dɔdzẽ ƒe nugbegblẽ le aklãa ŋu dzi akpɔtɔ eye wòana ʋumenugbagbeviɣidɔa nayi edzi blewu. Le dɔgbo ƒe dɔléle siwo nɔa anyi didi (abe dɔgbo ƒe dɔdzẽ kple Crohn ƒe dɔléle ene) me la, dɔgboa nɔa dɔdzẽ ƒe nɔnɔme si nɔa anyi didi me, si wɔnɛ be dɔgboa ƒe ʋukawo gblẽna eye wògblẽa nuɖuɖumeŋusẽ kple nuɖuɖu ƒe dɔwɔwɔ me. Vilon ate ŋu aɖɔ dɔgboa ƒe dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ɖo, ana dɔgboa ƒe nɔnɔme suewo nali ke, aɖe dɔdzẽ ƒe nugbegblẽ le dɔgboa ƒe lãkusi ŋu dzi akpɔtɔ, eye wòato esia me ana dɔnɔwo ƒe dzesiwo nanyo ɖe edzi. Tsɔ kpe ɖe eŋu la, le dɔléle siwo dɔlélenutsiŋutete ŋutɔ wɔna abe ƒunukpeƒetetedɔ ene me la, dɔlélenutsiŋutete dzea ŋutilãa ŋutɔ ƒe lãkusiwo dzi vodadatɔe, si wɔnɛ be dɔdzẽ nɔa ame ŋu atraɖii eye wònana ƒunukpeƒewo sea veve, wovuvuna, eye womewɔa dɔ nyuie o. Vilon ate ŋu ana dɔlélenutsiŋutete ƒe lãmenugbagbeviwo nawɔ dɔ nyuie, aɖɔ dɔlélenutsiŋutete ƒe dɔmawɔmawɔ nyuie ɖo, aɖe dɔdzẽ ƒe ŋuɖoɖowo dzi akpɔtɔ le ƒunukpeƒewo, eye wòaɖe dɔnɔwo ƒe vevesese dzi akpɔtɔ.
Nɔnɔmetata 2 Cytokines le aklãdɔléle me.
Dzoxɔxɔ ƒe ŋuɖoɖo kpata: Le dɔdzẽ ƒe ŋuɖoɖo kpata siwo dɔlékui alo nuveviwɔame hena vɛ me la, Vilon hã ƒe asixɔxɔ ate ŋu azãe. Le kpɔɖeŋu me, le dɔlékuiwo ƒe dɔléle sesẽ siwo hea dɔléle si nye systemic inflammatory response syndrome (SIRS) vɛ me la, dɔdzẽ ƒe ŋuɖoɖoa wɔa dɔ akpa, si ate ŋu ana ŋutinu geɖe nawɔ dɔ nyuie o. Vilon ate ŋu aɖɔ dɔdzẽ ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ɖo be wòaxe mɔ ɖe dɔdzẽ ƒe nusiwo dona fũu akpa nu, aɖe ŋutinuwo ƒe gbegblẽ si dɔdzẽ hena vɛ dzi akpɔtɔ, eye wòana dɔnɔwo ƒe agbetsitsi nanyo ɖe edzi. Le dɔdzẽ ƒe ŋuɖoɖo siwo dzɔna le afɔku megbe me la, Vilon ate ŋu ado dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ɖe ŋgɔ le abi ƒe teƒea, si ana abi nahaya kabakaba. Ate ŋu ado neutrophils ƒe chemotaxis kple phagocytosis ɖe ŋgɔ, aɖe dɔlékuiwo kple necrotic tissue ɖa le abiteƒea, esime wòle ɖoɖo wɔm ɖe dɔdzẽ ƒe nusiwo sɔ ƒe dodo ŋu to macrophages dzi be wòado lãmenugbagbeviwo ɖɔɖɔɖo kple gbugbɔgadzɔ ɖe ŋgɔ.
Suklidɔlélawo ƒe dɔdzẽ si do ƒome kple suklidɔ: Zi geɖe la, suklidɔlélawo ƒe dɔdzẽ si mede ŋgɔ o nɔa anyi didi, si do ƒome kplikplikpli kple suklidɔ ƒe kuxiwo.
Le suklidɔ ƒomevi 1 dɔnɔ tsitsiwo gome la, menye ɖeko Vilon, abe atikewɔwɔ blibo ƒe akpa aɖe ene, nana ʋu ƒe sisi kple ʋu ƒe sisi nyuie wu ko o, ke enaa dɔlélenutsiŋutete hã li ke. Vilon ate ŋu aɖɔ dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe xexlẽme kple dɔwɔwɔ ɖo, aɖe cytokines siwo do ƒome kple dɔdzẽ ƒe agbɔsɔsɔ dzi akpɔtɔ, aɖe dɔdzẽ ƒe nɔnɔme dzi akpɔtɔ le suklidɔlélawo me, eye wòato esia me aɖe suklidɔ ƒe kuxiwo ƒe afɔkua dzi akpɔtɔ. Suklidɔ ƒe ŋkume ƒe dɔléle nye suklidɔ ƒe ʋuka suesuesuewo ƒe kuxi siwo bɔ dometɔ ɖeka, eye dɔdzẽ wɔa akpa vevi aɖe le eƒe dɔléle dzɔdzɔ me. Vilon ate ŋu ana suklidɔ ƒe ŋkudɔ ƒe ŋgɔyiyi nagbɔdzɔ to ŋkua ƒe dɔdzẽ ƒe ŋuɖoɖowo dzi ɖeɖe kpɔtɔ me.
