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1kits （10Ibikoresho）
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HMGStructure Imiterere ya
Inkomoko: PubChem |
Inzira ya molekulari: C 9H 18O. Uburemere bwa molekuline: 142.24 g / mol Numero ya CAS: 61489-71-2 PubChem CID: 21888462 Synonyme: Menopausal Yumuntu Gonadotrophine ； 6,6-dimethylheptanal ； Menotrophine ； Menotropine |
Research Ubushakashatsi bwa HMG
Ni ubuhe bushakashatsi bwakozwe na HMG?
Iterambere ryimyororokere yambere ya Endocrine
Mu mpera z'ikinyejana cya 19 no mu ntangiriro z'ikinyejana cya 20, abahanga mu bya siyansi bamenye buhoro buhoro uruhare rukomeye rwa sisitemu ya endocrine mu kugenzura imikorere ya muntu. Hamwe n'ubushakashatsi bwimbitse bwimyororokere yimyororokere, abantu batangiye kumva ko gonadotropine isohorwa na glande ya pitoito igira uruhare runini mugutegeka iterambere rya gonad n'imikorere yimyororokere. Ibi byashyizeho urufatiro rwibanze rwo kuvumbura no gukora ubushakashatsi kuri HMG.
Ubuvumbuzi bwa HMG
Mu myaka ya za 1930, abashakashatsi basanze inkari z'abagore batangiye gucura zirimo ibintu bishobora guteza imbere iterambere rya gonado. Muri icyo gihe, binyuze muri bioassay, byagaragaye ko gutera inkari z’abagore nyuma yo gucura mu nyamaswa zigeragezwa bishobora gutera impinduka muri gonado y’inyamaswa. Ubu buvumbuzi bwatangije ubushakashatsi ku bintu bya gonadotropine mu nkari z'abagore batangiye gucura.
Nyuma y’imyaka myinshi y’ubushakashatsi no guteza imbere tekinike yo kweza, ni bwo mu myaka ya za 1950 ari bwo abahanga mu bya siyansi batandukanije ibintu n’ibikorwa bya gonadotropine bivuye mu nkari z’abagore batangiye gucura maze babyita Umuntu Menopausal Gonadotropin (HMG).
Inkomoko ya HMG
HMG ikomoka ahanini ku nkari z'abagore batangiye gucura. Nyuma yo gucura, imikorere yintanga yumugore iragabanuka, kandi imisemburo ya estrogene iragabanuka. Ingaruka mbi zo gutanga ibitekerezo kuri hypothalamus-pitoitar axis iracogora, bigatuma habaho kwiyongera kw'isohoka rya gonadotropine na glande ya pitoito, harimo na Follicle-Stimulating Hormone (FSH) na Luteinizing Hormone (LH). Iyi misemburo isohoka mu nkari binyuze mu mpyiko. Kubwibyo, HMG irashobora gukurwa no kwezwa muminkari yabagore batangiye gucura.
Ubushakashatsi bwimbitse butwarwa nubuvuzi bukenewe
Hamwe no kurushaho gusobanukirwa HMG, agaciro kayo kavuriro kagaragaye buhoro buhoro. Muri kiriya gihe, hari ibibazo byinshi byimyororokere byatewe na hypogonadism mubikorwa byubuvuzi, nk'indwara ya ovulation y'abagore na hypogonadotropic hypogonadism. Kugaragara kwa HMG byatanze uburyo bushya bwo kuvura izo ndwara.
Ni ubuhe buryo bwo gukora bwa HMG?
Gukangurira Iterambere rya Follicular:
Guteza Imbere Gukura:
HMG ikubiyemo imisemburo ya Follicle-Stimulating Hormone (FSH) hamwe na Luteinizing Hormone (LH). FSH igira uruhare runini mugihe cyambere cyo gukura. Irashobora gukangura udusimba twibanze muri ovary kugirango ikure mumyanya y'ibanze, kandi irusheho gutera imbere mumyanya ndangagitsina no gukura. Muguhuza reseptors kuri selile granulosa ya selile, FSH ikora inzira yerekana ibimenyetso byerekana inzira, igatera ikwirakwizwa ry'uturemangingo no gutandukana, kandi ikongera synthesis ya estrogene mumitsi. Ururenda rwa estrogene, na rwo, ruteza imbere imvugo ya reseptor ya FSH, rukora uburyo bwiza bwo gutanga ibitekerezo buteza imbere imikurire niterambere ryimitsi [1].
