Los ntawm Cocer Peptides 
1 month ago
Tag nrho cov kab lus thiab cov ntaub ntawv ntawm cov khoom lag luam muab rau ntawm lub vev xaib no tsuas yog rau cov ntaub ntawv tshaj tawm kev tshaj tawm thiab cov hom phiaj kev kawm.
Cov khoom muab rau hauv lub vev xaib no yog npaj tshwj xeeb rau kev tshawb fawb hauv vitro. Kev tshawb fawb hauv vitro (Latin: * hauv iav *, lub ntsiab lus hauv iav) yog ua los ntawm tib neeg lub cev. Cov khoom no tsis yog tshuaj, tsis tau txais kev pom zoo los ntawm US Food and Drug Administration (FDA), thiab yuav tsum tsis txhob siv los tiv thaiv, kho, lossis kho txhua yam mob, kab mob, lossis mob. Nws raug txwv nruj raws li txoj cai los qhia cov khoom no rau hauv tib neeg lossis tsiaj lub cev hauv txhua daim ntawv.
Hauv kev lag luam tshuaj thiab biology, inflammatory teb yog ib tug complex tiv thaiv cov tshuaj tiv thaiv ntawm lub cev rau ntau yam injurious stimuli. Cov lus teb inflammatory ntau dhau los yog tsis tswj tau tuaj yeem ua rau lub cev puas tsuaj thiab ua rau muaj ntau yam kab mob. Vilon, raws li ib yam khoom uas muaj cov yam ntxwv tshwj xeeb thiab kev ua haujlwm, tau ua kom pom lub luag haujlwm tshwj xeeb thiab kev siv lub peev xwm los tiv thaiv cov teebmeem.
Daim duab 1 Antioxidative mechanisms.
Cov peev txheej thiab cov qauv tsim ntawm Vilon
Vilon yog bioactive peptide nrog lub npe tag nrho L-Lys-L-Glu. Nws tau raug tsim los ntawm cov tshuaj Thymogen, uas muaj cov dipeptide L-Glu-L-Trp nrog kev tiv thaiv kab mob-modulating. Nyob rau hauv 1991, Morozov thiab Khavinson cais Naturalthymic yam (NTFs) los ntawm calf thymus, thiab tom qab ntawd tsim cov tshuaj Thymalin raws li NTFs, uas yog siv nyob rau hauv kev kho mob rau kev tiv thaiv thiab kev kho mob ntawm immunodeficiency kab mob. Tom qab ntawd, siv rov qab-theem ua kua chromatography, Thymogen uas muaj qhov tseem ceeb dipeptide raug cais tawm ntawm Thymalin, thiab Vilon tau txuas ntxiv los ntawm qhov no. Cov txheej txheem kev hloov pauv no los ntawm cov khoom siv ntuj tsim tau tsim lub hauv paus rau Vilon qhov tshwj xeeb los tiv thaiv kev ua haujlwm. Nws yog tsim los ntawm cov amino acid ib ntus, nrog L-Lys (lysine) thiab L-Glu (glutamic acid) txuas los ntawm peptide daim ntawv cog lus. Cov qauv no ua rau Vilon cuam tshuam nrog cell nto receptors lossis intracellular molecules, yog li pib ua cov lus teb los tiv thaiv kab mob.
Vilon txoj kev tswj cov teebmeem ntawm inflammatory cells thiab inflammatory yam
Cov teebmeem ntawm macrophages: Macrophages yog cov hlwb tseem ceeb hauv cov lus teb inflammatory. Thaum lub sij hawm o, macrophages yog qhib thiab tso tawm ntau yam pro-inflammatory yam thiab inflammatory mediators. Vilon cuam tshuam rau kev tso tawm ntawm cov tshuaj tiv thaiv kab mob IL-1β thiab TNF-α, nrog rau cov kab mob inflammatory NO, los ntawm nas peritoneal macrophages koom nrog cov lus teb inflammatory. Siv LPS-activated nas thawj kab lis kev cai peritoneal macrophages raws li kev tswj hwm zoo, thaum nas peritoneal macrophages tau co-stimulated nrog Vilon ntawm qhov ntau ntawm 0.1 μg / mL, 1 μg / mL, thiab 10 μg / mL, thiab LPS ntawm 1 μg / mL, Vilon tau nthuav tawm IL NO rau kev nce qib LPS-activated nas peritoneal macrophages, nrog rau kev sib raug zoo ntawm koob tshuaj. Qhov no qhia tau hais tias raws li qhov concentration ntawm Vilon nce, nws lub peev xwm los txhawb kev tso tawm ntawm cov tshuaj tiv thaiv kab mob los ntawm macrophages kuj nce. Tsis tas li ntawd, Vilon kuj txhawb kev qhia ntawm IL-1β, TNF-α, thiab iNOS mRNA.
Qhov no qhia tau hais tias Vilon tuaj yeem tswj cov synthesis ntawm inflammatory yam ntawm cov gene transcription theem, yog li cuam tshuam qhov kev loj hlob ntawm inflammatory teb. Txawm hais tias Vilon zoo nkaus li txhawb kev tso tawm ntawm cov kab mob inflammatory, qhov kev txhawb nqa no tuaj yeem ua haujlwm raws li kev tswj hwm kev tswj hwm hauv lub network nyuaj ntawm cov lus teb. Piv txwv li, qhov qis qis ntawm cov kab mob inflammatory pab pib lub cev lub cev tiv thaiv kab mob kom tshem tawm cov kab mob thiab lwm yam kev phom sij, thiab Vilon tuaj yeem tswj hwm cov qib secretion ntawm cov kab mob inflammatory los tswj lawv nyob rau theem uas pab txhawb kev mob ib txwm tsis ua rau lub cev puas tsuaj ntau.
Muaj peev xwm cuam tshuam rau lwm lub cev tiv thaiv kab mob: Ntxiv nrog rau macrophages, Vilon, raws li kev tswj hwm kev tiv thaiv kab mob, kuj tseem tuaj yeem cuam tshuam rau lwm lub cev tiv thaiv kab mob, tsis ncaj qha koom nrog cov txheej txheem tiv thaiv kab mob. Piv txwv li, nws tuaj yeem txhawb kev loj hlob, ua kom muaj zog, thiab sib txawv ntawm thymocytes. Lub thymus yog qhov chaw tseem ceeb rau kev loj hlob ntawm T lymphocytes, thiab Vilon cov teebmeem ntawm thymocytes tuaj yeem cuam tshuam rau tus lej thiab kev ua haujlwm ntawm T lymphocytes. T lymphocytes ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv kab mob thaum lub sij hawm inflammatory teb, nrog rau cov subtypes sib txawv ntawm T lymphocytes tswj kev siv thiab lub sij hawm ntawm o los ntawm cov txheej txheem xws li cytokine secretion. Los ntawm kev cuam tshuam thymocytes, Vilon tuaj yeem cuam tshuam ncaj qha rau T lymphocyte kev ua haujlwm, coj nws mus rau kev tiv thaiv kab mob. Tsis tas li ntawd, Vilon tuaj yeem txhim kho lub zog tiv thaiv kab mob ntawm cov hlwb splenic. Tus po yog ib qho tseem ceeb hauv lub cev tiv thaiv kab mob hauv lub cev, thiab cov hlwb splenic koom nrog ntau yam kev tiv thaiv kab mob, nrog rau kev tsim cov tshuaj tiv thaiv kab mob. Txhim kho lub cev tiv thaiv kab mob humoral ntawm cov hlwb splenic pab lub cev zoo dua rau cov kab mob thiab txo qhov mob tshwm sim los ntawm lub sijhawm ntev ntawm cov kab mob. Vilon kuj txhawb cov chemotaxis thiab phagocytosis ntawm neutrophils. Neutrophils yog thawj cov kab mob tiv thaiv kab mob tuaj txog ntawm qhov chaw mob. Txhim kho chemotaxis thiab phagocytic muaj peev xwm pab kom tshem tau cov kab mob sai dua thiab cov khib nyiab inflammatory, yog li txo qhov mob.
Daim ntawv thov kev cia siab ntawm Vilon nyob rau hauv Inflamation-Related Diseases
Cov kab mob inflammatory mob ntev: Muaj ntau yam kab mob uas muaj feem xyuam nrog cov lus teb tsis tu ncua. Hauv cov kab mob siab, mob ntev yog ib qho tseem ceeb hauv kev loj hlob ntawm cirrhosis. Vilon's anti-inflammatory zog ua rau nws muaj peev xwm kho tau tus kab mob rau cov kab mob siab mob ntev xws li cirrhosis. Los ntawm kev tswj lub zais ntawm cov kab mob inflammatory thiab cov neeg kho kom haum xeeb los ntawm cov kab mob inflammatory, nws tuaj yeem txo qis kev puas tsuaj rau daim siab thiab ua kom qeeb ntawm kev mob cirrhosis. Nyob rau hauv cov kab mob inflammatory plob tsis so tswj kab mob (xws li ulcerative colitis thiab Crohn tus kab mob), cov hnyuv nyob rau hauv ib tug ntev lub sij hawm inflammatory xeev, ua rau kev puas tsuaj rau lub plab hnyuv mucosa thiab impairing digestive thiab nqus dej. Vilon tuaj yeem tswj hwm kev ua haujlwm ntawm cov hnyuv hauv lub cev tiv thaiv kab mob, txhawb kev ruaj ntseg hauv plab hnyuv microenvironment, txo qis kev puas tsuaj rau cov hnyuv mucosa, thiab yog li txhim kho cov neeg mob cov tsos mob. Tsis tas li ntawd, nyob rau hauv cov kab mob autoimmune xws li mob caj dab rheumatoid, lub cev tiv thaiv kab mob ua rau lub cev tsis zoo ntawm cov ntaub so ntswg, ua rau mob ntev thiab ua rau mob pob qij txha, o, thiab ua haujlwm tsis zoo. Vilon tuaj yeem tswj hwm kev ua haujlwm ntawm lub cev tiv thaiv kab mob, kho lub cev tiv thaiv kab mob tsis zoo, txo cov lus teb rau qhov sib koom ua ke, thiab txo cov neeg mob tsis xis nyob.
Daim duab 2 Cytokine hauv kab mob siab.
Mob inflammatory teb: Nyob rau hauv mob inflammatory teb tshwm sim los ntawm kev kis kab mob los yog raug mob, Vilon kuj muaj peev xwm thov nqi. Piv txwv li, nyob rau hauv cov kab mob loj heev uas ua rau lub cev inflammatory teb syndrome (SIRS), cov lus teb inflammatory yog overly qhib, uas yuav ua rau ntau yam kab mob. Vilon tuaj yeem tswj hwm kev ua haujlwm ntawm cov kab mob inflammatory los tiv thaiv kev tso tawm ntau dhau ntawm cov kab mob inflammatory, txo cov kab mob uas ua rau lub cev puas tsuaj, thiab txhim kho cov neeg mob ciaj sia. Hauv cov lus teb tom qab raug mob, Vilon tuaj yeem txhawb kev ua haujlwm ntawm lub cev tiv thaiv kab mob ntawm lub qhov txhab, ua kom lub qhov txhab zoo. Nws tuaj yeem txhawb cov chemotaxis thiab phagocytosis ntawm neutrophils, tshem tawm cov kab mob thiab cov ntaub so ntswg necrotic los ntawm qhov chaw ntawm qhov txhab, thaum tswj kev tso tawm ntawm cov qib tsim nyog ntawm cov kab mob los ntawm macrophages los txhawb cov ntaub so ntswg kho thiab rov tsim dua tshiab.
Mob ntshav qab zib mellitus: Cov neeg mob ntshav qab zib feem ntau muaj mob qis qis, uas cuam tshuam nrog cov teeb meem ntshav qab zib.
Hauv cov neeg laus cov neeg mob ntshav qab zib hom 1, Vilon, ua ib feem ntawm kev kho mob, tsis tsuas yog ua kom cov coagulation thiab hemostasis tab sis kuj ua rau lub cev tsis muaj zog. Vilon tuaj yeem tswj hwm tus lej thiab kev ua haujlwm ntawm lub cev tiv thaiv kab mob, txo cov qib ntawm cov kab mob cytokines, txo cov mob hauv cov neeg mob ntshav qab zib, thiab yog li txo qhov kev pheej hmoo ntawm cov teeb meem ntshav qab zib. Mob ntshav qab zib retinopathy yog ib qho ntawm cov teeb meem microvascular ntawm cov ntshav qab zib mellitus, thiab o ua lub luag haujlwm tseem ceeb hauv nws cov kab mob. Vilon tuaj yeem ua rau qeeb ntawm kev mob ntshav qab zib retinopathy los ntawm kev txo qis cov lus teb hauv qhov muag.
Mechanisms ntawm Vilon's Anti-inflammatory Effects
Intracellular teeb liab txoj kev cai: Vilon yuav tswj inflammatory teb los ntawm influencing intracellular teeb liab txoj kev. Muaj ntau lub teeb liab txoj hauv kev uas cuam tshuam rau kev mob hauv cov hlwb, xws li NF-κB teeb liab txoj hauv kev. NF-κB yog ib qho tseem ceeb ntawm kev hloov pauv uas tau qhib rau hauv inflammatory stimuli, nkag mus rau hauv lub cell nucleus, thiab pib cov transcription ntawm ib tug series ntawm inflammatory yam noob caj noob ces. Vilon tuaj yeem txo cov synthesis thiab secretion ntawm inflammatory yam tseem ceeb los ntawm inhibiting lub activation ntawm NF-κB teeb liab txoj kev. Piv txwv li, Vilon tuaj yeem khi rau cov receptors ntawm lub xovtooj ntawm tes, ua kom cov kab hluav taws xob qis qis, thiab inhibit NF-κB kev ua haujlwm los ntawm kev hloov kho xws li phosphorylation, tiv thaiv nws los ntawm kev nkag mus rau hauv lub cell nucleus thiab pib cov ntaub ntawv ntawm inflammatory yam. Txoj kev taw qhia MAPK yog lwm txoj hauv kev tseem ceeb hauv cov lus teb, suav nrog cov ceg xws li ERK, JNK, thiab p38 MAPK. Vilon tuaj yeem tswj cov ceg no kom cuam tshuam rau kev nthuav tawm ntawm cov noob caj ces. Inhibiting lub phosphorylation ntawm p38 MAPK txo cov synthesis ntawm inflammatory yam xws li TNF-α thiab IL-1β.
Cov txheej txheem tswj kev tiv thaiv kab mob: Raws li tau hais ua ntej, Vilon muaj cov kev tswj hwm ntawm ntau lub cev tiv thaiv kab mob, uas yog ib qho tseem ceeb ntawm kev tiv thaiv kab mob. Los ntawm kev txhawb nqa kev loj hlob, kev sib txawv, thiab ua kom cov thymocytes, Vilon tuaj yeem tswj kev txhim kho thiab kev ua haujlwm ntawm T lymphocytes. Cov subtypes sib txawv ntawm T lymphocytes ua lub luag haujlwm sib txawv hauv cov lus teb inflammatory: Th1 hlwb feem ntau kho cov cellular tiv thaiv kab mob, Th2 hlwb feem ntau kho kom haum xeeb kev tiv thaiv kab mob, Th17 hlwb raug cuam tshuam nrog o thiab kab mob autoimmune, thiab Tregs hlwb pom cov tshuaj tiv thaiv kab mob. Vilon tswj qhov sib npaug ntawm cov T-lymphocytes subtypes, coj lub cev tiv thaiv kab mob mus rau kev tiv thaiv kev tiv thaiv. Txhawb kev sib txawv thiab kev ua haujlwm ntawm Tregs hlwb, inhibiting kev tiv thaiv kab mob ntau dhau thiab mob. Vilon qhov kev txhawb nqa ntawm kev humoral tiv thaiv kab mob hauv cov kab mob spleen pab lub cev tsim cov tshuaj tiv thaiv zoo dua los tshem tawm cov kab mob thiab txo qhov mob los ntawm cov kab mob. Tsis tas li ntawd, Vilon cov kev tswj xyuas cov teebmeem ntawm neutrophils thiab macrophages ncaj qha cuam tshuam rau lub cev tiv thaiv kab mob thiab kev muaj peev xwm tswj tau ntawm qhov chaw mob.
Kev cai ntawm noob caj noob ces: Vilon txoj cai ntawm cov noob qhia ntsig txog cov kab mob inflammatory thiab inflammatory mediators yog lub hauv paus tseem ceeb ntawm nws cov tshuaj tiv thaiv kab mob. Los ntawm cov tswv yim xws li RT-PCR, nws tau pom tias Vilon tuaj yeem txhawb lossis inhibit qhov mRNA qhia ntawm cov noob tshwj xeeb. Nws tuaj yeem txhawb nqa qhov kev qhia ntawm IL-1β, TNF-α, thiab iNOS mRNA, tab sis qhov kev txhawb nqa no yuav yog qhov kev tswj xyuas zoo ntawm cov lus teb inflammatory nyob rau hauv cov kab mob microenvironments tshwj xeeb. Vilon tuaj yeem cuam tshuam nrog intracellular transcription yam lossis lwm yam kev tswj hwm los cuam tshuam qhov pib, tus nqi, thiab kev txiav tawm ntawm cov noob hloov pauv. Nws kuj tseem tuaj yeem tswj cov synthesis ntawm cov kab mob ntsig txog cov protein los ntawm kev cuam tshuam mRNA stability thiab kev txhais lus zoo. Qhov kev tswj hwm ntau qib ntawm cov noob qhia no ua rau Vilon ua lub luag haujlwm ntawm ntau theem ntawm cov lus teb inflammatory, tswj kev sib npaug inflammatory.
Xaus
Raws li ib tug anti-inflammatory tshuaj, Vilon yog zoo rau kev kho mob ntawm inflammatory kab mob.
Qhov chaw
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[2] Kronborg TM, Ytting H, Hobolth L, et al. Novel Anti-inflammatory Treatments in Cirrhosis. Kev Kawm Ntawv Raws Li Kev Kawm [J]. Frontiers in Medicine, 2021,8:718896.DOI:10.3389/fmed.2021.718896.
[3] Kuznik BI, Isakova NV, Kliuchereva NN, et al. [Kev cuam tshuam ntawm vilon ntawm kev tiv thaiv kab mob thiab coagulation hemostasis hauv cov neeg mob uas muaj hnub nyoog sib txawv nrog ntshav qab zib mellitus].[J]. Advances in Gerontology = Uspekhi Gerontologii, 2007,20 2:106-115.
[4] Bi K, Nv I, Nn K, et al. Kev cuam tshuam ntawm vilon ntawm kev tiv thaiv kab mob thiab coagulation hemostasis hauv cov neeg mob ntawm cov hnub nyoog sib txawv nrog ntshav qab zib mellitus [J]. Advances in Gerontology, 2007, 20:106. https://api.semanticscholar.org/CorpusID:221168647.
Cov khoom muaj rau kev tshawb fawb siv nkaus xwb:
