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1 kits (10 Vials)
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▎ CJC1295 Babu Tsarin DAC
Source: PubChem |
Jeri: YADAXFXQSYRKVLAQLSARKLLQDXLSR Tsarin kwayoyin halitta: C 152H 252N 44O42 Nauyin Kwayoyin Halitta: 3367.9g/mol Lambar CAS: 446262-90-4 Saukewa: 91976842 |
▎ CJC1295 Babu Binciken DAC
Menene asalin bincike na CJC1295 babu DAC?
Ana amfani da hormone mai sakin hormone (GHRH) a cikin jiyya don haɓaka haɓakar haɓakar hormone girma (GH), amma yana da ƙayyadaddun ƙayyadaddun ƙayyadaddun ƙayyadaddun, wato, ɗan gajeren lokaci na aiki [1] . Wannan yana iyakance yawan aikace-aikacen asibiti na GHRH kuma yana sa masu bincike su nemi ƙarin hanyoyin da za su ɗauki lokaci mai tsawo. CJC1295 babu DAC maganin peptide ne wanda ya dogara da amino acid 30. Yana iya tayar da glandon pituitary don saki hormone girma (GH). Wannan maganin peptide ya bambanta da magungunan peptide na gargajiya. Bambancin sa ya ta'allaka ne a gaban ƙungiyar maleimide propionic acid mai amsawa, wacce zata iya haɗawa da thiols kyauta akan saman sunadaran plasma. Da zarar an ɗaure su da sunadaran plasma, lokacin aiki na CJC1295 babu DAC a cikin jini yana tsawaita sosai. Idan aka kwatanta da magungunan peptide da ba a ɗaure ba, waɗannan magungunan peptide marasa ɗaurin za a fitar da su cikin sauri daga jiki, yayin da CJC1295 daure babu DAC zai iya ci gaba da aiki a cikin jini na dogon lokaci. Wannan tsarin ɗaure yana sa CJC1295 babu DAC magani mai tasiri na musamman.
Menene tsarin aikin CJC1295 babu DAC?
Ƙarfafa glandar pituitary don saki hormone girma: Wannan magani zai iya motsa glandon pituitary don saki hormone girma (GH). Lokacin da CJC1295 babu DAC ya shiga cikin jiki, yana aiki akan glandar pituitary ta hanyar takamaiman tsari, yana haifar da ƙwayoyin pituitary don ƙara haɓakar GH. Musamman, yana iya ɗaure ga takamaiman masu karɓa akan saman sel pituitary, farawa jerin hanyoyin jigilar sigina, a ƙarshe yana haifar da haɓaka haɓakawa da sakin GH [1, 2].
Haɗewa da sunadaran plasma: CJC1295 babu DAC da ke da siffa ta musamman, wato, akwai ƙungiyar amsawa a cikin tsarinta, wanda zai iya haɗawa da thiols kyauta akan saman sunadaran plasma. Wannan ɗaurin yana ƙara tsawon lokacin da miyagun ƙwayoyi ke ci gaba da aiki a cikin jini. Idan aka kwatanta da magungunan peptide marasa ɗaure, ɗaure CJC1295 babu DAC yana da tsawon rabin rayuwa [2] . Wasu nazarin sun nuna cewa CJC-1295 ya haɗa ƙungiyar maleimide mai aiki a cikin C-terminus, yana ba shi damar haɗin gwiwa tare da sunadaran plasma kamar jini albumin. Da zarar an ɗaure, zai iya ƙarfafa samar da GH a cikin mutane fiye da kwanaki shida bayan gudanarwa ɗaya (Timms M, 2019, a).
Ƙara haɓakar haɓakar hormone girma: Bayan allurar guda ɗaya na CJC1295 babu DAC, zai haifar da haɓakar dogaro da kashi a cikin matsakaicin matsakaicin ƙwayar plasma GH. Wannan karuwa na iya ɗaukar kwanaki 6 ko fiye, tare da haɓakar kewayon 2 zuwa sau 10 [2-4] . A cikin binciken, bayan da manya masu lafiya sun sami allurar subcutaneous na CJC-1295, an sami ci gaba, karuwar dogaro da kashi a cikin matakan GH. Kimanin rabin rayuwar CJC-1295 shine 5.8 - 8.1 kwanaki (Teichman SL, 2006). A cikin berayen GHRH knockout (GHRHKO), an kuma nuna irin waɗannan kaddarorin. Gudanar da yau da kullun na CJC1295 na iya kiyaye tsarin jiki na yau da kullun da haɓaka [5].
Tasirin ɓoyayyen nau'in haɓakar insulin-kamar I: CJC1295 babu DAC kuma zai shafi haɓakar haɓakar haɓakar insulin-kamar I (IGF-I). Matsakaicin matsakaicin matsakaicin IGF-I na plasma zai karu a cikin hanyar dogara da kashi, tare da ƙara yawan adadin 1.5 zuwa sau 3, kuma tsawon lokaci shine 9 - 11 kwanaki [2-4] . Bayan gudanarwa da yawa na CJC1295 babu DAC kashi, matsakaicin matakin IGF-I ya kasance mafi girma fiye da matakin tushe har zuwa kwanaki 28 (Teichman SL, 2006). A cikin berayen GHRHKO, CJC1295 kuma ya haifar da haɓaka a cikin jimlar pituitary RNA da GH mRNA, yana nuna haɓakar ƙwayoyin ɓoye na hormone [5].
Matsalolin bacewar Plasma na CJC-1295 bayan allurar sc guda ɗaya. An nuna maƙasudin rabin rayuwar SD.
Source:PubMed [1]
Menene bambance-bambance a cikin hanyoyin magani na CJC1295 babu DAC ga marasa lafiya tare da raunin hormone girma na kungiyoyin shekaru daban-daban?
Marasa lafiya na yara: Yara suna cikin mawuyacin lokaci na girma da haɓaka, kuma hormone girma yana taka muhimmiyar rawa wajen haɓakawa da haɓaka ƙasusuwansu, tsokoki, da gabobinsu. Rashin ƙarancin hormone girma na iya haifar da matsaloli kamar jinkirin girma, ɗan gajeren tsayi, da jinkirta shekarun kashi a cikin yara.
CJC1295 babu DAC yana haɓaka haɓaka da haɓakar yara ta hanyar haɓaka glandar pituitary don ɓoye hormone girma. Zai iya ƙara yawan ɓoyewa da tsawon lokacin girma na hormone girma, da kuma haɓaka matakan girma na hormone girma da kuma insulin-like girma factor - I (IGF-I) a cikin jini [3] . IGF-I shine babban matsakanci na aikin hormone girma. Yana iya haɓaka haɓakar ƙwayoyin sel, bambance-bambance, da haɗin furotin, kuma yana da muhimmiyar rawa wajen haɓakawa da haɓaka ƙasusuwa, tsokoki, da gabobin. CJC1295 babu DAC kuma zai iya haɓaka haɓakar alamun haɓakar ƙashi kamar osteocalcin da alkaline phosphatase, wanda ke taimakawa haɓaka haɓakar ƙasusuwa. Bugu da ƙari, CJC1295 babu DAC ba shi da wani tasiri mai tasiri akan aikin thyroid kuma yana da babban matakin tsaro.
Manya marasa lafiya:
Manya marasa lafiya tare da raunin hormone girma na iya fuskantar matsaloli irin su rage yawan ƙwayar tsoka, ƙara yawan mai, rage ƙarfin jiki, ƙara haɗarin cututtukan zuciya da jijiyoyin jini, da osteoporosis. Idan aka kwatanta da yara marasa lafiya, girma da kuma ci gaban manya marasa lafiya an kammala m, da kuma mayar da hankali na jiyya shi ne a kan inganta metabolism da kuma ingancin rayuwa. Hanyar magani na CJC1295 babu DAC a cikin tsofaffi marasa lafiya shine yafi inganta ƙarfin tsoka, rage yawan kitsen mai, inganta aikin zuciya, jinkirta tsufa, da kuma hana osteoporosis ta hanyar haɓaka matakan girma da kuma IGF-I. Nazarin ya nuna cewa CJC1295 babu DAC da zai iya ƙara yawan nauyin jiki na manya marasa lafiya, rage yawan kitse na subcutaneous, inganta haɓakar insulin, da rage haɗarin cututtukan zuciya. Bugu da ƙari, CJC1295 babu DAC kuma zai iya inganta haɓaka da haɓakar ƙasusuwa, ƙara yawan kashi, da hana osteoporosis [3, 5].
Manya marasa lafiya:
Tare da karuwar shekaru, siginar hormone girma a cikin jikin mutum yana raguwa a hankali, yana haifar da matsaloli kamar raguwar ƙwayar tsoka, ƙara yawan kitsen jiki, kashi kashi, rage rigakafi. Tsofaffi marasa lafiya tare da raunin hormone girma suna da haɗarin cutar mafi girma, kuma magani ya fi wuya. Tsarin magani na CJC1295 babu DAC a cikin tsofaffi marasa lafiya yayi kama da na manya marasa lafiya, amma ana buƙatar daidaita sashi a hankali kuma ana buƙatar saka idanu mara kyau. Saboda raguwar ayyukan jiki na tsofaffi marasa lafiya da kuma raunin da ya faru na metabolize da fitar da kwayoyi, ana buƙatar rage yawan adadin miyagun ƙwayoyi don guje wa tarawar ƙwayoyi da kuma abubuwan da suka faru.
Bincike mai alaƙa
Menene sakamakon CJC1295 babu DAC?
Haɓaka siginar hormone girma:
A matsayin analogue na girma hormone-sakin hormone (GHRH), CJC1295 babu DAC iya ɗaure ga GHRH rabe a cikin na baya pituitary gland shine yake da kuma ta da kira da secretion na girma hormone ta girma hormone Kwayoyin. Hormone na girma yana da mahimmanci don haɓakar jiki da haɓakawa, metabolism, da hanyoyin gyaran nama. A wasu nazarin, bayan yin amfani da CJC1295 babu DAC, ana iya lura da karuwa a matakin girma na hormone girma a cikin jini, wanda ke taimakawa wajen bunkasa girma da gyaran kyallen takarda kamar kasusuwa da tsokoki.
Gudanar da metabolism:
Girman hormone yana taka muhimmiyar rawa wajen daidaita tsarin metabolism. CJC1295 babu DAC a kaikaice yana shafar tsarin rayuwa ta hanyar haɓaka haɓakar haɓakar hormone girma. Yana iya inganta rushewar kitse, yin amfani da kitse a matsayin tushen makamashi, wanda ke taimakawa wajen rage ajiyar kitse a cikin jiki da inganta rarraba mai. Har ila yau, yana iya haɓaka haɗin furotin, ƙara yawan adadin furotin a cikin kyallen jikin tsoka, wanda ke taimakawa wajen inganta ingancin tsoka da ƙarfi, da haɓaka ƙarfin motsa jiki da juriya na jiki. Bugu da ƙari, CJC1295 babu DAC kuma yana da wani tasiri akan metabolism na glucose, kuma yana iya ƙara haɓakar insulin, wanda ke taimakawa wajen kula da matakan glucose na jini na al'ada.
Haɓaka gyaran nama da sabuntawa:
Hormone na girma yana taka muhimmiyar rawa wajen gyarawa da sake farfado da ƙwayoyin da suka lalace. CJC1295 babu DAC yana inganta haɓakar haɓakar hormone girma, wanda hakan ke haifar da haɓakar ƙwayoyin cuta da bambance-bambance, yana hanzarta warkar da rauni, kuma yana haɓaka gyaran gyare-gyaren kyallen takarda. A wasu gwaje-gwajen dabba da nazarin asibiti, an gano cewa yana taimakawa wajen warkar da karaya, gyaran raunin tsoka, da warkar da raunukan fata, da dai sauransu, kuma yana da mahimmancin mahimmanci don inganta ƙarfin dawo da jiki da kuma dawo da aikin kyallen takarda.
Menene filayen aikace-aikacen CJC1295 babu DAC?
Jiyya na raunin hormone girma:
Ga marasa lafiya tare da raunin hormone girma, CJC-1295 Ba tare da DAC ba zai iya haifar da haɓakar haɓakar hormone girma, don haka inganta ci gaba da ci gaban jiki. Yana iya ba da sabon zaɓi na magani ga waɗancan marasa lafiya waɗanda ba su da amsa mara kyau ga jiyya na girma na al'ada [3].
Ka'idojin cututtukan metabolism:
Hormone na girma yana taka muhimmiyar rawa wajen daidaita tsarin rayuwa na jiki. CJC-1295 Ba tare da DAC ba na iya inganta juriya na insulin, daidaita tsarin metabolism na mai, da sauransu ta hanyar haɓaka haɓakar haɓakar hormone girma, kuma yana iya samun wasu yuwuwar warkewa don rikice-rikice na rayuwa kamar ciwon sukari da kiba [3].