Mɔnu Siwo Vilon Ƒe Dɔwɔna Siwo Tsi Tre Ðe Dzoxɔxɔ Ŋu
Lãmenugbagbeviwo me dzesimɔwo dzi kpɔkpɔ: Vilon ate ŋu aɖɔ dɔdzẽ ƒe ŋuɖoɖowo ɖo to ŋusẽkpɔkpɔ ɖe lãmenugbagbeviwo me dzesimɔwo dzi. Dzesimɔ geɖe li siwo do ƒome kple dɔdzẽ le lãmenugbagbeviwo me, abe NF-κB dzesimɔ ene. NF-κB nye nuŋɔŋlɔ ƒe akpa vevi aɖe si wɔa dɔ le dɔdzẽ ƒe nuwɔna te, gena ɖe lãmenugbagbeviwo ƒe nucleus me, eye wòdzea dɔdzẽ ƒe domenyiŋusẽfianu siwo kplɔ wo nɔewo ɖo ƒe nuŋɔŋlɔ gɔme. Vilon ate ŋu aɖe dɔdzẽ ƒe nuwɔna kple eƒe dodo dzi akpɔtɔ to mɔxexe ɖe NF-κB dzesimɔa ƒe dɔwɔwɔ nu me. Le kpɔɖeŋu me. MAPK ƒe dzesimɔ nye mɔ vevi bubu le dɔdzẽ ƒe ŋuɖoɖowo me, si me alɔdzewo abe ERK, JNK, kple p38 MAPK ene hã le. Vilon ate ŋu aɖɔ alɔ siawo ɖo be wòakpɔ ŋusẽ ɖe domenyiŋusẽfianu siwo do ƒome kple dɔdzẽ ƒe ɖeɖefia dzi. Mɔxexe ɖe p38 MAPK ƒe phosphorylation nu ɖea dɔdzẽ ƒe nusiwo le abe TNF-α kple IL-1β ene ƒe wɔwɔme dzi kpɔtɔna.
Dɔlélenutsiŋutete ƒe ɖoɖowɔwɔ ƒe mɔnuwo: Abe alesi míegblɔe va yi ene la, Vilon kpɔa ŋusẽ ɖe dɔlélenutsiŋutete ƒe lãmenugbagbevi vovovowo dzi, si nye eƒe dɔlékuiwutike veviwo dometɔ ɖeka. To thymocytes ƒe dzidziɖedzi, vovototodedeameme, kple dɔwɔwɔ dodo ɖe ŋgɔ me la, Vilon ate ŋu aɖɔ T lymphocytes ƒe tsitsi kple dɔwɔwɔ ɖo. T ʋumenugbagbevi sue vovovowo wɔa akpa vovovowo le dɔdzẽ ƒe ŋuɖoɖowo me: Th1 lãmenugbagbeviwo koŋue nyea domenɔla na lãmenugbagbeviwo ƒe dɔlélenutsiŋutete, Th2 lãmenugbagbeviwo koŋue nyea domenɔla na humoral dɔlélenutsiŋutete, Th17 lãmenugbagbeviwo do ƒome kplikplikpli kple dɔdzẽ kple dɔlélenutsiŋutete ƒe dɔlélewo, eye Tregs lãmenugbagbeviwo ɖea dɔlélenutsiŋutete ƒe ŋusẽkpɔɖeamedzi fiana. Vilon ɖɔa T ʋumenugbagbevi sue siawo ƒe dadasɔ ɖo, eye wòfiaa mɔ ŋutilãa ƒe dɔlélenutsiŋutete ƒe dɔwɔwɔ yia mɔ si tsi tre ɖe dɔdzẽ nu ŋu. Tregs lãmenugbagbeviwo ƒe vovototodedeameme kple dɔwɔwɔ dodo ɖe ŋgɔ, mɔxexe ɖe dɔlélenutsiŋutete ƒe ŋuɖoɖo si gbɔ eme kple dɔdzẽ nu. Vilon ƒe ŋusẽ si wòdona ɖe ŋgɔ le humoral immune responses le spleen cells me kpena ɖe ŋutilãa ŋu wòwɔa dɔlékuiwutike siwo wɔa dɔ nyuie wu be wòaɖe dɔlékuiwo ɖa eye wòaɖe abi si dɔlékuiwo ƒe dɔlékuiwo hena vɛ dzi akpɔtɔ. Tsɔ kpe ɖe eŋu la, Vilon ƒe ɖoɖowɔwɔ ƒe ŋusẽkpɔɖeamedzi ɖe neutrophils kple macrophages dzi kpɔa ŋusẽ ɖe dɔlélenutsiŋutete ƒe ametakpɔkpɔ kple dɔdzẽ ƒe ɖoɖowɔwɔ ƒe ŋutetewo dzi tẽ le afisi dɔdzẽa le.
