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1 ngwa (10 Vials)
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▎ SS-31 Ọdịdị
Isi mmalite: PubChem |
Usoro: RXKF Ụdị mkpụrụ ndụ: C 32H 49N 9O5 Arọ molekụla: 639.8g/mol Nọmba CAS: 736992-21-5 PubChem CID: 11764719 Ihe atụ: Elamipretide |
▎ SS-31 Nnyocha
Kedu ihe ndabere nyocha nke SS-31?
SS-31 bụ peptide opioid sitere na pheromone peptide. Achọpụtara ya na mbụ n'oge usoro nyocha nke pheromone peptide, nke na-egosipụta mmetụta analgesic siri ike yana mmapụta mkpụrụ ndụ cell, na-eduga na njirimara nke peptide antioxidant ezubere iche nke mitochondrial SS-311. Nchọpụta nyocha ya nwekwara njikọ chiri anya na ọmụmụ gbasara ọrịa ndị metụtara arụrụ arụ mitochondrial. Dị ka 'ụlọ ike' nke cell, mitochondrial dysfunction na-ejikọta na mmalite na ọganihu nke ọrịa dị iche iche, dị ka ischemia-reperfusion mmerụ, neurodegenerative ọrịa, obi mgbawa, na muscle ịka nká, ihe niile metụtara nrụgide oxidative kpatara n'ihi oke mmepụta nke free radical. SS-31 na-ebelata nrụgide oxidative nke ọma ma na-echebe ọrụ mitochondrial.
Gịnị bụ usoro nke edinam nke SS-31?
Njirimara electrostatic na-achịkwa akpụkpọ ahụ n'elu:
SS-31 na-emekọrịta ihe na akpụkpọ ahụ mitochondrial, na-agbanwe ihe ndị electrostatic nke akpụkpọ ahụ dị n'elu ka ọ na-emetụta nkesa ion na protein ndị bụ isi na oghere akpụkpọ ahụ. Nnyocha egosiwo na SS-31 nwere ike gbanwee nkesa nke cations dị iche iche na mpaghara membrane interface, si otú ahụ belata ibu ike nke mitochondrial calcium stress na ịnọgide na-enwe nkwụsi ike nke akpụkpọ anụ mitochondrial [1,2]..
Na-emetụta nhazi nke lipid:
Nke a peptide nwere ike ịkpata mgbanwe mgbanwe na nhazi lipid. Ọ bụ ezie na ọ naghị akpaghasị nkwụsi ike nke bilayer na oke njide dị elu, ọ nwere ike na-emetụta usoro physiological metụtara mitochondrial membrane, dị ka ọrụ protein akpụkpọ anụ na mmiri mmiri, si otú ahụ na-arụ ọrụ dị mma na ọrụ mitochondrial [1,2]..
Mgbochi nzaghachi mkpali:
N'ọmụmụ ihe metụtara sepsis, SS-31 chọpụtara iji belata ihe ndị na-egbuke egbuke dị ka interleukin-6 (IL-6), interleukin-1β (IL-1β), na tumor necrosis factor -α (TNF-α), si otú ahụ na-ebelata mmebi nke nzaghachi mkpali na anụ ahụ na akụkụ ahụ [3]..
Na-ebelata nrụgide oxidative:
SS-31 nwere ike ịkwalite ọrụ nke enzymes antioxidant dị ka superoxide dismutase (SOD) na glutathione peroxidase, belata ọkwa nke ngwaahịa oxidative dị ka malondialdehyde (MDA), na ibelata mmepụta nke ụdị oxygen na-emeghachi omume (ROS), si otú ahụ na-ebelata nrụgide oxidative na-akpata mmebi nke sel na anụ ahụ na ichebe 3 nkịtị ọrụ nke mito 3. .
Na-achịkwa ike mitochondrial:
N'ime ọmụmụ banyere sepsis-metụtara encephalopathy, SS-31 nwere ike igbochi oke ịgbalite protein metụtara mitochondrial fission dị ka dynamin metụtara protein 1 (Drp1), belata oke mitochondrial fission, na-ejigide mitochondrial morphology na ọrụ nkịtị, wee si otú ahụ na-emeziwanye ọrụ ọgụgụ isi [4]. .
Ọgụgụ 1. Nchịkọta na usoro antioxidant nke Szeto-Schiller-31 (SS-31) [5].
Isi mmalite: MDPI
Gịnị bụ ọrụ na ngwa nke SS-31?
Ọrụ
Mmetụta nchebe cellular:
N'ime hydrogen peroxide (H₂O₂) na-akpata mmebi nrụgide oxidative nke mkpụrụ ndụ ARPE-19, SS-31 nwere ike ime ka ọnụọgụ ndụ ndụ dị ndụ, belata ọdịnaya ROS intracellular, na-ejigide ikike nke mitochondrial, na ọnụ ọgụgụ ọnwụ cell, na-egosipụta mmetụta nchebe dị ukwuu na mkpụrụ ndụ mebiri site na nrụgide oxidative.
Mmelite nke ọrụ akụkụ ahụ
Obi: N'ụdị anụmanụ nke myocardial ischemia-reperfusion mmerụ, pretreatment na SS-31 tupu reperfusion budata belata myocardial infarct size, na-arụ ọrụ nke ọma na-ejikọta na ịdị njọ nke myocardial ischemia; n'oge oge ischemic, SS-31 belatara mpaghara na-adịghị eruba na mpaghara myocardial hypoperfused ma mee ka ọnọdụ na ịdị njọ nke arrhythmias dịkwuo mma. Na ọrịa myocardial sepsis kpatara, SS-31 nwere ike iweghachi mmebi morphological myocardial, gbochie nzaghachi mkpali, melite ụkọ ike myocardial, na-ejigide akpụkpọ anụ mitochondrial, ma chebe obi pụọ na mmebi [3]..
Akpa ume: SS-31 nwere ike ibelata mkpali exudation na edema na akpa ume anụ ahụ, obere akpa ume histology scores, mezie mkpali ihe na oxidative nchegbu metụtara egosi, na-eme ka nnukwu nku ume mmerụ.
Ụbụrụ: Intraperitoneal injections na-aga n'ihu nke SS-31 nwere ike imeziwanye ọrụ ọgụgụ isi na ọnụọgụ ndụ na ụmụ oke, belata mbufụt hippocampal, mmepụta ROS, na hyperdivision mitochondrial. N'ime ụdị òké agadi, ọgwụgwọ SS-31 na-ebute mgbanwe na proteome microvascular nke ụbụrụ ụbụrụ, na-emetụta okwu nke protein ndị metụtara mitochondrial, ma nwee mmetụta dị mma na mgbanwe microvascular metụtara afọ na ụbụrụ [4,6]..
Ngwa
Ọrịa obi:
N'inye mmetụta nchebe ya megide myocardial ischemia-reperfusion mmerụ na sepsis-induced myocardial dysfunction, SS-31 na-ejide uru ngwa ngwa na mgbochi na ọgwụgwọ nke ọrịa obi, na-enwe ike ịmepụta dị ka onye na-ahụ maka ọgwụgwọ ọhụrụ maka ọnọdụ ndị dị ka infarction myocardial na sepsis-induced cardiomyopathy [3].
Ọrịa Pulmonary:
Maka nnukwu mmerụ ahụ nku ume nke sepsis kpatara, SS-31 nwere ike ịrụ ọrụ dị ka onye na-ahụ maka ọgwụgwọ dị irè site n'ibelata mbufụt na nrụgide oxidative, si otú ahụ meziwanye ọrụ ngụgụ na ịnye nhọrọ ọgwụgwọ ọhụrụ maka ndị ọrịa nwere nnukwu mmerụ ahụ.
Ọrịa akwara:
Na sepsis metụtara encephalopathy na ọrịa akwara afọ metụtara afọ, SS-31 egosila ikike imeziwanye ọrụ ọgụgụ isi, na-atụ aro ikike ya maka mmepe na ọgwụgwọ ọrịa akwara ozi dị ka ọrịa Alzheimer na post-sepsis cognitive impairment [4,6]..
Atherosclerosis:
N'ihi mmetụta ọgwụgwọ ya na ApoE gene-knockout atherosclerotic oke, SS-31 nwere ike itinye n'ọrụ n'ịgwọ ọrịa atherosclerotic site na ibelata nrụgide oxidative na ibelata ọganihu ọrịa.
Mmechi
Na nchịkọta, SS-31 bụ mitochondrial-ezubere iche antioxidant peptide nke na-achịkwa akpụkpọ ahụ n'elu electrostatic Njirimara, na-egbochi mbufụt, na-ebelata oxidative nrụgide, na mma mitochondrial dynamics. Ọ na-echebe akụkụ ndị dị ka obi, ngụgụ, na ụbụrụ, na-ebelata mmerụ ahụ nke ischemia-reperfusion na mmebi metụtara sepsis, na-egbu oge ịka nká cellular, ma nwee ụfọdụ mmetụta ọgwụgwọ na mgbochi na ọgwụgwọ nke ọrịa obi, akwara ozi, na ọrịa ndị ọzọ nke usoro ahụ, yana atherosclerosis.
Banyere Onye dere ya
Ihe niile a kpọtụrụ aha n'elu bụ Cocer Peptides na-enyocha, dezie ma chịkọta ya.
Onye ode akwụkwọ akụkọ sayensị
Broome, Sophie C jikọtara ya na Mahadum Katọlik nke Australia na Mahadum Auckland. Nnyocha ya gbasara ọtụtụ ọzụzụ, gụnyere Science Sport, Physiology, Nutrition & Dietetics, Biochemistry & Molecular Biology, na Neurosciences & Neurology. Ọ na-enyocha mmetụta nke mmega ahụ na arụ ọrụ anụ ahụ na ahụike, na-enyocha nzaghachi physiological na mgbanwe maka mmega ahụ. Broome na-enyochakwa mmekọrịta dị n'etiti oriri na-edozi ahụ na ahụike, yana ngwa nke biochemistry na molecular bayoloji na sayensị mgbatị ahụ. Ọrụ ya na neurosciences na neurology na-agbakwụnye na nghọta anyị banyere ọrụ nke usoro ụjọ ahụ na nsogbu ndị metụtara ya, na-enye echiche bara uru na nke bara uru na sayensị egwuregwu na nchọpụta ahụike. Broome, Sophie C ka edepụtara na ntụnye aka [5].
