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1kits (Ebipipa 10) .
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▎ CJC1295 Tewali Nsengeka ya DAC
Ensibuko: PubChem |
Omutendera: YADAXFXQSYRKVLAQLSARKLLQDXLSR Ensengekera ya molekyu: C 152H 252N 44O42 Obuzito bwa molekyu: 3367.9g/mol Ennamba ya CAS: 446262-90-4 PubChem CID: 91976842. Enkola y’okukuuma eddagala lino |
▎ CJC1295 Tewali Kunoonyereza kwa DAC
Kiki ekiva mu kunoonyereza ku CJC1295 no DAC?
Obusimu obufulumya obusimu bw’okukula (GHRH) bukozesebwa mu bujjanjabi okutumbula okufulumya obusimu bw’okukula (GH), naye bulina ekkomo eddene, kwe kugamba, ebbanga ttono lye likola [1] . Kino kikoma ku kukozesebwa kwa GHRH mu bujjanjabi okubunye era kireetera abanoonyereza okunoonya ebirala ebimala ebbanga eddene. CJC1295 no DAC ddagala lya peptide nga lyesigamiziddwa ku amino acids 30. Kiyinza okusitula enseke z’omubiri (pituitary gland) okufulumya obusimu obukula (GH). Eddagala lino erya peptide lyawukana ku ddagala lya peptide ery’ekinnansi. Okwawukana kwayo kuli mu kubeerawo kw’ekibinja kya asidi wa maleimide propionic ekikola, ekiyinza okwesiba mu ngeri ya covalent ku thiols ez’eddembe ku ngulu kwa puloteyini za pulasima. Oluvannyuma lw’okusibibwa ku puloteyina za plasma, ekiseera ky’okukola ekya CJC1295 no DAC mu musaayi kiwanvuwa nnyo. Bw’ogeraageranya n’eddagala lya peptide eritali bisibiddwa, eddagala eryo erya peptide eritali lisibiddwa lijja kufulumizibwa mangu okuva mu mubiri, ate nga lisibiddwa CJC1295 no DAC liyinza okusigala nga likola mu musaayi okumala ebbanga eddene. Enkola eno ey’okusiba efuula CJC1295 no DAC eddagala eririna ekikolwa eky’enjawulo.
Enkola y’okukola kwa CJC1295 no DAC eri etya?
Okusitula enseke okufulumya obusimu obukula: Eddagala lino liyinza okusitula enseke okufulumya obusimu obukula (GH). CJC1295 no DAC bw’eyingira mu mubiri, ekola ku nseke y’omubiri (pituitary gland) ng’eyita mu nkola eyeetongodde, ekireetera obutoffaali bw’omubiri (pituitary cells) okwongera ku kufulumya GH. Okusingira ddala, kiyinza okwesiba ku bikwata ebitongole ku ngulu w’obutoffaali bwa pituitary, ne kitandika omuddirirwa gw’amakubo g’okukyusa obubonero, okukkakkana nga kivuddeko okweyongera mu kusengejja n’okufulumya GH [1, 2]..
Okusiba ku puloteyina za pulasima: CJC1295 tewali DAC erina ekintu eky’enjawulo, kwe kugamba, waliwo ekibinja ekikola mu nsengekera yaakyo, ekiyinza okusiba mu ngeri ya covalent ku thiols ez’eddembe ku ngulu kwa puloteyini za pulasima. Okusiba kuno kwongera nnyo ekiseera eddagala lye limala nga likola mu musaayi. Bw’ogeraageranya n’eddagala lya peptide eritali lisibiddwa, CJC1295 no DAC esibiddwa erina ekitundu ky’obulamu ekiwanvu [2] . Okunoonyereza okumu kulaga nti CJC-1295 erimu ekibinja kya maleimide ekikola ku C-terminus, ekigisobozesa okusiba mu ngeri ya covalent ku puloteyina za plasma nga serum albumin. Bw’emala okusibibwa, esobola okusitula okukola GH mu bantu okumala ennaku ezisukka mu mukaaga oluvannyuma lw’okugiwa omulundi gumu (Timms M, 2019, a).
