Na Cocer Peptides 
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INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.
Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.
Mubyerekeranye nubuvuzi na biyolojiya, igisubizo cyo gutwika ni uburyo bukomeye bwo kwirwanaho bwumubiri kubintu bitandukanye bikomeretsa. Ibisubizo bikabije cyangwa bitagenzuwe bishobora gutera kwangiza umubiri kandi bigatera indwara zitandukanye. Vilon, nkibintu bifite imiterere yihariye yimiterere nibikorwa, yerekanye uruhare rwihariye hamwe nubushobozi bwogukoresha mubikorwa byo kurwanya inflammatory.
Igishushanyo 1 Uburyo bwo kurwanya antioxyde.
Inkomoko nuburyo shingiro bwa Vilon
Vilon ni peptide ya bioactive ifite izina ryuzuye L-Lys-L-Glu. Yashizwemo ishingiye ku biyobyabwenge Thymogen, birimo dipeptide L-Glu-L-Trp hamwe n’ibikorwa byo kwirinda indwara. Mu 1991, Morozov na Khavinson batandukanije ibintu bya Naturalthymic (NTFs) inyana y’inyana, hanyuma baza gukora imiti Thymalin ishingiye kuri NTFs, ikoreshwa mu buvuzi mu gukumira no kuvura indwara z’ubudahangarwa bw'umubiri. Nyuma, ukoresheje chromatografi ya reaction ya feri, Thymogen irimo urufunguzo rwa dipeptide yatandukanijwe na Thymalin, kandi Vilon yarushijeho gushingira kuri ibi. Iyi nzira yo gukuramo intambwe ivuye mubintu karemano yashyizeho urufatiro rwibikorwa bidasanzwe bya Vilon byo kurwanya inflammatory. Igizwe na aside amine ikurikirana, hamwe na L-Lys (lysine) na L-Glu (glutamic aside) ihujwe na peptide. Iyi miterere ituma Vilon ikorana na selile yakira selile cyangwa molekile zo mu nda, bityo igatangiza urukurikirane rwibisubizo birwanya inflammatory.
Ingaruka za Vilon zigira ingaruka ku ngirabuzimafatizo no ku bintu bitera umuriro
Ingaruka kuri macrophage: Macrophage ni selile zingenzi mugusubiza umuriro. Mugihe cyo gutwika, macrophage irakora kandi igasohora ibintu bitandukanye bitera inflammatory hamwe nabunzi. Vilon igira uruhare runini mu gusohora ibintu bitera IL-1β na TNF-α, hamwe n’umuhuza w’umuriro OYA, na macrophage yimbeba peritoneal igira uruhare mugusubiza. Ukoresheje imbeba ya LPS ikoreshwa cyane yibanze ya macrophage ya peritoneyale nkigenzura ryiza, mugihe macrophage yimbeba ya peritoneal yafatanyijemo na Vilon yibitekerezo bya 0.1 μg / mL, 1 μg / mL, na 10 μg / mL, na LPS kuri 1 μg / mL, Vilon yerekanye ingaruka zikomeye zo kwamamaza kumasemburo ya IL-1β na OYA. Ibi byerekana ko uko kwibumbira hamwe kwa Vilon kwiyongera, ubushobozi bwayo bwo guteza imbere ururenda rwibi bintu bifitanye isano na macrophage nabyo byiyongera. Byongeye kandi, Vilon yateje imbere imvugo ya IL-1β, TNF-α, na iNOS mRNA.
Ibi birerekana ko Vilon ishobora kugenga synthesis yibintu bitera urwego rwa transcription ya gene, bityo bikagira ingaruka kumyitwarire yumuriro. Nubwo Vilon isa nkaho iteza imbere gusohora ibintu bitera umuriro, izi ngaruka zo kwamamaza zishobora kuba uburyo bwo kugenzura imiyoboro igoye yo gusubiza. Kurugero, gusohora mu buryo bushyize mu gaciro bifasha gutangiza uburyo bwo kwirinda indwara bwumubiri kugirango bikureho indwara ziterwa nizindi ndwara zangiza, kandi Vilon irashobora kugena neza urwego rwimyunyungugu rwibi bintu bitera umuriro kugirango ikomeze kurwego rworohereza iterambere risanzwe ridafite ingaruka mbi kumubiri.
Ingaruka zishobora kubaho ku zindi selile z'umubiri: Usibye macrophage, Vilon, nk'imikorere myinshi igenga ubudahangarwa bw'umubiri, irashobora no kugira ingaruka ku zindi selile z'umubiri, zikagira uruhare rutaziguye mu gikorwa cyo kurwanya inflammatory. Kurugero, irashobora guteza imbere ikwirakwizwa, gukora, no gutandukanya thymocytes. Thymus ni urubuga rukomeye rwo gukura kwa lymphocytes T, kandi ingaruka za Vilon kuri thymocytes zishobora guhindura umubare nimirimo ya Lymphocytes T. Lymphocytes T igira uruhare runini mugutegeka ubudahangarwa mugihe cyo gusubiza, hamwe nubwoko butandukanye bwa Lymphocytes T igenga ubukana nigihe cyokongoka hakoreshejwe uburyo nka sisitemu ya cytokine. Mu guhindura thymocytes, Vilon irashobora guhindura mu buryo butaziguye imikorere ya lymphocyte T, ikayerekeza ku cyerekezo cyo kurwanya inflammatory. Byongeye kandi, Vilon irashobora kongera ubudahangarwa bw'umubiri urinda ingirabuzimafatizo. Ururenda ni urugingo rukomeye rwumubiri mu mubiri, kandi selile zigira uruhare mubikorwa bitandukanye byubudahangarwa, harimo no gukora antibody. Kongera ubudahangarwa bw'umubiri wa selile splenic bifasha umubiri kwitabira neza kwandura indwara no kugabanya uburibwe buterwa no kumara igihe kirekire. Vilon kandi iteza imbere chemotaxis na fagocytose ya neutrophile. Neutrophile iri mu ngirabuzimafatizo za mbere z'umubiri zageze ahakongoka. Imiti ya chemotaxis hamwe nubushobozi bwa fagocyitike bifasha mugukuraho byihuse indwara ziterwa nindwara zangiza, bityo bikagabanya uburibwe.
Gushyira mu bikorwa ibyifuzo bya Vilon mu ndwara zifitanye isano
Indwara zidakira zidakira: Indwara nyinshi zidakira zifitanye isano rya hafi no guhora kwishura. Indwara z'umwijima, gutwika karande ni ikintu cy'ingenzi mu iterambere rya cirrhose. Indwara ya Vilon irwanya inflammatory ituma ishobora kuvura indwara zidakira zifata umwijima nka cirrhose. Muguhindura ururenda rwibintu bitera umuriro hamwe nabunzi hamwe ningirabuzimafatizo, birashobora kugabanya kwangirika kwumwijima no gutinda kwa cirrhose. Mu ndwara zidakira zifata amara (nka colitis ulcerative colitis n'indwara ya Crohn), amara aba ameze igihe kirekire, bigatera kwangirika kw'imitsi yo mu mara no kwangiza imikorere y'igifu no kwinjirira. Vilon irashobora kugenga imikorere yingirabuzimafatizo zo mu nda, igateza imbere ituze muri microen ibidukikije yo mu mara, kugabanya kwangirika kwangirika kwa mucosa yo mu mara, bityo bikagaragaza ibimenyetso by’abarwayi. Byongeye kandi, mu ndwara ziterwa na autoimmune nka rubagimpande ya rubagimpande, sisitemu yubudahangarwa yibeshya yibice byumubiri, bikabyara umuriro udakira kandi bigatera ububabare bufatanye, kubyimba, no kutagira imikorere. Vilon irashobora kugenga imikorere yumubiri wumubiri, ikosora sisitemu yumubiri idasanzwe, kugabanya ibisubizo byumuriro ahantu hamwe, no kugabanya abarwayi.
