Timosini Alfa-1 miligaramu 10

▎ Timosini Alfa-1 jɔcogo

▎ Timosini Alfa-1 Sɛgɛsɛgɛli

Timosini Alfa-1 ye mun ye?

Timosini Alfa-1 ye polipɛtidi ye min bɛ kɛ ni asidi aminiki 28 ye. A bɛ sɔrɔ a yɛrɛ la timisi la wa a jɔyɔrɔ ka bon T-cellw kɔgɔli ni u danfara la.

Thymosin Alpha-1 ka ɲininiw kɛcogo ye mun ye?

Timosini Alfa-1 ye polipɛtidi ye min bɛ baara kɛ ni fɛnɲɛnamaw ye, min bɔra timosini tilayɔrɔba 5 la ka saniya, a bɛ kɛ ni asidi aminiki 28 ye. Timi ye farikolo tangalan nafama dɔ ye, min bɛ fɛn suguya caman dilan minnu bɛ farikolo tangacogo ɲɛnabɔ, wa timosini ye o dɔ ye. Ni timi ka baarakɛcogo sɛgɛsɛgɛli kuncɛlen don, mɔgɔw y’a ye dɔɔni dɔɔni ko a kɔnɔfɛn minnu bɛ baara kɛ, olu bɛ se ka nafa sɔrɔ bana suguya caman furakɛli la.

Timosini Alfa-1 ka baara kɛcogo ye mun ye?

Banakisɛfagalanw tali: 

Timosini Alfa-1 ye fɛnɲɛnamafagalan ye min bɛ se ka farikolo tangalan suguya caman baara. A bɛ farikolo tangalanw ka baara ɲɛnabɔ kosɛbɛ ni T-cellw ka danfara ni u kɔgɔli sabatili ye (Sjogren MH, 2004; Mao L, 2023). Kɛrɛnkɛrɛnnenya la, Timosini Alfa-1 bɛ se ka nɔ bila timositɛriw la ni a bɛ u danfara lawuli walima k’u sɛmɛntiya ka kɛ T-cell baarakɛtaw ye.

Banakisɛfagalanw tali fɛɛrɛ: 

COVID-19 sɔgɔsɔgɔninjɛ furakɛli la, Thymosin Alpha-1 bɛ teliya ka kɛnɛya ka bɔ sɔgɔsɔgɔninjɛ la a ka banakisɛfagalanw fɛ. A bɛ se ka dɔ bɔ funu jaabi la, ka COVID-19 sɔgɔsɔgɔninjɛ taamasiɲɛw nɔgɔya i n’a fɔ sumaya ni sɛgɛn, ka fɛnɲɛnamafagalanw tali nɔgɔya, ka kɛnɛya teliya ka bɔ COVID-19 sɔgɔsɔgɔninjɛ la (Wang Z, 2023).

Thymalfasin bɛ tumokisɛw ka apoptose bila cogo di kansɛri furakɛli la?

Banakisɛfagalanw ka baara sabatili: 

Timalfasini ye timopepitidi dilannen ye min farikolo tangacogo ka bon. A bɛ se ka farikolo tangalanw ka fagali fanga bonya tumuw kan, o la, a bɛ tumuw ka apoptose (banakisɛfagalanw fagali) bila sen kan cogo la min tɛ ɲɛ. Misali la, tumuw ka sigida fitininw na, Timalfasin bɛ se ka T-cellw ka danfara ni u kɔgɔli sabati ani ka T-cellw ka baara caya. I n’a fɔ farikolo tangalan yɔrɔ nafama dɔ, T-cellw bɛ se ka tumuw dɔn ani ka bin u kan, ka tumuw ka apoptose (banakisɛfagalanw fagali) bila u la ni u bɛ sitotokisi fɛnw bɔ ani fɛɛrɛ wɛrɛw.

Banakisɛfagalanw ka jaabiw labɛnni: 

I n’a fɔ farikolo tangalan fangama, Timalfasin bɛ se ka farikolo tangacogo ɲɛnabɔ ani ka tumuw ka apoptose (banakisɛfagalanw fagali) bila mɔgɔ la. A bɛ se ka Th1 farikolo tangacogo ɲɛ. Th1 selilɛriw bɛ sitokiniw bɔ kosɛbɛ i n’a fɔ IFN-γ, olu bɛ se ka baara kɛ tumuw kan k’u ɲɛsin u ka apoptose ma. Ka fara o kan, Thymalfasin bɛ se fana ka farikolo tangalan wɛrɛw ka baara ɲɛnabɔ, i n’a fɔ ka NK selilɛriw ka baara caya. NK selilɛriw bɛ se ka tumuw faga k’a ɲɛsin u ma ani fana ka tumuw ka apoptose bila mɔgɔ la ni sitokiniw bɔli ye ani fɛɛrɛ wɛrɛw ^{[1] .}.

Farikolo tangacogo ɲɛnabɔli tumuw kɛlɛli waati: 

Tumu furakɛli senfɛ, banabagatɔw ka teli ka farikolo tangalanw sɔrɔ, o bɛna nɔ bila tumu furakɛli nafa la. Timalifasini bɛ se ka farikolo tangacogo ɲɛ, min bɛ sɔrɔ tumuw kɛlɛli furakɛli senfɛ, ka farikolo tangalanw seko bonya ka bin tumuw kan, ani o cogo la ka tumuw ka apoptose (banakisɛfagalanw fagali) bila mɔgɔ la. Misali la, chimiothérapie walima radiothérapie waati, banabagatɔ farikolo tangacogo bɛna tiɲɛ fo ka se hakɛ dɔ ma. Timalfasini bɛ se ka farikolo tangalanw kɛnɛyali ni u caya, ka farikolo tangalanw ka baara ɲɛ, ani ka mɔgɔfaga nɔ bonya tumuw la.

Timosini alfa 1 bɛ ni ɲɛnamaya kɛcogo caman ye.

Soso:PubMed ^{[6] Ɲɛjirali dɔw.}

Thymalfasin (Timalfasin) kɛcogo ye mun ye?

Banakisɛ minnu bɛ sɔrɔ banakisɛw fɛ: 

K’a sababu kɛ a farikolo tangacogo ye, a ka ca a la, Thymosin Alpha-1 bɛ kɛ ka banakisɛw furakɛ. Misali la, COVID-19 banaba waati la, a y’a jira ko a bɛ se ka kɛnɛyako ɲuman jira COVID-19 sɔgɔsɔgɔninjɛ furakɛli la. Sɛgɛsɛgɛliw y’a jira ko Timosini Alfa-1 bɛ se ka COVID-19 banakisɛ minnu bɛ sɔrɔ tuma caman na tangacogo ni banakisɛfagalanw tangacogo suguya caman fɛ ^farikolo , olu ka taa ɲɛ fo ka se sɔgɔsɔgɔninjɛ jugumanba ma, Kɛrɛnkɛrɛnnenya la, banabagatɔ minnu furakɛra ni Timosini Alfa-1 ye, dɔgɔtɔrɔso sigili surunyara kosɛbɛ, sɔgɔsɔgɔninjɛ taamasiɲɛw lafiyali hakɛ (i n’a fɔ sumaya ni sɛgɛn) tun ka ca kosɛbɛ ka tɛmɛ kɔrɔsili kulu ta kan, ani funu bɔli yɔrɔ min jirala CT fɛ, o fana tun ka dɔgɔ kosɛbɛ ka tɛmɛ kɔrɔsili kulu ^kan ta Ka fara o kan, Cox model analysis multivariate y’a jira ko banabagatɔ minnu ye Thymosin Alpha-1 ta ani banabagatɔ fitininw, olu ka COVID-19 antigènes jiginni jugumanba teliyalen ^kosɛbɛ don Tα1 (Thymosin Alpha-1 yɔrɔba) ye dɔ fara CD4+ T selilɛri hakɛ kan banabagatɔw la minnu ka oksizɛni fiyɛli dɛmɛni ka dɔgɔn u daminɛ na joona ka tɛmɛ furakɛlicogo kɔrɔ kan, wa a bɛ se ka jɔyɔrɔba ta dɔgɔtɔrɔso la banabagatɔw furakɛli la minnu ka jolidɛsɛ ni jolidɛsɛ bɛ sɔrɔ COVID-19 ^fɛ.

Sugunɛbilenni furakɛli: 

Timosini Alfa-1 fana bɛ nɔ dɔ bila sugunɛbilenni furakɛli la. A bɛ se ka kɛ sugunɛbilenni furakɛli kelen ye walima ni a ni interferon α-2b faralen don ɲɔgɔn kan sugunɛbilenni C furakɛli la Kɛrɛnkɛrɛnnenya la, sɛgɛsɛgɛli dɔ y’a jira ko sugunɛbilenni B furakɛli la, Timosini Alfa-1 nafa jateminɛna kɛnɛyaso sɛgɛsɛgɛli naani kɔnɔ minnu kɛra banabagatɔ 195 kan. Nin ɲinini dɔ la, banabagatɔ 17 minnu furakɛra ni Timosini Alfa-1 ye, olu 9 ye sugunɛbilenni banakisɛ (HBV) ADN bɔli sɔrɔ kalo wɔɔrɔ kɔnɔ, ni i ye o suma ni banabagatɔ 10 ye 16 la minnu furakɛra ni interferon α-2b ye ani banabagatɔ 4 ye 15 la minnu tun bɛ tariku kɔlɔsili kulu la.

Furakɛli dɛmɛnan : Timosini Alfa-1 fana bɛ kɛ ka caya kansɛri furakɛli la. Banabagatɔ minnu ka fogonfogon kansɛri tɛ se ka tigɛ (NSCLC) ani sugunɛ kansɛri, furakɛli dɛmɛnanw na, Timosini Alfa-1 bɛ se ka ɲɛnamaya hakɛ bɛɛ lajɛlen (OS) ɲɛ kosɛbɛ (Mao L, 2023). Banabagatɔ minnu ka NSCLC min tɛ se ka tigɛ, o ka jugu sigida la, Timosini Alfa-1 bɛ se ka dɔ bɔ kosɛbɛ farikolojidɛsɛ ni sɔgɔsɔgɔninjɛ la min bɛ sɔrɔ kɛnɛyaji ni chimiothérapie fɛ, wa OS bɛ ɲɛ ka taa a ^fɛ.

Tumu kɛlɛli farikolo tangacogo sabatili : 

Dalilu minnu kɛra ka kɔn kɛnɛyaso ɲɛ, olu b’a jira ko Timosini Alfa-1 bɛ se ka M2 polarize (M2 polarize) kɔsegin min bɛ sɔrɔ makɔrɔfagaw ka efɛrositɔsi fɛ, ka TLR7/SHIP1 aksidan baara, ka kansɛri furakɛli nafa bonya, ani ka tumuw kɛlɛli farikolo tangacogo sabati ni 'tumu nɛnɛma' caman cili ye ka kɛ 'tumu funteni' ye (Mao L, 2023). Ka fara o kan, Timosini Alfa-1 fana bɛ se ka mɔgɔ tanga koloci dɔgɔyali ma min bɛ sɔrɔ farikolo tangalanw fɛ (ICI) ani a bɛ se ka ICIw ka kɛnɛyako ^bonya nafa Tα1 i n’a fɔ furakɛli dɛmɛnan sugunɛ kansɛri bɔli kɔfɛ, o bɛ se ka sugunɛbilenni kansɛri fitini bɛ banabagatɔ minnu na, olu ka ɲɛnamaya ɲɛfɔcogo ɲɛ. Sɛgɛsɛgɛli dɔ la min kɛra kɔfɛ, sugunɛbilenni kansɛri fitini bɛ banabagatɔ minnu na, ni u ye sugunɛ tigɛ, olu tilalen don kulu fila ye, kulu A (resection + Tα1) ani kulu B (resection dɔrɔn). Kalo 47,0 kɔlɔsili kɔfɛ, san 1, san 3 ani san 5 kɔnɔ, banabagatɔ minnu bɛ kulu A kɔnɔ, olu ka ɲɛnamaya hakɛ bɛɛ lajɛlen ni u ka ɲɛnamaya hakɛ min tɛ segin ka kɛ, o tun ka ca ni kulu B ta ye ^..

Banakisɛfagalanw ka baarakɛcogo seginni ani boloci fanga bonya: 

Timosini Alfa-1 bɛ se ka kɛ ka farikolo tangalanw ni bana juguw furakɛ ani ka kɛ boloci jaabiw fanga bonyalan ye ^{[4, 6]} . A bɛ se ka farikolo tangacogo ɲɛnabɔ ani ka T-cell baara sabati, wa a bɛ se ka nafa sɔrɔ kɛnɛyaso la banaw la minnu farikolo tangacogo ka dɔgɔn walima minnu tɛ baara kɛ i n’a fɔ bana jugumanw ni bana basigilenw, kansɛri, ani boloci ^tɛ jaabi Kɔlɔsiliw y’a jira ko banakisɛfagalanw ka bana jugumanba la, a jirala ko Thymosin Alpha-1 bɛ farikolo tangacogo segin a cogo kɔrɔ la ani ka dɛmɛ don ka banabagatɔw ka saya hakɛ dɔgɔya ^{[4] .}.

COVID-19 banakisɛw ni gɛlɛyaw kunbɛnni banabagatɔw la minnu bɛ sugunɛbilenni kɛ : 

Banabagatɔ minnu bɛ sugunɛbana laban na (ESRD) minnu bɛ joli segin furakɛli (HD) kɛ, olu jatera ko u ka teli ka SARS-CoV2 banakisɛ sɔrɔ kɛrɛnkɛrɛnnenya la ka a sababu kɛ fɛn dɔw ye i n’a fɔ u kɔrɔbayali, bana wɛrɛw doni, fura tali, ani u ka kan ka taa diyalizi dɔgɔtɔrɔsow la tuma caman. Kalan fɔlɔw y’a jira ko Timosini Alfa-1, n’o ye kunfilanitu boloci dɛmɛnan ye, o bɛ se ka mɔgɔkɔrɔbaw (HD banabagatɔw fana sen bɛ o la) ka farikolo tangacogo ɲɛ kunfilanitu boloci la ani ka kunfilanitu banakisɛw dɔgɔya. COVID-19 bana daminɛ donw na, ɲininikɛlaw y’a jira ko ni Thymosin Alpha-1 dili HD banabagatɔw ma, o bɛ se ka dɔ bɔ COVID-19 banakisɛw sɔrɔli hakɛ n’a juguya la. San 2022 zuluyekalo tile fɔlɔ la, ESRD/HD banabagatɔ 254 minnu bɔra diyalizi yɔrɔ duuru la Kansas City, Missouri, olu tun bɛ nin sɛgɛsɛgɛli in na, banabagatɔ 194 tilalen don kulu A la (Timosini Alpha-1 miligaramu 1,6 pikiri fari jukɔrɔ siɲɛ fila dɔgɔkun kɔnɔ dɔgɔkun 8 kɔnɔ) ani kulu B (kɔlɔsili kulu, k’a sɔrɔ u ma Thymosin ta Alfa-1) ^{[7] ye.}.

Kuncɛli la, i n’a fɔ polipɛtidi min bɛ farikolo tangacogo baara kɛrɛnkɛrɛnnenw na, Timosini Alfa-1 y’a jira ko a bɛ se ka baara kɛ cogo caman na furakɛli siratigɛ la. Banakisɛfagalanw furakɛli la, a bɛ nɔba bila banaw la i n’a fɔ sugunɛbilenni ni COVID-19. A tɛ se ka bana taamasiɲɛw nɔgɔyali teliya dɔrɔn ani ka funu dɔgɔya, nka a bɛ se ka bana in ka taa ɲɛ fana ani ka banabagatɔw kɛnɛyali hakɛ ɲɛ. Tumu furakɛli siratigɛ la, a bɛ se ka tumuw ka apoptose bila sira caman fɛ, ka farikolo tangalanw ka fagali fanga bonya tumuw kan, ka farikolo tangacogo ɲɛ, ka baara ɲuman jira kansɛri suguya caman furakɛli la i n’a fɔ fogonfogon kansɛri ani sugunɛ kansɛri.

A sɛbɛnbaga ko la

Fɛn minnu kofɔlen dòn san fɛ, olu bɛɛ ɲinini Kɛra, k’u Labɛn ani k’u Lajɛ Cocer Peptides fɛ.