Domenyiŋusẽfianu ƒe ɖeɖefia ƒe ɖoɖowɔwɔ: Vilon ƒe domenyiŋusẽfianu ƒe ɖeɖefia si do ƒome kple dɔdzẽ ƒe nuwɔna kple dɔdzẽ ƒe domenɔlawo ƒe ɖoɖowɔwɔ nye gɔmeɖoanyi vevi aɖe na eƒe dɔlékuiwutikewo ƒe ŋusẽkpɔɖeamedzi. To mɔnuwo abe RT-PCR ene dzi la, wokpɔe be Vilon ate ŋu ado domenyiŋusẽfianu tɔxɛ aɖewo ƒe mRNA ɖeɖefia ɖe ŋgɔ alo axe mɔ ɖe enu. Ate ŋu ado IL-1β, TNF-α, kple iNOS mRNA ƒe ɖeɖefia ɖe ŋgɔ, gake dodoɖeŋgɔ ƒe ŋusẽkpɔɖeamedzi sia ate ŋu anye dɔdzẽ ƒe ŋuɖoɖo ƒe ɖoɖowɔwɔ nyuie le dɔdzẽ ƒe nɔnɔme sue tɔxɛ aɖewo me. Vilon ate ŋu awɔ nu kple lãmenugbagbeviwo me nuŋɔŋlɔ ƒe nusiwo alo ɖoɖowɔnu bubuwo be woakpɔ ŋusẽ ɖe domenyiŋusẽfianu ƒe nuŋɔŋlɔ ƒe gɔmedzedze, eƒe duƒuƒu, kple eƒe nuwuwu dzi. Ate ŋu aɖɔ protein siwo do ƒome kple dɔdzẽ ƒe wɔwɔme hã ɖo to ŋusẽkpɔkpɔ ɖe mRNA ƒe liƒo kple gbegɔmeɖeɖe ƒe ŋutete dzi. Domenyiŋusẽfianu ƒe ɖeɖefia ƒe ɖoɖowɔwɔ sia si le ɖoƒe vovovowo nana Vilon te ŋu wɔa akpa aɖe le dɔdzẽ ƒe ŋuɖoɖo ƒe akpa vovovowo me, si wɔnɛ be dɔdzẽ ƒe dadasɔ.
Nyanuwuwuw
Abe atike si tsia dzodzodzoetsitsi nu ene la, Vilon ɖea vi na dɔléle siwo do ƒome kple dɔdzẽ dada.
Dzɔtsoƒewo
[1] Husiev VM, Khapchenkova DS, Yermolenko S A. Peloidis zazã ƒe dɔwɔwɔ nyuie le dɔnɔ siwo xɔ ƒe si woate ŋu adzi vi siwo ŋu dɔdzẽ ƒe dɔléle siwo nɔa anyi didi le vidzidɔ ƒe lãkusiwo me le[J]. Acta Balneologica, 2024. 1999. Amesiwo xɔa ŋgɔ le lãmesẽnyawo gbɔ kpɔkpɔ me
[2] Kronborg T. M., Ytting H., Hobolth L., kple ame bubuwo. Atikewɔwɔ Yeye Siwo Tsi Tre Ðe Dzoxɔxɔ Ŋu le Cirrhosis Me. Nusɔsrɔ̃ si Wotu Ðe Agbalẽwo Dzi[J]. Liƒowo le Atikewɔwɔ me, 2021,8:718896.DOI:10.3389/fmed.2021.718896.
[3] Kuznik B. I., Isakova N. V., Kliuchereva N. N., kple ame bubuwo. [Ŋusẽ si vilon kpɔna ɖe dɔlélenutsiŋutete ƒe nɔnɔme kple ʋumenugbagbeviɣidɔ dzi le dɔnɔ siwo xɔ ƒe vovovowo siwo ŋu suklidɔ le].[J]. Ŋgɔyiyi le Amegãkukuŋutinunya me = Uspekhi Gerontologii, 2007,20 2:106-115.
[4] Bi K, Nv I, Nn K, kple ame bubuwo. Ŋusẽ si vilon kpɔna ɖe dɔlélenutsiŋutete ƒe nɔnɔme kple ʋumenugbagbeviɣidɔ dzi le dɔnɔ siwo xɔ ƒe vovovowo siwo ŋu suklidɔ le[J]. Ŋgɔyiyi le Amegãkukuŋutinunya me, 2007,20:106. https://api.semanticscholar.org/CorpusID: 221168647 ƒe ƒuƒoƒo.
Adzɔnu si li na numekuku zazã ɖeɖeko:
