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1kits (10Vials) .
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▎ HMG ƒe Dɔwɔɖoɖo
Dzɔtsoƒe: PubChem |
Molekyulãwo ƒe Mɔfiame: C 9H 18O Molekyulãwo ƒe Kpekpeme: 142.24 g/mol CAS ƒe xexlẽdzesi: 61489-71-2 PubChem ƒe CID: 21888462 Nya siwo sɔ kple wo nɔewo: Amegbetɔ ƒe Dzinukpɔkpɔ ƒe Gonadotrophin;6,6-dimethylheptanal;Menotrophin;Menotropin |
▎ HMG Numekuku
Nukae nye HMG ƒe numekuku?
Vidzidzi Gbãtɔ ƒe Dɔlékuiwutikewo Ŋuti Nufiafia ƒe Ŋgɔyiyi
Le ƒe alafa 19 lia ƒe nuwuwu kple ƒe alafa 20 lia ƒe gɔmedzedze la, vivivi la, dzɔdzɔmeŋutinunyalawo va kpɔ akpa vevi si lãmenugbagbeviwo ƒe dɔwɔwɔ wɔna le amegbetɔ ƒe ŋutilã ƒe dɔwɔwɔ dzi kpɔkpɔ me dze sii. Esi wosrɔ̃ nu tso vidzidzi ƒe ŋutilã ƒe dɔwɔwɔ ŋu tsitotsito la, amewo va se egɔme be gonadotropin siwo ƒunukpeƒetetedɔa ɖena ɖe go wɔa akpa vevi aɖe le ɖoɖowɔwɔ me le vidzidzi ƒe dɔwɔwɔ kple vidzidzi ƒe dɔwɔwɔ me. Esiae ɖo nukpɔsusu ƒe gɔmeɖoanyi na HMG si ŋu woke ɖo kple numekuku si wowɔ emegbe.
Nusi Ŋu Woke Ðe HMG Ŋu
Le ƒe 1930-awo me la, numekulawo kpɔe be nu aɖe le nyɔnu siwo tsi dzinukpɔkpɔ megbe ƒe aɖuɖɔ me si ate ŋu ana vidzidɔa natsi. Ɣemaɣi la, to bioassays me la, wode dzesii be ne wodo nyɔnu siwo tsi dzinukpɔkpɔ megbe ƒe aɖuɖɔ ɖe lã siwo wodo kpɔ me la, ate ŋu ana tɔtrɔwo nava lãawo ƒe lãkusiwo me. Nusi ŋu woke ɖo siae dze numekuku gɔme tso gonadotropin-nu siwo le nyɔnu siwo tsi dzinukpɔkpɔ megbe ƒe aɖuɖɔ me ŋu.
Le numekuku ƒe geɖe kple dzadzɛnyenye ƒe mɔnuwo toto vɛ megbe la, ƒe 1950-awo me hafi dzɔdzɔmeŋutinunyalawo ɖe nusi ŋu gonadotropin ƒe dɔwɔwɔ le ɖe vovo tso nyɔnu siwo tsi dzinukpɔkpɔ megbe ƒe aɖuɖɔ me dzidzedzetɔe eye wotsɔ ŋkɔ nɛ be Human Menopausal Gonadotropin (HMG).
HMG ƒe Dzɔtsoƒe
Nyɔnu siwo tsi dzinu megbe ƒe aɖuɖɔ koŋue wokpɔna tso HMG me. Le dzinukpɔkpɔ megbe la, nyɔnuwo ƒe azigolo ƒe dɔwɔwɔ dzi ɖena kpɔtɔna, eye estrogen ƒe dodo dzi ɖena kpɔtɔna. Nyaŋuɖoɖo gbegblẽ ƒe ŋusẽkpɔɖeamedzi ɖe hypothalamus-pituitary axis dzi gbɔdzɔna, si wɔnɛ be gonadotropins ƒe dodo le pituitary gland me dzina ɖe edzi, siwo dometɔ aɖewoe nye Follicle-Stimulating Hormone (FSH) kple Luteinizing Hormone (LH). Wotoa ayikuwo dzi dona le lãmetsi siawo me yia aɖuɖɔ me. Eyata woate ŋu aɖe HMG le nyɔnu siwo tsi dzinukpɔkpɔ megbe ƒe aɖuɖɔ me ahakɔ eŋu.
Numekuku Deto Si Dɔdaƒe ƒe Hiahiãwo Ʋuʋu
Esi HMG gɔmesese va le goglom ɖe edzi la, asixɔxɔ si le eŋudɔwɔwɔ le dɔdamɔnu me va do vivivi. Ɣemaɣi la, vidzidzidɔléle geɖe siwo tsoa ʋuka me ʋu ƒe sisi gbɔ nɔ anyi le atikewɔƒewo, abe nyɔnuwo ƒe azigolo ƒe dɔléle kple ŋutsu ƒe ʋuka me ʋu ƒe sisi le lãme na ame ene. HMG ƒe dodo na wokpɔ dɔléle siawo dadamɔnu yeye aɖe.
Nukae nye HMG ƒe dɔwɔwɔ ƒe mɔnu?
Follicular Tsitsi ƒe Dzideƒo:
Follicular Tsitsi Dodo Ðe Ŋgɔ:
Lãmetsiŋusẽ si doa ŋusẽ lãkusi (FSH) kple Luteinizing Hormone (LH) ƒe akpa aɖewo le HMG me. FSH wɔa akpa vevi aɖe le lãkusi ƒe tsitsi ƒe gɔmedzedze. Ate ŋu aʋã lãkusi gbãtɔ siwo le azigolo me be woatsi ava zu lãkusi gbãtɔwo, eye woagatsi ɖe edzi azu lãkusi evelia kple lãkusi tsitsiwo. To FSH ƒe kadodo kple lãmenugbagbevi siwo le lãmenugbagbevi siwo nye granulosa dzi la, enaa dzesimɔ si le lãmenugbagbeviwo me la wɔa dɔ, edoa lãmenugbagbeviwo ƒe dzidziɖedzi kple vovototodedeameme ɖe ŋgɔ, eye wònaa estrogen ƒe wɔwɔme dzina ɖe edzi le lãkusiawo me. Estrogen ƒe dodo hã doa FSH xɔlawo ƒe ɖeɖefia ɖe ŋgɔ, si wɔnɛ be nyaŋuɖoɖo nyui ƒe mɔnu si gadoa lãkusiawo ƒe tsitsi kple tsitsi ɖe ŋgɔ [1] ..
Dɔlélenutsitsi ƒe Tsitsi ƒe Dadasɔ Ŋuti Ðoɖowɔwɔ:
LH wɔa akpa vevi aɖe le lãkusi ƒe tsitsi ƒe akpa si va yi me. Ebla ɖe lãmenugbagbevi siwo le lãkusiawo ƒe theca lãmenugbagbeviwo dzi ŋu eye wòdoa ŋusẽ androgens ƒe wɔwɔme. Wotrɔa androgens zua estrogen le granulosa lãmenugbagbeviwo me, si gadea lãmenugbagbeviwo ƒe tsitsi kple tsitsi ɖe ŋgɔ. LH ƒe akpa si le HMG me ate ŋu aɖɔ FSH kple LH ƒe sɔsɔme ɖo, ana lãkusi ƒe tsitsi nada asɔ, eye wòaƒo asa na ʋuʋu fũ alo esi mesɔ gbɔ o [1]..
Ovulation ƒe Ʋuʋu:
Ovulation ƒe Dɔwɔna ƒe Dzesidede:
Ne lãkusiawo tsi la, LH ƒe akpa si le HMG me ate ŋu aʋã azigoloa ƒe dodo. LH ƒe kɔkɔƒe ana azigoloa ƒe gli nagbã eye azi tsitsiwo nado. Le ɣeyiɣi ma ke me la, LH ate ŋu ado corpus luteum, si ɖea progesterone ɖe go hã ƒe wɔwɔ ɖe ŋgɔ, si ana nɔnɔme si sɔ na azi si wodzi la dede kple fugboea ƒe tsitsi kaba [1] ..
Dɔlékuiwutikewo Ŋuti Ðoɖowɔwɔ:
Lãmetsiŋusẽ ƒe Agbɔsɔsɔme Ŋusẽkpɔɖeamedzi:
HMG kpɔa ŋusẽ ɖe lãmetsiŋusẽ ƒe agbɔsɔsɔ si le nyɔnuwo ƒe ŋutilã me dzi to azigolo ƒe dɔwɔwɔ dzi kpɔkpɔ me. Ate ŋu ana estrogen, progesterone, kple androgens ƒe dodo nadzi ɖe edzi, eye lãmetsi siawo wɔa akpa vevi aɖe le nyɔnuwo ƒe vidzidziŋusẽ, ƒuwo, dzitodzitowo, kple bubuawo me. progesterone ate ŋu alé fufɔfɔ ɖe te eye wòaɖɔ dzinukpɔkpɔ ƒe ɣeyiɣi ɖo, kple bubuawo [1] ..
Nyaŋuɖoɖowo Ŋuti Ðoɖowɔwɔ ƒe Mɔnu:
HMG ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ dzi kpɔkpɔ hã lɔ nyaŋuɖoɖo ƒe ɖoɖowɔwɔ ƒe mɔnu aɖe ɖe eme. Ne lãmetsiŋusẽ ƒe agbɔsɔsɔ le ŋutilãa me dzi ɖe edzi la, woaxe mɔ na hypothalamus kple pituitary gland be woagaɖe Gonadotropin-Releasing Hormone (GnRH), FSH, kple LH o to nyaŋuɖoɖo manyomanyo ƒe mɔnu aɖe dzi, si ana lãmetsiŋusẽ ƒe agbɔsɔsɔme nasɔ eye wòana lãmenugbagbeviwo ƒe dɔwɔwɔ nada asɔ [1] ..
Ɣeyiɣi ƒe didime si wotsɔ do lãmetsiwo dodo kple estrus kpɔkpɔ le ƒuƒoƒo siwo ŋu wosrɔ̃ nu tsoe me.
Dzɔtsoƒe:PubMed [3] .
Nukae nye HMG ƒe dɔwɔwɔ?
1. Nyɔnuwo ƒe Vidzidzi Si Do Ƒome Kple Idiopathic Hypogonadotropic Hypogonadism (IHH) .
Woate ŋu azã HMG atsɔ ada nyɔnuwo ƒe vidzidzi si IHH hena vɛ. To FSH kple LH nana me la, HMG ate ŋu ana fugboewo natsi eye woaɖe fu, si ana dɔnɔwo nafɔ fu alo afɔ fu le dzɔdzɔme nu to vidzidzi mɔ̃ɖaŋununya siwo ŋu wokpena ɖo me. Le dɔnɔ siwo mewɔa nu nyuie ɖe HMG ƒe agbɔsɔsɔ si wozãna ɖaa ŋu o gome la, woate ŋu abu HMG ƒe agbɔsɔsɔ si sɔ alo atike bubuwo (abe letrozole ene) zazã atsɔ ana lãkusi ƒe dɔwɔwɔ nanyo ɖe edzi [2]..
2. Atikewɔwɔ na Diminished Ovarian Reserve (DOR) .
Le nyɔnu siwo ƒe azigolowo ƒe agbɔsɔsɔ si dzi ɖe kpɔtɔ gome la, HMG ate ŋu aʋã azigolowo ƒe tsitsi to FSH ƒe agbɔsɔsɔ si sɔ gbɔ nana me, si ana mɔnukpɔkpɔ si li be woafɔ fu nadzi ɖe edzi.
3. Mɔxexe Ðe Ovarian Hyperstimulation Syndrome (OHSS) ƒe Mɔxexe Ðe Eŋu Kple Edzikpɔkpɔ .
Le vidzidzi mɔ̃ɖaŋununya siwo kpena ɖe ame ŋu me la, ele be woaɖɔ ŋu ɖo le HMG zazã me be woaƒo asa na Ovarian Hyperstimulation Syndrome (OHSS) ƒe dzɔdzɔ. Ne wotrɔ asi le agbɔsɔsɔme si wozãna ŋu eye wolé ŋku ɖe lãkusi ƒe tsitsi ŋu la, woate ŋu aɖe OHSS ƒe afɔkua dzi akpɔtɔ nyuie.
4. Ŋutsuwo ƒe Vidzidzimakpɔmakpɔ ƒe Atikewɔwɔ
Lãmetsiŋusẽ si doa ŋusẽ ʋumenugbagbeviɣidɔ (FSH) kple lãmetsi si naa lãmetsi si woyɔna be Luteinizing Hormone (LH) le HMG me. Akpa si FSH wɔna ate ŋu aʋã seminiferous tubules siwo le vidzidɔa me ƒe tsitsi kple tsitsi eye wòado tsinyenye ƒe dzɔdzɔ ɖe ŋgɔ. FSH wɔa dɔ ɖe Sertoli lãmenugbagbevi siwo le vidzidɔ me dzi, edoa Sertoli lãmenugbagbeviwo ɖe ŋgɔ be woaɖe protein si blaa androgen, si naa androgens ƒe agbɔsɔsɔ le vidzidɔa me dzina ɖe edzi, eye wònaa nɔnɔme si sɔ na tsinyenye ƒe dzɔdzɔ. Human Chorionic Gonadotropin (HCG) srɔ̃a akpa si LH wɔna eye wòʋãa Leydig lãmenugbagbevi siwo le vidzidɔa me be woaɖe testosterone ɖa. Testosterone nye gbɔdɔdɔ ƒe lãmetsi vevitɔwo dometɔ ɖeka le ŋutsuwo me eye wòwɔa akpa vevi aɖe le ŋutsu ƒe gbɔdɔdɔ ƒe nɔnɔme evelia kple tsinyenye ƒe dɔwɔwɔ me léle ɖe asi me. Testosterone ƒe agbɔsɔsɔ si sɔ ate ŋu ana tsinyenye natsi eye wòaɖe asi le eŋu. HMG kple Human Chorionic Gonadotropin (HCG) zazã ɖekae ate ŋu asrɔ̃ dzɔdzɔmeŋusẽ si FSH kple LH wɔna le ŋutilã me eye wòado ŋutsu ƒe tsinyenye ɖe ŋgɔ le ɖekawɔwɔ me. Atikewɔwɔmɔnu sia si wotsɔ ƒo ƒui ate ŋu ana gbɔdɔdɔ ƒe lãmetsiŋusẽ ƒe agbɔsɔsɔ nadzi ɖe edzi le vidzidɔa me, ana tsinyenye ƒe nɔnɔme nanyo ɖe edzi, eye wòana tsinyenye ƒe agbɔsɔsɔ kple nyonyome nadzi ɖe edzi.
5. Dɔwɔwɔ le Vidzidzi Mɔ̃ɖaŋununya Siwo Kpena Ðe Ame Ŋu Me
Superovulation dodo ɖe ŋgɔ:
Numekuku aɖewo ɖee fia be le alẽwo ƒe azigolo ƒe ɖoɖo si wowɔna me la, HMG dodo zi ɖeka gbesiagbe kple Follicle-Stimulating Hormone (FSH) dodo zi eve gbesiagbe hena ŋkeke ene ate ŋu ana superovulation ƒe ŋuɖoɖo siwo sɔ kple fugboe ƒe asitɔtrɔ kple fugboe ƒe ʋuʋu ƒe emetsonu siwo sɔ [1] . Esia fia be HMG ate ŋu axɔ ɖe FSH teƒe eye wòaɖe atike siwo wodona na ame ƒe xexlẽme dzi akpɔtɔ, si ana tiatia si woate ŋu awɔ na lãwo ƒe superovulation protocol.
Le vidzidzi mɔ̃ɖaŋununya siwo amegbetɔ kpena ɖe ame ŋu me la, wozãa HMG hã geɖe tsɔ doa azigolo ƒe azigolo ɖe ŋgɔ. To azigolo siwo le azigolo me ƒe tsitsi dzi la, enaa azi tsitsiwo ƒe xexlẽme dzina ɖe edzi eye wònaa mɔnukpɔkpɔ si li be woafɔ fu la nyona ɖe edzi.
Estrus ƒe ʋuʋu:
Le Awassi alẽwo me la, HMG zazã hena estrus induction ɖea estrus ƒe agbɔsɔsɔ kple fufɔfɔ ƒe agbɔsɔsɔ si lolo wu fiana ne wotsɔe sɔ kple Pregnant Mare Serum Gonadotropin (PMSG) [3] . Etɔxɛe la, estrus ƒe ŋuɖoɖo ƒe alafa memamã le HMG dɔdamɔnu ƒe ƒuƒoƒoa me nye 85% (17/20), eye fufɔfɔ ƒe agbɔsɔsɔme nye 85% (17/20). Esia ɖee fia be HMG kpɔ dzidzedze gã aɖe le estrus synchronization ɖoɖoa me na alẽwo.
HMG nye gonadotropin vevi aɖe si wozãna geɖe le ŋutsuwo ƒe vidzidzi, nyɔnuwo ƒe vidzidzi ƒomevi aɖewo koŋ, kple vidzidzi mɔ̃ɖaŋununya siwo kpena ɖe ame ŋu dada me. Eƒe dɔ vevitɔe nye be wòatsɔ exogenous Follicle-Stimulating Hormone (FSH) kple Luteinizing Hormone (LH) akpe ɖe eŋu be wòagbugbɔ lãmetsiŋusẽ ƒe dadasɔ aɖo ŋutilãa me, si ana lãkusi ƒe tsitsi, azigolo ƒe dodo, kple tsinyenye ƒe dzɔdzɔ ɖe ŋgɔ. Mɔnu sia kpena ɖe ame ŋu wòɖɔa vidzidzi ƒe dɔwɔwɔ ɖo to amegbetɔ ƒe ŋutilã ƒe dzɔdzɔme lãmetsiŋusẽ ƒe nɔnɔme sɔsrɔ̃ me, vevietɔ ewɔa akpa vevi aɖe le vidzidzi ƒe mɔ̃ɖaŋununya siwo kpena ɖe ame ŋu me.
Le Agbalẽŋlɔla La Ŋu
Nusiwo míeyɔ ɖe etame la katã nye esiwo ŋu Cocer Peptides wɔ numekuku le, trɔ asi le wo ŋu eye woƒo wo nu ƒu.
Dzɔdzɔmeŋutinunya ƒe Agbalẽŋlɔla
Zhang J nye numekula si do ƒome kple Hebei Agbledede Yunivɛsiti. Eƒe dɔa ku ɖe Lãwo ƒe Dzɔdzɔmeŋutinunya, Agbledede, Vidzidzi Ŋuti Nunya, Biochemistry & Molecular Biology, kple Genetics & Heredity ŋu. Ewɔ akpa vevi aɖe le go siawo me to eƒe numekuku kple sukudɔwo me. Woŋlɔ Zhang J ŋkɔ ɖe nyayɔyɔ ƒe numekugbalẽ [1] me.