Igishushanyo 2 Cytokine mu ndwara zumwijima.
Igisubizo gikaze: Mubisubizo bikaze byatewe no kwandura cyangwa guhahamuka, Vilon nayo ifite agaciro gashoboka. Kurugero, mu ndwara ziterwa na bagiteri zikomeye ziganisha kuri syndrome de sisitemu (SIRS), igisubizo cyo gutwika gikora cyane, gishobora gutera imikorere mibi yingingo nyinshi. Vilon irashobora kugenga imikorere ya selile yumuriro kugirango irinde kurekura gukabije ibintu bitera umuriro, kugabanya kwangirika kwingingo ziterwa no gutwika, no kuzamura imibereho yabarwayi. Nyuma yo guhahamuka nyuma yo guhahamuka, Vilon irashobora guteza imbere imikorere yingirabuzimafatizo aho yakomeretse, byihuta gukira ibikomere. Irashobora guteza imbere imiti ya chemotaxis na fagocytose ya neutrophile, ikuraho indwara ziterwa na virusi na nekrotique aho yakomeretse, mugihe igenga ururenda rwibintu bikwiye byatewe na macrophage kugirango iteze imbere gusana no kuvugurura.
Indwara ya Diyabete: Abarwayi ba diyabete bakunze kugira umuriro udakira wo mu rwego rwo hasi, ibyo bikaba bifitanye isano rya bugufi n'ingaruka za diyabete.
Ku barwayi ba diyabete yo mu bwoko bwa 1 bageze mu zabukuru, Vilon, mu rwego rwo kuvura byimazeyo, ntabwo ihindura gusa coagulation na hemostasis ahubwo inashimangira ubudahangarwa bw'umubiri. Vilon irashobora kugenzura umubare n'imikorere y'uturemangingo tw'umubiri, kugabanya urugero rwa cytokine ziterwa no gutwika, kugabanya imiterere y’umuriro ku barwayi ba diyabete, bityo bikagabanya ibyago byo kurwara diyabete. Indwara ya diabete ni imwe mu ngaruka ziterwa na diyabete, kandi gutwika bigira uruhare runini mu kuyitera. Vilon irashobora kudindiza iterambere rya retinopatie diabete igabanya ibisubizo bitera amaso.
Uburyo bwa Vilon's Anti-inflammatory Ingaruka
Inzira yerekana ibimenyetso byerekana inzira: Vilon irashobora kugenga ibisubizo byumuriro muguhindura inzira yibimenyetso. Hariho inzira nyinshi zerekana inzira zijyanye no gutwika muri selile, nka NF-κB inzira yinzira. NF-κB ni ikintu cyingenzi cyo kwandukura gikoreshwa mugihe cyo gukongeza umuriro, cyinjira muri selile, kandi kigatangira kwandukura urukurikirane rw'ibintu bitera indwara. Vilon irashobora kugabanya synthesis hamwe no gusohora ibintu bitera umuriro muguhagarika imikorere yinzira ya NF-κB. Kurugero, Vilon irashobora guhambira kubyakirwa hejuru yakagari, igakora molekules zoherejwe zoherejwe munsi, kandi ikabuza ibikorwa bya NF-κB binyuze mubihinduka nka fosifora, ikabuza kwinjira muri nucleus selile no gutangira kwandukura ibintu bitera umuriro. Inzira ya MAPK yerekana inzira niyindi nzira yingenzi mubisubizo byokongoka, harimo amashami nka ERK, JNK, na p38 MAPK. Vilon irashobora kugenga ayo mashami kugirango igire ingaruka kumagambo ya gen. Kubuza fosifora ya p38 MAPK bigabanya synthesis yibintu bitera nka TNF-α na IL-1β.
Uburyo bwo gukingira indwara: Nkuko byavuzwe haruguru, Vilon igira ingaruka ku ngirabuzimafatizo zitandukanye, ni bumwe mu buryo bukomeye bwo kurwanya indwara. Mugutezimbere ikwirakwizwa, gutandukanya, no gukora thymocytes, Vilon irashobora kugenzura iterambere nimikorere ya Lymphocytes T. Ubwoko butandukanye bwa lymphocytes T bugira uruhare rutandukanye mubisubizo byokongoka: selile Th1 ihuza cyane cyane ubudahangarwa bwimikorere ya selile, selile Th2 ihuza cyane cyane ubudahangarwa bwimitsi, selile Th17 zifitanye isano rya bugufi nindwara ziterwa na autoimmune, kandi selile Tregs zigaragaza ingaruka zubudahangarwa bw'umubiri. Vilon igenga uburinganire bwubwoko bwa lymphocyte T, ikayobora ubudahangarwa bw'umubiri bwerekeza ku cyerekezo cyo kurwanya inflammatory. Guteza imbere gutandukanya n'imikorere ya selile Tregs, kubuza gukabya gukingira indwara no gutwika. Ingaruka ya Vilon itera imbaraga zo gukingira indwara zifata ingirabuzimafatizo zifasha umubiri gukora antibodiyite nziza zo gukuraho indwara ziterwa no kugabanya indwara ziterwa na virusi. Byongeye kandi, ingaruka za Vilon zigenga kuri neutrophile na macrophage zigira ingaruka zitaziguye zo kwirinda indwara hamwe nubushobozi bwo kugenzura ibicanwa aho byatwitse.
Amabwiriza agenga imiterere: Igenamigambi rya Vilon ryerekana imiterere ya gene ijyanye nibintu bitera umuriro hamwe nabunzi ba inflammatory ni umusingi wingenzi wingaruka zayo zo kurwanya inflammatory. Binyuze mu buhanga nka RT-PCR, byagaragaye ko Vilon ishobora guteza imbere cyangwa guhagarika imvugo ya mRNA ya genes yihariye. Irashobora guteza imbere imvugo ya IL-1β, TNF-α, na iNOS mRNA, ariko iyi ngaruka yo kwamamaza irashobora kuba uburyo bwiza bwo kugenzura igisubizo cyumuriro mugihe cya mikorobe yihariye. Vilon irashobora gukorana nibintu byandikirwa mungingo cyangwa ibindi bintu bigenga kugirango bigire ingaruka ku itangizwa, igipimo, no guhagarika kwanduza gene. Irashobora kandi kugenga synthesis ya proteine zijyanye no gutwika bigira ingaruka kuri mRNA itajegajega no gukora neza. Iri tegeko-nzego nyinshi zerekana imiterere ya gene ituma Vilon agira uruhare mubyiciro bitandukanye byo gusubiza umuriro, bikomeza kuringaniza umuriro.
Umwanzuro
Nibintu birwanya inflammatory, Vilon ni ingirakamaro mu kuvura indwara ziterwa n’umuriro.
Inkomoko
. Acta Balneologica, 2024. Https://api.semanticscholar.org/CorpusID:270107068
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[3] Kuznik BI, Isakova NV, Kliuchereva NN, n'abandi. [Ingaruka za vilon kumiterere yubudahangarwa hamwe na coagulation hemostasis ku barwayi bafite imyaka itandukanye barwaye diyabete]. [J] Iterambere muri Gerontologiya = Uspekhi Gerontologii, 2007,20 2: 106-115.
[4] Bi K, Nv I, Nn K, n'abandi. Ingaruka za vilon kumiterere yubudahangarwa na coagulation hemostasis kubarwayi bafite imyaka itandukanye barwaye diyabete [J]. Iterambere muri Gerontologiya, 2007,20: 106. https://api.semanticscholar.org/CorpusID:221168647.
Ibicuruzwa biboneka mubushakashatsi bukoreshwa gusa:
