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▎ HMG ka sigicogo
Sɔrɔyɔrɔ: PubChem |
Formula molekilɛri: C 9H 18O Molecules girinya: 142,24 g/mol CAS nimɔrɔ: 61489-71-2 PubChem ka CID: 21888462. Bamako, Mali Kɔrɔɲɔgɔnmaw: Adamaden ka kalolabɔ la Gonadotrophin;6,6-dimethylheptanal;Menotrophin;Menotropin |
▎ HMG Sɛgɛsɛgɛli
HMG ka ɲininiw kɛcogo ye mun ye?
Bangekɔlɔsi fɛɛrɛw yiriwali
San kɛmɛ 19nan laban na ani san kɛmɛ 20nan daminɛ na, dɔnnikɛlaw y’a dɔn dɔɔnin dɔɔnin ko endocrine system jɔyɔrɔ ka bon hadamaden farikolo baarakɛcogo ɲɛnabɔli la. Bangekɔlɔsi fɛɛrɛw sɛgɛsɛgɛli kuncɛlen fɛ, mɔgɔw y’a daminɛ k’a faamu ko gonadotropin minnu bɛ bɔ pituitaire gland fɛ, olu jɔyɔrɔ ka bon kosɛbɛ labɛnni na kɔnɔbaraw ni bangekɔlɔsi baarakɛcogo yiriwali la. O ye hakilinata jusigilan sigi HMG sɔrɔli n’a ɲinini kɔfɛ.
HMG ka sɔrɔli
San 1930 waatiw la, ɲininikɛlaw y’a ye ko fɛn dɔ bɛ musow ka sugunɛ na min bɛ se ka ɲɛgɛnɛsiraw yiriwali sabati. O waati la, biyoassays fɛ, a kɔlɔsira ko musow ka sugunɛ pikiri kɛli baganw na minnu bɛ kɛ k’a lajɛ, o bɛ se ka fɛn caman Changer baganw ka ɲɛgɛnɛsiraw la. O sɔrɔli in ye ɲinini daminɛ gonadotropin fɛnw kan minnu bɛ musow ka sugunɛ na minnu bɛ musoya dabila kɔfɛ.
San caman ɲinini kɔfɛ ani saniya fɛɛrɛw yiriwali kɔfɛ, san 1950 waatiw de la, dɔnnikɛlaw ye se ka o fɛn in bɔ musow ka sugunɛ na minnu bɛ kalolabɔ kɔfɛ, k’a tɔgɔ da ko Human Menopausal Gonadotropin (HMG).
HMG ka sɔrɔyɔrɔ
HMG bɛ sɔrɔ kosɛbɛ musow ka sugunɛ na minnu bɛ kalolabɔ kɔfɛ. Musow ka kalolabɔ kɔfɛ, musow ka kɔnɔbara baara bɛ dɔgɔya, ani ɔrimɔni bɔli bɛ dɔgɔya. Kɔnɔnafili jugu minnu bɛ sɔrɔ hipotalamus-pituitaire axis la, o bɛ fanga dɔgɔya, o bɛ na ni gonadotropins bɔli caya ye pituitaire gland fɛ, i n’a fɔ Follicle-Stimulating Hormone (FSH) ani Luteinizing Hormone (LH). O ɔrimɔni ninnu bɛ bɔ sugunɛ na sugunɛ fɛ. O la, HMG bɛ se ka bɔ ka saniya musow ka sugunɛ na minnu bɛ kalolabɔ kɔfɛ.
Sɛgɛsɛgɛli kuncɛlen min bɛ ɲɛminɛ kɛnɛyaso magow fɛ
HMG faamuyali juguyalen kɔfɛ, a kɛcogo nafa bɔra kɛnɛyaso la dɔɔni dɔɔni. O waati la, bangekɔlɔsi gɛlɛya caman tun bɛ yen minnu bɛ sɔrɔ jolidɛsɛ fɛ dɔgɔtɔrɔso la, i n’a fɔ muso ka kɔnɔbara basigilen ani cɛw ka kɔnɔbara basigilen. HMG bɔli ye furakɛli fɛɛrɛ kura di o bana ninnu ma.
HMG ka baarakɛcogo ye mun ye?
Folikili yiriwali lawulili:
Folikiliw ka bonya sabatili:
HMG kɔnɔ, Follicules-Stimulateur Hormone (FSH) ani Luteinizing Hormone (LH) yɔrɔw bɛ sɔrɔ. FSH jɔyɔrɔ ka bon foli daminɛ na. A bɛ se ka kɔnɔbara basigilen fɔlɔw lawuli walasa u ka bonya ka kɛ ɲɛgɛnɛsira fɔlɔw ye, ka taa a fɛ ka kɛ ɲɛgɛnɛsira filananw ye ani ɲɛgɛnɛsira kɔgɔlenw. Ni FSH sirilen don fɛn minɛbagaw la minnu bɛ ɲɛgɛnɛsiraw ka granulosa selilɛriw kan, o bɛ selilu kɔnɔ taamasiɲɛw sira baara, ka seliluw caya ni u danfara sabati, ani ka dɔ fara ɔrimɔni sɔrɔli kan ɲɛgɛnɛsiraw kɔnɔ. Ositorojɛni bɔli fana bɛ FSH minɛbagaw jirali sabati, o bɛ kɛ sababu ye ka jaabi ɲuman di min bɛ folikɛlanw bonya ni u yiriwali sabati ka taa a fɛ [1] ..
Folikiliw ka bonya balansi labɛnni:
LH jɔyɔrɔ ka bon folikɔli yiriwali kɔfɛ. A bɛ siri fɛnw na minnu bɛ folikisɛw ka theca cellules kan ani ka andorogènes (androgènes) sɔrɔli lawuli. Andorojɛniw bɛ wuli ka kɛ ɔrimɔni ye granulose selilɛriw kɔnɔ, o bɛ dɔ fara folikiw ka bonya ni u kɔgɔli kan. LH yɔrɔ min bɛ HMG kɔnɔ, o bɛ se ka FSH ni LH hakɛ labɛn, ka folikɛlanw falenni balansi mara, ani ka a yɛrɛ tanga wuli kojugu walima lawulili dafalen ma [1] ..
Ovulation (Ovulation (Ovulation) bila mɔgɔ la):
Ovulation (Ovulation) taabolo daminɛni:
Ni folikɛlanw kɔgɔra, LH yɔrɔ min bɛ HMG kɔnɔ, o bɛ se ka kɔnɔbara basigilen daminɛ. LH kuncɛlen bɛna kɛ sababu ye ka kɔnɔbara kogo kari ani ka kɔnɔ kɔgɔlenw bɔ. O waati kelen na, LH bɛ se ka kɛ sababu ye fana ka ɲɛgɛnɛsiralabanaw (corpus luteum sɔrɔli sabati, o min bɛ porojɛsitɛri bɔ, o bɛ sigida bɛnnen di kɔnɔbara falen doncogo ma ani den ka yiriwali joona) .
Endocrine System (Endocrine System) labɛnni:
Aw bɛ nɔ bila ɔrimɔni hakɛ la:
HMG bɛ nɔ bila ɔrimɔni hakɛ la musow farikolo la, a kɛtɔ ka kɔnɔbara baara ɲɛnabɔ. A bɛ se ka dɔ fara ɔrimɔni, porojɛsitɛri ani andorojɛni bɔli kan, wa o ɔrimɔni ninnu jɔyɔrɔ ka bon ka ɲɛsin musow ka bangekɔlɔsi fɛɛrɛw ma, u kolo, dusukun ni jolisiraw, a ɲɔgɔnnaw Misali la, ɔrimɔni bɛ se ka musow ka bangekɔlɔsi fɛɛrɛw baara sabati, ka kɔnɔbara basigilen bonya ani k’a dilan, ani ka koloci bali porojɛsitɛri bɛ se ka kɔnɔmaya sabati ani ka kalolabɔ kɛcogo ɲɛnabɔ, a ɲɔgɔnnaw [1] ..
Jaabiw labɛnni fɛɛrɛ:
HMG ka endocrine system (banakisɛfagalanw) labɛnni fana bɛ tali kɛ feedback (fɔlikan) labɛnni fɛɛrɛ dɔ la. Ni ɔrimɔni hakɛ cayara farikolo la, hipotalamus ni pituitaire gland bɛna bali ka Gonadotropin-Releasing Hormone (GnRH), FSH ani LH bɔli kɛ ni jaabi jugu ye, o la, ɔrimɔni bɔli hakɛ bɛ labɛn ani ka endocrine system balansi mara.
Hormones pikiri ni estrus detection waati hakɛ sɛgɛsɛgɛli kuluw kɔnɔ.
Soso:PubMed [3] Ɲɛjirali dɔw.
HMG baarakɛcogo ye mun ye?
1. Muso ka bangebaliya min bɛ tali kɛ idiopathique Hypogonadotropic Hypogonadism (IHH) la .
HMG bɛ se ka kɛ ka muso ka bangekɔlɔsi furakɛ min bɛ sɔrɔ IHH fɛ. Ni HMG ye FSH ni LH di, a bɛ se ka kɛ sababu ye ka kɔnɔbara falenni ni kɔnɔbara bɔ, o la, a bɛ banabagatɔw dɛmɛ ka kɔnɔta walima kɔnɔmaya sɔrɔ u yɛrɛ la, bangekɔlɔsi fɛɛrɛ dɛmɛnanw fɛ. Banabagatɔ minnu tɛ HMG tata hakɛ kɔrɔtalen jaabi ka ɲɛ, HMG tata hakɛ caman tali walima a faralen ɲɔgɔn kan ni fura wɛrɛw ye (i n’a fɔ letrozole) bɛ se ka jateminɛ ka foli jaabi ɲɛ.
2. Furakɛli min bɛ kɛ ni kɔnɔbara basigilen dɔgɔyalen ye (DOR) .
Muso minnu ka kɔnɔbara basigilen dɔgɔyara, HMG bɛ se ka foli yiriwali lawuli ni FSH hakɛ caman di u ma, o bɛ dɔ fara kɔnɔta hakɛ kan.
3. Ovari hyperstimulation Syndrome (OHSS) kunbɛnni ni a furakɛcogo .
Bangekɔlɔsi fɛɛrɛ dɛmɛnanw na, HMG tali ka kan ka kɛ ni hakilijagabɔ ye walasa ka a yɛrɛ tanga Ovarian Hyperstimulation Syndrome (OHSS) sɔrɔli ma. Ni aw ye a tata hakɛ ladilan ani ka folikɛcogo kɔlɔsi, OHSS farati bɛ se ka dɔgɔya kosɛbɛ.
4. Cɛw ka bangebaliya furakɛli
HMG kɔnɔ, farikolojɔli dumuni (FSH) ani Luteinizing Hormone (LH) bɛ sɔrɔ. A bɛ FSH jɔyɔrɔ min di, o bɛ se ka cɛya tubuw falenni ni u yiriwali lawuli cɛya la ani ka cɛya sɔrɔcogo sabati. FSH bɛ baara kɛ Sertoli selilɛriw kan cɛya la, ka Sertoli selilɛriw bila ka andorojɛni sirili farikolojɔli dumuniw bɔ, ka dɔ fara andorojɛni hakɛ kan cɛya la, ani ka sigida bɛnnen di cɛya sɔrɔli ma. Adamaden ka Gonadotropin (HCG) bɛ LH jɔyɔrɔ ladege ani ka Leydig selilɛriw lawuli cɛya la walasa ka tetarasikilini bɔ. Testosterone ye cɛnimusoya hormones nafama dɔ ye cɛw la, wa a jɔyɔrɔ ka bon cɛw ka cɛnimusoya kɛcogo filananw ni cɛya baara sabatili la. Testosterone hakɛ caman bɛ se ka kɛ sababu ye ka cɛya kɔgɔ ani ka a bɔli sabati. HMG ni Human Chorionic Gonadotropin (HCG) tali faralen ɲɔgɔn kan, o bɛ se ka FSH ni LH nɔw ladege farikolo la ani ka cɛya sɔrɔcogo sabati ɲɔgɔn fɛ. Nin furakɛlicogo faralen ɲɔgɔn kan, o bɛ se ka dɔ fara cɛya ni musoya hormones hakɛ kan cɛya la, ka cɛya sɔrɔyɔrɔ ɲɛ, ka dɔ fara cɛya hakɛ ni a jogo kan.
5. Baarakɛcogo minnu bɛ kɛ bangeko dɛmɛnanw na
Superovulation (Superovulation) sabatili:
Kalan dɔw y’a jira ko sagaw ka superovulation protocole kɔnɔ, ka HMG pikiri siɲɛ kelen tile kɔnɔ ani ka Follicle-Stimulating Hormone (FSH) pikiri kɛ siɲɛ fila tile kɔnɔ tile naani kɔnɔ, o bɛ se ka superovulation jaabiw ni denw cili jaabiw lase minnu bɛ se ka suma ma ɲɔgɔn O kɔrɔ ye ko HMG bɛ se ka FSH bila a nɔ na ani ka pikiri hakɛ dɔgɔya, o bɛ kɛ sababu ye ka sugandili kɛ baganw ka superovulation protocole la.
Adamadenw dɛmɛni fɛɛrɛw la, HMG fana bɛ kɛ ka caya walasa ka kɔnɔbara basigilenw bɔli sabati. Ni a bɛ kɔnɔbara basigilenw falenni lawuli, o bɛ dɔ fara kɔnɔbara kɔgɔlenw hakɛ kan ani ka kɔnɔta cogoya ɲɛ.
Ka Estrus bila mɔgɔ la:
Awassi sagaw la, ni HMG kɛra ka kɔnɔmaya daminɛ, o bɛ kɔnɔmaya hakɛ ni kɔnɔmaya hakɛ caman jira ni i ye a suma ni Pregnant Mare Serum Gonadotropin (PMSG) ye [3] . Kɛrɛnkɛrɛnnenya la, kɔnɔmaya jaabi kɛmɛsarada la HMG furakɛli kulu la, o ye 85% ye (17/20), ani kɔnɔmaya hakɛ ye 85% ye (17/20). O b’a jira ko HMG ka ɲɛtaa hakɛ ka bon sagaw ka estrus synchronisation porogaramu la.
HMG ye gonadotropin jɔnjɔn ye min bɛ kɛ ka caya cɛw ka bangekɔlɔsi furakɛli la, muso ka bangekɔlɔsi suguya kɛrɛnkɛrɛnnenw furakɛli la, ani bangekɔlɔsi fɛɛrɛ dɛmɛnanw na. A ka baara koloma bɛ bɔ kɛnɛma folikɛlan (FSH) ni Luteinizing Hormone (LH) farali la walasa ka ɔrimɔni balansi sabati farikolo la, o la, a bɛ folikɛlanw yiriwali, kɔnɔbara bɔli ani cɛya bɔli sabati. O fɛɛrɛ in bɛ dɛmɛ don ka bangekɔlɔsi fɛɛrɛw labɛn ni hadamaden farikolo ka ɔrimɔni sigida ladege ye, kɛrɛnkɛrɛnnenya la, a jɔyɔrɔ ka bon bangekɔlɔsi fɛɛrɛ dɛmɛnanw na.
A sɛbɛnbaga ko la
Fɛn minnu kofɔlen dòn san fɛ, olu bɛɛ ɲinini Kɛra, k’u Labɛn ani k’u Lajɛ Cocer Peptides fɛ.
Dɔnniya gafe sɛbɛnbaga
Zhang J ye ɲininikɛla ye min ni Hebei sɛnɛko Iniwɛrisite bɛ ɲɔgɔn fɛ. A ka baara ɲɛsinnen bɛ baganmara dɔnniyaw ma, sɛnɛko, bangeko dɔnniya, Biochimie & Molecular Biology, ani Genetics & Heredity. A ye dɛmɛba Kɛ o baara ninnu na a ka ɲininiw ni kàlanko baaraw fɛ. Zhang J tɔgɔ sɛbɛnnen bɛ citation [1] ka ɲɛfɔli kɔnɔ.