Okwongera ku kufulumya obusimu bw’okukula: Oluvannyuma lw’okukuba empiso emu eya CJC1295 no DAC, kijja kuleeta okweyongera okusinziira ku ddoozi mu kigero kya GH ekya wakati mu plasma. Okweyongera kuno kuyinza okumala ennaku 6 oba okusingawo, nga kweyongera emirundi 2 ku 10 [2-4] . Mu kunoonyereza, oluvannyuma lw’abantu abakulu abalamu okufuna empiso ya CJC-1295 wansi w’olususu, waaliwo okweyongera okutambula obutasalako, okusinziira ku ddoozi mu miwendo gya GH. Ekitundu ky’obulamu bwa CJC-1295 ekibalirirwamu kyali kya nnaku 5.8 - 8.1 (Teichman SL, 2006). Mu mbeba za GHRH knockout (GHRHKO), eby’obugagga ebifaanagana nabyo byalagibwa. Okuweebwa CJC1295 buli lunaku kisobola okukuuma ebitonde by’omubiri ebya bulijjo n’okukula [5]..
Okukosa okufulumya ensonga y’okukula eringa insulini I: CJC1295 tewali DAC nayo ejja kukosa okufulumya ensonga y’okukula eringa insulini I (IGF-I). Ekirungo kya IGF-I mu plasma ekya wakati kijja kweyongera mu ngeri eyesigamiziddwa ku ddoozi, nga kweyongera okuva ku mirundi 1.5 okutuuka ku 3, era obudde buba ennaku 9 - 11 [2-4] . Oluvannyuma lw’okuweebwa emirundi mingi CJC1295 no DAC dose, average IGF-I level esigala waggulu okusinga ku baseline level okutuuka ku nnaku 28 (Teichman SL, 2006). Mu mbeba za GHRHKO, CJC1295 era yaleeta okweyongera mu total pituitary RNA ne GH mRNA, ekiraga okukula kw’obutoffaali obufulumya obusimu bw’okukula [5]..
Plasma disappearance curves za CJC-1295 oluvannyuma lw’okukuba empiso ya sc emu. Ebiragiddwa bye kitundu ky’obulamu bwa SD obw’ekigero.
Ensibuko:PubMed [1] .
Njawulo ki mu nkola y’obujjanjabi bwa CJC1295 no DAC eri abalwadde abalina obutaba na busimu bw’okukula mu bibinja by’emyaka egy’enjawulo?
Abalwadde b’abaana: Abaana bali mu kiseera kizibu eky’okukula n’okukula, era obusimu obukula bukola kinene nnyo mu kukula n’okukula kw’amagumba gaabwe, ebinywa n’ebitundu by’omubiri byabwe. Obutabeera na busimu bw’okukula kiyinza okuvaako obuzibu ng’okukula mpola, obuwanvu obumpi, n’okulwawo okukula kw’amagumba mu baana.
CJC1295 no DAC etumbula okukula n’enkula y’abaana nga esitula enseke okufulumya obusimu bw’okukula. Kiyinza okwongera ku bungi bw’okufulumya n’obudde bw’obusimu obukula, n’okulinnyisa emiwendo gy’obusimu obukula n’ekirungo ky’okukula ekiringa insulini - I (IGF-I) mu musaayi [3] . IGF-I ye mutabaganya omukulu mu kikolwa ky’obusimu obukula. Kisobola okutumbula okukula kw’obutoffaali, okwawukana, n’okusengejja obutoffaali, era kirina omulimu munene mu kukula n’okukula kw’amagumba, ebinywa n’ebitundu by’omubiri. CJC1295 no DAC era esobola okutumbula okweyongera kw’ebiraga enkyukakyuka y’amagumba nga osteocalcin ne alkaline phosphatase, ekiyamba okukula n’okufuuka eby’obutonde mu magumba. Okugatta ku ekyo, CJC1295 no DAC terina kye kikola ku nkola ya thyroid era erina obukuumi bwa waggulu.
Abalwadde abakulu:
Abalwadde abakulu abalina obuzibu mu busimu bw’okukula bayinza okufuna ebizibu ng’okukendeera kw’ebinywa, amasavu okweyongera, amaanyi g’omubiri okukendeera, obulabe bw’okulwala endwadde z’emisuwa n’emisuwa okweyongera, n’okusannyalala kw’amagumba. Bw’ogeraageranya n’abalwadde abato, okukula n’okukula kw’abalwadde abakulu okusinga kuwedde, era essira ly’obujjanjabi liri ku kulongoosa enkola y’enkyukakyuka y’emmere n’omutindo gw’obulamu. Enkola y’obujjanjabi bwa CJC1295 no DAC mu balwadde abakulu okusinga ya kulongoosa maanyi ga binywa, okukendeeza amasavu, okulongoosa enkola y’omutima, okulwawo okukaddiwa, n’okuziyiza obulwadde bw’amagumba nga bongera ku miwendo gy’obusimu obukula ne IGF-I. Okunoonyereza kulaga nti CJC1295 no DAC esobola okwongera ku mubiri omugonvu ogw’abalwadde abakulu, okukendeeza ku masavu agali wansi w’olususu, okulongoosa enkola ya insulini, n’okukendeeza ku bulabe bw’endwadde z’emisuwa. Okugatta ku ekyo, CJC1295 no DAC era esobola okutumbula okukula n’okuzimba amagumba, okwongera ku density y’amagumba, n’okuziyiza okuzimba amagumba [3, 5]..
Abalwadde abakadde:
Emyaka bwe gyeyongera, okufulumya obusimu bw’okukula mu mubiri gw’omuntu kukendeera mpolampola ekivaako obuzibu ng’okukendeera kw’ebinywa, amasavu okweyongera, okuzimba amagumba, n’okukendeera kw’abaserikale b’omubiri. Abalwadde abakadde abalina obuzibu bw’obusimu bw’okukula balina akabi ak’okulwala, era obujjanjabi buba buzibu nnyo. Enkola y’obujjanjabi bwa CJC1295 no DAC mu balwadde abakadde efaananako n’eyo eri mu balwadde abakulu, naye ddoozi yeetaaga okutereezebwa n’obwegendereza era ebizibu ebivaamu byetaaga okulondoolebwa. Olw’okukendeera kw’emirimu gy’omubiri gw’abalwadde abakadde n’obusobozi bw’okukyusakyusa n’okufulumya eddagala okukendeera, ddoozi y’eddagala lyetaaga okukendeezebwa okwewala okukuŋŋaanyizibwa kw’eddagala n’okubaawo kw’ebizibu ebivaamu.
Okunoonyereza okukwatagana
Biki ebiva mu CJC1295 no DAC?
Okutumbula okufulumya obusimu bw’okukula:
Nga analogue ya growth hormone-releasing hormone (GHRH), CJC1295 tewali DAC esobola kwesiba ku GHRH receptors mu anterior pituitary gland n’okusitula okusengejja n’okufulumya obusimu obukula obutoffaali bw’obusimu obukula. Obusimu bw’okukula bukulu nnyo mu kukula n’enkula y’omubiri, okukyusakyusa mu mubiri, n’enkola y’okuddaabiriza ebitundu by’omubiri. Mu kunoonyereza okumu, oluvannyuma lw’okukozesa CJC1295 no DAC, okweyongera kw’obusimu obukula mu musaayi kuyinza okulabibwa, ekiyamba okutumbula okukula n’okuddaabiriza ebitundu by’omubiri ng’amagumba n’ebinywa.
Okulungamya enkyukakyuka mu mubiri:
Obusimu bw’okukula bukola kinene mu kulungamya enkyukakyuka mu mubiri. CJC1295 no DAC mu ngeri etali butereevu ekosa enkola y’okukyusakyusa ebiriisa nga etumbula okufulumya obusimu bw’okukula. Kiyinza okutumbula okumenya amasavu, ekifuula amasavu okukozesebwa ng’ensibuko y’amaanyi, ekiyamba okukendeeza ku kutereka amasavu mu mubiri n’okulongoosa ensaasaanya y’amasavu mu mubiri. Mu kiseera kye kimu, era esobola okutumbula okukola puloteyina, okwongera okuteekebwa kwa puloteyina mu bitundu by’ebinywa, ekiyamba okutumbula omutindo n’amaanyi g’ebinywa, n’okutumbula obusobozi bw’omubiri n’okugumiikiriza. Okugatta ku ekyo, CJC1295 no DAC nayo erina akakwate akamu ku nkyukakyuka ya glucose, era eyinza okwongera ku insulin sensitivity, ekiyamba okukuuma glucose mu musaayi ogwa bulijjo.
Okutumbula okuddaabiriza n’okuzza obuggya ebitundu by’omubiri:
Obusimu obuyamba okukula bukola kinene mu kuddaabiriza n’okuzza obuggya ebitundu ebyonooneddwa. CJC1295 no DAC etumbula okufulumya obusimu bw’okukula, nga kino nakyo kisitula okukula kw’obutoffaali n’okwawukana, okwanguya ebiwundu okuwona, n’okutumbula okuddaabiriza ebitundu ebyonooneddwa. Mu kugezesa okumu ku bisolo n’okunoonyereza mu bujjanjabi, kizuuliddwa nti kiyamba mu kuwona okumenya, okuddaabiriza obuvune bw’ebinywa, n’okuwona ebiwundu by’olususu, n’ebirala, era nga kiyinza okuba n’amakulu mu kulongoosa obusobozi bw’omubiri okudda engulu n’okuzzaawo enkola y’ebitundu ebyonooneddwa.
Biki ebikola emirimu gya CJC1295 no DAC?
Obujjanjabi bw’obutaba na busimu bw’okukula:
Ku balwadde abalina obuzibu mu busimu bw’okukula, CJC-1295 Without DAC esobola okusitula okufulumya obusimu bw’okukula, bwe kityo n’etumbula okukula n’okukula kw’omubiri. Kiyinza okuwa obujjanjabi obupya eri abalwadde abo abalina okuddamu obubi ku bujjanjabi obw’ekinnansi obw’obusimu bw’okukula [3]..
Okulungamya obuzibu mu nkyukakyuka y’emmere:
Obusimu bw’okukula bukola kinene mu kulungamya enkola y’omubiri gw’omubiri. CJC-1295 Awatali DAC esobola okulongoosa obuziyiza bwa insulini, okutereeza enkyukakyuka y’amasavu, n’ebirala nga eyongera ku kufulumya obusimu obukula, era eyinza okuba n’obusobozi obumu obw’obujjanjabi eri obuzibu mu nkyukakyuka y’emmere nga sukaali n’omugejjo [3]..
Okuzza obuggya olususu:
Obusimu obuyamba okukula busobola okutumbula okukola kwa kolagini, okwongera okunyirira kw’olususu, n’okukendeeza ku nnyindo. CJC-1295 Awatali DAC eyinza okutuuka ku kuzza obuggya olususu nga esitula okufulumya obusimu bw’okukula [6]..
Okulongoosa enkola y’omubiri:
Emyaka bwe gyeyongera, emirimu egy’enjawulo egy’omubiri gijja kukendeera mpolampola. Obusimu obukula busobola okwongera amaanyi g’ebinywa, okulongoosa amagumba, n’okutumbula abaserikale b’omubiri, n’ebirala CJC-1295 Awatali DAC eyinza okuyamba okulwawo enkola y’okukaddiwa n’okutumbula omutindo gw’obulamu bw’abakadde [3]..
Okwongera ku maanyi g’ebinywa:
Obusimu bw’okukula busobola okutumbula okukola puloteyina n’okwongera ku buzito bw’ebinywa. Ku bannabyamizannyo n’abawagizi ba fitness, CJC-1295 Without DAC eyinza okuyamba okutumbula amaanyi g’ebinywa n’okugumiikiriza [6]..
Okutumbula okuddamu okukola dduyiro:
Oluvannyuma lw’okukola dduyiro ow’amaanyi, omubiri gwetaaga obudde okudda engulu. Obusimu obuyamba okukula busobola okwanguya okuddaabiriza ebitundu ebyonooneddwa n’okukendeeza ku kuzimba. CJC-1295 Awatali DAC eyinza okuyamba okukendeeza ku budde bw’okuwona oluvannyuma lw’okukola dduyiro n’okulongoosa enkola y’okukola dduyiro [3]..
Okulwanyisa okukaddiwa:
Olw’okufaayo okweyongera ku kulwanyisa okukaddiwa, CJC1295 no DAC nayo abantu abamu bagitwala ng’erina obusobozi bw’okulwanyisa okukaddiwa. Obusimu bw’okukula ne IGF-I bukola kinene mu kukuuma emirimu gya bulijjo egy’omubiri egy’omubiri n’okuddaabiriza ebitundu by’omubiri. N’olwekyo, ekintu kino kiyinza okuba n’akakwate ku nkola y’okukaddiwa nga kitereeza ensonga zino [3]..
Nga analogue y’obusimu obufulumya obusimu bw’okukula, CJC1295 no DAC erina ebikosa ebinene. Kiyinza okusitula enseke z’omubiri (pituitary gland) okufulumya obusimu obukula, okulung’amya okufulumya kw’ekirungo ekikula ekiringa insulini I, era bwe kityo ne kikosa enkula n’enkyukakyuka y’omubiri. Mu kunoonyereza kwa ssaayansi, kiwa obuyambi obukulu mu kunoonyereza ku nkola y’okukola kw’obusimu obukula era kitumbula enkulaakulana y’endowooza ezikwatagana. Mu nkola z’obujjanjabi, eri abalwadde abalina obutaba na busimu bw’okukula, kisuubirwa okusitula okufulumya obusimu bw’okukula obw’omunda n’okulongoosa enkula n’enkula n’obutabeera bulungi mu nkyukakyuka y’emmere. Era kiraga obusobozi okutereeza emiwendo gy’obusimu n’okulwanyisa enkyukakyuka mu kukaddiwa mu kunoonyereza ku kulwanyisa okukaddiwa. Okutwaliza awamu, kya makulu nnyo mu kunoonyereza kwa ssaayansi n’eby’obujjanjabi, okuleeta emikisa emipya egy’okunoonyereza okukwatagana n’okujjanjaba endwadde.
Ebikwata ku Muwandiisi
Ebintu ebyogeddwako waggulu byonna binoonyerezeddwako, birongooseddwa era ne bikung’aanyizibwa kkampuni ya Cocer Peptides.
Omuwandiisi wa Scientific Journal
Teichman SL mukugu alina obumanyirivu bungi era alina obuyinza mu by’obusawo n’okukola eddagala. Alina enkolagana ey’oku lusegere n’ebitongole n’ebitongole bingi ebimanyiddwa, omuli Organizations Concentr Analges Inc, Teichman Drug Dev Consulting, Wroclaw Medical University, BEAT Biotherapeut Corp, Corthera Inc ne kkampuni yaayo ekwatagana nayo Corthera, Chiasma, ARYx Therapeut Inc, n’ebirala Okugatta ku ekyo, era alina akakwate n’amatendekero g’ebyenjigiriza nga University of Athens Hospital ne Albert Einstein College of Eddagala, ekiraga nti alina obumanyirivu bungi mu kunoonyereza ku by’obusawo n’enkola y’obujjanjabi. Ebitundu bye eby’ekikugu bikwata ku bintu ebingi ng’enkola y’emisuwa n’emitima, eddagala ly’omunda mu bulambalamba n’enkola eya bulijjo, yinginiya, endocrinology n’enkyukakyuka y’emmere, n’eddagala n’eddagala naddala ng’akola eby’ekitalo n’okuyamba mu kukola eddagala n’obujjanjabi bw’ebiramu. Teichman SL ewandiikiddwa mu kiwandiiko ekijuliziddwa [1].