Kugena impirimbanyi zo gukura kwa Follicular:
LH igira uruhare runini mugice cyanyuma cyiterambere. Ihuza ibyakirwa kuri selile ya selile ya folicles kandi igatera synthesis ya androgene. Andorogene ihindurwamo estrogene mu ngirabuzimafatizo za granulosa, bikomeza guteza imbere gukura no gukura kw'imitsi. Ibigize LH muri HMG birashobora kugena igipimo cya FSH na LH, kugumana uburinganire bwimikurire yimitsi, no kwirinda gukabya gukabije cyangwa kudahagije [1].
Gutera Intanga:
Gukurura intanga ngore:
Iyo umusemburo ukuze, igice cya LH muri HMG gishobora gutera intanga ngore. Impinga ya LH izatera gucikamo urukuta rw'imitsi no kurekura amagi akuze. Muri icyo gihe, LH irashobora kandi guteza imbere ishingwa rya corpus luteum, isohora progesterone, igatanga ibidukikije bikwiye byo gutera amagi yatewe no gukura hakiri kare urusoro [1].
Kugenga Sisitemu ya Endocrine:
Ingaruka Urwego rwa Hormone:
HMG igira ingaruka ku misemburo mu mibiri y'abagore igenga imikorere yintanga. Irashobora kongera ururenda rwa estrogene, progesterone, na androgene, kandi iyi misemburo igira uruhare runini mu kugenzura imyororokere y’abagore, amagufwa, sisitemu y’umutima, n’ibindi. progesterone irashobora gukomeza gutwita no kugenga ukwezi, nibindi [1].
Uburyo bwo kugenzura ibitekerezo:
Amabwiriza ya sisitemu ya endocrine na HMG nayo akubiyemo uburyo bwo gutanga ibitekerezo. Iyo imisemburo ya hormone mu mubiri yiyongereye, hypothalamus na glande ya pituito bizabuzwa gusohora Gonadotropin-Releasing Hormone (GnRH), FSH, na LH hakoreshejwe uburyo butari bwo bwo gutanga ibitekerezo, bityo bikagenga imisemburo ya hormone kandi bikagumana uburinganire bwa sisitemu ya endocrine [1].
Igipimo cyigihe cyo gutera imisemburo no kumenya estrus mumatsinda yize.
Inkomoko: Byatangajwe [3]
Ni ubuhe buryo bukoreshwa na HMG?
1. Ubugumba bw'umugore bujyanye na Idiopathic Hypogonadotropic Hypogonadism (IHH)
HMG irashobora gukoreshwa mukuvura ubugumba bwumugore buterwa na IHH. Mugutanga FSH na LH, HMG irashobora gutera imikurire no gutera intanga, bityo igafasha abarwayi gusama cyangwa gutwita bisanzwe hakoreshejwe ikoranabuhanga ryimyororokere. Ku barwayi batitabira neza igipimo gisanzwe cya HMG, gukoresha urugero rwinshi rwa HMG cyangwa guhuza n’ibindi biyobyabwenge (nka letrozole) bishobora gutekerezwa kunoza igisubizo cy’imitsi [2].
2. Kuvura Ovarian Reserve yagabanutse (DOR)
Ku bagore bafite intanga ngore zagabanutse, HMG irashobora gutera imbaraga mu mikurire itanga FSH nyinshi, bityo bikongerera amahirwe yo gutwita.
3. Gukumira no gucunga indwara ya Ovarian Hyperstimulation Syndrome (OHSS)
Muri tekinoroji yimyororokere ifashwa, gukoresha HMG bigomba kwitonda kugirango wirinde kubaho kwa Ovarian Hyperstimulation Syndrome (OHSS). Muguhindura igipimo no gukurikirana iterambere ryimitsi, ibyago bya OHSS birashobora kugabanuka neza.
4. Kuvura ubugumba bwumugabo
HMG irimo imisemburo ya Follicle-Stimulating Hormone (FSH) na Luteinizing Hormone (LH). Uruhare rwa FSH itanga rushobora gutera imikurire niterambere ryimyanya ndangagitsina muri testis no guteza imbere intanga ngabo. F. Chorionic Gonadotropin yumuntu (HCG) yigana uruhare rwa LH kandi ikangurira selile Leydig muri testis gusohora testosterone. Testosterone ni imwe mu misemburo ikomeye y’imibonano mpuzabitsina ku bagabo kandi igira uruhare runini mu gukomeza imiterere y’imibonano mpuzabitsina ya kabiri y’abagabo n’imikorere ya spermatogenic. Ubwinshi bwa testosterone irashobora guteza imbere gukura no kurekura intanga. Gukoresha hamwe HMG na Chorionic Gonadotropine (HCG) birashobora kwigana ingaruka kamere za FSH na LH mumubiri kandi bigatera hamwe gutera intanga ngabo. Ubu buryo bwo kuvura bushobora kongera imisemburo yimibonano mpuzabitsina muri testis, guteza imbere intanga ngabo, no kongera ubwinshi nubwiza bwintanga.
5. Porogaramu muri Tekinoroji Yimyororokere Ifashwa
Gutezimbere Superovulation:
Ubushakashatsi bumwe bwerekanye ko muri protocole ya superovulation yintama, gutera HMG inshuro imwe kumunsi no gutera inshinge za Follicle-Stimulating Hormone (FSH) kabiri kumunsi iminsi ine bishobora gutanga ibisubizo bigereranywa na superovulation hamwe nibisubizo byo kohereza urusoro [1] . Ibi bivuze ko HMG ishobora gusimbuza FSH no kugabanya umubare watewe inshinge, igatanga amahitamo ashoboka kuri protocole ya superovulation yinyamaswa.
Muri tekinoroji yimyororokere ifashwa nabantu, HMG nayo ikoreshwa cyane mugutezimbere intanga ngore. Mugukangura imikurire yintanga ngore, byongera umubare wamagi akuze kandi bikongerera amahirwe yo gutwita.
Gutera Estrus:
Mu ntama za Awassi, gukoresha HMG mu kwinjiza estrus byerekana igipimo kinini cya estrus n’igipimo cyo gutwita ugereranije na Mare Serum Gonadotropin utwite (PMSG) [3] . By'umwihariko, ijanisha rya estrus mu itsinda rya HMG rivura ni 85% (17/20), naho inda ni 85% (17/20). Ibi byerekana ko HMG ifite igipimo kinini cyo gutsinda muri gahunda yo guhuza intama za estrus.
HMG ni urufunguzo rwa gonadotropine rukoreshwa cyane mu kuvura ubugumba bw'abagabo, ubwoko bwihariye bw'ubugumba bw'umugore, hamwe n'ikoranabuhanga ry'imyororokere. Igikorwa cyacyo nyamukuru kiri mukuzuza imisemburo ya Follicle-Stimulating Hormone (FSH) na Luteinizing Hormone (LH) kugirango yubake imisemburo ya hormone mumubiri, bityo itume imikurire yimitsi, ovulation, na spermatogenez. Ubu buryo bufasha kugenzura imikorere yimyororokere yigana ibidukikije bya hormone bisanzwe byumubiri wumuntu, cyane cyane bigira uruhare runini muburyo bwimyororokere ifasha.
Ibyerekeye Umwanditsi
Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.
Umwanditsi w'ikinyamakuru
Zhang J numushakashatsi ufitanye isano na kaminuza yubuhinzi ya Hebei. Ibikorwa bye byibanze ku bumenyi bw'amatungo, ubuhinzi, ibinyabuzima byororoka, ibinyabuzima na Molecular Biologiya, na Genetika & Irage. Yatanze umusanzu ukomeye muri izi nzego binyuze mu bushakashatsi bwe n'ibikorwa by'amasomo. Zhang J yanditse murutonde rwibisobanuro [1].