Gyaran fata:
Hormone na girma zai iya inganta haɓakar collagen, ƙara haɓakar fata, da rage wrinkles. CJC-1295 Ba tare da DAC ba na iya cimma farfaɗowar fata ta hanyar haɓaka siginar hormone girma [6].
Inganta aikin jiki:
Tare da karuwar shekaru, ayyuka daban-daban na jiki zasu ragu a hankali. Hormone mai girma zai iya ƙara ƙarfin tsoka, haɓaka ƙasusuwa, da haɓaka rigakafi, da dai sauransu CJC-1295 Ba tare da DAC ba na iya taimakawa wajen jinkirta tsarin tsufa da inganta rayuwar tsofaffi [3].
Ƙara ƙarfin tsoka:
Hormone na girma zai iya inganta haɓakar furotin da ƙara yawan ƙwayar tsoka. Ga 'yan wasa da masu sha'awar motsa jiki, CJC-1295 Ba tare da DAC ba na iya taimakawa wajen inganta ƙarfin tsoka da jimiri [6].
Inganta farfadowar motsa jiki:
Bayan motsa jiki mai tsanani, jiki yana buƙatar lokaci don farfadowa. Hormone na girma zai iya hanzarta gyaran kyallen takarda da suka lalace kuma ya rage amsawar kumburi. CJC-1295 Ba tare da DAC ba na iya taimakawa wajen rage lokacin dawowa bayan motsa jiki da inganta aikin motsa jiki [3].
Maganin tsufa:
Tare da karuwar hankali ga tsufa, CJC1295 babu DAC kuma wasu mutane suna la'akari da su don samun damar rigakafin tsufa. Girman hormone da IGF-I suna taka muhimmiyar rawa wajen kiyaye ayyukan al'ada na jiki da gyaran nama. Saboda haka, wannan abu na iya yin tasiri a kan tsarin tsufa ta hanyar daidaita waɗannan abubuwan [3].
A matsayin analogue na hormone mai sakin hormone girma, CJC1295 babu DAC yana da tasiri mai mahimmanci. Yana iya tayar da glandon pituitary don sakin hormone girma, daidaita tsarin siginar insulin-kamar girma factor I, kuma ta haka yana rinjayar ci gaban jiki da metabolism na jiki. A cikin binciken kimiyya, yana ba da taimako mai mahimmanci don bincika tsarin aikin hormone girma kuma yana inganta ci gaban ka'idodin da suka dace. A cikin aikace-aikacen asibiti, ga marasa lafiya da ƙarancin haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓaka da haɓaka haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar ƙwayar cuta. Hakanan yana nuna yuwuwar daidaita matakan hormone da magance canjin tsufa a cikin binciken rigakafin tsufa. Gabaɗaya, yana da mahimmanci a cikin binciken kimiyya da fannonin asibiti, yana kawo sabbin damammaki don bincike mai alaƙa da cututtukan cututtukan.
Game da Marubuci
Abubuwan da aka ambata a sama duk bincike ne, gyara su kuma Cocer Peptides ne suka haɗa su.
Mawallafin Jaridar Kimiyya
Teichman SL kwararre ne mai ƙware mai ƙware da tasiri a fagagen magunguna da haɓaka magunguna. Yana da haɗin gwiwa tare da sanannun cibiyoyi da masana'antu da yawa, ciki har da Organizations Concentr Analges Inc, Teichman Drug Dev Consulting, Wroclaw Medical University, BEAT Biotherapeut Corp, Corthera Inc da haɗin gwiwar kamfanin Corthera, Chiasma, ARYx Therapeut Inc, da dai sauransu Bugu da kari, yana da alaƙa da cibiyoyin ilimi kamar asibitin Athens da Jami'ar E. zurfin baya a cikin binciken likita da aikin asibiti. Ayyukansa na ƙwararru sun haɗa da abubuwa da yawa kamar tsarin zuciya da jijiyoyin jini da ilimin zuciya, likitancin ciki na gabaɗaya da aikin gabaɗaya, injiniyanci, endocrinology da metabolism, da harhada magunguna da kantin magani, musamman tare da nasarori masu ban mamaki da gudummawar ci gaban ƙwayoyi da ilimin halittu. An jera Teichman SL a cikin ambaton ambaton [1].