Dɔnniya gafe sɛbɛnbaga

Wang Z ye ɲininikɛla ye min ka kalanko dɔnniya tɛ kelen ye ani a ka jɛkafɔ dɔnniya ka bon baarada caman kɔnɔ. U ka ɲininiw ɲɛsinnen bɛ baarabolodalenw ma i n’a fɔ Ɛntɛrinɛti, spektroskɔpi, Simi, Denso, Da kɔnɔ opereli & furakɛli, ani Fiziki. Wang Z ye tɔnba ni iniwɛrisite tɔgɔba dɔw jɛ, i n’a fɔ Sinuwa Iniwɛrisite ka dɔnniyakalanso (CAS), Yunnan Iniwɛrisite, Pekin Iniwɛrisite, Hunan Sɛnɛko Iniwɛrisite, Shanghai Jiao Tong Iniwɛrisite, ani mɔgɔ caman wɛrɛw. U ka baara b’a jira ko u sinsinnen don kosɛbɛ kokuradonni ni jɛkafɔ kan, kɛrɛnkɛrɛnnenya la, yɔrɔ minnu ɲɛsinnen bɛ izini yeelenma ɲɛnayeli, furakɛli baarakɛcogo, ani fɛnw dɔnniya ɲɛtaa ma. Jɛɲɔgɔnya sababu fɛ ni baaradaw ye i n’a fɔ Jiangsu mara ɲininikɛyɔrɔ min bɛ wele ko Light Industrial Optoelectronic Engineering & Technology ani Air Force Military Medical University, Wang Z ye dɛmɛ don hakililata ɲɛtaa ni waleyali waleyali fila bɛɛ la u ka dɔnniya siratigɛ la. Wang Z tɔgɔ sɛbɛnnen bɛ citation (citation) ɲɛfɔli sɛbɛn kɔnɔ [2].

▎ Sɛbɛn minnu bɛ tali kɛ o la

[1] Sjogren M H. Thymalfasin: farikolo tangalan ye min bɛ sugunɛbana furakɛ.[J]. Gastroenterologie et hepatologie gafe, 2004,19 Suppl 6:S69-S72. DOI:10.1111/j.1440-1746.2004.03635.x. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew

[2] Wang Z, Wang C, Fei X, ani a ɲɔgɔnnaw. Timalfasin furakɛli bɛ COVID-19 sɔgɔsɔgɔninjɛ furakɛli teliya ni banakisɛfagalanw ye[J]. Sɔgɔsɔgɔninjɛ, 2023,15(1).DOI:10.1186/s41479-023-00116-6.

[3] Shehadeh F, Benitez G, Mylona E. K., ani mɔgɔ wɛrɛw. Timalfasin (Thymosin-α-1) sɛgɛsɛgɛli piloti dɔ walasa ka dɔgɔtɔrɔso banabagatɔw furakɛ minnu ka jolidɛsɛ ni farikolojidɛsɛ bɛ u la ka da Coronavirus bana 2019 banakisɛ kan[J]. Banakisɛfagalanw ka gafe, 2023,227(2):226-235.DOI:10.1093/infdis/jiac362.

[4] Mao L. Thymosin alpha 1-Aw ye a kɛcogo caman jateminɛ kokura farikolo tangalanw ni kansɛri furakɛli waati la[J]. Duniya kɔnɔ farikolo tangalanw, 2023,117.DOI:10.1016/j.intimp.2023.109952.

[5] He C, Peng W, Li C, ani a ɲɔgɔnnaw. Timalfasini, o ye furakɛli dɛmɛnan ye min bɛ layidu ta sugunɛbilenni kansɛri misɛnniw na sugunɛ tigɛlen kɔfɛ[J]. Furakɛcogo, 2017,96(16).DOI:10.1097/MD.000000000006606.

[6] Dominari A, Hathaway Iii D, Pandav K, ani a ɲɔgɔnnaw. Timosini alfa 1: Sɛbɛnw lajɛcogo bɛɛ lajɛlen.[J]. Diɲɛ kɔnɔ banakisɛfagalanw ka gafe, 2020,9(5):67-78.DOI:10.5501/wjv.v9.i5.67.

[7] Tuthill C. W., Awad A., Parrigon M., ani a ɲɔgɔnnaw. Thymalfasin (Ta1) sɛgɛsɛgɛli fɔlɔ dɔ kɛra walasa ka covid-19 banakisɛw ni banaw bali sugunɛbilenni banabagatɔw la: Laseli fɔlɔ[J]. Duniya kɔnɔ farikolo tangalanw, 2023,117.DOI:10.1016/j.intimp.2023.109950.

BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, U BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.  

Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *glasi kɔnɔ*, o kɔrɔ ye gilasi la) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.